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Protein

Centromere protein V

Gene

CENPV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ameboidal-type cell migration Source: MGI
  • cell division Source: UniProtKB-KW
  • centromere complex assembly Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • pericentric heterochromatin assembly Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of chromosome organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein V
Short name:
CENP-V
Alternative name(s):
Nuclear protein p30
Proline-rich protein 6
Gene namesi
Name:CENPV
Synonyms:PRR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29920. CENPV.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytoplasm Source: HPA
  • kinetochore Source: UniProtKB
  • microtubule cytoskeleton Source: MGI
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • spindle midzone Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi172 – 1721C → A: Abolishes chromatin hypercondensation phenotype induced by overexpression of wild-type protein; when associated with A-177. 1 Publication
Mutagenesisi174 – 1741C → A: Abolishes chromatin hypercondensation phenotype induced by overexpression of wild-type protein. 1 Publication
Mutagenesisi177 – 1771C → A: Abolishes chromatin hypercondensation phenotype induced by overexpression of wild-type protein; when associated with A-172. 1 Publication

Organism-specific databases

PharmGKBiPA164717842.

Polymorphism and mutation databases

DMDMi74750244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Centromere protein VPRO_0000244359Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei98 – 981PhosphothreonineCombined sources
Modified residuei101 – 1011PhosphothreonineCombined sources
Modified residuei103 – 1031PhosphothreonineCombined sources
Modified residuei257 – 2571PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z7K6.
MaxQBiQ7Z7K6.
PaxDbiQ7Z7K6.
PRIDEiQ7Z7K6.

PTM databases

iPTMnetiQ7Z7K6.
PhosphoSiteiQ7Z7K6.

Expressioni

Gene expression databases

BgeeiQ7Z7K6.
CleanExiHS_CENPV.
ExpressionAtlasiQ7Z7K6. baseline and differential.
GenevisibleiQ7Z7K6. HS.

Organism-specific databases

HPAiHPA042529.
HPA042616.

Interactioni

Protein-protein interaction databases

BioGridi128365. 23 interactions.
IntActiQ7Z7K6. 17 interactions.
MINTiMINT-4533675.
STRINGi9606.ENSP00000299736.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7K6.
SMRiQ7Z7K6. Positions 150-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 3614Poly-AlaAdd
BLAST
Compositional biasi59 – 10244Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Gfa family.Curated

Phylogenomic databases

eggNOGiKOG4192. Eukaryota.
COG3791. LUCA.
GeneTreeiENSGT00390000003183.
HOGENOMiHOG000090254.
InParanoidiQ7Z7K6.
OMAiGTITHVH.
OrthoDBiEOG7X3QTD.
PhylomeDBiQ7Z7K6.
TreeFamiTF313636.

Family and domain databases

Gene3Di3.90.1590.10. 1 hit.
InterProiIPR006913. GFA/CENP-V.
IPR011057. Mss4-like.
[Graphical view]
PfamiPF04828. GFA. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z7K6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRSRSSAAA KLRGQKRSGA SGASAAPAAS AAAALAPSAT RTRRSASQAG
60 70 80 90 100
SKSQAVEKPP SEKPRLRRSS PRAQEEGPGE PPPPELALLP PPPPPPPTPA
110 120 130 140 150
TPTSSASNLD LGEQRERWET FQKRQKLTSE GAAKLLLDTF EYQGLVKHTG
160 170 180 190 200
GCHCGAVRFE VWASADLHIF DCNCSICKKK QNRHFIVPAS RFKLLKGAEH
210 220 230 240 250
ITTYTFNTHK AQHTFCKRCG VQSFYTPRSN PGGFGIAPHC LDEGTVRSMV
260 270
TEEFNGSDWE KAMKEHKTIK NMSKE
Length:275
Mass (Da):29,946
Last modified:October 1, 2003 - v1
Checksum:iE9A69F1F9BA746D8
GO
Isoform 2 (identifier: Q7Z7K6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MRRSRSSAAA...SADLHIFDCN → MQVAAHNLEFALSFCS

Show »
Length:118
Mass (Da):13,415
Checksum:iD2AFAF27CE996704
GO
Isoform 3 (identifier: Q7Z7K6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-20: Missing.

Show »
Length:272
Mass (Da):29,731
Checksum:i3E3A33B9CEBFDB3E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 173173MRRSR…IFDCN → MQVAAHNLEFALSFCS in isoform 2. 1 PublicationVSP_019549Add
BLAST
Alternative sequencei18 – 203Missing in isoform 3. 2 PublicationsVSP_019550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382899 mRNA. Translation: AAR24368.1.
BC052604 mRNA. Translation: AAH52604.1.
BC137486 mRNA. Translation: AAI37487.1.
BC137487 mRNA. Translation: AAI37488.1.
AF514992 mRNA. Translation: AAM76703.1.
CCDSiCCDS32575.1. [Q7Z7K6-3]
RefSeqiNP_859067.2. NM_181716.2. [Q7Z7K6-3]
UniGeneiHs.433422.

Genome annotation databases

EnsembliENST00000299736; ENSP00000299736; ENSG00000166582. [Q7Z7K6-3]
GeneIDi201161.
KEGGihsa:201161.
UCSCiuc002gpw.4. human. [Q7Z7K6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382899 mRNA. Translation: AAR24368.1.
BC052604 mRNA. Translation: AAH52604.1.
BC137486 mRNA. Translation: AAI37487.1.
BC137487 mRNA. Translation: AAI37488.1.
AF514992 mRNA. Translation: AAM76703.1.
CCDSiCCDS32575.1. [Q7Z7K6-3]
RefSeqiNP_859067.2. NM_181716.2. [Q7Z7K6-3]
UniGeneiHs.433422.

3D structure databases

ProteinModelPortaliQ7Z7K6.
SMRiQ7Z7K6. Positions 150-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128365. 23 interactions.
IntActiQ7Z7K6. 17 interactions.
MINTiMINT-4533675.
STRINGi9606.ENSP00000299736.

PTM databases

iPTMnetiQ7Z7K6.
PhosphoSiteiQ7Z7K6.

Polymorphism and mutation databases

DMDMi74750244.

Proteomic databases

EPDiQ7Z7K6.
MaxQBiQ7Z7K6.
PaxDbiQ7Z7K6.
PRIDEiQ7Z7K6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299736; ENSP00000299736; ENSG00000166582. [Q7Z7K6-3]
GeneIDi201161.
KEGGihsa:201161.
UCSCiuc002gpw.4. human. [Q7Z7K6-1]

Organism-specific databases

CTDi201161.
GeneCardsiCENPV.
H-InvDBHIX0027142.
HGNCiHGNC:29920. CENPV.
HPAiHPA042529.
HPA042616.
MIMi608139. gene.
neXtProtiNX_Q7Z7K6.
PharmGKBiPA164717842.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4192. Eukaryota.
COG3791. LUCA.
GeneTreeiENSGT00390000003183.
HOGENOMiHOG000090254.
InParanoidiQ7Z7K6.
OMAiGTITHVH.
OrthoDBiEOG7X3QTD.
PhylomeDBiQ7Z7K6.
TreeFamiTF313636.

Miscellaneous databases

ChiTaRSiCENPV. human.
GenomeRNAii201161.
PROiQ7Z7K6.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z7K6.
CleanExiHS_CENPV.
ExpressionAtlasiQ7Z7K6. baseline and differential.
GenevisibleiQ7Z7K6. HS.

Family and domain databases

Gene3Di3.90.1590.10. 1 hit.
InterProiIPR006913. GFA/CENP-V.
IPR011057. Mss4-like.
[Graphical view]
PfamiPF04828. GFA. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel splice variant of nuclear protein p30."
    Zheng H., Xie Y., Mao Y.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Blood.
  3. "Proteomic analysis of the mammalian nuclear pore complex."
    Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
    J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-275 (ISOFORM 3), SUBCELLULAR LOCATION.
  4. "CENP-V is required for centromere organization, chromosome alignment and cytokinesis."
    Tadeu A.M.B., Ribeiro S., Johnston J., Goldberg I., Gerloff D., Earnshaw W.C.
    EMBO J. 27:2510-2522(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-172; CYS-174 AND CYS-177.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-98; THR-101 AND THR-103, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCENPV_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7K6
Secondary accession number(s): B2RPK2, Q3L8N5, Q8NFH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.