Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 467

Gene

ZNF467

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 18223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 467
Gene namesi
Name:ZNF467
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23154. ZNF467.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886769.

Polymorphism and mutation databases

BioMutaiZNF467.
DMDMi74762444.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Zinc finger protein 467PRO_0000247517Add
BLAST

Proteomic databases

PaxDbiQ7Z7K2.
PeptideAtlasiQ7Z7K2.
PRIDEiQ7Z7K2.
TopDownProteomicsiQ7Z7K2.

PTM databases

iPTMnetiQ7Z7K2.
PhosphoSiteiQ7Z7K2.

Expressioni

Gene expression databases

BgeeiENSG00000181444.
CleanExiHS_ZNF467.
ExpressionAtlasiQ7Z7K2. baseline and differential.
GenevisibleiQ7Z7K2. HS.

Organism-specific databases

HPAiHPA042907.

Interactioni

Subunit structurei

Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000304769.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7K2.
SMRiQ7Z7K2. Positions 125-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 18223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130023.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z7K2.
OMAiERSFFCP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z7K2.
TreeFamiTF326846.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRETLEALSS LGFSVGQPEM APQSEPREGS HNAQEQMSSS REERALGVCS
60 70 80 90 100
GHEAPTPEEG AHTEQAEAPC RGQACSAQKA QPVGTCPGEE WMIRKVKVED
110 120 130 140 150
EDQEAEEEVE WPQHLSLLPS PFPAPDLGHL AAAYKLEPGA PGALSGLALS
160 170 180 190 200
GWGPMPEKPY GCGECERRFR DQLTLRLHQR LHRGEGPCAC PDCGRSFTQR
210 220 230 240 250
AHMLLHQRSH RGERPFPCSE CDKRFSKKAH LTRHLRTHTG ERPYPCAECG
260 270 280 290 300
KRFSQKIHLG SHQKTHTGER PFPCTECEKR FRKKTHLIRH QRIHTGERPY
310 320 330 340 350
QCAQCARSFT HKQHLVRHQR VHQTAGPARP SPDSSASPHS TAPSPTPSFP
360 370 380 390 400
GPKPFACSDC GLSFGWKKNL ATHQCLHRSE GRPFGCDECA LGATVDAPAA
410 420 430 440 450
KPLASAPGGP GCGPGSDPVV PQRAPSGERS FFCPDCGRGF SHGQHLARHP
460 470 480 490 500
RVHTGERPFA CTQCDRRFGS RPNLVAHSRA HSGARPFACA QCGRRFSRKS
510 520 530 540 550
HLGRHQAVHT GSRPHACAVC ARSFSSKTNL VRHQAIHTGS RPFSCPQCGK
560 570 580 590
SFSRKTHLVR HQLIHGEAAH AAPDAALAAP AWSAPPEVAP PPLFF
Length:595
Mass (Da):65,124
Last modified:October 1, 2003 - v1
Checksum:i8D0C6EEE42310BF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241T → A.
Corresponds to variant rs6965332 [ dbSNP | Ensembl ].
VAR_052835

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052625 mRNA. Translation: AAH52625.1.
CCDSiCCDS5899.1.
RefSeqiNP_997219.1. NM_207336.1.
XP_005250016.1. XM_005249959.4.
XP_005250017.1. XM_005249960.4.
XP_005250018.1. XM_005249961.4.
XP_011514160.1. XM_011515858.1.
UniGeneiHs.726477.

Genome annotation databases

EnsembliENST00000302017; ENSP00000304769; ENSG00000181444.
GeneIDi168544.
KEGGihsa:168544.
UCSCiuc003wgd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052625 mRNA. Translation: AAH52625.1.
CCDSiCCDS5899.1.
RefSeqiNP_997219.1. NM_207336.1.
XP_005250016.1. XM_005249959.4.
XP_005250017.1. XM_005249960.4.
XP_005250018.1. XM_005249961.4.
XP_011514160.1. XM_011515858.1.
UniGeneiHs.726477.

3D structure databases

ProteinModelPortaliQ7Z7K2.
SMRiQ7Z7K2. Positions 125-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304769.

PTM databases

iPTMnetiQ7Z7K2.
PhosphoSiteiQ7Z7K2.

Polymorphism and mutation databases

BioMutaiZNF467.
DMDMi74762444.

Proteomic databases

PaxDbiQ7Z7K2.
PeptideAtlasiQ7Z7K2.
PRIDEiQ7Z7K2.
TopDownProteomicsiQ7Z7K2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302017; ENSP00000304769; ENSG00000181444.
GeneIDi168544.
KEGGihsa:168544.
UCSCiuc003wgd.3. human.

Organism-specific databases

CTDi168544.
GeneCardsiZNF467.
HGNCiHGNC:23154. ZNF467.
HPAiHPA042907.
MIMi614040. gene.
neXtProtiNX_Q7Z7K2.
PharmGKBiPA134886769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130023.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z7K2.
OMAiERSFFCP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z7K2.
TreeFamiTF326846.

Miscellaneous databases

GenomeRNAii168544.
PROiQ7Z7K2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181444.
CleanExiHS_ZNF467.
ExpressionAtlasiQ7Z7K2. baseline and differential.
GenevisibleiQ7Z7K2. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN467_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.