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Protein

COX assembly mitochondrial protein homolog

Gene

CMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COX assembly mitochondrial protein homolog
Short name:
Cmc1p
Gene namesi
Name:CMC1
Synonyms:C3orf68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28783. CMC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

MalaCardsiCMC1.
PharmGKBiPA162382538.

Polymorphism and mutation databases

BioMutaiCMC1.
DMDMi74738888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 106105COX assembly mitochondrial protein homologPRO_0000317185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z7K0.
MaxQBiQ7Z7K0.
PaxDbiQ7Z7K0.
PRIDEiQ7Z7K0.

PTM databases

iPTMnetiQ7Z7K0.
PhosphoSiteiQ7Z7K0.

Expressioni

Gene expression databases

BgeeiQ7Z7K0.
CleanExiHS_CMC1.
ExpressionAtlasiQ7Z7K0. baseline and differential.
GenevisibleiQ7Z7K0. HS.

Organism-specific databases

HPAiHPA043333.

Interactioni

Subunit structurei

Component of some MITRAC complex.1 Publication

Protein-protein interaction databases

IntActiQ7Z7K0. 3 interactions.
STRINGi9606.ENSP00000418348.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CMC family.Curated

Phylogenomic databases

eggNOGiKOG4624. Eukaryota.
ENOG4111YK0. LUCA.
GeneTreeiENSGT00390000018696.
HOGENOMiHOG000008534.
HOVERGENiHBG060799.
InParanoidiQ7Z7K0.
KOiK18171.
OrthoDBiEOG7S4X7Z.
PhylomeDBiQ7Z7K0.
TreeFamiTF314632.

Family and domain databases

InterProiIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamiPF08583. Cmc1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDPADQHL RHVEKDVLIP KIMREKAKER CSEQVQDFTK CCKNSGVLMV
60 70 80 90 100
VKCRKENSAL KECLTAYYND PAFYEECKME YLKEREEFRK TGIPTKKRLQ

KLPTSM
Length:106
Mass (Da):12,490
Last modified:October 1, 2003 - v1
Checksum:iCBC29CCCB76BA721
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681Missing in CAH18223 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749370 mRNA. Translation: CAH18223.1.
CH471055 Genomic DNA. Translation: EAW64390.1.
BC052644 mRNA. Translation: AAH52644.1.
CCDSiCCDS33722.1.
RefSeqiNP_872329.1. NM_182523.1.
UniGeneiHs.444724.

Genome annotation databases

EnsembliENST00000466830; ENSP00000418348; ENSG00000187118.
GeneIDi152100.
KEGGihsa:152100.
UCSCiuc003cea.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749370 mRNA. Translation: CAH18223.1.
CH471055 Genomic DNA. Translation: EAW64390.1.
BC052644 mRNA. Translation: AAH52644.1.
CCDSiCCDS33722.1.
RefSeqiNP_872329.1. NM_182523.1.
UniGeneiHs.444724.

3D structure databases

ProteinModelPortaliQ7Z7K0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z7K0. 3 interactions.
STRINGi9606.ENSP00000418348.

PTM databases

iPTMnetiQ7Z7K0.
PhosphoSiteiQ7Z7K0.

Polymorphism and mutation databases

BioMutaiCMC1.
DMDMi74738888.

Proteomic databases

EPDiQ7Z7K0.
MaxQBiQ7Z7K0.
PaxDbiQ7Z7K0.
PRIDEiQ7Z7K0.

Protocols and materials databases

DNASUi152100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466830; ENSP00000418348; ENSG00000187118.
GeneIDi152100.
KEGGihsa:152100.
UCSCiuc003cea.4. human.

Organism-specific databases

CTDi152100.
GeneCardsiCMC1.
HGNCiHGNC:28783. CMC1.
HPAiHPA043333.
MalaCardsiCMC1.
MIMi615166. gene.
neXtProtiNX_Q7Z7K0.
PharmGKBiPA162382538.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4624. Eukaryota.
ENOG4111YK0. LUCA.
GeneTreeiENSGT00390000018696.
HOGENOMiHOG000008534.
HOVERGENiHBG060799.
InParanoidiQ7Z7K0.
KOiK18171.
OrthoDBiEOG7S4X7Z.
PhylomeDBiQ7Z7K0.
TreeFamiTF314632.

Miscellaneous databases

ChiTaRSiCMC1. human.
GenomeRNAii152100.
PROiQ7Z7K0.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z7K0.
CleanExiHS_CMC1.
ExpressionAtlasiQ7Z7K0. baseline and differential.
GenevisibleiQ7Z7K0. HS.

Family and domain databases

InterProiIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamiPF08583. Cmc1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. "Cmc1p is a conserved mitochondrial twin CX(9)C protein involved in cytochrome c oxidase biogenesis."
    Horn D., Al-Ali H., Barrientos A.
    Mol. Cell. Biol. 28:4354-4364(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation."
    Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P.
    Cell 151:1528-1541(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SOME MITRAC COMPLEX.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOXM1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7K0
Secondary accession number(s): Q68DJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.