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Protein

COX assembly mitochondrial protein homolog

Gene

CMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31004-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COX assembly mitochondrial protein homolog
Short name:
Cmc1p
Gene namesi
Name:CMC1
Synonyms:C3orf68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28783. CMC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi152100.
MalaCardsiCMC1.
OpenTargetsiENSG00000187118.
PharmGKBiPA162382538.

Polymorphism and mutation databases

BioMutaiCMC1.
DMDMi74738888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003171852 – 106COX assembly mitochondrial protein homologAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Disulfide bondi31 ↔ 63PROSITE-ProRule annotation
Disulfide bondi41 ↔ 53PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ7Z7K0.
MaxQBiQ7Z7K0.
PaxDbiQ7Z7K0.
PeptideAtlasiQ7Z7K0.
PRIDEiQ7Z7K0.

PTM databases

iPTMnetiQ7Z7K0.
PhosphoSitePlusiQ7Z7K0.

Expressioni

Gene expression databases

BgeeiENSG00000187118.
CleanExiHS_CMC1.
ExpressionAtlasiQ7Z7K0. baseline and differential.
GenevisibleiQ7Z7K0. HS.

Organism-specific databases

HPAiHPA043333.

Interactioni

Subunit structurei

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14.1 Publication

Protein-protein interaction databases

IntActiQ7Z7K0. 3 interactors.
STRINGi9606.ENSP00000418348.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 71CHCHPROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 41Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi53 – 63Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the CMC family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4624. Eukaryota.
ENOG4111YK0. LUCA.
GeneTreeiENSGT00390000018696.
HOGENOMiHOG000008534.
HOVERGENiHBG060799.
InParanoidiQ7Z7K0.
KOiK18171.
PhylomeDBiQ7Z7K0.
TreeFamiTF314632.

Family and domain databases

InterProiIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamiPF08583. Cmc1. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDPADQHL RHVEKDVLIP KIMREKAKER CSEQVQDFTK CCKNSGVLMV
60 70 80 90 100
VKCRKENSAL KECLTAYYND PAFYEECKME YLKEREEFRK TGIPTKKRLQ

KLPTSM
Length:106
Mass (Da):12,490
Last modified:October 1, 2003 - v1
Checksum:iCBC29CCCB76BA721
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68Missing in CAH18223 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749370 mRNA. Translation: CAH18223.1.
CH471055 Genomic DNA. Translation: EAW64390.1.
BC052644 mRNA. Translation: AAH52644.1.
CCDSiCCDS33722.1.
RefSeqiNP_872329.1. NM_182523.1.
UniGeneiHs.444724.

Genome annotation databases

EnsembliENST00000466830; ENSP00000418348; ENSG00000187118.
GeneIDi152100.
KEGGihsa:152100.
UCSCiuc003cea.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749370 mRNA. Translation: CAH18223.1.
CH471055 Genomic DNA. Translation: EAW64390.1.
BC052644 mRNA. Translation: AAH52644.1.
CCDSiCCDS33722.1.
RefSeqiNP_872329.1. NM_182523.1.
UniGeneiHs.444724.

3D structure databases

ProteinModelPortaliQ7Z7K0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z7K0. 3 interactors.
STRINGi9606.ENSP00000418348.

PTM databases

iPTMnetiQ7Z7K0.
PhosphoSitePlusiQ7Z7K0.

Polymorphism and mutation databases

BioMutaiCMC1.
DMDMi74738888.

Proteomic databases

EPDiQ7Z7K0.
MaxQBiQ7Z7K0.
PaxDbiQ7Z7K0.
PeptideAtlasiQ7Z7K0.
PRIDEiQ7Z7K0.

Protocols and materials databases

DNASUi152100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466830; ENSP00000418348; ENSG00000187118.
GeneIDi152100.
KEGGihsa:152100.
UCSCiuc003cea.4. human.

Organism-specific databases

CTDi152100.
DisGeNETi152100.
GeneCardsiCMC1.
HGNCiHGNC:28783. CMC1.
HPAiHPA043333.
MalaCardsiCMC1.
MIMi615166. gene.
neXtProtiNX_Q7Z7K0.
OpenTargetsiENSG00000187118.
PharmGKBiPA162382538.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4624. Eukaryota.
ENOG4111YK0. LUCA.
GeneTreeiENSGT00390000018696.
HOGENOMiHOG000008534.
HOVERGENiHBG060799.
InParanoidiQ7Z7K0.
KOiK18171.
PhylomeDBiQ7Z7K0.
TreeFamiTF314632.

Enzyme and pathway databases

BioCyciZFISH:G66-31004-MONOMER.

Miscellaneous databases

ChiTaRSiCMC1. human.
GenomeRNAii152100.
PROiQ7Z7K0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187118.
CleanExiHS_CMC1.
ExpressionAtlasiQ7Z7K0. baseline and differential.
GenevisibleiQ7Z7K0. HS.

Family and domain databases

InterProiIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamiPF08583. Cmc1. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOXM1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7K0
Secondary accession number(s): Q68DJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.