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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene

CAMK2N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent and specific inhibitor of CaM-kinase II (CAMK2).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Alternative name(s):
CaMKII inhibitory protein alpha
Short name:
CaMKIIN-alpha
Gene namesi
Name:CAMK2N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24190. CAMK2N1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672209.

Polymorphism and mutation databases

BioMutaiCAMK2N1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878Calcium/calmodulin-dependent protein kinase II inhibitor 1PRO_0000338393Add
BLAST

Proteomic databases

MaxQBiQ7Z7J9.
PaxDbiQ7Z7J9.
PRIDEiQ7Z7J9.

PTM databases

PhosphoSiteiQ7Z7J9.

Expressioni

Tissue specificityi

Widely expressed. Nor detected in skeletal muscle.1 Publication

Developmental stagei

Regulated in a cell cycle-dependent manner: abundant at S and G2/M phases and low in G0/G1 phase.

Gene expression databases

BgeeiQ7Z7J9.
CleanExiHS_CAMK2N1.
GenevisibleiQ7Z7J9. HS.

Interactioni

Subunit structurei

Interacts with CAMK2B; the presence of Ca2+/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca2+.By similarity1 Publication

Protein-protein interaction databases

BioGridi120671. 1 interaction.
STRINGi9606.ENSP00000364219.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 6828CAMK2 inhibitory domainAdd
BLAST

Domaini

CAMK2 inhibitory domain is also called 'conserved inhibitory region' or 27CIR.

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOVERGENiHBG104926.
InParanoidiQ7Z7J9.
OMAiDEGHLSF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ7Z7J9.
TreeFamiTF333175.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ NKRPPKLGQI
60 70
GRSKRVVIED DRIDDVLKNM TDKAPPGV
Length:78
Mass (Da):8,553
Last modified:October 1, 2003 - v1
Checksum:i31866C5DA10B606F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204901 mRNA. Translation: AAO49802.1.
AL391357 Genomic DNA. Translation: CAH73469.1.
CH471134 Genomic DNA. Translation: EAW94923.1.
CCDSiCCDS207.1.
RefSeqiNP_061054.2. NM_018584.5.
UniGeneiHs.731383.

Genome annotation databases

EnsembliENST00000375078; ENSP00000364219; ENSG00000162545.
GeneIDi55450.
KEGGihsa:55450.
UCSCiuc001bdh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204901 mRNA. Translation: AAO49802.1.
AL391357 Genomic DNA. Translation: CAH73469.1.
CH471134 Genomic DNA. Translation: EAW94923.1.
CCDSiCCDS207.1.
RefSeqiNP_061054.2. NM_018584.5.
UniGeneiHs.731383.

3D structure databases

ProteinModelPortaliQ7Z7J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120671. 1 interaction.
STRINGi9606.ENSP00000364219.

PTM databases

PhosphoSiteiQ7Z7J9.

Polymorphism and mutation databases

BioMutaiCAMK2N1.

Proteomic databases

MaxQBiQ7Z7J9.
PaxDbiQ7Z7J9.
PRIDEiQ7Z7J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375078; ENSP00000364219; ENSG00000162545.
GeneIDi55450.
KEGGihsa:55450.
UCSCiuc001bdh.4. human.

Organism-specific databases

CTDi55450.
GeneCardsiCAMK2N1.
HGNCiHGNC:24190. CAMK2N1.
MIMi614986. gene.
neXtProtiNX_Q7Z7J9.
PharmGKBiPA142672209.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOVERGENiHBG104926.
InParanoidiQ7Z7J9.
OMAiDEGHLSF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ7Z7J9.
TreeFamiTF333175.

Miscellaneous databases

ChiTaRSiCAMK2N1. human.
GenomeRNAii55450.
NextBioi59845.
PROiQ7Z7J9.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z7J9.
CleanExiHS_CAMK2N1.
GenevisibleiQ7Z7J9. HS.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization."
    Wang C., Li N., Liu X., Zheng Y., Cao X.
    J. Biol. Chem. 283:11565-11574(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CAMK2A, TISSUE SPECIFICITY.
    Tissue: Bone marrow stroma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCK2N1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.