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Protein

Lipoma HMGIC fusion partner-like 4 protein

Gene

LHFPL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma HMGIC fusion partner-like 4 protein
Gene namesi
Name:LHFPL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29568. LHFPL4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164741909.

Polymorphism and mutation databases

BioMutaiLHFPL4.
DMDMi74713775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Lipoma HMGIC fusion partner-like 4 proteinPRO_0000285961Add
BLAST

Proteomic databases

EPDiQ7Z7J7.
PaxDbiQ7Z7J7.
PeptideAtlasiQ7Z7J7.
PRIDEiQ7Z7J7.

PTM databases

PhosphoSiteiQ7Z7J7.

Expressioni

Gene expression databases

BgeeiENSG00000156959.
CleanExiHS_LHFPL4.
GenevisibleiQ7Z7J7. HS.

Organism-specific databases

HPAiHPA041421.

Interactioni

Protein-protein interaction databases

BioGridi131972. 4 interactions.
STRINGi9606.ENSP00000287585.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000294163.
HOVERGENiHBG056723.
InParanoidiQ7Z7J7.
OMAiDLQTDNK.
OrthoDBiEOG091G0H85.
PhylomeDBiQ7Z7J7.
TreeFamiTF321143.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSQEASKL YHEHYMRNSR AIGVLWAIFT ICFAIINVVV FIQPYWVGDS
60 70 80 90 100
VSTPKPGYFG LFHYCVGSGL AGRELTCRGS FTDFSTIPSS AFKAAAFFVL
110 120 130 140 150
LSMVLILGCI TCFSLFFFCN TATVYKICAW MQLLAALCLV LGCMIFPDGW
160 170 180 190 200
DAETIRDMCG AKTGKYSLGD CSVRWAYILA IIGILNALIL SFLAFVLGNR
210 220 230 240
QTDLLQEELK PENKDFVGST VSSVLRPGGD VSGWGVLPCP VAHSQGP
Length:247
Mass (Da):27,007
Last modified:October 1, 2003 - v1
Checksum:i911F73F696DBE515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278320 mRNA. Translation: AAP37013.1.
AC026194 Genomic DNA. No translation available.
CCDSiCCDS33691.1.
RefSeqiNP_940962.1. NM_198560.2.
UniGeneiHs.56782.

Genome annotation databases

EnsembliENST00000287585; ENSP00000287585; ENSG00000156959.
GeneIDi375323.
KEGGihsa:375323.
UCSCiuc003bry.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278320 mRNA. Translation: AAP37013.1.
AC026194 Genomic DNA. No translation available.
CCDSiCCDS33691.1.
RefSeqiNP_940962.1. NM_198560.2.
UniGeneiHs.56782.

3D structure databases

ProteinModelPortaliQ7Z7J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131972. 4 interactions.
STRINGi9606.ENSP00000287585.

PTM databases

PhosphoSiteiQ7Z7J7.

Polymorphism and mutation databases

BioMutaiLHFPL4.
DMDMi74713775.

Proteomic databases

EPDiQ7Z7J7.
PaxDbiQ7Z7J7.
PeptideAtlasiQ7Z7J7.
PRIDEiQ7Z7J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287585; ENSP00000287585; ENSG00000156959.
GeneIDi375323.
KEGGihsa:375323.
UCSCiuc003bry.3. human.

Organism-specific databases

CTDi375323.
GeneCardsiLHFPL4.
HGNCiHGNC:29568. LHFPL4.
HPAiHPA041421.
MIMi610240. gene.
neXtProtiNX_Q7Z7J7.
PharmGKBiPA164741909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000294163.
HOVERGENiHBG056723.
InParanoidiQ7Z7J7.
OMAiDLQTDNK.
OrthoDBiEOG091G0H85.
PhylomeDBiQ7Z7J7.
TreeFamiTF321143.

Miscellaneous databases

ChiTaRSiLHFPL4. human.
GenomeRNAii375323.
PROiQ7Z7J7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156959.
CleanExiHS_LHFPL4.
GenevisibleiQ7Z7J7. HS.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7J7
Secondary accession number(s): A6NH76, Q29RV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.