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Protein

Developmental pluripotency-associated protein 2

Gene

DPPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 2
Alternative name(s):
Pluripotent embryonic stem cell-related gene 1 protein
Gene namesi
Name:DPPA2
Synonyms:PESCRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19197. DPPA2.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944028.

Polymorphism and mutation databases

BioMutaiDPPA2.
DMDMi116241341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Developmental pluripotency-associated protein 2PRO_0000239263Add
BLAST

Proteomic databases

MaxQBiQ7Z7J5.
PaxDbiQ7Z7J5.
PRIDEiQ7Z7J5.

PTM databases

iPTMnetiQ7Z7J5.
PhosphoSiteiQ7Z7J5.
SwissPalmiQ7Z7J5.

Expressioni

Tissue specificityi

Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues.1 Publication

Gene expression databases

BgeeiQ7Z7J5.
CleanExiHS_DPPA2.
GenevisibleiQ7Z7J5. HS.

Organism-specific databases

HPAiHPA036134.

Interactioni

Subunit structurei

Interacts with DPPA4.By similarity

Protein-protein interaction databases

BioGridi127407. 20 interactions.
IntActiQ7Z7J5. 16 interactions.
MINTiMINT-1438136.
STRINGi9606.ENSP00000417710.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 12635SAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJEN. Eukaryota.
ENOG4111ADR. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG095578.
InParanoidiQ7Z7J5.
OMAiTLRDWCQ.
OrthoDBiEOG7SN8D1.
PhylomeDBiQ7Z7J5.
TreeFamiTF338129.

Family and domain databases

InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDANLDSSK KNFLEGEVDD EESVILTLVP VKDDANMEQM EPSVSSTSDV
60 70 80 90 100
KLEKPKKYNP GHLLQTNEQF TAPQKARCKI PALPLPTILP PINKVCRDTL
110 120 130 140 150
RDWCQQLGLS TNGKKIEVYL RLHRHAYPEQ RQDMPEMSQE TRLQRCSRKR
160 170 180 190 200
KAVTKRARLQ RSYEMNERAE ETNTVEVITS APGAMLASWA RIAARAVQPK
210 220 230 240 250
ALNSCSIPVS VEAFLMQASG VRWCVVHGRL LSADTKGWVR LQFHAGQAWV
260 270 280 290
PTTHRRMISL FLLPACIFPS PGIEDNMLCP DCAKRNKKMM KRLMTVEK
Length:298
Mass (Da):33,784
Last modified:October 17, 2006 - v2
Checksum:i87FBCCCF52E88B5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891L → S in AAP37285 (PubMed:15583978).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311R → Q.
Corresponds to variant rs9809030 [ dbSNP | Ensembl ].
VAR_028087

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283672 mRNA. Translation: AAP37285.1.
BC018070 mRNA. Translation: AAH18070.1.
CCDSiCCDS2956.1.
RefSeqiNP_620170.3. NM_138815.3.
XP_011510746.1. XM_011512444.1.
XP_011510747.1. XM_011512445.1.
UniGeneiHs.351113.

Genome annotation databases

EnsembliENST00000478945; ENSP00000417710; ENSG00000163530.
GeneIDi151871.
KEGGihsa:151871.
UCSCiuc003dxo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283672 mRNA. Translation: AAP37285.1.
BC018070 mRNA. Translation: AAH18070.1.
CCDSiCCDS2956.1.
RefSeqiNP_620170.3. NM_138815.3.
XP_011510746.1. XM_011512444.1.
XP_011510747.1. XM_011512445.1.
UniGeneiHs.351113.

3D structure databases

ProteinModelPortaliQ7Z7J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127407. 20 interactions.
IntActiQ7Z7J5. 16 interactions.
MINTiMINT-1438136.
STRINGi9606.ENSP00000417710.

PTM databases

iPTMnetiQ7Z7J5.
PhosphoSiteiQ7Z7J5.
SwissPalmiQ7Z7J5.

Polymorphism and mutation databases

BioMutaiDPPA2.
DMDMi116241341.

Proteomic databases

MaxQBiQ7Z7J5.
PaxDbiQ7Z7J5.
PRIDEiQ7Z7J5.

Protocols and materials databases

DNASUi151871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000478945; ENSP00000417710; ENSG00000163530.
GeneIDi151871.
KEGGihsa:151871.
UCSCiuc003dxo.3. human.

Organism-specific databases

CTDi151871.
GeneCardsiDPPA2.
HGNCiHGNC:19197. DPPA2.
HPAiHPA036134.
MIMi614445. gene.
neXtProtiNX_Q7Z7J5.
PharmGKBiPA134944028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJEN. Eukaryota.
ENOG4111ADR. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG095578.
InParanoidiQ7Z7J5.
OMAiTLRDWCQ.
OrthoDBiEOG7SN8D1.
PhylomeDBiQ7Z7J5.
TreeFamiTF338129.

Miscellaneous databases

GeneWikiiDevelopmental_pluripotency_associated_2.
GenomeRNAii151871.
PROiQ7Z7J5.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z7J5.
CleanExiHS_DPPA2.
GenevisibleiQ7Z7J5. HS.

Family and domain databases

InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell."
    Du J., Lin G., Nie Z.Y., Lu G.X.
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:542-547(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiDPPA2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7J5
Secondary accession number(s): Q8WVF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.