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Protein

39S ribosomal protein L10, mitochondrial

Gene

MRPL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L10, mitochondrial
Short name:
L10mt
Short name:
MRP-L10
Alternative name(s):
39S ribosomal protein L8, mitochondrial
Short name:
L8mt
Short name:
MRP-L8
Gene namesi
Name:MRPL10
Synonyms:MRPL8, RPML8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14055. MRPL10.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi124995.
OpenTargetsiENSG00000159111.
PharmGKBiPA30939.

Polymorphism and mutation databases

BioMutaiMRPL10.
DMDMi215274216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
ChainiPRO_000027307529 – 26139S ribosomal protein L10, mitochondrialAdd BLAST233

Proteomic databases

EPDiQ7Z7H8.
MaxQBiQ7Z7H8.
PaxDbiQ7Z7H8.
PeptideAtlasiQ7Z7H8.
PRIDEiQ7Z7H8.

PTM databases

iPTMnetiQ7Z7H8.
PhosphoSitePlusiQ7Z7H8.

Expressioni

Gene expression databases

BgeeiENSG00000159111.
CleanExiHS_MRPL10.
ExpressionAtlasiQ7Z7H8. baseline and differential.
GenevisibleiQ7Z7H8. HS.

Organism-specific databases

HPAiHPA021234.
HPA029885.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.1 Publication2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125910. 71 interactors.
DIPiDIP-59717N.
IntActiQ7Z7H8. 10 interactors.
MINTiMINT-1410295.
STRINGi9606.ENSP00000290208.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 50Combined sources9
Turni62 – 64Combined sources3
Helixi78 – 92Combined sources15
Beta strandi94 – 99Combined sources6
Beta strandi102 – 104Combined sources3
Helixi106 – 118Combined sources13
Beta strandi121 – 124Combined sources4
Helixi128 – 138Combined sources11
Turni142 – 146Combined sources5
Beta strandi152 – 158Combined sources7
Helixi161 – 170Combined sources10
Beta strandi180 – 185Combined sources6
Helixi188 – 196Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40I1-261[»]
3J9Melectron microscopy3.50I1-261[»]
ProteinModelPortaliQ7Z7H8.
SMRiQ7Z7H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L10P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4241. Eukaryota.
ENOG4111GA4. LUCA.
GeneTreeiENSGT00390000000603.
HOGENOMiHOG000231069.
HOVERGENiHBG080095.
InParanoidiQ7Z7H8.
KOiK02864.
OMAiFHSNHCI.
OrthoDBiEOG090A0AEU.
PhylomeDBiQ7Z7H8.
TreeFamiTF321349.

Family and domain databases

InterProiView protein in InterPro
IPR001790. Ribosomal_L10P.
PfamiView protein in Pfam
PF00466. Ribosomal_L10. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z7H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV
60 70 80 90 100
TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ
110 120 130 140 150
NVALSAEDKL LMRHQLRKHK ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH
160 170 180 190 200
NMLLVSEEPK VKEMVRILRT VPFLPLLGGC IDDTILSRQG FINYSKLPSL
210 220 230 240 250
PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ REKDSVMSAN
260
GKPDPDTVPD S
Length:261
Mass (Da):29,283
Last modified:November 25, 2008 - v3
Checksum:iCB4C2EBA74A29098
GO
Isoform 2 (identifier: Q7Z7H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAAVAGMLRGGLLPQA → MISAHCNLHLPGSSDSPASASQVAGIT

Show »
Length:271
Mass (Da):30,307
Checksum:iCEDA1030EC72A3EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030078125V → I1 PublicationCorresponds to variant dbSNP:rs16948568Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444811 – 17MAAAV…LLPQA → MISAHCNLHLPGSSDSPASA SQVAGIT in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127167 mRNA. Translation: BAG54446.1.
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94796.1.
CH471109 Genomic DNA. Translation: EAW94798.1.
BC015904 mRNA. Translation: AAH15904.1.
BC052601 mRNA. Translation: AAH52601.1.
AB051618 Genomic DNA. Translation: BAB54946.1.
CCDSiCCDS11516.1. [Q7Z7H8-1]
CCDS11517.1. [Q7Z7H8-2]
RefSeqiNP_660298.2. NM_145255.3. [Q7Z7H8-1]
NP_683685.1. NM_148887.2. [Q7Z7H8-2]
UniGeneiHs.347535.

Genome annotation databases

EnsembliENST00000290208; ENSP00000290208; ENSG00000159111. [Q7Z7H8-2]
ENST00000351111; ENSP00000324100; ENSG00000159111. [Q7Z7H8-1]
ENST00000414011; ENSP00000395870; ENSG00000159111. [Q7Z7H8-2]
GeneIDi124995.
KEGGihsa:124995.
UCSCiuc002ily.4. human. [Q7Z7H8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127167 mRNA. Translation: BAG54446.1.
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94796.1.
CH471109 Genomic DNA. Translation: EAW94798.1.
BC015904 mRNA. Translation: AAH15904.1.
BC052601 mRNA. Translation: AAH52601.1.
AB051618 Genomic DNA. Translation: BAB54946.1.
CCDSiCCDS11516.1. [Q7Z7H8-1]
CCDS11517.1. [Q7Z7H8-2]
RefSeqiNP_660298.2. NM_145255.3. [Q7Z7H8-1]
NP_683685.1. NM_148887.2. [Q7Z7H8-2]
UniGeneiHs.347535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40I1-261[»]
3J9Melectron microscopy3.50I1-261[»]
ProteinModelPortaliQ7Z7H8.
SMRiQ7Z7H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125910. 71 interactors.
DIPiDIP-59717N.
IntActiQ7Z7H8. 10 interactors.
MINTiMINT-1410295.
STRINGi9606.ENSP00000290208.

PTM databases

iPTMnetiQ7Z7H8.
PhosphoSitePlusiQ7Z7H8.

Polymorphism and mutation databases

BioMutaiMRPL10.
DMDMi215274216.

Proteomic databases

EPDiQ7Z7H8.
MaxQBiQ7Z7H8.
PaxDbiQ7Z7H8.
PeptideAtlasiQ7Z7H8.
PRIDEiQ7Z7H8.

Protocols and materials databases

DNASUi124995.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290208; ENSP00000290208; ENSG00000159111. [Q7Z7H8-2]
ENST00000351111; ENSP00000324100; ENSG00000159111. [Q7Z7H8-1]
ENST00000414011; ENSP00000395870; ENSG00000159111. [Q7Z7H8-2]
GeneIDi124995.
KEGGihsa:124995.
UCSCiuc002ily.4. human. [Q7Z7H8-1]

Organism-specific databases

CTDi124995.
DisGeNETi124995.
GeneCardsiMRPL10.
HGNCiHGNC:14055. MRPL10.
HPAiHPA021234.
HPA029885.
MIMi611825. gene.
neXtProtiNX_Q7Z7H8.
OpenTargetsiENSG00000159111.
PharmGKBiPA30939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4241. Eukaryota.
ENOG4111GA4. LUCA.
GeneTreeiENSGT00390000000603.
HOGENOMiHOG000231069.
HOVERGENiHBG080095.
InParanoidiQ7Z7H8.
KOiK02864.
OMAiFHSNHCI.
OrthoDBiEOG090A0AEU.
PhylomeDBiQ7Z7H8.
TreeFamiTF321349.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL10. human.
GeneWikiiMRPL10.
GenomeRNAii124995.
PROiQ7Z7H8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159111.
CleanExiHS_MRPL10.
ExpressionAtlasiQ7Z7H8. baseline and differential.
GenevisibleiQ7Z7H8. HS.

Family and domain databases

InterProiView protein in InterPro
IPR001790. Ribosomal_L10P.
PfamiView protein in Pfam
PF00466. Ribosomal_L10. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM10_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7H8
Secondary accession number(s): A6NGJ4, Q96B80, Q96Q55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 25, 2008
Last modified: February 15, 2017
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.