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Q7Z7H8

- RM10_HUMAN

UniProt

Q7Z7H8 - RM10_HUMAN

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Protein

39S ribosomal protein L10, mitochondrial

Gene

MRPL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. ribosome biogenesis Source: InterPro
  2. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L10, mitochondrial
Short name:
L10mt
Short name:
MRP-L10
Alternative name(s):
39S ribosomal protein L8, mitochondrial
Short name:
L8mt
Short name:
MRP-L8
Gene namesi
Name:MRPL10
Synonyms:MRPL8, RPML8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14055. MRPL10.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: UniProtKB
  2. mitochondrion Source: HPA
  3. ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionBy similarityAdd
BLAST
Chaini29 – 26123339S ribosomal protein L10, mitochondrialPRO_0000273075Add
BLAST

Proteomic databases

MaxQBiQ7Z7H8.
PaxDbiQ7Z7H8.
PRIDEiQ7Z7H8.

PTM databases

PhosphoSiteiQ7Z7H8.

Expressioni

Gene expression databases

BgeeiQ7Z7H8.
CleanExiHS_MRPL10.
ExpressionAtlasiQ7Z7H8. baseline and differential.
GenevestigatoriQ7Z7H8.

Organism-specific databases

HPAiHPA021234.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi125910. 26 interactions.
DIPiDIP-59717N.
IntActiQ7Z7H8. 2 interactions.
MINTiMINT-1410295.
STRINGi9606.ENSP00000324100.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L10P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG303354.
GeneTreeiENSGT00390000000603.
HOGENOMiHOG000231069.
HOVERGENiHBG080095.
InParanoidiQ7Z7H8.
KOiK02864.
OMAiVFPNQVL.
OrthoDBiEOG73RBCF.
PhylomeDBiQ7Z7H8.
TreeFamiTF321349.

Family and domain databases

InterProiIPR001790. Ribosomal_L10/acidic_P0.
[Graphical view]
PfamiPF00466. Ribosomal_L10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z7H8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV
60 70 80 90 100
TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ
110 120 130 140 150
NVALSAEDKL LMRHQLRKHK ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH
160 170 180 190 200
NMLLVSEEPK VKEMVRILRT VPFLPLLGGC IDDTILSRQG FINYSKLPSL
210 220 230 240 250
PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ REKDSVMSAN
260
GKPDPDTVPD S
Length:261
Mass (Da):29,283
Last modified:November 25, 2008 - v3
Checksum:iCB4C2EBA74A29098
GO
Isoform 2 (identifier: Q7Z7H8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAAVAGMLRGGLLPQA → MISAHCNLHLPGSSDSPASASQVAGIT

Show »
Length:271
Mass (Da):30,307
Checksum:iCEDA1030EC72A3EE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251V → I.1 Publication
Corresponds to variant rs16948568 [ dbSNP | Ensembl ].
VAR_030078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MAAAV…LLPQA → MISAHCNLHLPGSSDSPASA SQVAGIT in isoform 2. 1 PublicationVSP_044481Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127167 mRNA. Translation: BAG54446.1.
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94796.1.
CH471109 Genomic DNA. Translation: EAW94798.1.
BC015904 mRNA. Translation: AAH15904.1.
BC052601 mRNA. Translation: AAH52601.1.
AB051618 Genomic DNA. Translation: BAB54946.1.
CCDSiCCDS11516.1. [Q7Z7H8-1]
CCDS11517.1. [Q7Z7H8-2]
RefSeqiNP_660298.2. NM_145255.3. [Q7Z7H8-1]
NP_683685.1. NM_148887.2. [Q7Z7H8-2]
UniGeneiHs.347535.

Genome annotation databases

EnsembliENST00000290208; ENSP00000290208; ENSG00000159111. [Q7Z7H8-2]
ENST00000351111; ENSP00000324100; ENSG00000159111. [Q7Z7H8-1]
ENST00000414011; ENSP00000395870; ENSG00000159111. [Q7Z7H8-2]
GeneIDi124995.
KEGGihsa:124995.
UCSCiuc002ily.3. human. [Q7Z7H8-2]
uc002ilz.3. human. [Q7Z7H8-1]

Polymorphism databases

DMDMi215274216.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127167 mRNA. Translation: BAG54446.1 .
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94796.1 .
CH471109 Genomic DNA. Translation: EAW94798.1 .
BC015904 mRNA. Translation: AAH15904.1 .
BC052601 mRNA. Translation: AAH52601.1 .
AB051618 Genomic DNA. Translation: BAB54946.1 .
CCDSi CCDS11516.1. [Q7Z7H8-1 ]
CCDS11517.1. [Q7Z7H8-2 ]
RefSeqi NP_660298.2. NM_145255.3. [Q7Z7H8-1 ]
NP_683685.1. NM_148887.2. [Q7Z7H8-2 ]
UniGenei Hs.347535.

3D structure databases

ProteinModelPortali Q7Z7H8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125910. 26 interactions.
DIPi DIP-59717N.
IntActi Q7Z7H8. 2 interactions.
MINTi MINT-1410295.
STRINGi 9606.ENSP00000324100.

PTM databases

PhosphoSitei Q7Z7H8.

Polymorphism databases

DMDMi 215274216.

Proteomic databases

MaxQBi Q7Z7H8.
PaxDbi Q7Z7H8.
PRIDEi Q7Z7H8.

Protocols and materials databases

DNASUi 124995.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290208 ; ENSP00000290208 ; ENSG00000159111 . [Q7Z7H8-2 ]
ENST00000351111 ; ENSP00000324100 ; ENSG00000159111 . [Q7Z7H8-1 ]
ENST00000414011 ; ENSP00000395870 ; ENSG00000159111 . [Q7Z7H8-2 ]
GeneIDi 124995.
KEGGi hsa:124995.
UCSCi uc002ily.3. human. [Q7Z7H8-2 ]
uc002ilz.3. human. [Q7Z7H8-1 ]

Organism-specific databases

CTDi 124995.
GeneCardsi GC17M045900.
HGNCi HGNC:14055. MRPL10.
HPAi HPA021234.
MIMi 611825. gene.
neXtProti NX_Q7Z7H8.
PharmGKBi PA30939.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303354.
GeneTreei ENSGT00390000000603.
HOGENOMi HOG000231069.
HOVERGENi HBG080095.
InParanoidi Q7Z7H8.
KOi K02864.
OMAi VFPNQVL.
OrthoDBi EOG73RBCF.
PhylomeDBi Q7Z7H8.
TreeFami TF321349.

Miscellaneous databases

ChiTaRSi MRPL10. human.
GeneWikii MRPL10.
GenomeRNAii 124995.
NextBioi 35462551.
PROi Q7Z7H8.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z7H8.
CleanExi HS_MRPL10.
ExpressionAtlasi Q7Z7H8. baseline and differential.
Genevestigatori Q7Z7H8.

Family and domain databases

InterProi IPR001790. Ribosomal_L10/acidic_P0.
[Graphical view ]
Pfami PF00466. Ribosomal_L10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Caudate nucleus.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-125.
    Tissue: Pancreas and Skin.
  5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 235-261.
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM10_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7H8
Secondary accession number(s): A6NGJ4, Q96B80, Q96Q55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3