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Q7Z7H8

- RM10_HUMAN

UniProt

Q7Z7H8 - RM10_HUMAN

Protein

39S ribosomal protein L10, mitochondrial

Gene

MRPL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. ribosome biogenesis Source: InterPro
    2. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L10, mitochondrial
    Short name:
    L10mt
    Short name:
    MRP-L10
    Alternative name(s):
    39S ribosomal protein L8, mitochondrial
    Short name:
    L8mt
    Short name:
    MRP-L8
    Gene namesi
    Name:MRPL10
    Synonyms:MRPL8, RPML8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14055. MRPL10.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: HPA
    3. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30939.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionBy similarityAdd
    BLAST
    Chaini29 – 26123339S ribosomal protein L10, mitochondrialPRO_0000273075Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z7H8.
    PaxDbiQ7Z7H8.
    PRIDEiQ7Z7H8.

    PTM databases

    PhosphoSiteiQ7Z7H8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z7H8.
    BgeeiQ7Z7H8.
    CleanExiHS_MRPL10.
    GenevestigatoriQ7Z7H8.

    Organism-specific databases

    HPAiHPA021234.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

    Protein-protein interaction databases

    BioGridi125910. 20 interactions.
    DIPiDIP-59717N.
    IntActiQ7Z7H8. 2 interactions.
    MINTiMINT-1410295.
    STRINGi9606.ENSP00000324100.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L10P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG303354.
    HOGENOMiHOG000231069.
    HOVERGENiHBG080095.
    KOiK02864.
    OMAiVFPNQVL.
    OrthoDBiEOG73RBCF.
    PhylomeDBiQ7Z7H8.
    TreeFamiTF321349.

    Family and domain databases

    InterProiIPR001790. Ribosomal_L10/acidic_P0.
    [Graphical view]
    PfamiPF00466. Ribosomal_L10. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z7H8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV    50
    TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ 100
    NVALSAEDKL LMRHQLRKHK ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH 150
    NMLLVSEEPK VKEMVRILRT VPFLPLLGGC IDDTILSRQG FINYSKLPSL 200
    PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ REKDSVMSAN 250
    GKPDPDTVPD S 261
    Length:261
    Mass (Da):29,283
    Last modified:November 25, 2008 - v3
    Checksum:iCB4C2EBA74A29098
    GO
    Isoform 2 (identifier: Q7Z7H8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MAAAVAGMLRGGLLPQA → MISAHCNLHLPGSSDSPASASQVAGIT

    Show »
    Length:271
    Mass (Da):30,307
    Checksum:iCEDA1030EC72A3EE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251V → I.1 Publication
    Corresponds to variant rs16948568 [ dbSNP | Ensembl ].
    VAR_030078

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1717MAAAV…LLPQA → MISAHCNLHLPGSSDSPASA SQVAGIT in isoform 2. 1 PublicationVSP_044481Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127167 mRNA. Translation: BAG54446.1.
    AC003665 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94796.1.
    CH471109 Genomic DNA. Translation: EAW94798.1.
    BC015904 mRNA. Translation: AAH15904.1.
    BC052601 mRNA. Translation: AAH52601.1.
    AB051618 Genomic DNA. Translation: BAB54946.1.
    CCDSiCCDS11516.1. [Q7Z7H8-1]
    CCDS11517.1. [Q7Z7H8-2]
    RefSeqiNP_660298.2. NM_145255.3. [Q7Z7H8-1]
    NP_683685.1. NM_148887.2. [Q7Z7H8-2]
    UniGeneiHs.347535.

    Genome annotation databases

    EnsembliENST00000290208; ENSP00000290208; ENSG00000159111. [Q7Z7H8-2]
    ENST00000351111; ENSP00000324100; ENSG00000159111. [Q7Z7H8-1]
    ENST00000414011; ENSP00000395870; ENSG00000159111. [Q7Z7H8-2]
    GeneIDi124995.
    KEGGihsa:124995.
    UCSCiuc002ily.3. human. [Q7Z7H8-2]
    uc002ilz.3. human. [Q7Z7H8-1]

    Polymorphism databases

    DMDMi215274216.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127167 mRNA. Translation: BAG54446.1 .
    AC003665 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94796.1 .
    CH471109 Genomic DNA. Translation: EAW94798.1 .
    BC015904 mRNA. Translation: AAH15904.1 .
    BC052601 mRNA. Translation: AAH52601.1 .
    AB051618 Genomic DNA. Translation: BAB54946.1 .
    CCDSi CCDS11516.1. [Q7Z7H8-1 ]
    CCDS11517.1. [Q7Z7H8-2 ]
    RefSeqi NP_660298.2. NM_145255.3. [Q7Z7H8-1 ]
    NP_683685.1. NM_148887.2. [Q7Z7H8-2 ]
    UniGenei Hs.347535.

    3D structure databases

    ProteinModelPortali Q7Z7H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125910. 20 interactions.
    DIPi DIP-59717N.
    IntActi Q7Z7H8. 2 interactions.
    MINTi MINT-1410295.
    STRINGi 9606.ENSP00000324100.

    PTM databases

    PhosphoSitei Q7Z7H8.

    Polymorphism databases

    DMDMi 215274216.

    Proteomic databases

    MaxQBi Q7Z7H8.
    PaxDbi Q7Z7H8.
    PRIDEi Q7Z7H8.

    Protocols and materials databases

    DNASUi 124995.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290208 ; ENSP00000290208 ; ENSG00000159111 . [Q7Z7H8-2 ]
    ENST00000351111 ; ENSP00000324100 ; ENSG00000159111 . [Q7Z7H8-1 ]
    ENST00000414011 ; ENSP00000395870 ; ENSG00000159111 . [Q7Z7H8-2 ]
    GeneIDi 124995.
    KEGGi hsa:124995.
    UCSCi uc002ily.3. human. [Q7Z7H8-2 ]
    uc002ilz.3. human. [Q7Z7H8-1 ]

    Organism-specific databases

    CTDi 124995.
    GeneCardsi GC17M045900.
    HGNCi HGNC:14055. MRPL10.
    HPAi HPA021234.
    MIMi 611825. gene.
    neXtProti NX_Q7Z7H8.
    PharmGKBi PA30939.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303354.
    HOGENOMi HOG000231069.
    HOVERGENi HBG080095.
    KOi K02864.
    OMAi VFPNQVL.
    OrthoDBi EOG73RBCF.
    PhylomeDBi Q7Z7H8.
    TreeFami TF321349.

    Miscellaneous databases

    ChiTaRSi MRPL10. human.
    GeneWikii MRPL10.
    GenomeRNAii 124995.
    NextBioi 35462551.
    PROi Q7Z7H8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z7H8.
    Bgeei Q7Z7H8.
    CleanExi HS_MRPL10.
    Genevestigatori Q7Z7H8.

    Family and domain databases

    InterProi IPR001790. Ribosomal_L10/acidic_P0.
    [Graphical view ]
    Pfami PF00466. Ribosomal_L10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Caudate nucleus.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-125.
      Tissue: Pancreas and Skin.
    5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 235-261.
    6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM10_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7H8
    Secondary accession number(s): A6NGJ4, Q96B80, Q96Q55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3