Q7Z7H8 (RM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L10, mitochondrial
Short name=L10mt
Short name=MRP-L10

Alternative name(s):
39S ribosomal protein L8, mitochondrial
Short name=L8mt
Short name=MRP-L8

Gene names

Name:	MRPL10
Synonyms:	MRPL8, RPML8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein L10P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ribosome biogenesis Inferred from electronic annotation. Source: InterPro translation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	mitochondrial large ribosomal subunit Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z7H8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z7H8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAAVAGMLRGGLLPQA → MISAHCNLHLPGSSDSPASASQVAGIT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion By similarity
	Chain	29 – 261	233	39S ribosomal protein L10, mitochondrial		PRO_0000273075
Natural variations
	Alternative sequence	1 – 17	17	MAAAV…LLPQA → MISAHCNLHLPGSSDSPASA SQVAGIT in isoform 2.		VSP_044481
	Natural variant	125	1	V → I. Ref.4 Corresponds to variant rs16948568 [ dbSNP | Ensembl ].		VAR_030078

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: CB4C2EBA74A29098	FASTA	261	29,283
	10 20 30 40 50 60 MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI 70 80 90 100 110 120 HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ NVALSAEDKL LMRHQLRKHK 130 140 150 160 170 180 ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH NMLLVSEEPK VKEMVRILRT VPFLPLLGGC 190 200 210 220 230 240 IDDTILSRQG FINYSKLPSL PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ 250 260 REKDSVMSAN GKPDPDTVPD S
	Isoform 2 [UniParc]. Checksum: CEDA1030EC72A3EE	FASTA	271	30,307
	10 20 30 40 50 60 MISAHCNLHL PGSSDSPASA SQVAGITGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV 70 80 90 100 110 120 TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ NVALSAEDKL 130 140 150 160 170 180 LMRHQLRKHK ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH NMLLVSEEPK VKEMVRILRT 190 200 210 220 230 240 VPFLPLLGGC IDDTILSRQG FINYSKLPSL PLVQGELVGG LTCLTAQTHS LLQHQPLQLT 250 260 270 TLLDQYIREQ REKDSVMSAN GKPDPDTVPD S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Caudate nucleus.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-125. Tissue: Pancreas and Skin.
[5]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 235-261.
[6]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK127167 mRNA. Translation: BAG54446.1. AC003665 Genomic DNA. No translation available. CH471109 Genomic DNA. Translation: EAW94796.1. CH471109 Genomic DNA. Translation: EAW94798.1. BC015904 mRNA. Translation: AAH15904.1. BC052601 mRNA. Translation: AAH52601.1. AB051618 Genomic DNA. Translation: BAB54946.1.
IPI	IPI00170877. IPI00376448.
RefSeq	NP_660298.2. NM_145255.3. NP_683685.1. NM_148887.2.
UniGene	Hs.347535.
3D structure databases
ProteinModelPortal	Q7Z7H8.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59717N.
IntAct	Q7Z7H8. 1 interaction.
MINT	MINT-1410295.
STRING	9606.ENSP00000324100.
PTM databases
PhosphoSite	Q7Z7H8.
Polymorphism databases
DMDM	215274216.
Proteomic databases
PaxDb	Q7Z7H8.
PRIDE	Q7Z7H8.
Protocols and materials databases
DNASU	124995.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290208; ENSP00000290208; ENSG00000159111. ENST00000351111; ENSP00000324100; ENSG00000159111. ENST00000414011; ENSP00000395870; ENSG00000159111.
GeneID	124995.
KEGG	hsa:124995.
UCSC	uc002ily.3. human. uc002ilz.3. human.
Organism-specific databases
CTD	124995.
GeneCards	GC17M045900.
HGNC	HGNC:14055. MRPL10.
HPA	HPA021234.
MIM	611825. gene.
neXtProt	NX_Q7Z7H8.
PharmGKB	PA30939.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303354.
HOGENOM	HOG000231069.
HOVERGEN	HBG080095.
KO	K02864.
OMA	VFPNQVL.
OrthoDB	EOG4X0MTH.
Gene expression databases
ArrayExpress	Q7Z7H8.
Bgee	Q7Z7H8.
CleanEx	HS_MRPL10.
Genevestigator	Q7Z7H8.
Family and domain databases
InterPro	IPR001790. Ribosomal_L10/acidic_P0. [Graphical view]
Pfam	PF00466. Ribosomal_L10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL10. human.
GenomeRNAi	124995.
NextBio	35462551.
SOURCE	Search...

Entry information

Entry name

RM10_HUMAN

Accession

Primary (citable) accession number: Q7Z7H8
Secondary accession number(s): A6NGJ4, Q96B80, Q96Q55

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	November 25, 2008
Last modified:	May 29, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.