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Protein

39S ribosomal protein L10, mitochondrial

Gene

MRPL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L10, mitochondrial
Short name:
L10mt
Short name:
MRP-L10
Alternative name(s):
39S ribosomal protein L8, mitochondrial
Short name:
L8mt
Short name:
MRP-L8
Mitochondrial large ribosomal subunit protein uL10m1 Publication
Gene namesi
Name:MRPL10
Synonyms:MRPL8, RPML8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000159111.12
HGNCiHGNC:14055 MRPL10
MIMi611825 gene
neXtProtiNX_Q7Z7H8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi124995
OpenTargetsiENSG00000159111
PharmGKBiPA30939

Polymorphism and mutation databases

BioMutaiMRPL10
DMDMi215274216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
ChainiPRO_000027307529 – 26139S ribosomal protein L10, mitochondrialAdd BLAST233

Proteomic databases

EPDiQ7Z7H8
MaxQBiQ7Z7H8
PaxDbiQ7Z7H8
PeptideAtlasiQ7Z7H8
PRIDEiQ7Z7H8

PTM databases

iPTMnetiQ7Z7H8
PhosphoSitePlusiQ7Z7H8

Expressioni

Gene expression databases

BgeeiENSG00000159111
CleanExiHS_MRPL10
ExpressionAtlasiQ7Z7H8 baseline and differential
GenevisibleiQ7Z7H8 HS

Organism-specific databases

HPAiHPA021234
HPA029885

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. uL10m contributes a single cysteine residue to a zinc-binding site with mL66.1 Publication2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125910, 73 interactors
CORUMiQ7Z7H8
DIPiDIP-59717N
IntActiQ7Z7H8, 13 interactors
MINTiQ7Z7H8
STRINGi9606.ENSP00000290208

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 50Combined sources9
Helixi62 – 64Combined sources3
Helixi78 – 92Combined sources15
Beta strandi94 – 99Combined sources6
Beta strandi102 – 104Combined sources3
Helixi106 – 117Combined sources12
Turni118 – 120Combined sources3
Beta strandi122 – 125Combined sources4
Helixi128 – 137Combined sources10
Beta strandi141 – 143Combined sources3
Turni144 – 146Combined sources3
Beta strandi152 – 158Combined sources7
Helixi161 – 168Combined sources8
Beta strandi170 – 172Combined sources3
Beta strandi179 – 181Combined sources3
Beta strandi184 – 186Combined sources3
Helixi188 – 196Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40I1-261[»]
3J9Melectron microscopy3.50I1-261[»]
5OOLelectron microscopy3.06I1-261[»]
5OOMelectron microscopy3.03I1-261[»]
ProteinModelPortaliQ7Z7H8
SMRiQ7Z7H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4241 Eukaryota
ENOG4111GA4 LUCA
GeneTreeiENSGT00390000000603
HOGENOMiHOG000231069
HOVERGENiHBG080095
InParanoidiQ7Z7H8
KOiK02864
OMAiFHSNHCI
OrthoDBiEOG091G0IXY
PhylomeDBiQ7Z7H8
TreeFamiTF321349

Family and domain databases

InterProiView protein in InterPro
IPR001790 Ribosomal_L10P
PfamiView protein in Pfam
PF00466 Ribosomal_L10, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z7H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV
60 70 80 90 100
TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ
110 120 130 140 150
NVALSAEDKL LMRHQLRKHK ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH
160 170 180 190 200
NMLLVSEEPK VKEMVRILRT VPFLPLLGGC IDDTILSRQG FINYSKLPSL
210 220 230 240 250
PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ REKDSVMSAN
260
GKPDPDTVPD S
Length:261
Mass (Da):29,283
Last modified:November 25, 2008 - v3
Checksum:iCB4C2EBA74A29098
GO
Isoform 2 (identifier: Q7Z7H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAAVAGMLRGGLLPQA → MISAHCNLHLPGSSDSPASASQVAGIT

Show »
Length:271
Mass (Da):30,307
Checksum:iCEDA1030EC72A3EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030078125V → I1 PublicationCorresponds to variant dbSNP:rs11538868Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444811 – 17MAAAV…LLPQA → MISAHCNLHLPGSSDSPASA SQVAGIT in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127167 mRNA Translation: BAG54446.1
AC003665 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94796.1
CH471109 Genomic DNA Translation: EAW94798.1
BC015904 mRNA Translation: AAH15904.1
BC052601 mRNA Translation: AAH52601.1
AB051618 Genomic DNA Translation: BAB54946.1
CCDSiCCDS11516.1 [Q7Z7H8-1]
CCDS11517.1 [Q7Z7H8-2]
RefSeqiNP_660298.2, NM_145255.3 [Q7Z7H8-1]
NP_683685.1, NM_148887.2 [Q7Z7H8-2]
UniGeneiHs.347535

Genome annotation databases

EnsembliENST00000290208; ENSP00000290208; ENSG00000159111 [Q7Z7H8-2]
ENST00000351111; ENSP00000324100; ENSG00000159111 [Q7Z7H8-1]
ENST00000414011; ENSP00000395870; ENSG00000159111 [Q7Z7H8-2]
GeneIDi124995
KEGGihsa:124995
UCSCiuc002ily.4 human [Q7Z7H8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM10_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7H8
Secondary accession number(s): A6NGJ4, Q96B80, Q96Q55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 25, 2008
Last modified: February 28, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health