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Q7Z7H8 (RM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L10, mitochondrial

Short name=L10mt
Short name=MRP-L10
Alternative name(s):
39S ribosomal protein L8, mitochondrial
Short name=L8mt
Short name=MRP-L8
Gene names
Name:MRPL10
Synonyms:MRPL8, RPML8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the ribosomal protein L10P family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z7H8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z7H8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAAVAGMLRGGLLPQA → MISAHCNLHLPGSSDSPASASQVAGIT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion By similarity
Chain29 – 26123339S ribosomal protein L10, mitochondrial
PRO_0000273075

Natural variations

Alternative sequence1 – 1717MAAAV…LLPQA → MISAHCNLHLPGSSDSPASA SQVAGIT in isoform 2.
VSP_044481
Natural variant1251V → I. Ref.4
Corresponds to variant rs16948568 [ dbSNP | Ensembl ].
VAR_030078

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: CB4C2EBA74A29098

FASTA26129,283
        10         20         30         40         50         60 
MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI 

        70         80         90        100        110        120 
HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ NVALSAEDKL LMRHQLRKHK 

       130        140        150        160        170        180 
ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH NMLLVSEEPK VKEMVRILRT VPFLPLLGGC 

       190        200        210        220        230        240 
IDDTILSRQG FINYSKLPSL PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ 

       250        260 
REKDSVMSAN GKPDPDTVPD S 

« Hide

Isoform 2 [UniParc].

Checksum: CEDA1030EC72A3EE
Show »

FASTA27130,307

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Caudate nucleus.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-125.
Tissue: Pancreas and Skin.
[5]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 235-261.
[6]"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK127167 mRNA. Translation: BAG54446.1.
AC003665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94796.1.
CH471109 Genomic DNA. Translation: EAW94798.1.
BC015904 mRNA. Translation: AAH15904.1.
BC052601 mRNA. Translation: AAH52601.1.
AB051618 Genomic DNA. Translation: BAB54946.1.
CCDSCCDS11516.1. [Q7Z7H8-1]
CCDS11517.1. [Q7Z7H8-2]
RefSeqNP_660298.2. NM_145255.3. [Q7Z7H8-1]
NP_683685.1. NM_148887.2. [Q7Z7H8-2]
UniGeneHs.347535.

3D structure databases

ProteinModelPortalQ7Z7H8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125910. 20 interactions.
DIPDIP-59717N.
IntActQ7Z7H8. 2 interactions.
MINTMINT-1410295.
STRING9606.ENSP00000324100.

PTM databases

PhosphoSiteQ7Z7H8.

Polymorphism databases

DMDM215274216.

Proteomic databases

MaxQBQ7Z7H8.
PaxDbQ7Z7H8.
PRIDEQ7Z7H8.

Protocols and materials databases

DNASU124995.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290208; ENSP00000290208; ENSG00000159111. [Q7Z7H8-2]
ENST00000351111; ENSP00000324100; ENSG00000159111. [Q7Z7H8-1]
ENST00000414011; ENSP00000395870; ENSG00000159111. [Q7Z7H8-2]
GeneID124995.
KEGGhsa:124995.
UCSCuc002ily.3. human. [Q7Z7H8-2]
uc002ilz.3. human. [Q7Z7H8-1]

Organism-specific databases

CTD124995.
GeneCardsGC17M045900.
HGNCHGNC:14055. MRPL10.
HPAHPA021234.
MIM611825. gene.
neXtProtNX_Q7Z7H8.
PharmGKBPA30939.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303354.
HOGENOMHOG000231069.
HOVERGENHBG080095.
KOK02864.
OMAVFPNQVL.
OrthoDBEOG73RBCF.
PhylomeDBQ7Z7H8.
TreeFamTF321349.

Gene expression databases

ArrayExpressQ7Z7H8.
BgeeQ7Z7H8.
CleanExHS_MRPL10.
GenevestigatorQ7Z7H8.

Family and domain databases

InterProIPR001790. Ribosomal_L10/acidic_P0.
[Graphical view]
PfamPF00466. Ribosomal_L10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMRPL10. human.
GeneWikiMRPL10.
GenomeRNAi124995.
NextBio35462551.
PROQ7Z7H8.
SOURCESearch...

Entry information

Entry nameRM10_HUMAN
AccessionPrimary (citable) accession number: Q7Z7H8
Secondary accession number(s): A6NGJ4, Q96B80, Q96Q55
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM