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Protein

Complexin-4

Gene

CPLX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Positively regulates a late step in synaptic vesicle exocytosis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-4
Alternative name(s):
Complexin IV
Short name:
CPX IV
Gene namesi
Name:CPLX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24330. CPLX4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi339302.
OpenTargetsiENSG00000166569.
PharmGKBiPA134902350.

Polymorphism and mutation databases

BioMutaiCPLX4.
DMDMi74750239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002402351 – 157Complexin-4Add BLAST157
PropeptideiPRO_0000240236158 – 160Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157Cysteine methyl esterBy similarity1
Lipidationi157S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ7Z7G2.
PeptideAtlasiQ7Z7G2.
PRIDEiQ7Z7G2.

PTM databases

PhosphoSitePlusiQ7Z7G2.

Expressioni

Gene expression databases

BgeeiENSG00000166569.
CleanExiHS_CPLX4.
ExpressionAtlasiQ7Z7G2. baseline and differential.

Interactioni

Subunit structurei

Weakly binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

Protein-protein interaction databases

BioGridi130863. 9 interactors.
STRINGi9606.ENSP00000299721.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Phylogenomic databases

eggNOGiENOG410IGJR. Eukaryota.
ENOG4111JE6. LUCA.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ7Z7G2.
KOiK15295.
OMAiMERDADF.
OrthoDBiEOG091G0X1S.
PhylomeDBiQ7Z7G2.
TreeFamiTF331867.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLMKSMIS NQVKNLGFGG GSEENKEEGG ASDPAAAQGM TREEYEEYQK
60 70 80 90 100
QMIEEKMERD AAFTQKKAER ACLRVHLREK YRLPKSEMDE NQIQMAGDDV
110 120 130 140 150
DLPEDLRKMV DEDQEEEEDK DSILGQIQNL QNMDLDTIKE KAQATFTEIK
160
QTAEQKCSVM
Length:160
Mass (Da):18,336
Last modified:October 1, 2003 - v1
Checksum:iE812EE05BD47E179
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286502 mRNA. Translation: AAP41128.1.
AK123184 mRNA. Translation: BAC85549.1.
BX640655 mRNA. Translation: CAE45797.1.
AB593158 mRNA. Translation: BAJ84090.1.
CH471096 Genomic DNA. Translation: EAW63095.1.
BC106887 mRNA. Translation: AAI06888.1.
BC106888 mRNA. Translation: AAI06889.1.
CCDSiCCDS11973.1.
RefSeqiNP_857637.1. NM_181654.3.
UniGeneiHs.449884.

Genome annotation databases

EnsembliENST00000299721; ENSP00000299721; ENSG00000166569.
GeneIDi339302.
KEGGihsa:339302.
UCSCiuc002lhy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286502 mRNA. Translation: AAP41128.1.
AK123184 mRNA. Translation: BAC85549.1.
BX640655 mRNA. Translation: CAE45797.1.
AB593158 mRNA. Translation: BAJ84090.1.
CH471096 Genomic DNA. Translation: EAW63095.1.
BC106887 mRNA. Translation: AAI06888.1.
BC106888 mRNA. Translation: AAI06889.1.
CCDSiCCDS11973.1.
RefSeqiNP_857637.1. NM_181654.3.
UniGeneiHs.449884.

3D structure databases

ProteinModelPortaliQ7Z7G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130863. 9 interactors.
STRINGi9606.ENSP00000299721.

PTM databases

PhosphoSitePlusiQ7Z7G2.

Polymorphism and mutation databases

BioMutaiCPLX4.
DMDMi74750239.

Proteomic databases

PaxDbiQ7Z7G2.
PeptideAtlasiQ7Z7G2.
PRIDEiQ7Z7G2.

Protocols and materials databases

DNASUi339302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299721; ENSP00000299721; ENSG00000166569.
GeneIDi339302.
KEGGihsa:339302.
UCSCiuc002lhy.4. human.

Organism-specific databases

CTDi339302.
DisGeNETi339302.
GeneCardsiCPLX4.
HGNCiHGNC:24330. CPLX4.
MIMi609586. gene.
neXtProtiNX_Q7Z7G2.
OpenTargetsiENSG00000166569.
PharmGKBiPA134902350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJR. Eukaryota.
ENOG4111JE6. LUCA.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ7Z7G2.
KOiK15295.
OMAiMERDADF.
OrthoDBiEOG091G0X1S.
PhylomeDBiQ7Z7G2.
TreeFamiTF331867.

Miscellaneous databases

ChiTaRSiCPLX4. human.
GenomeRNAii339302.
PROiQ7Z7G2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166569.
CleanExiHS_CPLX4.
ExpressionAtlasiQ7Z7G2. baseline and differential.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPLX4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7G2
Secondary accession number(s): F1T0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.