Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z7G0

- TARSH_HUMAN

UniProt

Q7Z7G0 - TARSH_HUMAN

Protein

Target of Nesh-SH3

Gene

ABI3BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: Ensembl
    2. positive regulation of cell-substrate adhesion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Target of Nesh-SH3
    Short name:
    Tarsh
    Alternative name(s):
    ABI gene family member 3-binding protein
    Nesh-binding protein
    Short name:
    NeshBP
    Gene namesi
    Name:ABI3BP
    Synonyms:NESHBP, TARSH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17265. ABI3BP.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL
    2. interstitial matrix Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977769.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 10751047Target of Nesh-SH3PRO_0000022472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ7Z7G0.
    PaxDbiQ7Z7G0.
    PRIDEiQ7Z7G0.

    PTM databases

    PhosphoSiteiQ7Z7G0.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, lung, liver, pancreas kidney and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z7G0.
    BgeeiQ7Z7G0.
    CleanExiHS_ABI3BP.
    GenevestigatoriQ7Z7G0.

    Organism-specific databases

    HPAiHPA044127.

    Interactioni

    Subunit structurei

    Probably interacts with ABI3.

    Protein-protein interaction databases

    BioGridi117399. 8 interactions.
    IntActiQ7Z7G0. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7G0.
    SMRiQ7Z7G0. Positions 121-203, 837-931.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini123 – 22199Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini840 – 93394Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi419 – 756338Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG04687.
    HOGENOMiHOG000065723.
    HOVERGENiHBG056157.
    InParanoidiQ7Z7G0.
    PhylomeDBiQ7Z7G0.
    TreeFamiTF331037.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z7G0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGGKCNMLS SLGCLLLCGS ITLALGNAQK LPKGKRPNLK VHINTTSDSI     50
    LLKFLRPSPN VKLEGLLLGY GSNVSPNQYF PLPAEGKFTE AIVDAEPKYL 100
    IVVRPAPPPS QKKSCSGKTR SRKPLQLVVG TLTPSSVFLS WGFLINPHHD 150
    WTLPSHCPND RFYTIRYREK DKEKKWIFQI CPATETIVEN LKPNTVYEFG 200
    VKDNVEGGIW SKIFNHKTVV GSKKVNGKIQ STYDQDHTVP AYVPRKLIPI 250
    TIIKQVIQNV THKDSAKSPE KAPLGGVILV HLIIPGLNET TVKLPASLMF 300
    EISDALKTQL AKNETLALPA ESKTPEVEKI SARPTTVTPE TVPRSTKPTT 350
    SSALDVSETT LASSEKPWIV PTAKISEDSK VLQPQTATYD VFSSPTTSDE 400
    PEISDSYTAT SDRILDSIPP KTSRTLEQPR ATLAPSETPF VPQKLEIFTS 450
    PEMQPTTPAP QQTTSIPSTP KRRPRPKPPR TKPERTTSAG TITPKISKSP 500
    EPTWTTPAPG KTQFISLKPK IPLSPEVTHT KPAPKQTPRA PPKPKTSPRP 550
    RIPQTQPVPK VPQRVTAKPK TSPSPEVSYT TPAPKDVLLP HKPYPEVSQS 600
    EPAPLETRGI PFIPMISPSP SQEELQTTLE ETDQSTQEPF TTKIPRTTEL 650
    AKTTQAPHRF YTTVRPRTSD KPHIRPGVKQ APRPSGADRN VSVDSTHPTK 700
    KPGTRRPPLP PRPTHPRRKP LPPNNVTGKP GSAGIISSGP ITTPPLRSTP 750
    RPTGTPLERI ETDIKQPTVP ASGEELENIT DFSSSPTRET DPLGKPRFKG 800
    PHVRYIQKPD NSPCSITDSV KRFPKEEATE GNATSPPQNP PTNLTVVTVE 850
    GCPSFVILDW EKPLNDTVTE YEVISRENGS FSGKNKSIQM TNQTFSTVEN 900
    LKPNTSYEFQ VKPKNPLGEG PVSNTVAFST ESADPRVSEP VSAGRDAIWT 950
    ERPFNSDSYS ECKGKQYVKR TWYKKFVGVQ LCNSLRYKIY LSDSLTGKFY 1000
    NIGDQRGHGE DHCQFVDSFL DGRTGQQLTS DQLPIKEGYF RAVRQEPVQF 1050
    GEIGGHTQIN YVQWYECGTT IPGKW 1075
    Length:1,075
    Mass (Da):118,642
    Last modified:October 1, 2003 - v1
    Checksum:i52FF60EE360FA0F1
    GO
    Isoform 2 (identifier: Q7Z7G0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-614: Missing.
         676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

    Show »
    Length:486
    Mass (Da):53,888
    Checksum:i790AEBE657E0D766
    GO
    Isoform 3 (identifier: Q7Z7G0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-316: Missing.
         317-446: Missing.
         447-531: IFTSPEMQPT...PLSPEVTHTK → MTESLPVSDV...LPSPDEPQTE
         676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

    Note: No experimental confirmation available.

    Show »
    Length:655
    Mass (Da):72,267
    Checksum:iBA728A5D1FAC9343
    GO
    Isoform 4 (identifier: Q7Z7G0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-316: Missing.
         317-530: ALPAESKTPE...IPLSPEVTHT → MTIVPTTDIE...TTPRPEAPES
         676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

    Note: No experimental confirmation available.

    Show »
    Length:784
    Mass (Da):86,789
    Checksum:iF981C59445ACC6FF
    GO

    Sequence cautioni

    The sequence CAB56034.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 614614Missing in isoform 2. 2 PublicationsVSP_010860Add
    BLAST
    Alternative sequencei1 – 316316Missing in isoform 3 and isoform 4. 1 PublicationVSP_010862Add
    BLAST
    Alternative sequencei317 – 530214ALPAE…EVTHT → MTIVPTTDIEPVTVRTEATV TTLAPKTSQRTRTRRPRPKH KTTPRPETLQTKLDFGPITP GTSSAPTTTTKRTRRPHPKP KTTPHPEVPQTKLAPKVPQR THRPHPKPKTTLSPEELQTE LVPVTDLGPVTFRTEIPATT LATKTSKRTRPPRPRPKTTP SPQAPETKPVPATVLEPVTL RPEASTTLASKTSQRTRRPR LRTKTTPRPEAPES in isoform 4. 1 PublicationVSP_010865Add
    BLAST
    Alternative sequencei317 – 446130Missing in isoform 3. 1 PublicationVSP_010863Add
    BLAST
    Alternative sequencei447 – 53185IFTSP…VTHTK → MTESLPVSDVLESVTLSTES PKETIAPAKTDYVYPTAKAP LWPEEPKTEVVESITYVSEP PETTLETSPLPSQSITLPSP DEPQTE in isoform 3. 1 PublicationVSP_010864Add
    BLAST
    Alternative sequencei676 – 6761P → PVLNRTTTRPTRPKPSGMPS GNGVGT in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_010861

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB056106 mRNA. Translation: BAB32867.1.
    AK093861 mRNA. Translation: BAG52776.1.
    AK123737 mRNA. Translation: BAC85685.1.
    AK123748 mRNA. Translation: BAC85687.1.
    CH471052 Genomic DNA. Translation: EAW79811.1.
    BC030221 mRNA. Translation: AAH30221.1.
    AL117664 mRNA. Translation: CAB56034.1. Different initiation.
    CCDSiCCDS46880.1. [Q7Z7G0-1]
    PIRiT17344.
    RefSeqiNP_056244.2. NM_015429.3. [Q7Z7G0-1]
    UniGeneiHs.477015.

    Genome annotation databases

    EnsembliENST00000284322; ENSP00000284322; ENSG00000154175. [Q7Z7G0-1]
    GeneIDi25890.
    KEGGihsa:25890.
    UCSCiuc003duj.3. human. [Q7Z7G0-3]
    uc003duk.3. human. [Q7Z7G0-4]
    uc003dum.3. human. [Q7Z7G0-2]
    uc003dun.3. human. [Q7Z7G0-1]

    Polymorphism databases

    DMDMi50401533.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB056106 mRNA. Translation: BAB32867.1 .
    AK093861 mRNA. Translation: BAG52776.1 .
    AK123737 mRNA. Translation: BAC85685.1 .
    AK123748 mRNA. Translation: BAC85687.1 .
    CH471052 Genomic DNA. Translation: EAW79811.1 .
    BC030221 mRNA. Translation: AAH30221.1 .
    AL117664 mRNA. Translation: CAB56034.1 . Different initiation.
    CCDSi CCDS46880.1. [Q7Z7G0-1 ]
    PIRi T17344.
    RefSeqi NP_056244.2. NM_015429.3. [Q7Z7G0-1 ]
    UniGenei Hs.477015.

    3D structure databases

    ProteinModelPortali Q7Z7G0.
    SMRi Q7Z7G0. Positions 121-203, 837-931.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117399. 8 interactions.
    IntActi Q7Z7G0. 7 interactions.

    PTM databases

    PhosphoSitei Q7Z7G0.

    Polymorphism databases

    DMDMi 50401533.

    Proteomic databases

    MaxQBi Q7Z7G0.
    PaxDbi Q7Z7G0.
    PRIDEi Q7Z7G0.

    Protocols and materials databases

    DNASUi 25890.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284322 ; ENSP00000284322 ; ENSG00000154175 . [Q7Z7G0-1 ]
    GeneIDi 25890.
    KEGGi hsa:25890.
    UCSCi uc003duj.3. human. [Q7Z7G0-3 ]
    uc003duk.3. human. [Q7Z7G0-4 ]
    uc003dum.3. human. [Q7Z7G0-2 ]
    uc003dun.3. human. [Q7Z7G0-1 ]

    Organism-specific databases

    CTDi 25890.
    GeneCardsi GC03M100468.
    HGNCi HGNC:17265. ABI3BP.
    HPAi HPA044127.
    MIMi 606279. gene.
    neXtProti NX_Q7Z7G0.
    PharmGKBi PA134977769.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG04687.
    HOGENOMi HOG000065723.
    HOVERGENi HBG056157.
    InParanoidi Q7Z7G0.
    PhylomeDBi Q7Z7G0.
    TreeFami TF331037.

    Miscellaneous databases

    GenomeRNAii 25890.
    NextBioi 47318.
    PROi Q7Z7G0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z7G0.
    Bgeei Q7Z7G0.
    CleanExi HS_ABI3BP.
    Genevestigatori Q7Z7G0.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
      Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
      J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 706-1075.
      Tissue: Uterus.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44.
      Tissue: Liver.

    Entry informationi

    Entry nameiTARSH_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7G0
    Secondary accession number(s): B3KSL4
    , Q6ZW20, Q6ZW22, Q9C082, Q9UFI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3