Q7Z7G0 (TARSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Target of Nesh-SH3
Short name=Tarsh

Alternative name(s):
ABI gene family member 3-binding protein
Nesh-binding protein
Short name=NeshBP

Gene names

Name:	ABI3BP
Synonyms:	NESHBP, TARSH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1075 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Probably interacts with ABI3.
Subcellular location	Secreted Potential.
Tissue specificity	Expressed in brain, heart, lung, liver, pancreas kidney and placenta. Ref.1
Sequence similarities	Contains 2 fibronectin type-III domains.
Sequence caution	The sequence CAB56034.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extracellular matrix organization Inferred from electronic annotation. Source: Compara positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from direct assay PubMed 20551380. Source: BHF-UCL interstitial matrix Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z7G0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z7G0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Isoform 3 (identifier: Q7Z7G0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-446: Missing.
     447-531: IFTSPEMQPT...PLSPEVTHTK → MTESLPVSDV...LPSPDEPQTE
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Note: No experimental confirmation available.

Isoform 4 (identifier: Q7Z7G0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-530: ALPAESKTPE...IPLSPEVTHT → MTIVPTTDIE...TTPRPEAPES
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1075	1047	Target of Nesh-SH3		PRO_0000022472
Regions
	Domain	120 – 219	100	Fibronectin type-III 1
	Domain	837 – 930	94	Fibronectin type-III 2
	Compositional bias	419 – 756	338	Pro-rich
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) Ref.6
Natural variations
	Alternative sequence	1 – 614	614	Missing in isoform 2.		VSP_010860
	Alternative sequence	1 – 316	316	Missing in isoform 3 and isoform 4.		VSP_010862
	Alternative sequence	317 – 530	214	ALPAE…EVTHT → MTIVPTTDIEPVTVRTEATV TTLAPKTSQRTRTRRPRPKH KTTPRPETLQTKLDFGPITP GTSSAPTTTTKRTRRPHPKP KTTPHPEVPQTKLAPKVPQR THRPHPKPKTTLSPEELQTE LVPVTDLGPVTFRTEIPATT LATKTSKRTRPPRPRPKTTP SPQAPETKPVPATVLEPVTL RPEASTTLASKTSQRTRRPR LRTKTTPRPEAPES in isoform 4.		VSP_010865
	Alternative sequence	317 – 446	130	Missing in isoform 3.		VSP_010863
	Alternative sequence	447 – 531	85	IFTSP…VTHTK → MTESLPVSDVLESVTLSTES PKETIAPAKTDYVYPTAKAP LWPEEPKTEVVESITYVSEP PETTLETSPLPSQSITLPSP DEPQTE in isoform 3.		VSP_010864
	Alternative sequence	676	1	P → PVLNRTTTRPTRPKPSGMPS GNGVGT in isoform 2, isoform 3 and isoform 4.		VSP_010861

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 52FF60EE360FA0F1	FASTA	1,075	118,642
	10 20 30 40 50 60 MRGGKCNMLS SLGCLLLCGS ITLALGNAQK LPKGKRPNLK VHINTTSDSI LLKFLRPSPN 70 80 90 100 110 120 VKLEGLLLGY GSNVSPNQYF PLPAEGKFTE AIVDAEPKYL IVVRPAPPPS QKKSCSGKTR 130 140 150 160 170 180 SRKPLQLVVG TLTPSSVFLS WGFLINPHHD WTLPSHCPND RFYTIRYREK DKEKKWIFQI 190 200 210 220 230 240 CPATETIVEN LKPNTVYEFG VKDNVEGGIW SKIFNHKTVV GSKKVNGKIQ STYDQDHTVP 250 260 270 280 290 300 AYVPRKLIPI TIIKQVIQNV THKDSAKSPE KAPLGGVILV HLIIPGLNET TVKLPASLMF 310 320 330 340 350 360 EISDALKTQL AKNETLALPA ESKTPEVEKI SARPTTVTPE TVPRSTKPTT SSALDVSETT 370 380 390 400 410 420 LASSEKPWIV PTAKISEDSK VLQPQTATYD VFSSPTTSDE PEISDSYTAT SDRILDSIPP 430 440 450 460 470 480 KTSRTLEQPR ATLAPSETPF VPQKLEIFTS PEMQPTTPAP QQTTSIPSTP KRRPRPKPPR 490 500 510 520 530 540 TKPERTTSAG TITPKISKSP EPTWTTPAPG KTQFISLKPK IPLSPEVTHT KPAPKQTPRA 550 560 570 580 590 600 PPKPKTSPRP RIPQTQPVPK VPQRVTAKPK TSPSPEVSYT TPAPKDVLLP HKPYPEVSQS 610 620 630 640 650 660 EPAPLETRGI PFIPMISPSP SQEELQTTLE ETDQSTQEPF TTKIPRTTEL AKTTQAPHRF 670 680 690 700 710 720 YTTVRPRTSD KPHIRPGVKQ APRPSGADRN VSVDSTHPTK KPGTRRPPLP PRPTHPRRKP 730 740 750 760 770 780 LPPNNVTGKP GSAGIISSGP ITTPPLRSTP RPTGTPLERI ETDIKQPTVP ASGEELENIT 790 800 810 820 830 840 DFSSSPTRET DPLGKPRFKG PHVRYIQKPD NSPCSITDSV KRFPKEEATE GNATSPPQNP 850 860 870 880 890 900 PTNLTVVTVE GCPSFVILDW EKPLNDTVTE YEVISRENGS FSGKNKSIQM TNQTFSTVEN 910 920 930 940 950 960 LKPNTSYEFQ VKPKNPLGEG PVSNTVAFST ESADPRVSEP VSAGRDAIWT ERPFNSDSYS 970 980 990 1000 1010 1020 ECKGKQYVKR TWYKKFVGVQ LCNSLRYKIY LSDSLTGKFY NIGDQRGHGE DHCQFVDSFL 1030 1040 1050 1060 1070 DGRTGQQLTS DQLPIKEGYF RAVRQEPVQF GEIGGHTQIN YVQWYECGTT IPGKW
	Isoform 2 [UniParc]. Checksum: 790AEBE657E0D766	FASTA	486	53,888
	10 20 30 40 50 60 MISPSPSQEE LQTTLEETDQ STQEPFTTKI PRTTELAKTT QAPHRFYTTV RPRTSDKPHI 70 80 90 100 110 120 RPVLNRTTTR PTRPKPSGMP SGNGVGTGVK QAPRPSGADR NVSVDSTHPT KKPGTRRPPL 130 140 150 160 170 180 PPRPTHPRRK PLPPNNVTGK PGSAGIISSG PITTPPLRST PRPTGTPLER IETDIKQPTV 190 200 210 220 230 240 PASGEELENI TDFSSSPTRE TDPLGKPRFK GPHVRYIQKP DNSPCSITDS VKRFPKEEAT 250 260 270 280 290 300 EGNATSPPQN PPTNLTVVTV EGCPSFVILD WEKPLNDTVT EYEVISRENG SFSGKNKSIQ 310 320 330 340 350 360 MTNQTFSTVE NLKPNTSYEF QVKPKNPLGE GPVSNTVAFS TESADPRVSE PVSAGRDAIW 370 380 390 400 410 420 TERPFNSDSY SECKGKQYVK RTWYKKFVGV QLCNSLRYKI YLSDSLTGKF YNIGDQRGHG 430 440 450 460 470 480 EDHCQFVDSF LDGRTGQQLT SDQLPIKEGY FRAVRQEPVQ FGEIGGHTQI NYVQWYECGT TIPGKW
	Isoform 3 [UniParc]. Checksum: BA728A5D1FAC9343	FASTA	655	72,267
	10 20 30 40 50 60 MTESLPVSDV LESVTLSTES PKETIAPAKT DYVYPTAKAP LWPEEPKTEV VESITYVSEP 70 80 90 100 110 120 PETTLETSPL PSQSITLPSP DEPQTEPAPK QTPRAPPKPK TSPRPRIPQT QPVPKVPQRV 130 140 150 160 170 180 TAKPKTSPSP EVSYTTPAPK DVLLPHKPYP EVSQSEPAPL ETRGIPFIPM ISPSPSQEEL 190 200 210 220 230 240 QTTLEETDQS TQEPFTTKIP RTTELAKTTQ APHRFYTTVR PRTSDKPHIR PVLNRTTTRP 250 260 270 280 290 300 TRPKPSGMPS GNGVGTGVKQ APRPSGADRN VSVDSTHPTK KPGTRRPPLP PRPTHPRRKP 310 320 330 340 350 360 LPPNNVTGKP GSAGIISSGP ITTPPLRSTP RPTGTPLERI ETDIKQPTVP ASGEELENIT 370 380 390 400 410 420 DFSSSPTRET DPLGKPRFKG PHVRYIQKPD NSPCSITDSV KRFPKEEATE GNATSPPQNP 430 440 450 460 470 480 PTNLTVVTVE GCPSFVILDW EKPLNDTVTE YEVISRENGS FSGKNKSIQM TNQTFSTVEN 490 500 510 520 530 540 LKPNTSYEFQ VKPKNPLGEG PVSNTVAFST ESADPRVSEP VSAGRDAIWT ERPFNSDSYS 550 560 570 580 590 600 ECKGKQYVKR TWYKKFVGVQ LCNSLRYKIY LSDSLTGKFY NIGDQRGHGE DHCQFVDSFL 610 620 630 640 650 DGRTGQQLTS DQLPIKEGYF RAVRQEPVQF GEIGGHTQIN YVQWYECGTT IPGKW
	Isoform 4 [UniParc]. Checksum: F981C59445ACC6FF	FASTA	784	86,789
	10 20 30 40 50 60 MTIVPTTDIE PVTVRTEATV TTLAPKTSQR TRTRRPRPKH KTTPRPETLQ TKLDFGPITP 70 80 90 100 110 120 GTSSAPTTTT KRTRRPHPKP KTTPHPEVPQ TKLAPKVPQR THRPHPKPKT TLSPEELQTE 130 140 150 160 170 180 LVPVTDLGPV TFRTEIPATT LATKTSKRTR PPRPRPKTTP SPQAPETKPV PATVLEPVTL 190 200 210 220 230 240 RPEASTTLAS KTSQRTRRPR LRTKTTPRPE APESKPAPKQ TPRAPPKPKT SPRPRIPQTQ 250 260 270 280 290 300 PVPKVPQRVT AKPKTSPSPE VSYTTPAPKD VLLPHKPYPE VSQSEPAPLE TRGIPFIPMI 310 320 330 340 350 360 SPSPSQEELQ TTLEETDQST QEPFTTKIPR TTELAKTTQA PHRFYTTVRP RTSDKPHIRP 370 380 390 400 410 420 VLNRTTTRPT RPKPSGMPSG NGVGTGVKQA PRPSGADRNV SVDSTHPTKK PGTRRPPLPP 430 440 450 460 470 480 RPTHPRRKPL PPNNVTGKPG SAGIISSGPI TTPPLRSTPR PTGTPLERIE TDIKQPTVPA 490 500 510 520 530 540 SGEELENITD FSSSPTRETD PLGKPRFKGP HVRYIQKPDN SPCSITDSVK RFPKEEATEG 550 560 570 580 590 600 NATSPPQNPP TNLTVVTVEG CPSFVILDWE KPLNDTVTEY EVISRENGSF SGKNKSIQMT 610 620 630 640 650 660 NQTFSTVENL KPNTSYEFQV KPKNPLGEGP VSNTVAFSTE SADPRVSEPV SAGRDAIWTE 670 680 690 700 710 720 RPFNSDSYSE CKGKQYVKRT WYKKFVGVQL CNSLRYKIYL SDSLTGKFYN IGDQRGHGED 730 740 750 760 770 780 HCQFVDSFLD GRTGQQLTSD QLPIKEGYFR AVRQEPVQFG EIGGHTQINY VQWYECGTTI PGKW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3." Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M. J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Trachea.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 706-1075. Tissue: Uterus.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB056106 mRNA. Translation: BAB32867.1. AK093861 mRNA. Translation: BAG52776.1. AK123737 mRNA. Translation: BAC85685.1. AK123748 mRNA. Translation: BAC85687.1. CH471052 Genomic DNA. Translation: EAW79811.1. BC030221 mRNA. Translation: AAH30221.1. AL117664 mRNA. Translation: CAB56034.1. Different initiation.
IPI	IPI00419966. IPI00440822. IPI00440825. IPI00794737.
PIR	T17344.
RefSeq	NP_056244.2. NM_015429.3.
UniGene	Hs.477015.
3D structure databases
ProteinModelPortal	Q7Z7G0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z7G0. 7 interactions.
PTM databases
PhosphoSite	Q7Z7G0.
Polymorphism databases
DMDM	50401533.
Proteomic databases
PaxDb	Q7Z7G0.
PRIDE	Q7Z7G0.
Protocols and materials databases
DNASU	25890.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284322; ENSP00000284322; ENSG00000154175.
GeneID	25890.
KEGG	hsa:25890.
UCSC	uc003duj.3. human. uc003dum.3. human. uc003dun.3. human.
Organism-specific databases
CTD	25890.
GeneCards	GC03M100468.
HGNC	HGNC:17265. ABI3BP.
HPA	HPA044127.
MIM	606279. gene.
neXtProt	NX_Q7Z7G0.
PharmGKB	PA134977769.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG04687.
HOGENOM	HOG000065723.
HOVERGEN	HBG056157.
InParanoid	Q7Z7G0.
Gene expression databases
ArrayExpress	Q7Z7G0.
Bgee	Q7Z7G0.
CleanEx	HS_ABI3BP.
Genevestigator	Q7Z7G0.
GermOnline	ENSG00000154175. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF00041. fn3. 1 hit. [Graphical view]
SMART	SM00060. FN3. 2 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25890.
NextBio	47318.
SOURCE	Search...

Entry information

Entry name

TARSH_HUMAN

Accession

Primary (citable) accession number: Q7Z7G0
Secondary accession number(s): B3KSL4 , Q6ZW20, Q6ZW22, Q9C082, Q9UFI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.