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Q7Z7G0 (TARSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Target of Nesh-SH3

Short name=Tarsh
Alternative name(s):
ABI gene family member 3-binding protein
Nesh-binding protein
Short name=NeshBP
Gene names
Name:ABI3BP
Synonyms:NESHBP, TARSH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1075 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Probably interacts with ABI3.

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in brain, heart, lung, liver, pancreas kidney and placenta. Ref.1

Sequence similarities

Contains 2 fibronectin type-III domains.

Sequence caution

The sequence CAB56034.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z7G0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z7G0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT
Isoform 3 (identifier: Q7Z7G0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-446: Missing.
     447-531: IFTSPEMQPT...PLSPEVTHTK → MTESLPVSDV...LPSPDEPQTE
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT
Note: No experimental confirmation available.
Isoform 4 (identifier: Q7Z7G0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-530: ALPAESKTPE...IPLSPEVTHT → MTIVPTTDIE...TTPRPEAPES
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 10751047Target of Nesh-SH3
PRO_0000022472

Regions

Domain123 – 22199Fibronectin type-III 1
Domain840 – 93394Fibronectin type-III 2
Compositional bias419 – 756338Pro-rich

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Ref.6

Natural variations

Alternative sequence1 – 614614Missing in isoform 2.
VSP_010860
Alternative sequence1 – 316316Missing in isoform 3 and isoform 4.
VSP_010862
Alternative sequence317 – 530214ALPAE…EVTHT → MTIVPTTDIEPVTVRTEATV TTLAPKTSQRTRTRRPRPKH KTTPRPETLQTKLDFGPITP GTSSAPTTTTKRTRRPHPKP KTTPHPEVPQTKLAPKVPQR THRPHPKPKTTLSPEELQTE LVPVTDLGPVTFRTEIPATT LATKTSKRTRPPRPRPKTTP SPQAPETKPVPATVLEPVTL RPEASTTLASKTSQRTRRPR LRTKTTPRPEAPES in isoform 4.
VSP_010865
Alternative sequence317 – 446130Missing in isoform 3.
VSP_010863
Alternative sequence447 – 53185IFTSP…VTHTK → MTESLPVSDVLESVTLSTES PKETIAPAKTDYVYPTAKAP LWPEEPKTEVVESITYVSEP PETTLETSPLPSQSITLPSP DEPQTE in isoform 3.
VSP_010864
Alternative sequence6761P → PVLNRTTTRPTRPKPSGMPS GNGVGT in isoform 2, isoform 3 and isoform 4.
VSP_010861

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 52FF60EE360FA0F1

FASTA1,075118,642
        10         20         30         40         50         60 
MRGGKCNMLS SLGCLLLCGS ITLALGNAQK LPKGKRPNLK VHINTTSDSI LLKFLRPSPN 

        70         80         90        100        110        120 
VKLEGLLLGY GSNVSPNQYF PLPAEGKFTE AIVDAEPKYL IVVRPAPPPS QKKSCSGKTR 

       130        140        150        160        170        180 
SRKPLQLVVG TLTPSSVFLS WGFLINPHHD WTLPSHCPND RFYTIRYREK DKEKKWIFQI 

       190        200        210        220        230        240 
CPATETIVEN LKPNTVYEFG VKDNVEGGIW SKIFNHKTVV GSKKVNGKIQ STYDQDHTVP 

       250        260        270        280        290        300 
AYVPRKLIPI TIIKQVIQNV THKDSAKSPE KAPLGGVILV HLIIPGLNET TVKLPASLMF 

       310        320        330        340        350        360 
EISDALKTQL AKNETLALPA ESKTPEVEKI SARPTTVTPE TVPRSTKPTT SSALDVSETT 

       370        380        390        400        410        420 
LASSEKPWIV PTAKISEDSK VLQPQTATYD VFSSPTTSDE PEISDSYTAT SDRILDSIPP 

       430        440        450        460        470        480 
KTSRTLEQPR ATLAPSETPF VPQKLEIFTS PEMQPTTPAP QQTTSIPSTP KRRPRPKPPR 

       490        500        510        520        530        540 
TKPERTTSAG TITPKISKSP EPTWTTPAPG KTQFISLKPK IPLSPEVTHT KPAPKQTPRA 

       550        560        570        580        590        600 
PPKPKTSPRP RIPQTQPVPK VPQRVTAKPK TSPSPEVSYT TPAPKDVLLP HKPYPEVSQS 

       610        620        630        640        650        660 
EPAPLETRGI PFIPMISPSP SQEELQTTLE ETDQSTQEPF TTKIPRTTEL AKTTQAPHRF 

       670        680        690        700        710        720 
YTTVRPRTSD KPHIRPGVKQ APRPSGADRN VSVDSTHPTK KPGTRRPPLP PRPTHPRRKP 

       730        740        750        760        770        780 
LPPNNVTGKP GSAGIISSGP ITTPPLRSTP RPTGTPLERI ETDIKQPTVP ASGEELENIT 

       790        800        810        820        830        840 
DFSSSPTRET DPLGKPRFKG PHVRYIQKPD NSPCSITDSV KRFPKEEATE GNATSPPQNP 

       850        860        870        880        890        900 
PTNLTVVTVE GCPSFVILDW EKPLNDTVTE YEVISRENGS FSGKNKSIQM TNQTFSTVEN 

       910        920        930        940        950        960 
LKPNTSYEFQ VKPKNPLGEG PVSNTVAFST ESADPRVSEP VSAGRDAIWT ERPFNSDSYS 

       970        980        990       1000       1010       1020 
ECKGKQYVKR TWYKKFVGVQ LCNSLRYKIY LSDSLTGKFY NIGDQRGHGE DHCQFVDSFL 

      1030       1040       1050       1060       1070 
DGRTGQQLTS DQLPIKEGYF RAVRQEPVQF GEIGGHTQIN YVQWYECGTT IPGKW 

« Hide

Isoform 2 [UniParc].

Checksum: 790AEBE657E0D766
Show »

FASTA48653,888
Isoform 3 [UniParc].

Checksum: BA728A5D1FAC9343
Show »

FASTA65572,267
Isoform 4 [UniParc].

Checksum: F981C59445ACC6FF
Show »

FASTA78486,789

References

« Hide 'large scale' references
[1]"Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Placenta.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Trachea.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 706-1075.
Tissue: Uterus.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB056106 mRNA. Translation: BAB32867.1.
AK093861 mRNA. Translation: BAG52776.1.
AK123737 mRNA. Translation: BAC85685.1.
AK123748 mRNA. Translation: BAC85687.1.
CH471052 Genomic DNA. Translation: EAW79811.1.
BC030221 mRNA. Translation: AAH30221.1.
AL117664 mRNA. Translation: CAB56034.1. Different initiation.
PIRT17344.
RefSeqNP_056244.2. NM_015429.3.
UniGeneHs.477015.

3D structure databases

ProteinModelPortalQ7Z7G0.
SMRQ7Z7G0. Positions 122-206, 837-930.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117399. 8 interactions.
IntActQ7Z7G0. 7 interactions.

PTM databases

PhosphoSiteQ7Z7G0.

Polymorphism databases

DMDM50401533.

Proteomic databases

PaxDbQ7Z7G0.
PRIDEQ7Z7G0.

Protocols and materials databases

DNASU25890.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284322; ENSP00000284322; ENSG00000154175. [Q7Z7G0-1]
GeneID25890.
KEGGhsa:25890.
UCSCuc003duj.3. human. [Q7Z7G0-3]
uc003duk.3. human. [Q7Z7G0-4]
uc003dum.3. human. [Q7Z7G0-2]
uc003dun.3. human. [Q7Z7G0-1]

Organism-specific databases

CTD25890.
GeneCardsGC03M100468.
HGNCHGNC:17265. ABI3BP.
HPAHPA044127.
MIM606279. gene.
neXtProtNX_Q7Z7G0.
PharmGKBPA134977769.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG04687.
HOGENOMHOG000065723.
HOVERGENHBG056157.
InParanoidQ7Z7G0.
PhylomeDBQ7Z7G0.
TreeFamTF331037.

Gene expression databases

ArrayExpressQ7Z7G0.
BgeeQ7Z7G0.
CleanExHS_ABI3BP.
GenevestigatorQ7Z7G0.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi25890.
NextBio47318.
PROQ7Z7G0.
SOURCESearch...

Entry information

Entry nameTARSH_HUMAN
AccessionPrimary (citable) accession number: Q7Z7G0
Secondary accession number(s): B3KSL4 expand/collapse secondary AC list , Q6ZW20, Q6ZW22, Q9C082, Q9UFI6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM