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Q7Z7G0

- TARSH_HUMAN

UniProt

Q7Z7G0 - TARSH_HUMAN

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Protein

Target of Nesh-SH3

Gene

ABI3BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
  2. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Target of Nesh-SH3
Short name:
Tarsh
Alternative name(s):
ABI gene family member 3-binding protein
Nesh-binding protein
Short name:
NeshBP
Gene namesi
Name:ABI3BP
Synonyms:NESHBP, TARSH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:17265. ABI3BP.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. interstitial matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 10751047Target of Nesh-SH3PRO_0000022472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7Z7G0.
PaxDbiQ7Z7G0.
PRIDEiQ7Z7G0.

PTM databases

PhosphoSiteiQ7Z7G0.

Expressioni

Tissue specificityi

Expressed in brain, heart, lung, liver, pancreas kidney and placenta.1 Publication

Gene expression databases

BgeeiQ7Z7G0.
CleanExiHS_ABI3BP.
ExpressionAtlasiQ7Z7G0. baseline and differential.
GenevestigatoriQ7Z7G0.

Organism-specific databases

HPAiHPA044127.

Interactioni

Subunit structurei

Probably interacts with ABI3.

Protein-protein interaction databases

BioGridi117399. 8 interactions.
IntActiQ7Z7G0. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7G0.
SMRiQ7Z7G0. Positions 120-227, 837-931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 22199Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini840 – 93394Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi419 – 756338Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG04687.
GeneTreeiENSGT00530000063558.
HOGENOMiHOG000065723.
HOVERGENiHBG056157.
InParanoidiQ7Z7G0.
PhylomeDBiQ7Z7G0.
TreeFamiTF331037.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z7G0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGGKCNMLS SLGCLLLCGS ITLALGNAQK LPKGKRPNLK VHINTTSDSI
60 70 80 90 100
LLKFLRPSPN VKLEGLLLGY GSNVSPNQYF PLPAEGKFTE AIVDAEPKYL
110 120 130 140 150
IVVRPAPPPS QKKSCSGKTR SRKPLQLVVG TLTPSSVFLS WGFLINPHHD
160 170 180 190 200
WTLPSHCPND RFYTIRYREK DKEKKWIFQI CPATETIVEN LKPNTVYEFG
210 220 230 240 250
VKDNVEGGIW SKIFNHKTVV GSKKVNGKIQ STYDQDHTVP AYVPRKLIPI
260 270 280 290 300
TIIKQVIQNV THKDSAKSPE KAPLGGVILV HLIIPGLNET TVKLPASLMF
310 320 330 340 350
EISDALKTQL AKNETLALPA ESKTPEVEKI SARPTTVTPE TVPRSTKPTT
360 370 380 390 400
SSALDVSETT LASSEKPWIV PTAKISEDSK VLQPQTATYD VFSSPTTSDE
410 420 430 440 450
PEISDSYTAT SDRILDSIPP KTSRTLEQPR ATLAPSETPF VPQKLEIFTS
460 470 480 490 500
PEMQPTTPAP QQTTSIPSTP KRRPRPKPPR TKPERTTSAG TITPKISKSP
510 520 530 540 550
EPTWTTPAPG KTQFISLKPK IPLSPEVTHT KPAPKQTPRA PPKPKTSPRP
560 570 580 590 600
RIPQTQPVPK VPQRVTAKPK TSPSPEVSYT TPAPKDVLLP HKPYPEVSQS
610 620 630 640 650
EPAPLETRGI PFIPMISPSP SQEELQTTLE ETDQSTQEPF TTKIPRTTEL
660 670 680 690 700
AKTTQAPHRF YTTVRPRTSD KPHIRPGVKQ APRPSGADRN VSVDSTHPTK
710 720 730 740 750
KPGTRRPPLP PRPTHPRRKP LPPNNVTGKP GSAGIISSGP ITTPPLRSTP
760 770 780 790 800
RPTGTPLERI ETDIKQPTVP ASGEELENIT DFSSSPTRET DPLGKPRFKG
810 820 830 840 850
PHVRYIQKPD NSPCSITDSV KRFPKEEATE GNATSPPQNP PTNLTVVTVE
860 870 880 890 900
GCPSFVILDW EKPLNDTVTE YEVISRENGS FSGKNKSIQM TNQTFSTVEN
910 920 930 940 950
LKPNTSYEFQ VKPKNPLGEG PVSNTVAFST ESADPRVSEP VSAGRDAIWT
960 970 980 990 1000
ERPFNSDSYS ECKGKQYVKR TWYKKFVGVQ LCNSLRYKIY LSDSLTGKFY
1010 1020 1030 1040 1050
NIGDQRGHGE DHCQFVDSFL DGRTGQQLTS DQLPIKEGYF RAVRQEPVQF
1060 1070
GEIGGHTQIN YVQWYECGTT IPGKW
Length:1,075
Mass (Da):118,642
Last modified:October 1, 2003 - v1
Checksum:i52FF60EE360FA0F1
GO
Isoform 2 (identifier: Q7Z7G0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Show »
Length:486
Mass (Da):53,888
Checksum:i790AEBE657E0D766
GO
Isoform 3 (identifier: Q7Z7G0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-446: Missing.
     447-531: IFTSPEMQPT...PLSPEVTHTK → MTESLPVSDV...LPSPDEPQTE
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Note: No experimental confirmation available.

Show »
Length:655
Mass (Da):72,267
Checksum:iBA728A5D1FAC9343
GO
Isoform 4 (identifier: Q7Z7G0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-530: ALPAESKTPE...IPLSPEVTHT → MTIVPTTDIE...TTPRPEAPES
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Note: No experimental confirmation available.

Show »
Length:784
Mass (Da):86,789
Checksum:iF981C59445ACC6FF
GO

Sequence cautioni

The sequence CAB56034.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 614614Missing in isoform 2. 2 PublicationsVSP_010860Add
BLAST
Alternative sequencei1 – 316316Missing in isoform 3 and isoform 4. 1 PublicationVSP_010862Add
BLAST
Alternative sequencei317 – 530214ALPAE…EVTHT → MTIVPTTDIEPVTVRTEATV TTLAPKTSQRTRTRRPRPKH KTTPRPETLQTKLDFGPITP GTSSAPTTTTKRTRRPHPKP KTTPHPEVPQTKLAPKVPQR THRPHPKPKTTLSPEELQTE LVPVTDLGPVTFRTEIPATT LATKTSKRTRPPRPRPKTTP SPQAPETKPVPATVLEPVTL RPEASTTLASKTSQRTRRPR LRTKTTPRPEAPES in isoform 4. 1 PublicationVSP_010865Add
BLAST
Alternative sequencei317 – 446130Missing in isoform 3. 1 PublicationVSP_010863Add
BLAST
Alternative sequencei447 – 53185IFTSP…VTHTK → MTESLPVSDVLESVTLSTES PKETIAPAKTDYVYPTAKAP LWPEEPKTEVVESITYVSEP PETTLETSPLPSQSITLPSP DEPQTE in isoform 3. 1 PublicationVSP_010864Add
BLAST
Alternative sequencei676 – 6761P → PVLNRTTTRPTRPKPSGMPS GNGVGT in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_010861

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB056106 mRNA. Translation: BAB32867.1.
AK093861 mRNA. Translation: BAG52776.1.
AK123737 mRNA. Translation: BAC85685.1.
AK123748 mRNA. Translation: BAC85687.1.
CH471052 Genomic DNA. Translation: EAW79811.1.
BC030221 mRNA. Translation: AAH30221.1.
AL117664 mRNA. Translation: CAB56034.1. Different initiation.
CCDSiCCDS46880.1. [Q7Z7G0-1]
PIRiT17344.
RefSeqiNP_056244.2. NM_015429.3. [Q7Z7G0-1]
UniGeneiHs.477015.

Genome annotation databases

EnsembliENST00000284322; ENSP00000284322; ENSG00000154175. [Q7Z7G0-1]
GeneIDi25890.
KEGGihsa:25890.
UCSCiuc003duj.3. human. [Q7Z7G0-3]
uc003duk.3. human. [Q7Z7G0-4]
uc003dum.3. human. [Q7Z7G0-2]
uc003dun.3. human. [Q7Z7G0-1]

Polymorphism databases

DMDMi50401533.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB056106 mRNA. Translation: BAB32867.1 .
AK093861 mRNA. Translation: BAG52776.1 .
AK123737 mRNA. Translation: BAC85685.1 .
AK123748 mRNA. Translation: BAC85687.1 .
CH471052 Genomic DNA. Translation: EAW79811.1 .
BC030221 mRNA. Translation: AAH30221.1 .
AL117664 mRNA. Translation: CAB56034.1 . Different initiation.
CCDSi CCDS46880.1. [Q7Z7G0-1 ]
PIRi T17344.
RefSeqi NP_056244.2. NM_015429.3. [Q7Z7G0-1 ]
UniGenei Hs.477015.

3D structure databases

ProteinModelPortali Q7Z7G0.
SMRi Q7Z7G0. Positions 120-227, 837-931.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117399. 8 interactions.
IntActi Q7Z7G0. 7 interactions.

PTM databases

PhosphoSitei Q7Z7G0.

Polymorphism databases

DMDMi 50401533.

Proteomic databases

MaxQBi Q7Z7G0.
PaxDbi Q7Z7G0.
PRIDEi Q7Z7G0.

Protocols and materials databases

DNASUi 25890.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284322 ; ENSP00000284322 ; ENSG00000154175 . [Q7Z7G0-1 ]
GeneIDi 25890.
KEGGi hsa:25890.
UCSCi uc003duj.3. human. [Q7Z7G0-3 ]
uc003duk.3. human. [Q7Z7G0-4 ]
uc003dum.3. human. [Q7Z7G0-2 ]
uc003dun.3. human. [Q7Z7G0-1 ]

Organism-specific databases

CTDi 25890.
GeneCardsi GC03M100468.
HGNCi HGNC:17265. ABI3BP.
HPAi HPA044127.
MIMi 606279. gene.
neXtProti NX_Q7Z7G0.
PharmGKBi PA134977769.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG04687.
GeneTreei ENSGT00530000063558.
HOGENOMi HOG000065723.
HOVERGENi HBG056157.
InParanoidi Q7Z7G0.
PhylomeDBi Q7Z7G0.
TreeFami TF331037.

Miscellaneous databases

GenomeRNAii 25890.
NextBioi 47318.
PROi Q7Z7G0.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z7G0.
CleanExi HS_ABI3BP.
ExpressionAtlasi Q7Z7G0. baseline and differential.
Genevestigatori Q7Z7G0.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3."
    Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N., Yamaki K., Hayakawa T., Hamaguchi M.
    J. Hum. Genet. 46:483-486(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 706-1075.
    Tissue: Uterus.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44.
    Tissue: Liver.

Entry informationi

Entry nameiTARSH_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7G0
Secondary accession number(s): B3KSL4
, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3