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Protein

39S ribosomal protein L55, mitochondrial

Gene

MRPL55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L55, mitochondrial
Short name:
L55mt
Short name:
MRP-L55
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL31m1 Publication
Mitochondrial large ribosomal subunit protein mL551 Publication
Gene namesi
Name:MRPL55
ORF Names:UNQ5835/PRO19675
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162910.18.
HGNCiHGNC:16686. MRPL55.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162910.
PharmGKBiPA30988.

Polymorphism and mutation databases

BioMutaiMRPL55.
DMDMi74750237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000027309934 – 12839S ribosomal protein L55, mitochondrialAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z7F7.
MaxQBiQ7Z7F7.
PaxDbiQ7Z7F7.
PeptideAtlasiQ7Z7F7.
PRIDEiQ7Z7F7.
TopDownProteomicsiQ7Z7F7-1. [Q7Z7F7-1]

PTM databases

iPTMnetiQ7Z7F7.
PhosphoSitePlusiQ7Z7F7.

Expressioni

Gene expression databases

BgeeiENSG00000162910.
CleanExiHS_MRPL55.
ExpressionAtlasiQ7Z7F7. baseline and differential.
GenevisibleiQ7Z7F7. HS.

Organism-specific databases

HPAiHPA027641.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi126105. 55 interactors.
CORUMiQ7Z7F7.
IntActiQ7Z7F7. 17 interactors.
MINTiMINT-8052096.
STRINGi9606.ENSP00000355692.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 39Combined sources3
Beta strandi45 – 47Combined sources3
Beta strandi53 – 61Combined sources9
Beta strandi64 – 67Combined sources4
Beta strandi74 – 76Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50m1-128[»]
5OOLelectron microscopy3.06m1-128[»]
5OOMelectron microscopy3.03m1-128[»]
ProteinModelPortaliQ7Z7F7.
SMRiQ7Z7F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4616. Eukaryota.
ENOG41124VE. LUCA.
GeneTreeiENSGT00390000010309.
HOGENOMiHOG000006834.
HOVERGENiHBG080171.
InParanoidiQ7Z7F7.
KOiK17436.
OMAiERYRQFW.
OrthoDBiEOG091G11CW.
PhylomeDBiQ7Z7F7.
TreeFamiTF320422.

Family and domain databases

InterProiView protein in InterPro
IPR018615. Ribosomal_L55_mit.
PANTHERiPTHR34095. PTHR34095. 1 hit.
PfamiView protein in Pfam
PF09776. Mitoc_L55. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z7F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR
60 70 80 90 100
LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEERR ARLRKREAQL
110 120
QSRKEYEQEL SDDLHVERYR QFWTRTKK
Length:128
Mass (Da):15,128
Last modified:October 1, 2003 - v1
Checksum:iA7808C869855C994
GO
Isoform 2 (identifier: Q7Z7F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: G → GLAASSWLGGQNASDHSLWLLRKPRGSSCPGTGHQLC

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,903
Checksum:iAC44E758A2D54D49
GO

Sequence cautioni

The sequence CAI23115 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI23118 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03008224R → C. Corresponds to variant dbSNP:rs822730Ensembl.1
Natural variantiVAR_05204542R → H. Corresponds to variant dbSNP:rs35265990Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0224779G → GLAASSWLGGQNASDHSLWL LRKPRGSSCPGTGHQLC in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358771 mRNA. Translation: AAQ89131.1.
AL136379 Genomic DNA. Translation: CAI23115.1. Sequence problems.
AL136379 Genomic DNA. Translation: CAI23116.1.
AL136379 Genomic DNA. Translation: CAI23117.1.
AL136379 Genomic DNA. Translation: CAI23118.1. Sequence problems.
BC052806 mRNA. Translation: AAH52806.1.
CCDSiCCDS1567.1. [Q7Z7F7-1]
CCDS44325.1. [Q7Z7F7-2]
RefSeqiNP_001308213.1. NM_001321284.1. [Q7Z7F7-1]
NP_852106.1. NM_181441.2. [Q7Z7F7-1]
NP_852119.1. NM_181454.2. [Q7Z7F7-1]
NP_852120.1. NM_181455.2. [Q7Z7F7-1]
NP_852121.1. NM_181456.2. [Q7Z7F7-1]
NP_852127.2. NM_181462.2. [Q7Z7F7-2]
NP_852128.1. NM_181463.2. [Q7Z7F7-1]
NP_852129.1. NM_181464.2. [Q7Z7F7-1]
NP_852130.1. NM_181465.2. [Q7Z7F7-1]
XP_005273116.1. XM_005273059.3. [Q7Z7F7-1]
XP_005273118.1. XM_005273061.4. [Q7Z7F7-1]
XP_005273119.1. XM_005273062.3. [Q7Z7F7-1]
XP_005273120.1. XM_005273063.4. [Q7Z7F7-1]
XP_011542396.1. XM_011544094.2. [Q7Z7F7-1]
XP_011542397.1. XM_011544095.2. [Q7Z7F7-1]
UniGeneiHs.63236.

Genome annotation databases

EnsembliENST00000295008; ENSP00000295008; ENSG00000162910. [Q7Z7F7-1]
ENST00000336300; ENSP00000337361; ENSG00000162910. [Q7Z7F7-1]
ENST00000336520; ENSP00000337342; ENSG00000162910. [Q7Z7F7-1]
ENST00000348259; ENSP00000338189; ENSG00000162910. [Q7Z7F7-1]
ENST00000366733; ENSP00000355694; ENSG00000162910. [Q7Z7F7-1]
ENST00000366734; ENSP00000355695; ENSG00000162910. [Q7Z7F7-1]
ENST00000366735; ENSP00000355696; ENSG00000162910. [Q7Z7F7-1]
ENST00000366736; ENSP00000355697; ENSG00000162910. [Q7Z7F7-1]
ENST00000366738; ENSP00000355699; ENSG00000162910. [Q7Z7F7-2]
ENST00000366739; ENSP00000355700; ENSG00000162910. [Q7Z7F7-1]
ENST00000366740; ENSP00000355701; ENSG00000162910. [Q7Z7F7-1]
ENST00000366741; ENSP00000355702; ENSG00000162910. [Q7Z7F7-1]
ENST00000366742; ENSP00000355703; ENSG00000162910. [Q7Z7F7-1]
ENST00000366744; ENSP00000355705; ENSG00000162910. [Q7Z7F7-1]
ENST00000366746; ENSP00000355707; ENSG00000162910. [Q7Z7F7-1]
ENST00000366747; ENSP00000355708; ENSG00000162910. [Q7Z7F7-1]
ENST00000391867; ENSP00000375740; ENSG00000162910. [Q7Z7F7-1]
ENST00000430433; ENSP00000403614; ENSG00000162910. [Q7Z7F7-2]
GeneIDi128308.
KEGGihsa:128308.
UCSCiuc001hrz.5. human. [Q7Z7F7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM55_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7F7
Secondary accession number(s): Q5TBY3, Q5TBY6, Q6UWI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families