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Protein

39S ribosomal protein L55, mitochondrial

Gene

MRPL55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L55, mitochondrial
Short name:
L55mt
Short name:
MRP-L55
Gene namesi
Name:MRPL55
ORF Names:UNQ5835/PRO19675
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16686. MRPL55.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30988.

Polymorphism and mutation databases

BioMutaiMRPL55.
DMDMi74750237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence analysisAdd
BLAST
Chaini34 – 1289539S ribosomal protein L55, mitochondrialPRO_0000273099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z7F7.
MaxQBiQ7Z7F7.
PaxDbiQ7Z7F7.
PeptideAtlasiQ7Z7F7.
PRIDEiQ7Z7F7.
TopDownProteomicsiQ7Z7F7-1. [Q7Z7F7-1]

PTM databases

iPTMnetiQ7Z7F7.
PhosphoSiteiQ7Z7F7.

Expressioni

Gene expression databases

BgeeiENSG00000162910.
CleanExiHS_MRPL55.
ExpressionAtlasiQ7Z7F7. baseline and differential.
GenevisibleiQ7Z7F7. HS.

Organism-specific databases

HPAiHPA027641.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi126105. 48 interactions.
IntActiQ7Z7F7. 16 interactions.
MINTiMINT-8052096.
STRINGi9606.ENSP00000355692.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50m1-128[»]
ProteinModelPortaliQ7Z7F7.
SMRiQ7Z7F7. Positions 34-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4616. Eukaryota.
ENOG41124VE. LUCA.
GeneTreeiENSGT00390000010309.
HOGENOMiHOG000006834.
HOVERGENiHBG080171.
InParanoidiQ7Z7F7.
KOiK17436.
OMAiERYRQFW.
OrthoDBiEOG091G11CW.
PhylomeDBiQ7Z7F7.
TreeFamiTF320422.

Family and domain databases

InterProiIPR018615. Ribosomal_L55_mit.
[Graphical view]
PfamiPF09776. Mitoc_L55. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z7F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR
60 70 80 90 100
LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEERR ARLRKREAQL
110 120
QSRKEYEQEL SDDLHVERYR QFWTRTKK
Length:128
Mass (Da):15,128
Last modified:October 1, 2003 - v1
Checksum:iA7808C869855C994
GO
Isoform 2 (identifier: Q7Z7F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: G → GLAASSWLGGQNASDHSLWLLRKPRGSSCPGTGHQLC

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,903
Checksum:iAC44E758A2D54D49
GO

Sequence cautioni

The sequence CAI23115 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI23118 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → C.
Corresponds to variant rs822730 [ dbSNP | Ensembl ].
VAR_030082
Natural varianti42 – 421R → H.
Corresponds to variant rs35265990 [ dbSNP | Ensembl ].
VAR_052045

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 91G → GLAASSWLGGQNASDHSLWL LRKPRGSSCPGTGHQLC in isoform 2. 1 PublicationVSP_022477

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358771 mRNA. Translation: AAQ89131.1.
AL136379 Genomic DNA. Translation: CAI23115.1. Sequence problems.
AL136379 Genomic DNA. Translation: CAI23116.1.
AL136379 Genomic DNA. Translation: CAI23117.1.
AL136379 Genomic DNA. Translation: CAI23118.1. Sequence problems.
BC052806 mRNA. Translation: AAH52806.1.
CCDSiCCDS1567.1. [Q7Z7F7-1]
CCDS44325.1. [Q7Z7F7-2]
RefSeqiNP_001308213.1. NM_001321284.1. [Q7Z7F7-1]
NP_852106.1. NM_181441.2. [Q7Z7F7-1]
NP_852119.1. NM_181454.2. [Q7Z7F7-1]
NP_852120.1. NM_181455.2. [Q7Z7F7-1]
NP_852121.1. NM_181456.2. [Q7Z7F7-1]
NP_852127.2. NM_181462.2. [Q7Z7F7-2]
NP_852128.1. NM_181463.2. [Q7Z7F7-1]
NP_852129.1. NM_181464.2. [Q7Z7F7-1]
NP_852130.1. NM_181465.2. [Q7Z7F7-1]
XP_005273116.1. XM_005273059.3. [Q7Z7F7-1]
XP_005273118.1. XM_005273061.4. [Q7Z7F7-1]
XP_005273119.1. XM_005273062.3. [Q7Z7F7-1]
XP_005273120.1. XM_005273063.4. [Q7Z7F7-1]
XP_011542396.1. XM_011544094.2. [Q7Z7F7-1]
XP_011542397.1. XM_011544095.2. [Q7Z7F7-1]
UniGeneiHs.63236.

Genome annotation databases

EnsembliENST00000295008; ENSP00000295008; ENSG00000162910. [Q7Z7F7-1]
ENST00000336300; ENSP00000337361; ENSG00000162910. [Q7Z7F7-1]
ENST00000336520; ENSP00000337342; ENSG00000162910. [Q7Z7F7-1]
ENST00000348259; ENSP00000338189; ENSG00000162910. [Q7Z7F7-1]
ENST00000366733; ENSP00000355694; ENSG00000162910. [Q7Z7F7-1]
ENST00000366734; ENSP00000355695; ENSG00000162910. [Q7Z7F7-1]
ENST00000366735; ENSP00000355696; ENSG00000162910. [Q7Z7F7-1]
ENST00000366736; ENSP00000355697; ENSG00000162910. [Q7Z7F7-1]
ENST00000366738; ENSP00000355699; ENSG00000162910. [Q7Z7F7-2]
ENST00000366739; ENSP00000355700; ENSG00000162910. [Q7Z7F7-1]
ENST00000366740; ENSP00000355701; ENSG00000162910. [Q7Z7F7-1]
ENST00000366741; ENSP00000355702; ENSG00000162910. [Q7Z7F7-1]
ENST00000366742; ENSP00000355703; ENSG00000162910. [Q7Z7F7-1]
ENST00000366744; ENSP00000355705; ENSG00000162910. [Q7Z7F7-1]
ENST00000366746; ENSP00000355707; ENSG00000162910. [Q7Z7F7-1]
ENST00000366747; ENSP00000355708; ENSG00000162910. [Q7Z7F7-1]
ENST00000391867; ENSP00000375740; ENSG00000162910. [Q7Z7F7-1]
ENST00000430433; ENSP00000403614; ENSG00000162910. [Q7Z7F7-2]
GeneIDi128308.
KEGGihsa:128308.
UCSCiuc001hrz.5. human. [Q7Z7F7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358771 mRNA. Translation: AAQ89131.1.
AL136379 Genomic DNA. Translation: CAI23115.1. Sequence problems.
AL136379 Genomic DNA. Translation: CAI23116.1.
AL136379 Genomic DNA. Translation: CAI23117.1.
AL136379 Genomic DNA. Translation: CAI23118.1. Sequence problems.
BC052806 mRNA. Translation: AAH52806.1.
CCDSiCCDS1567.1. [Q7Z7F7-1]
CCDS44325.1. [Q7Z7F7-2]
RefSeqiNP_001308213.1. NM_001321284.1. [Q7Z7F7-1]
NP_852106.1. NM_181441.2. [Q7Z7F7-1]
NP_852119.1. NM_181454.2. [Q7Z7F7-1]
NP_852120.1. NM_181455.2. [Q7Z7F7-1]
NP_852121.1. NM_181456.2. [Q7Z7F7-1]
NP_852127.2. NM_181462.2. [Q7Z7F7-2]
NP_852128.1. NM_181463.2. [Q7Z7F7-1]
NP_852129.1. NM_181464.2. [Q7Z7F7-1]
NP_852130.1. NM_181465.2. [Q7Z7F7-1]
XP_005273116.1. XM_005273059.3. [Q7Z7F7-1]
XP_005273118.1. XM_005273061.4. [Q7Z7F7-1]
XP_005273119.1. XM_005273062.3. [Q7Z7F7-1]
XP_005273120.1. XM_005273063.4. [Q7Z7F7-1]
XP_011542396.1. XM_011544094.2. [Q7Z7F7-1]
XP_011542397.1. XM_011544095.2. [Q7Z7F7-1]
UniGeneiHs.63236.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50m1-128[»]
ProteinModelPortaliQ7Z7F7.
SMRiQ7Z7F7. Positions 34-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126105. 48 interactions.
IntActiQ7Z7F7. 16 interactions.
MINTiMINT-8052096.
STRINGi9606.ENSP00000355692.

PTM databases

iPTMnetiQ7Z7F7.
PhosphoSiteiQ7Z7F7.

Polymorphism and mutation databases

BioMutaiMRPL55.
DMDMi74750237.

Proteomic databases

EPDiQ7Z7F7.
MaxQBiQ7Z7F7.
PaxDbiQ7Z7F7.
PeptideAtlasiQ7Z7F7.
PRIDEiQ7Z7F7.
TopDownProteomicsiQ7Z7F7-1. [Q7Z7F7-1]

Protocols and materials databases

DNASUi128308.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295008; ENSP00000295008; ENSG00000162910. [Q7Z7F7-1]
ENST00000336300; ENSP00000337361; ENSG00000162910. [Q7Z7F7-1]
ENST00000336520; ENSP00000337342; ENSG00000162910. [Q7Z7F7-1]
ENST00000348259; ENSP00000338189; ENSG00000162910. [Q7Z7F7-1]
ENST00000366733; ENSP00000355694; ENSG00000162910. [Q7Z7F7-1]
ENST00000366734; ENSP00000355695; ENSG00000162910. [Q7Z7F7-1]
ENST00000366735; ENSP00000355696; ENSG00000162910. [Q7Z7F7-1]
ENST00000366736; ENSP00000355697; ENSG00000162910. [Q7Z7F7-1]
ENST00000366738; ENSP00000355699; ENSG00000162910. [Q7Z7F7-2]
ENST00000366739; ENSP00000355700; ENSG00000162910. [Q7Z7F7-1]
ENST00000366740; ENSP00000355701; ENSG00000162910. [Q7Z7F7-1]
ENST00000366741; ENSP00000355702; ENSG00000162910. [Q7Z7F7-1]
ENST00000366742; ENSP00000355703; ENSG00000162910. [Q7Z7F7-1]
ENST00000366744; ENSP00000355705; ENSG00000162910. [Q7Z7F7-1]
ENST00000366746; ENSP00000355707; ENSG00000162910. [Q7Z7F7-1]
ENST00000366747; ENSP00000355708; ENSG00000162910. [Q7Z7F7-1]
ENST00000391867; ENSP00000375740; ENSG00000162910. [Q7Z7F7-1]
ENST00000430433; ENSP00000403614; ENSG00000162910. [Q7Z7F7-2]
GeneIDi128308.
KEGGihsa:128308.
UCSCiuc001hrz.5. human. [Q7Z7F7-1]

Organism-specific databases

CTDi128308.
GeneCardsiMRPL55.
HGNCiHGNC:16686. MRPL55.
HPAiHPA027641.
MIMi611859. gene.
neXtProtiNX_Q7Z7F7.
PharmGKBiPA30988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4616. Eukaryota.
ENOG41124VE. LUCA.
GeneTreeiENSGT00390000010309.
HOGENOMiHOG000006834.
HOVERGENiHBG080171.
InParanoidiQ7Z7F7.
KOiK17436.
OMAiERYRQFW.
OrthoDBiEOG091G11CW.
PhylomeDBiQ7Z7F7.
TreeFamiTF320422.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL55. human.
GeneWikiiMRPL55.
GenomeRNAii128308.
PROiQ7Z7F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162910.
CleanExiHS_MRPL55.
ExpressionAtlasiQ7Z7F7. baseline and differential.
GenevisibleiQ7Z7F7. HS.

Family and domain databases

InterProiIPR018615. Ribosomal_L55_mit.
[Graphical view]
PfamiPF09776. Mitoc_L55. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM55_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7F7
Secondary accession number(s): Q5TBY3, Q5TBY6, Q6UWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.