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Q7Z7D3

- VTCN1_HUMAN

UniProt

Q7Z7D3 - VTCN1_HUMAN

Protein

V-set domain-containing T-cell activation inhibitor 1

Gene

VTCN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.By similarity4 Publications

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW
    2. interferon-gamma secretion Source: Ensembl
    3. interleukin-4 secretion Source: Ensembl
    4. negative regulation of T cell activation Source: Ensembl
    5. response to protozoan Source: Ensembl

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-set domain-containing T-cell activation inhibitor 1
    Alternative name(s):
    B7 homolog 4
    Short name:
    B7-H4
    B7h.5
    Immune costimulatory protein B7-H4
    Protein B7S1
    T-cell costimulatory molecule B7x
    Gene namesi
    Name:VTCN1Imported
    Synonyms:B7H4Imported
    ORF Names:UNQ659/PRO1291
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28873. VTCN1.

    Subcellular locationi

    Cell membrane Sequence Analysis; Single-pass type I membrane protein Curated
    Note: Expressed at the cell surface. A soluble form has also been detected.3 PublicationsSequence Analysis

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670611.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 282258V-set domain-containing T-cell activation inhibitor 1Sequence AnalysisPRO_0000339237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
    Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein

    Proteomic databases

    PaxDbiQ7Z7D3.
    PRIDEiQ7Z7D3.

    Expressioni

    Tissue specificityi

    Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.7 Publications

    Inductioni

    Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs).3 Publications

    Gene expression databases

    ArrayExpressiQ7Z7D3.
    BgeeiQ7Z7D3.
    CleanExiHS_VTCN1.
    GenevestigatoriQ7Z7D3.

    Organism-specific databases

    HPAiHPA054200.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000358470.

    Structurei

    Secondary structure

    1
    282
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 424
    Beta strandi44 – 474
    Beta strandi52 – 587
    Helixi64 – 663
    Beta strandi68 – 736
    Beta strandi77 – 848
    Helixi95 – 973
    Beta strandi101 – 1033
    Turni105 – 1073
    Helixi108 – 1103
    Beta strandi115 – 1195
    Helixi122 – 1243
    Beta strandi126 – 1349
    Beta strandi137 – 14812

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GOSX-ray1.59A30-148[»]
    ProteinModelPortaliQ7Z7D3.
    SMRiQ7Z7D3. Positions 35-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 259235ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini281 – 2822CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 146112Ig-like V-type 1Sequence AnalysisAdd
    BLAST
    Domaini153 – 24189Ig-like V-type 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG87575.
    HOGENOMiHOG000139645.
    HOVERGENiHBG097943.
    InParanoidiQ7Z7D3.
    KOiK06747.
    OrthoDBiEOG7FBRH9.
    PhylomeDBiQ7Z7D3.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 17 Publications (identifier: Q7Z7D3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE    50
    DGILSCTFEP DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR 100
    TAVFADQVIV GNASLRLKNV QLTDAGTYKC YIITSKGKGN ANLEYKTGAF 150
    SMPEVNVDYN ASSETLRCEA PRWFPQPTVV WASQVDQGAN FSEVSNTSFE 200
    LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TESEIKRRSH 250
    LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK 282
    Length:282
    Mass (Da):30,878
    Last modified:October 1, 2003 - v1
    Checksum:i1C9C565A9242E78C
    GO
    Isoform 21 Publication (identifier: Q7Z7D3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-148: Missing.

    Show »
    Length:166
    Mass (Da):18,275
    Checksum:i30FFF157B8C66DE2
    GO
    Isoform 31 Publication (identifier: Q7Z7D3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-87: GRHSITVTTV...GLVHEFKEGK → EVSVWLSAMK...WGGWNPELHF
         88-282: Missing.

    Show »
    Length:87
    Mass (Da):9,875
    Checksum:i1006690A861AB006
    GO
    Isoform 4 (identifier: Q7Z7D3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-95: Missing.

    Show »
    Length:187
    Mass (Da):20,743
    Checksum:i9AED6155AEED4E63
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291F → L in ABI16083. 1 PublicationCurated
    Sequence conflicti54 – 541L → Q in BAB15349. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9595Missing in isoform 4. 2 PublicationsVSP_045423Add
    BLAST
    Alternative sequencei33 – 148116Missing in isoform 2. 1 PublicationVSP_052841Add
    BLAST
    Alternative sequencei33 – 8755GRHSI…FKEGK → EVSVWLSAMKGWCRSSKASL SIDLCFLNFRETLHHSHYCR LSWEHWGGWNPELHF in isoform 3. 1 PublicationVSP_052842Add
    BLAST
    Alternative sequencei88 – 282195Missing in isoform 3. 1 PublicationVSP_052843Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280972 mRNA. Translation: AAP37283.1.
    AY346100 mRNA. Translation: AAQ24206.1.
    DQ103757 mRNA. Translation: AAZ17406.1.
    AY442303 mRNA. Translation: AAS13400.1.
    AY358352 mRNA. Translation: AAQ88718.1.
    AK026071 mRNA. Translation: BAB15349.1.
    AK303466 mRNA. Translation: BAH13967.1.
    AL391476 Genomic DNA. Translation: CAI12739.1.
    CH471122 Genomic DNA. Translation: EAW56672.1.
    CH471122 Genomic DNA. Translation: EAW56673.1.
    BC065717 mRNA. Translation: AAH65717.1.
    BC074729 mRNA. Translation: AAH74729.1.
    DQ836392 mRNA. Translation: ABI16083.1.
    CCDSiCCDS58019.1. [Q7Z7D3-4]
    CCDS58020.1. [Q7Z7D3-2]
    CCDS894.1. [Q7Z7D3-1]
    RefSeqiNP_001240778.1. NM_001253849.1. [Q7Z7D3-4]
    NP_001240779.1. NM_001253850.1. [Q7Z7D3-2]
    NP_078902.2. NM_024626.3. [Q7Z7D3-1]
    UniGeneiHs.546434.

    Genome annotation databases

    EnsembliENST00000328189; ENSP00000328168; ENSG00000134258. [Q7Z7D3-2]
    ENST00000369458; ENSP00000358470; ENSG00000134258. [Q7Z7D3-1]
    ENST00000539893; ENSP00000444724; ENSG00000134258. [Q7Z7D3-4]
    GeneIDi79679.
    KEGGihsa:79679.
    UCSCiuc001ehb.3. human. [Q7Z7D3-1]
    uc009whf.2. human. [Q7Z7D3-2]

    Polymorphism databases

    DMDMi74759262.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280972 mRNA. Translation: AAP37283.1 .
    AY346100 mRNA. Translation: AAQ24206.1 .
    DQ103757 mRNA. Translation: AAZ17406.1 .
    AY442303 mRNA. Translation: AAS13400.1 .
    AY358352 mRNA. Translation: AAQ88718.1 .
    AK026071 mRNA. Translation: BAB15349.1 .
    AK303466 mRNA. Translation: BAH13967.1 .
    AL391476 Genomic DNA. Translation: CAI12739.1 .
    CH471122 Genomic DNA. Translation: EAW56672.1 .
    CH471122 Genomic DNA. Translation: EAW56673.1 .
    BC065717 mRNA. Translation: AAH65717.1 .
    BC074729 mRNA. Translation: AAH74729.1 .
    DQ836392 mRNA. Translation: ABI16083.1 .
    CCDSi CCDS58019.1. [Q7Z7D3-4 ]
    CCDS58020.1. [Q7Z7D3-2 ]
    CCDS894.1. [Q7Z7D3-1 ]
    RefSeqi NP_001240778.1. NM_001253849.1. [Q7Z7D3-4 ]
    NP_001240779.1. NM_001253850.1. [Q7Z7D3-2 ]
    NP_078902.2. NM_024626.3. [Q7Z7D3-1 ]
    UniGenei Hs.546434.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GOS X-ray 1.59 A 30-148 [» ]
    ProteinModelPortali Q7Z7D3.
    SMRi Q7Z7D3. Positions 35-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000358470.

    Protein family/group databases

    MEROPSi I43.001.

    Polymorphism databases

    DMDMi 74759262.

    Proteomic databases

    PaxDbi Q7Z7D3.
    PRIDEi Q7Z7D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328189 ; ENSP00000328168 ; ENSG00000134258 . [Q7Z7D3-2 ]
    ENST00000369458 ; ENSP00000358470 ; ENSG00000134258 . [Q7Z7D3-1 ]
    ENST00000539893 ; ENSP00000444724 ; ENSG00000134258 . [Q7Z7D3-4 ]
    GeneIDi 79679.
    KEGGi hsa:79679.
    UCSCi uc001ehb.3. human. [Q7Z7D3-1 ]
    uc009whf.2. human. [Q7Z7D3-2 ]

    Organism-specific databases

    CTDi 79679.
    GeneCardsi GC01M117686.
    H-InvDB HIX0000935.
    HGNCi HGNC:28873. VTCN1.
    HPAi HPA054200.
    MIMi 608162. gene.
    neXtProti NX_Q7Z7D3.
    PharmGKBi PA142670611.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87575.
    HOGENOMi HOG000139645.
    HOVERGENi HBG097943.
    InParanoidi Q7Z7D3.
    KOi K06747.
    OrthoDBi EOG7FBRH9.
    PhylomeDBi Q7Z7D3.
    TreeFami TF331083.

    Miscellaneous databases

    GeneWikii VTCN1.
    GenomeRNAii 79679.
    NextBioi 68926.
    PROi Q7Z7D3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z7D3.
    Bgeei Q7Z7D3.
    CleanExi HS_VTCN1.
    Genevestigatori Q7Z7D3.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."
      Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L.
      Immunity 18:849-861(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Placenta1 Publication.
    2. "B7x: a widely expressed B7 family member that inhibits T cell activation."
      Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J.P.
      Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "B7-H3 and B7-H4 expression in non-small-cell lung cancer."
      Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X.
      Lung Cancer 53:143-151(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "A new splice variant of B7-H4."
      Mao Y., Zhang X.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Kidney epithelium1 Publication and Thymus.
    7. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: BrainImported and Prostate.
    10. Huang G., Bai Y., Zhang L., Zhang L., Song M.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-167 (ISOFORM 1).
      Tissue: Peripheral blood.
    11. "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family."
      Choi I.-H., Zhu G., Sica G.L., Strome S.E., Cheville J.C., Lau J.S., Zhu Y., Flies D.B., Tamada K., Chen L.
      J. Immunol. 171:4650-4654(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    12. "The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation."
      Salceda S., Tang T., Kmet M., Munteanu A., Ghosh M., Macina R., Liu W., Pilkington G., Papkoff J.
      Exp. Cell Res. 306:128-141(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
    13. "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma."
      Kryczek I., Zou L., Rodriguez P., Zhu G., Wei S., Mottram P., Brumlik M., Cheng P., Curiel T., Myers L., Lackner A., Alvarez X., Ochoa A., Chen L., Zou W.
      J. Exp. Med. 203:871-881(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    14. "Induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells."
      Kryczek I., Wei S., Zou L., Zhu G., Mottram P., Xu H., Chen L., Zou W.
      J. Immunol. 177:40-44(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    15. "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival."
      Krambeck A.E., Thompson R.H., Dong H., Lohse C.M., Park E.S., Kuntz S.M., Leibovich B.C., Blute M.L., Cheville J.C., Kwon E.D.
      Proc. Natl. Acad. Sci. U.S.A. 103:10391-10396(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, USE AS A MARKER FOR RENAL CELL CANCER.
    16. "Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma."
      Kryczek I., Wei S., Zhu G., Myers L., Mottram P., Cheng P., Chen L., Coukos G., Zou W.
      Cancer Res. 67:8900-8905(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    17. "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration."
      Miyatake T., Tringler B., Liu W., Liu S.-H., Papkoff J., Enomoto T., Torkko K.C., Dehn D.L., Swisher A., Shroyer K.R.
      Gynecol. Oncol. 106:119-127(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiVTCN1_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7D3
    Secondary accession number(s): Q0GN76
    , Q45VN0, Q5WPZ3, Q6P097, Q9H6B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    May serve as a predictive marker for renal cell carcinoma.1 Publication

    Caution

    The mouse ortholog has been shown to be a GPI-anchored protein but the Gly residue which is predicted to be the modified site in mouse and rat is not conserved in human.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3