Q7Z7D3 (VTCN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-set domain-containing T-cell activation inhibitor 1

Alternative name(s):
B7h.5
Immune costimulatory protein B7-H4
Protein B7S1
T-cell costimulatory molecule B7x

Gene names

Name:	VTCN1
Synonyms:	B7H4
ORF Names:	UNQ659/PRO1291

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Ref.12 Ref.13 Ref.16 Ref.17 UniProtKB Q7TSP5
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential. Note: Expressed at the cell surface. A soluble form has also been detected. Ref.1 Ref.3 Ref.12
Tissue specificity	Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. Ref.1 Ref.3 Ref.11 Ref.12 Ref.13 Ref.15 Ref.17
Induction	Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs). Ref.13 Ref.14 Ref.16
Post-translational modification	N-glycosylated. Ref.12
Miscellaneous	May serve as a predictive marker for renal cell carcinoma. Ref.15
Sequence similarities	Belongs to the immunoglobulin superfamily. BTN/MOG family. UniProtKB Q5ZPR3 Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Caution	The mouse ortholog has been shown (PubMed:12818166) to be a GPI-anchored protein but the Gly residue which is predicted to be the modified site in mouse and rat is not conserved in human.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Lipoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	interferon-gamma secretion Inferred from electronic annotation. Source: Compara interleukin-4 secretion Inferred from electronic annotation. Source: Compara negative regulation of T cell activation Inferred from electronic annotation. Source: Compara response to protozoan Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 (identifier: Q7Z7D3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.3 (identifier: Q7Z7D3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     33-148: Missing.

Isoform 3 Ref.4 (identifier: Q7Z7D3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     33-87: GRHSITVTTV...GLVHEFKEGK → EVSVWLSAMK...WGGWNPELHF
     88-282: Missing.

Isoform 4 (identifier: Q7Z7D3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Potential

Chain

25 – 282

258

V-set domain-containing T-cell activation inhibitor 1

PRO_0000339237

Regions

Topological domain

25 – 259

235

Extracellular Potential

Transmembrane

260 – 280

21

Helical; Potential

Topological domain

281 – 282

2

Cytoplasmic Potential

Domain

35 – 146

112

Ig-like V-type 1

Domain

153 – 241

89

Ig-like V-type 2

Amino acid modifications

Glycosylation

216

1

N-linked (GlcNAc...) Potential

Disulfide bond

56 ↔ 130

By similarity

Disulfide bond

168 ↔ 225

By similarity

Natural variations

Alternative sequence

1 – 95

95

Missing in isoform 4.

VSP_045423

Alternative sequence

33 – 148

116

Missing in isoform 2. Ref.3

VSP_052841

Alternative sequence

33 – 87

55

GRHSI…FKEGK → EVSVWLSAMKGWCRSSKASL SIDLCFLNFRETLHHSHYCR LSWEHWGGWNPELHF in isoform 3. Ref.4

VSP_052842

Alternative sequence

88 – 282

195

Missing in isoform 3. Ref.4

VSP_052843

Experimental info

Sequence conflict

29

1

F → L in ABI16083. Ref.10

Sequence conflict

54

1

L → Q in BAB15349. Ref.6

Secondary structure

1

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282

Helix Strand Turn

Details...

Beta strand

39 – 42

4

Beta strand

44 – 47

4

Beta strand

52 – 58

7

Helix

64 – 66

3

Beta strand

68 – 73

6

Beta strand

77 – 84

8

Helix

95 – 97

3

Beta strand

101 – 103

3

Turn

105 – 107

3

Helix

108 – 110

3

Beta strand

115 – 119

5

Helix

122 – 124

3

Beta strand

126 – 134

9

Beta strand

137 – 148

12

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 1C9C565A9242E78C	FASTA	282	30,878
	10 20 30 40 50 60 MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE DGILSCTFEP 70 80 90 100 110 120 DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR TAVFADQVIV GNASLRLKNV 130 140 150 160 170 180 QLTDAGTYKC YIITSKGKGN ANLEYKTGAF SMPEVNVDYN ASSETLRCEA PRWFPQPTVV 190 200 210 220 230 240 WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV 250 260 270 280 TESEIKRRSH LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK
	Isoform 2 [UniParc]. Checksum: 30FFF157B8C66DE2	FASTA	166	18,275
	10 20 30 40 50 60 MASLGQILFW SIISIIIILA GAIALIIGFG ISAFSMPEVN VDYNASSETL RCEAPRWFPQ 70 80 90 100 110 120 PTVVWASQVD QGANFSEVSN TSFELNSENV TMKVVSVLYN VTINNTYSCM IENDIAKATG 130 140 150 160 DIKVTESEIK RRSHLQLLNS KASLCVSSFF AISWALLPLS PYLMLK
	Isoform 3 [UniParc]. Checksum: 1006690A861AB006	FASTA	87	9,875
	10 20 30 40 50 60 MASLGQILFW SIISIIIILA GAIALIIGFG ISEVSVWLSA MKGWCRSSKA SLSIDLCFLN 70 80 FRETLHHSHY CRLSWEHWGG WNPELHF
	Isoform 4 [UniParc]. Checksum: 9AED6155AEED4E63	FASTA	187	20,743
	10 20 30 40 50 60 MFRGRTAVFA DQVIVGNASL RLKNVQLTDA GTYKCYIITS KGKGNANLEY KTGAFSMPEV 70 80 90 100 110 120 NVDYNASSET LRCEAPRWFP QPTVVWASQV DQGANFSEVS NTSFELNSEN VTMKVVSVLY 130 140 150 160 170 180 NVTINNTYSC MIENDIAKAT GDIKVTESEI KRRSHLQLLN SKASLCVSSF FAISWALLPL SPYLMLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"B7-H4, a molecule of the B7 family, negatively regulates T cell immunity." Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L. Immunity 18:849-861(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"B7x: a widely expressed B7 family member that inhibits T cell activation." Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J.P. Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"B7-H3 and B7-H4 expression in non-small-cell lung cancer." Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X. Lung Cancer 53:143-151(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	"A new splice variant of B7-H4." Mao Y., Zhang X. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Kidney epithelium and Thymus.
[7]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain and Prostate.
[10]	Huang G., Bai Y., Zhang L., Zhang L., Song M. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-167 (ISOFORM 1). Tissue: Peripheral blood.
[11]	"Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family." Choi I.-H., Zhu G., Sica G.L., Strome S.E., Cheville J.C., Lau J.S., Zhu Y., Flies D.B., Tamada K., Chen L. J. Immunol. 171:4650-4654(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[12]	"The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation." Salceda S., Tang T., Kmet M., Munteanu A., Ghosh M., Macina R., Liu W., Pilkington G., Papkoff J. Exp. Cell Res. 306:128-141(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
[13]	"B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma." Kryczek I., Zou L., Rodriguez P., Zhu G., Wei S., Mottram P., Brumlik M., Cheng P., Curiel T., Myers L., Lackner A., Alvarez X., Ochoa A., Chen L., Zou W. J. Exp. Med. 203:871-881(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
[14]	"Induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells." Kryczek I., Wei S., Zou L., Zhu G., Mottram P., Xu H., Chen L., Zou W. J. Immunol. 177:40-44(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[15]	"B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival." Krambeck A.E., Thompson R.H., Dong H., Lohse C.M., Park E.S., Kuntz S.M., Leibovich B.C., Blute M.L., Cheville J.C., Kwon E.D. Proc. Natl. Acad. Sci. U.S.A. 103:10391-10396(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, USE AS A MARKER FOR RENAL CELL CANCER.
[16]	"Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma." Kryczek I., Wei S., Zhu G., Myers L., Mottram P., Cheng P., Chen L., Coukos G., Zou W. Cancer Res. 67:8900-8905(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[17]	"B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration." Miyatake T., Tringler B., Liu W., Liu S.-H., Papkoff J., Enomoto T., Torkko K.C., Dehn D.L., Swisher A., Shroyer K.R. Gynecol. Oncol. 106:119-127(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY280972 mRNA. Translation: AAP37283.1.
AY346100 mRNA. Translation: AAQ24206.1.
DQ103757 mRNA. Translation: AAZ17406.1.
AY442303 mRNA. Translation: AAS13400.1.
AY358352 mRNA. Translation: AAQ88718.1.
AK026071 mRNA. Translation: BAB15349.1.
AK303466 mRNA. Translation: BAH13967.1.
AL391476 Genomic DNA. Translation: CAI12739.1.
CH471122 Genomic DNA. Translation: EAW56672.1.
CH471122 Genomic DNA. Translation: EAW56673.1.
BC065717 mRNA. Translation: AAH65717.1.
BC074729 mRNA. Translation: AAH74729.1.
DQ836392 mRNA. Translation: ABI16083.1.

IPI

IPI00479574.
IPI00640575.
IPI00644574.

RefSeq

NP_001240778.1. NM_001253849.1.
NP_001240779.1. NM_001253850.1.
NP_078902.2. NM_024626.3.

UniGene

Hs.546434.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4GOS	X-ray	1.59	A	30-148	[»]

ProteinModelPortal

Q7Z7D3.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000358470.

Protein family/group databases

MEROPS

I43.001.

Polymorphism databases

DMDM

74759262.

Proteomic databases

PaxDb

Q7Z7D3.

PRIDE

Q7Z7D3.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000328189; ENSP00000328168; ENSG00000134258.
ENST00000369458; ENSP00000358470; ENSG00000134258.
ENST00000539893; ENSP00000444724; ENSG00000134258.

GeneID

79679.

KEGG

hsa:79679.

UCSC

uc001ehb.3. human.
uc009whf.2. human.

Organism-specific databases

CTD

79679.

GeneCards

GC01M117686.

H-InvDB

HIX0000935.

HGNC

HGNC:28873. VTCN1.

HPA

HPA054200.

MIM

608162. gene.

neXtProt

NX_Q7Z7D3.

PharmGKB

PA142670611.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG87575.

HOGENOM

HOG000139645.

HOVERGEN

HBG097943.

InParanoid

Q7Z7D3.

KO

K06747.

OrthoDB

EOG4MGS84.

PhylomeDB

Q7Z7D3.

Gene expression databases

ArrayExpress

Q7Z7D3.

Bgee

Q7Z7D3.

CleanEx

HS_VTCN1.

Genevestigator

Q7Z7D3.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00409. IG. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

79679.

NextBio

68926.

SOURCE

Search...

Entry information

Entry name

VTCN1_HUMAN

Accession

Primary (citable) accession number: Q7Z7D3
Secondary accession number(s): Q0GN76 , Q45VN0, Q5WPZ3, Q6P097, Q9H6B2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.