ID VTCN1_HUMAN Reviewed; 282 AA. AC Q7Z7D3; Q0GN76; Q45VN0; Q5WPZ3; Q6P097; Q9H6B2; DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 14-OCT-2015, entry version 117. DE RecName: Full=V-set domain-containing T-cell activation inhibitor 1; DE AltName: Full=B7 homolog 4; DE Short=B7-H4; DE AltName: Full=B7h.5; DE AltName: Full=Immune costimulatory protein B7-H4; DE AltName: Full=Protein B7S1; DE AltName: Full=T-cell costimulatory molecule B7x; DE Flags: Precursor; GN Name=VTCN1 {ECO:0000312|EMBL:EAW56672.1}; GN Synonyms=B7H4 {ECO:0000312|EMBL:AAS13400.1}; ORFNames=UNQ659/PRO1291; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAP37283.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND RP TISSUE SPECIFICITY. RC TISSUE=Placenta {ECO:0000269|PubMed:17509674}; RX PubMed=12818165; DOI=10.1016/S1074-7613(03)00152-3; RA Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., RA Chapoval A.I., Flies D.B., Bajorath J., Chen L.; RT "B7-H4, a molecule of the B7 family, negatively regulates T cell RT immunity."; RL Immunity 18:849-861(2003). RN [2] {ECO:0000305, ECO:0000312|EMBL:AAQ24206.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=12920180; DOI=10.1073/pnas.1434299100; RA Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J.P.; RT "B7x: a widely expressed B7 family member that inhibits T cell RT activation."; RL Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003). RN [3] {ECO:0000305, ECO:0000312|EMBL:AAZ17406.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND RP TISSUE SPECIFICITY. RX PubMed=16782226; DOI=10.1016/j.lungcan.2006.05.012; RA Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X.; RT "B7-H3 and B7-H4 expression in non-small-cell lung cancer."; RL Lung Cancer 53:143-151(2006). RN [4] {ECO:0000305, ECO:0000312|EMBL:AAS13400.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). RA Mao Y., Zhang X.; RT "A new splice variant of B7-H4."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000305, ECO:0000312|EMBL:AAQ88718.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [6] {ECO:0000305, ECO:0000312|EMBL:BAB15349.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). RC TISSUE=Kidney epithelium {ECO:0000269|PubMed:14702039}, and Thymus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [7] {ECO:0000312|EMBL:CAI12739.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [8] {ECO:0000305, ECO:0000312|EMBL:AAS13400.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000305, ECO:0000312|EMBL:AAH74729.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). RC TISSUE=Brain {ECO:0000312|EMBL:AAH74729.1}, and Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [10] {ECO:0000305, ECO:0000312|EMBL:AAS13400.1} RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-167 (ISOFORM 1). RC TISSUE=Peripheral blood; RA Huang G., Bai Y., Zhang L., Zhang L., Song M.; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000305} RP ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY. RX PubMed=14568939; DOI=10.4049/jimmunol.171.9.4650; RA Choi I.-H., Zhu G., Sica G.L., Strome S.E., Cheville J.C., Lau J.S., RA Zhu Y., Flies D.B., Tamada K., Chen L.; RT "Genomic organization and expression analysis of B7-H4, an immune RT inhibitory molecule of the B7 family."; RL J. Immunol. 171:4650-4654(2003). RN [12] {ECO:0000305} RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION. RX PubMed=15878339; DOI=10.1016/j.yexcr.2005.01.018; RA Salceda S., Tang T., Kmet M., Munteanu A., Ghosh M., Macina R., RA Liu W., Pilkington G., Papkoff J.; RT "The immunomodulatory protein B7-H4 is overexpressed in breast and RT ovarian cancers and promotes epithelial cell transformation."; RL Exp. Cell Res. 306:128-141(2005). RN [13] {ECO:0000305} RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION. RX PubMed=16606666; DOI=10.1084/jem.20050930; RA Kryczek I., Zou L., Rodriguez P., Zhu G., Wei S., Mottram P., RA Brumlik M., Cheng P., Curiel T., Myers L., Lackner A., Alvarez X., RA Ochoa A., Chen L., Zou W.; RT "B7-H4 expression identifies a novel suppressive macrophage population RT in human ovarian carcinoma."; RL J. Exp. Med. 203:871-881(2006). RN [14] {ECO:0000305} RP INDUCTION. RX PubMed=16785496; DOI=10.4049/jimmunol.177.1.40; RA Kryczek I., Wei S., Zou L., Zhu G., Mottram P., Xu H., Chen L., RA Zou W.; RT "Induction of B7-H4 on APCs through IL-10: novel suppressive mode for RT regulatory T cells."; RL J. Immunol. 177:40-44(2006). RN [15] {ECO:0000305} RP TISSUE SPECIFICITY, AND USE AS A MARKER FOR RENAL CELL CANCER. RX PubMed=16798883; DOI=10.1073/pnas.0600937103; RA Krambeck A.E., Thompson R.H., Dong H., Lohse C.M., Park E.S., RA Kuntz S.M., Leibovich B.C., Blute M.L., Cheville J.C., Kwon E.D.; RT "B7-H4 expression in renal cell carcinoma and tumor vasculature: RT associations with cancer progression and survival."; RL Proc. Natl. Acad. Sci. U.S.A. 103:10391-10396(2006). RN [16] {ECO:0000305} RP FUNCTION, AND INDUCTION. RX PubMed=17875732; DOI=10.1158/0008-5472.CAN-07-1866; RA Kryczek I., Wei S., Zhu G., Myers L., Mottram P., Cheng P., Chen L., RA Coukos G., Zou W.; RT "Relationship between B7-H4, regulatory T cells, and patient outcome RT in human ovarian carcinoma."; RL Cancer Res. 67:8900-8905(2007). RN [17] {ECO:0000305} RP FUNCTION. RX PubMed=17509674; DOI=10.1016/j.ygyno.2007.03.039; RA Miyatake T., Tringler B., Liu W., Liu S.-H., Papkoff J., Enomoto T., RA Torkko K.C., Dehn D.L., Swisher A., Shroyer K.R.; RT "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid RT adenocarcinomas and inversely correlated with tumor T-cell RT infiltration."; RL Gynecol. Oncol. 106:119-127(2007). CC -!- FUNCTION: Negatively regulates T-cell-mediated immune response by CC inhibiting T-cell activation, proliferation, cytokine production CC and development of cytotoxicity. When expressed on the cell CC surface of tumor macrophages, plays an important role, together CC with regulatory T-cells (Treg), in the suppression of tumor- CC associated antigen-specific T-cell immunity. Involved in promoting CC epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, CC ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, CC ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass CC type I membrane protein {ECO:0000305}. Note=Expressed at the cell CC surface. A soluble form has also been detected. {ECO:0000255, CC ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, CC ECO:0000269|PubMed:16782226}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1 {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12920180, CC ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039, CC ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16710414, CC ECO:0000269|PubMed:16782226}; CC IsoId=Q7Z7D3-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:16782226}; CC IsoId=Q7Z7D3-2; Sequence=VSP_052841; CC Name=3 {ECO:0000269|Ref.4}; CC IsoId=Q7Z7D3-3; Sequence=VSP_052842, VSP_052843; CC Name=4; CC IsoId=Q7Z7D3-4; Sequence=VSP_045423; CC -!- TISSUE SPECIFICITY: Overexpressed in breast, ovarian, endometrial, CC renal cell (RCC) and non-small-cell lung cancers (NSCLC). CC Expressed on activated T- and B-cells, monocytes and dendritic CC cells, but not expressed in most normal tissues (at protein CC level). Widely expressed, including in kidney, liver, lung, ovary, CC placenta, spleen and testis. {ECO:0000269|PubMed:12818165, CC ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, CC ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, CC ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}. CC -!- INDUCTION: Up-regulated by IL6/interleukin-6 and IL10/interleukin- CC 10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen- CC presenting cells (APCs). {ECO:0000269|PubMed:16606666, CC ECO:0000269|PubMed:16785496, ECO:0000269|PubMed:17875732}. CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:15878339}. CC -!- MISCELLANEOUS: May serve as a predictive marker for renal cell CC carcinoma. {ECO:0000269|PubMed:16798883}. CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG CC family. {ECO:0000250|UniProtKB:Q5ZPR3}. CC -!- SIMILARITY: Contains 2 Ig-like V-type (immunoglobulin-like) CC domains. {ECO:0000255}. CC -!- CAUTION: The mouse ortholog has been shown to be a GPI-anchored CC protein but the Gly residue which is predicted to be the modified CC site in mouse and rat is not conserved in human. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology CC and Haematology; CC URL="http://atlasgeneticsoncology.org/Genes/VTCN1ID44144ch1p13.html"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY280972; AAP37283.1; -; mRNA. DR EMBL; AY346100; AAQ24206.1; -; mRNA. DR EMBL; DQ103757; AAZ17406.1; -; mRNA. DR EMBL; AY442303; AAS13400.1; -; mRNA. DR EMBL; AY358352; AAQ88718.1; -; mRNA. DR EMBL; AK026071; BAB15349.1; -; mRNA. DR EMBL; AK303466; BAH13967.1; -; mRNA. DR EMBL; AL391476; CAI12739.1; -; Genomic_DNA. DR EMBL; CH471122; EAW56672.1; -; Genomic_DNA. DR EMBL; CH471122; EAW56673.1; -; Genomic_DNA. DR EMBL; BC065717; AAH65717.1; -; mRNA. DR EMBL; BC074729; AAH74729.1; -; mRNA. DR EMBL; DQ836392; ABI16083.1; -; mRNA. DR CCDS; CCDS58019.1; -. [Q7Z7D3-4] DR CCDS; CCDS58020.1; -. [Q7Z7D3-2] DR CCDS; CCDS894.1; -. [Q7Z7D3-1] DR RefSeq; NP_001240778.1; NM_001253849.1. [Q7Z7D3-4] DR RefSeq; NP_001240779.1; NM_001253850.1. [Q7Z7D3-2] DR RefSeq; NP_078902.2; NM_024626.3. [Q7Z7D3-1] DR UniGene; Hs.546434; -. DR PDB; 4GOS; X-ray; 1.59 A; A=30-148. DR PDBsum; 4GOS; -. DR ProteinModelPortal; Q7Z7D3; -. DR SMR; Q7Z7D3; 35-241. DR BioGrid; 122803; 1. DR STRING; 9606.ENSP00000358470; -. DR MEROPS; I43.001; -. DR BioMuta; VTCN1; -. DR DMDM; 74759262; -. DR PaxDb; Q7Z7D3; -. DR PRIDE; Q7Z7D3; -. DR Ensembl; ENST00000328189; ENSP00000328168; ENSG00000134258. [Q7Z7D3-2] DR Ensembl; ENST00000369458; ENSP00000358470; ENSG00000134258. [Q7Z7D3-1] DR Ensembl; ENST00000539893; ENSP00000444724; ENSG00000134258. [Q7Z7D3-4] DR GeneID; 79679; -. DR KEGG; hsa:79679; -. DR UCSC; uc001ehb.3; human. [Q7Z7D3-1] DR UCSC; uc009whf.2; human. [Q7Z7D3-2] DR CTD; 79679; -. DR GeneCards; VTCN1; -. DR H-InvDB; HIX0000935; -. DR HGNC; HGNC:28873; VTCN1. DR HPA; HPA054200; -. DR MIM; 608162; gene. DR neXtProt; NX_Q7Z7D3; -. DR PharmGKB; PA142670611; -. DR eggNOG; NOG87575; -. DR GeneTree; ENSGT00700000104325; -. DR HOGENOM; HOG000139645; -. DR HOVERGEN; HBG097943; -. DR InParanoid; Q7Z7D3; -. DR KO; K06747; -. DR OrthoDB; EOG7FBRH9; -. DR PhylomeDB; Q7Z7D3; -. DR TreeFam; TF331083; -. DR GeneWiki; VTCN1; -. DR GenomeRNAi; 79679; -. DR NextBio; 68926; -. DR PRO; PR:Q7Z7D3; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; Q7Z7D3; -. DR CleanEx; HS_VTCN1; -. DR ExpressionAtlas; Q7Z7D3; baseline and differential. DR Genevisible; Q7Z7D3; HS. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0072643; P:interferon-gamma secretion; IEA:Ensembl. DR GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl. DR GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl. DR GO; GO:1900042; P:positive regulation of interleukin-2 secretion; IEA:Ensembl. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0001562; P:response to protozoan; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR PROSITE; PS50835; IG_LIKE; 2. PE 1: Evidence at protein level; KW 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; KW Complete proteome; Disulfide bond; Glycoprotein; Immunity; KW Immunoglobulin domain; Lipoprotein; Membrane; Reference proteome; KW Repeat; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 282 V-set domain-containing T-cell activation FT inhibitor 1. {ECO:0000255}. FT /FTId=PRO_0000339237. FT TOPO_DOM 25 259 Extracellular. {ECO:0000255}. FT TRANSMEM 260 280 Helical. {ECO:0000255}. FT TOPO_DOM 281 282 Cytoplasmic. {ECO:0000255}. FT DOMAIN 35 146 Ig-like V-type 1. {ECO:0000255}. FT DOMAIN 153 241 Ig-like V-type 2. {ECO:0000255}. FT CARBOHYD 216 216 N-linked (GlcNAc...). {ECO:0000255}. FT DISULFID 56 130 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 168 225 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 1 95 Missing (in isoform 4). FT {ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334}. FT /FTId=VSP_045423. FT VAR_SEQ 33 148 Missing (in isoform 2). FT {ECO:0000303|PubMed:16782226}. FT /FTId=VSP_052841. FT VAR_SEQ 33 87 GRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLK FT EGVLGLVHEFKEGK -> EVSVWLSAMKGWCRSSKASLSID FT LCFLNFRETLHHSHYCRLSWEHWGGWNPELHF (in FT isoform 3). {ECO:0000303|Ref.4}. FT /FTId=VSP_052842. FT VAR_SEQ 88 282 Missing (in isoform 3). FT {ECO:0000303|Ref.4}. FT /FTId=VSP_052843. FT CONFLICT 29 29 F -> L (in Ref. 10; ABI16083). FT {ECO:0000305}. FT CONFLICT 54 54 L -> Q (in Ref. 6; BAB15349). FT {ECO:0000305}. FT STRAND 39 42 {ECO:0000244|PDB:4GOS}. FT STRAND 44 47 {ECO:0000244|PDB:4GOS}. FT STRAND 52 58 {ECO:0000244|PDB:4GOS}. FT HELIX 64 66 {ECO:0000244|PDB:4GOS}. FT STRAND 68 73 {ECO:0000244|PDB:4GOS}. FT STRAND 77 84 {ECO:0000244|PDB:4GOS}. FT HELIX 95 97 {ECO:0000244|PDB:4GOS}. FT STRAND 101 103 {ECO:0000244|PDB:4GOS}. FT TURN 105 107 {ECO:0000244|PDB:4GOS}. FT HELIX 108 110 {ECO:0000244|PDB:4GOS}. FT STRAND 115 119 {ECO:0000244|PDB:4GOS}. FT HELIX 122 124 {ECO:0000244|PDB:4GOS}. FT STRAND 126 134 {ECO:0000244|PDB:4GOS}. FT STRAND 137 148 {ECO:0000244|PDB:4GOS}. SQ SEQUENCE 282 AA; 30878 MW; 1C9C565A9242E78C CRC64; MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE DGILSCTFEP DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR TAVFADQVIV GNASLRLKNV QLTDAGTYKC YIITSKGKGN ANLEYKTGAF SMPEVNVDYN ASSETLRCEA PRWFPQPTVV WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TESEIKRRSH LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK //