true
2008-06-10
2024-01-24
164
VTCN1_HUMAN
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Sica G.L.
Choi I.-H.
Zhu G.
Tamada K.
Wang S.-D.
Tamura H.
Chapoval A.I.
Flies D.B.
Bajorath J.
Chen L.
doi:10.1016/s1074-7613(03)00152-3
2003
Immunity
18
849-861
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
Placenta
B7x: a widely expressed B7 family member that inhibits T cell activation.
Zang X.
Loke P.
Kim J.
Murphy K.
Waitz R.
Allison J.P.
doi:10.1073/pnas.1434299100
2003
Proc. Natl. Acad. Sci. U.S.A.
100
10388-10392
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
B7-H3 and B7-H4 expression in non-small-cell lung cancer.
Sun Y.
Wang Y.
Zhao J.
Gu M.
Giscombe R.
Lefvert A.K.
Wang X.
doi:10.1016/j.lungcan.2006.05.012
2006
Lung Cancer
53
143-151
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
A new splice variant of B7-H4.
Mao Y.
Zhang X.
2003-10
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark H.F.
Gurney A.L.
Abaya E.
Baker K.
Baldwin D.T.
Brush J.
Chen J.
Chow B.
Chui C.
Crowley C.
Currell B.
Deuel B.
Dowd P.
Eaton D.
Foster J.S.
Grimaldi C.
Gu Q.
Hass P.E.
Heldens S.
Huang A.
Kim H.S.
Klimowski L.
Jin Y.
Johnson S.
Lee J.
Lewis L.
Liao D.
Mark M.R.
Robbie E.
Sanchez C.
Schoenfeld J.
Seshagiri S.
Simmons L.
Singh J.
Smith V.
Stinson J.
Vagts A.
Vandlen R.L.
Watanabe C.
Wieand D.
Woods K.
Xie M.-H.
Yansura D.G.
Yi S.
Yu G.
Yuan J.
Zhang M.
Zhang Z.
Goddard A.D.
Wood W.I.
Godowski P.J.
Gray A.M.
doi:10.1101/gr.1293003
2003
Genome Res.
13
2265-2270
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.'
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.'
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.'
Ohara O.
Isogai T.
Sugano S.
doi:10.1038/ng1285
2004
Nat. Genet.
36
40-45
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
Kidney epithelium
Thymus
The DNA sequence and biological annotation of human chromosome 1.
Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.A.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.S.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.J.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.I.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.W.
McLaren S.
Milne S.
Mistry S.
Moore M.J.F.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.M.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
doi:10.1038/nature04727
2006
Nature
441
315-321
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Mural R.J.
Istrail S.
Sutton G.G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.
2005-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
Brain
Prostate
Huang G.
Bai Y.
Zhang L.
Zhang L.'
Song M.
2006-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA] OF 1-167 (ISOFORM 1)
Peripheral blood
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.
Choi I.-H.
Zhu G.
Sica G.L.
Strome S.E.
Cheville J.C.
Lau J.S.
Zhu Y.
Flies D.B.
Tamada K.
Chen L.
doi:10.4049/jimmunol.171.9.4650
2003
J. Immunol.
171
4650-4654
ALTERNATIVE SPLICING
TISSUE SPECIFICITY
The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation.
Salceda S.
Tang T.
Kmet M.
Munteanu A.
Ghosh M.
Macina R.
Liu W.
Pilkington G.
Papkoff J.
doi:10.1016/j.yexcr.2005.01.018
2005
Exp. Cell Res.
306
128-141
FUNCTION
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
GLYCOSYLATION
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
Kryczek I.
Zou L.
Rodriguez P.
Zhu G.
Wei S.
Mottram P.
Brumlik M.
Cheng P.
Curiel T.
Myers L.
Lackner A.
Alvarez X.
Ochoa A.
Chen L.
Zou W.
doi:10.1084/jem.20050930
2006
J. Exp. Med.
203
871-881
FUNCTION
TISSUE SPECIFICITY
INDUCTION
Induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.
Kryczek I.
Wei S.
Zou L.
Zhu G.
Mottram P.
Xu H.
Chen L.
Zou W.
doi:10.4049/jimmunol.177.1.40
2006
J. Immunol.
177
40-44
INDUCTION
B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival.
Krambeck A.E.
Thompson R.H.
Dong H.
Lohse C.M.
Park E.S.
Kuntz S.M.
Leibovich B.C.
Blute M.L.
Cheville J.C.
Kwon E.D.
doi:10.1073/pnas.0600937103
2006
Proc. Natl. Acad. Sci. U.S.A.
103
10391-10396
TISSUE SPECIFICITY
USE AS A MARKER FOR RENAL CELL CANCER
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Kryczek I.
Wei S.
Zhu G.
Myers L.
Mottram P.
Cheng P.
Chen L.
Coukos G.
Zou W.
doi:10.1158/0008-5472.can-07-1866
2007
Cancer Res.
67
8900-8905
FUNCTION
INDUCTION
B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration.
Miyatake T.
Tringler B.
Liu W.
Liu S.-H.
Papkoff J.
Enomoto T.
Torkko K.C.
Dehn D.L.
Swisher A.
Shroyer K.R.
doi:10.1016/j.ygyno.2007.03.039
2007
Gynecol. Oncol.
106
119-127
FUNCTION
Atlas of Genetics and Cytogenetics in Oncology and Haematology
1.59
A=30-148
18
2
5 N-Linked glycans (1 site)
2 sites, 5 glycans
2 sites, 5 N-linked glycans (1 site)
36 sequenced antibodies
975 antibodies from 45 providers
2 antibodies
human
VTCN1
Tissue enhanced (breast, fallopian tube, pancreas)
gene
Eukaryota
10 hits in 1141 CRISPR screens
human
Tbio
Protein
Expressed in palpebral conjunctiva and 91 other cell types or tissues
baseline and differential
HS
IgV_B7-H4
Immunoglobulins
Ig-like_dom
Ig-like_dom_sf
Ig-like_fold
Ig_sub
Ig_V-set
BUTYROPHILIN
V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1
V-set
IG
Immunoglobulin
IG_LIKE
V-set domain-containing T-cell activation inhibitor 1
B7 homolog 4
B7-H4
B7h.5
Immune costimulatory protein B7-H4
Protein B7S1
T-cell costimulatory molecule B7x
VTCN1
B7H4
UNQ659/PRO1291
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Expressed at the cell surface. A soluble form has also been detected.
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs).
N-glycosylated.
May serve as a predictive marker for renal cell carcinoma.
Belongs to the immunoglobulin superfamily. BTN/MOG family.
The mouse ortholog has been shown to be a GPI-anchored protein but the Gly residue which is predicted to be the modified site in mouse and rat is not conserved in human.
1
24
V-set domain-containing T-cell activation inhibitor 1
28381
25
282
Extracellular
259
Helical
260
280
Cytoplasmic
281
Ig-like V-type 1
35
146
Ig-like V-type 2
153
241
N-linked (GlcNAc...) asparagine
216
56
130
168
225
In isoform 4.
95
In isoform 2.
33
148
In isoform 3.
EVSVWLSAMKGWCRSSKASLSIDLCFLNFRETLHHSHYCRLSWEHWGGWNPELHF
87
In isoform 3.
88
L
29
Q
54
39
42
44
47
52
58
64
66
68
73
77
84
97
101
103
105
107
108
110
115
119
122
124
126
134
137
2003-10-01
1
true
30878
10c79aea96edb93048dfb50d16845b26
1
MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK
2
MASLGQILFWSIISIIIILAGAIALIIGFGISAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK
3
MASLGQILFWSIISIIIILAGAIALIIGFGISEVSVWLSAMKGWCRSSKASLSIDLCFLNFRETLHHSHYCRLSWEHWGGWNPELHF
4
MFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true