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Q7Z7D3

- VTCN1_HUMAN

UniProt

Q7Z7D3 - VTCN1_HUMAN

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Protein

V-set domain-containing T-cell activation inhibitor 1

Gene

VTCN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.By similarity4 Publications

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
  2. interferon-gamma secretion Source: Ensembl
  3. interleukin-4 secretion Source: Ensembl
  4. negative regulation of T cell activation Source: Ensembl
  5. positive regulation of interleukin-2 secretion Source: Ensembl
  6. positive regulation of T cell proliferation Source: Ensembl
  7. response to protozoan Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set domain-containing T-cell activation inhibitor 1
Alternative name(s):
B7 homolog 4
Short name:
B7-H4
B7h.5
Immune costimulatory protein B7-H4
Protein B7S1
T-cell costimulatory molecule B7x
Gene namesi
Name:VTCN1Imported
Synonyms:B7H4Imported
ORF Names:UNQ659/PRO1291
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28873. VTCN1.

Subcellular locationi

Cell membrane Sequence Analysis; Single-pass type I membrane protein Curated
Note: Expressed at the cell surface. A soluble form has also been detected.3 PublicationsSequence Analysis

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 282258V-set domain-containing T-cell activation inhibitor 1Sequence AnalysisPRO_0000339237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ7Z7D3.
PRIDEiQ7Z7D3.

Expressioni

Tissue specificityi

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.7 Publications

Inductioni

Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs).3 Publications

Gene expression databases

BgeeiQ7Z7D3.
CleanExiHS_VTCN1.
ExpressionAtlasiQ7Z7D3. baseline and differential.
GenevestigatoriQ7Z7D3.

Organism-specific databases

HPAiHPA054200.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358470.

Structurei

Secondary structure

1
282
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 424
Beta strandi44 – 474
Beta strandi52 – 587
Helixi64 – 663
Beta strandi68 – 736
Beta strandi77 – 848
Helixi95 – 973
Beta strandi101 – 1033
Turni105 – 1073
Helixi108 – 1103
Beta strandi115 – 1195
Helixi122 – 1243
Beta strandi126 – 1349
Beta strandi137 – 14812

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GOSX-ray1.59A30-148[»]
ProteinModelPortaliQ7Z7D3.
SMRiQ7Z7D3. Positions 35-241.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 259235ExtracellularSequence AnalysisAdd
BLAST
Topological domaini281 – 2822CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 146112Ig-like V-type 1Sequence AnalysisAdd
BLAST
Domaini153 – 24189Ig-like V-type 2Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity
Contains 2 Ig-like V-type (immunoglobulin-like) domains.Sequence Analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG87575.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ7Z7D3.
KOiK06747.
OrthoDBiEOG7FBRH9.
PhylomeDBiQ7Z7D3.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 17 Publications (identifier: Q7Z7D3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE
60 70 80 90 100
DGILSCTFEP DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR
110 120 130 140 150
TAVFADQVIV GNASLRLKNV QLTDAGTYKC YIITSKGKGN ANLEYKTGAF
160 170 180 190 200
SMPEVNVDYN ASSETLRCEA PRWFPQPTVV WASQVDQGAN FSEVSNTSFE
210 220 230 240 250
LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TESEIKRRSH
260 270 280
LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK
Length:282
Mass (Da):30,878
Last modified:October 1, 2003 - v1
Checksum:i1C9C565A9242E78C
GO
Isoform 21 Publication (identifier: Q7Z7D3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-148: Missing.

Show »
Length:166
Mass (Da):18,275
Checksum:i30FFF157B8C66DE2
GO
Isoform 31 Publication (identifier: Q7Z7D3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-87: GRHSITVTTV...GLVHEFKEGK → EVSVWLSAMK...WGGWNPELHF
     88-282: Missing.

Show »
Length:87
Mass (Da):9,875
Checksum:i1006690A861AB006
GO
Isoform 4 (identifier: Q7Z7D3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:187
Mass (Da):20,743
Checksum:i9AED6155AEED4E63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291F → L in ABI16083. 1 PublicationCurated
Sequence conflicti54 – 541L → Q in BAB15349. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9595Missing in isoform 4. 2 PublicationsVSP_045423Add
BLAST
Alternative sequencei33 – 148116Missing in isoform 2. 1 PublicationVSP_052841Add
BLAST
Alternative sequencei33 – 8755GRHSI…FKEGK → EVSVWLSAMKGWCRSSKASL SIDLCFLNFRETLHHSHYCR LSWEHWGGWNPELHF in isoform 3. 1 PublicationVSP_052842Add
BLAST
Alternative sequencei88 – 282195Missing in isoform 3. 1 PublicationVSP_052843Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY280972 mRNA. Translation: AAP37283.1.
AY346100 mRNA. Translation: AAQ24206.1.
DQ103757 mRNA. Translation: AAZ17406.1.
AY442303 mRNA. Translation: AAS13400.1.
AY358352 mRNA. Translation: AAQ88718.1.
AK026071 mRNA. Translation: BAB15349.1.
AK303466 mRNA. Translation: BAH13967.1.
AL391476 Genomic DNA. Translation: CAI12739.1.
CH471122 Genomic DNA. Translation: EAW56672.1.
CH471122 Genomic DNA. Translation: EAW56673.1.
BC065717 mRNA. Translation: AAH65717.1.
BC074729 mRNA. Translation: AAH74729.1.
DQ836392 mRNA. Translation: ABI16083.1.
CCDSiCCDS58019.1. [Q7Z7D3-4]
CCDS58020.1. [Q7Z7D3-2]
CCDS894.1. [Q7Z7D3-1]
RefSeqiNP_001240778.1. NM_001253849.1. [Q7Z7D3-4]
NP_001240779.1. NM_001253850.1. [Q7Z7D3-2]
NP_078902.2. NM_024626.3. [Q7Z7D3-1]
UniGeneiHs.546434.

Genome annotation databases

EnsembliENST00000328189; ENSP00000328168; ENSG00000134258. [Q7Z7D3-2]
ENST00000369458; ENSP00000358470; ENSG00000134258. [Q7Z7D3-1]
ENST00000539893; ENSP00000444724; ENSG00000134258. [Q7Z7D3-4]
GeneIDi79679.
KEGGihsa:79679.
UCSCiuc001ehb.3. human. [Q7Z7D3-1]
uc009whf.2. human. [Q7Z7D3-2]

Polymorphism databases

DMDMi74759262.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY280972 mRNA. Translation: AAP37283.1 .
AY346100 mRNA. Translation: AAQ24206.1 .
DQ103757 mRNA. Translation: AAZ17406.1 .
AY442303 mRNA. Translation: AAS13400.1 .
AY358352 mRNA. Translation: AAQ88718.1 .
AK026071 mRNA. Translation: BAB15349.1 .
AK303466 mRNA. Translation: BAH13967.1 .
AL391476 Genomic DNA. Translation: CAI12739.1 .
CH471122 Genomic DNA. Translation: EAW56672.1 .
CH471122 Genomic DNA. Translation: EAW56673.1 .
BC065717 mRNA. Translation: AAH65717.1 .
BC074729 mRNA. Translation: AAH74729.1 .
DQ836392 mRNA. Translation: ABI16083.1 .
CCDSi CCDS58019.1. [Q7Z7D3-4 ]
CCDS58020.1. [Q7Z7D3-2 ]
CCDS894.1. [Q7Z7D3-1 ]
RefSeqi NP_001240778.1. NM_001253849.1. [Q7Z7D3-4 ]
NP_001240779.1. NM_001253850.1. [Q7Z7D3-2 ]
NP_078902.2. NM_024626.3. [Q7Z7D3-1 ]
UniGenei Hs.546434.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GOS X-ray 1.59 A 30-148 [» ]
ProteinModelPortali Q7Z7D3.
SMRi Q7Z7D3. Positions 35-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000358470.

Protein family/group databases

MEROPSi I43.001.

Polymorphism databases

DMDMi 74759262.

Proteomic databases

PaxDbi Q7Z7D3.
PRIDEi Q7Z7D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328189 ; ENSP00000328168 ; ENSG00000134258 . [Q7Z7D3-2 ]
ENST00000369458 ; ENSP00000358470 ; ENSG00000134258 . [Q7Z7D3-1 ]
ENST00000539893 ; ENSP00000444724 ; ENSG00000134258 . [Q7Z7D3-4 ]
GeneIDi 79679.
KEGGi hsa:79679.
UCSCi uc001ehb.3. human. [Q7Z7D3-1 ]
uc009whf.2. human. [Q7Z7D3-2 ]

Organism-specific databases

CTDi 79679.
GeneCardsi GC01M117686.
H-InvDB HIX0000935.
HGNCi HGNC:28873. VTCN1.
HPAi HPA054200.
MIMi 608162. gene.
neXtProti NX_Q7Z7D3.
PharmGKBi PA142670611.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87575.
GeneTreei ENSGT00700000104325.
HOGENOMi HOG000139645.
HOVERGENi HBG097943.
InParanoidi Q7Z7D3.
KOi K06747.
OrthoDBi EOG7FBRH9.
PhylomeDBi Q7Z7D3.
TreeFami TF331083.

Miscellaneous databases

GeneWikii VTCN1.
GenomeRNAii 79679.
NextBioi 68926.
PROi Q7Z7D3.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z7D3.
CleanExi HS_VTCN1.
ExpressionAtlasi Q7Z7D3. baseline and differential.
Genevestigatori Q7Z7D3.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."
    Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L.
    Immunity 18:849-861(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta1 Publication.
  2. "B7x: a widely expressed B7 family member that inhibits T cell activation."
    Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J.P.
    Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "B7-H3 and B7-H4 expression in non-small-cell lung cancer."
    Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X.
    Lung Cancer 53:143-151(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "A new splice variant of B7-H4."
    Mao Y., Zhang X.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Kidney epithelium1 Publication and Thymus.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: BrainImported and Prostate.
  10. Huang G., Bai Y., Zhang L., Zhang L., Song M.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-167 (ISOFORM 1).
    Tissue: Peripheral blood.
  11. "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family."
    Choi I.-H., Zhu G., Sica G.L., Strome S.E., Cheville J.C., Lau J.S., Zhu Y., Flies D.B., Tamada K., Chen L.
    J. Immunol. 171:4650-4654(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  12. "The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation."
    Salceda S., Tang T., Kmet M., Munteanu A., Ghosh M., Macina R., Liu W., Pilkington G., Papkoff J.
    Exp. Cell Res. 306:128-141(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
  13. "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma."
    Kryczek I., Zou L., Rodriguez P., Zhu G., Wei S., Mottram P., Brumlik M., Cheng P., Curiel T., Myers L., Lackner A., Alvarez X., Ochoa A., Chen L., Zou W.
    J. Exp. Med. 203:871-881(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  14. "Induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells."
    Kryczek I., Wei S., Zou L., Zhu G., Mottram P., Xu H., Chen L., Zou W.
    J. Immunol. 177:40-44(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  15. "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival."
    Krambeck A.E., Thompson R.H., Dong H., Lohse C.M., Park E.S., Kuntz S.M., Leibovich B.C., Blute M.L., Cheville J.C., Kwon E.D.
    Proc. Natl. Acad. Sci. U.S.A. 103:10391-10396(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, USE AS A MARKER FOR RENAL CELL CANCER.
  16. "Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma."
    Kryczek I., Wei S., Zhu G., Myers L., Mottram P., Cheng P., Chen L., Coukos G., Zou W.
    Cancer Res. 67:8900-8905(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  17. "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration."
    Miyatake T., Tringler B., Liu W., Liu S.-H., Papkoff J., Enomoto T., Torkko K.C., Dehn D.L., Swisher A., Shroyer K.R.
    Gynecol. Oncol. 106:119-127(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVTCN1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7D3
Secondary accession number(s): Q0GN76
, Q45VN0, Q5WPZ3, Q6P097, Q9H6B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May serve as a predictive marker for renal cell carcinoma.1 Publication

Caution

The mouse ortholog has been shown to be a GPI-anchored protein but the Gly residue which is predicted to be the modified site in mouse and rat is not conserved in human.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3