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Protein

V-set domain-containing T-cell activation inhibitor 1

Gene

VTCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.By similarity4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set domain-containing T-cell activation inhibitor 1
Alternative name(s):
B7 homolog 4
Short name:
B7-H4
B7h.5
Immune costimulatory protein B7-H4
Protein B7S1
T-cell costimulatory molecule B7x
Gene namesi
Name:VTCN1Imported
Synonyms:B7H4Imported
ORF Names:UNQ659/PRO1291
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28873. VTCN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 259ExtracellularSequence analysisAdd BLAST235
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 282CytoplasmicSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79679.
OpenTargetsiENSG00000134258.
PharmGKBiPA142670611.

Polymorphism and mutation databases

BioMutaiVTCN1.
DMDMi74759262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000033923725 – 282V-set domain-containing T-cell activation inhibitor 1Sequence analysisAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ7Z7D3.
PeptideAtlasiQ7Z7D3.
PRIDEiQ7Z7D3.

PTM databases

iPTMnetiQ7Z7D3.
PhosphoSitePlusiQ7Z7D3.

Expressioni

Tissue specificityi

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.7 Publications

Inductioni

Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs).3 Publications

Gene expression databases

BgeeiENSG00000134258.
CleanExiHS_VTCN1.
ExpressionAtlasiQ7Z7D3. baseline and differential.
GenevisibleiQ7Z7D3. HS.

Organism-specific databases

HPAiHPA054200.

Interactioni

Protein-protein interaction databases

BioGridi122803. 1 interactor.
STRINGi9606.ENSP00000358470.

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 42Combined sources4
Beta strandi44 – 47Combined sources4
Beta strandi52 – 58Combined sources7
Helixi64 – 66Combined sources3
Beta strandi68 – 73Combined sources6
Beta strandi77 – 84Combined sources8
Helixi95 – 97Combined sources3
Beta strandi101 – 103Combined sources3
Turni105 – 107Combined sources3
Helixi108 – 110Combined sources3
Beta strandi115 – 119Combined sources5
Helixi122 – 124Combined sources3
Beta strandi126 – 134Combined sources9
Beta strandi137 – 148Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GOSX-ray1.59A30-148[»]
ProteinModelPortaliQ7Z7D3.
SMRiQ7Z7D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 146Ig-like V-type 1Sequence analysisAdd BLAST112
Domaini153 – 241Ig-like V-type 2Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity
Contains 2 Ig-like V-type (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKB5. Eukaryota.
ENOG4111T2B. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ7Z7D3.
KOiK06747.
PhylomeDBiQ7Z7D3.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 17 Publications (identifier: Q7Z7D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE
60 70 80 90 100
DGILSCTFEP DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR
110 120 130 140 150
TAVFADQVIV GNASLRLKNV QLTDAGTYKC YIITSKGKGN ANLEYKTGAF
160 170 180 190 200
SMPEVNVDYN ASSETLRCEA PRWFPQPTVV WASQVDQGAN FSEVSNTSFE
210 220 230 240 250
LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TESEIKRRSH
260 270 280
LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK
Length:282
Mass (Da):30,878
Last modified:October 1, 2003 - v1
Checksum:i1C9C565A9242E78C
GO
Isoform 21 Publication (identifier: Q7Z7D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-148: Missing.

Show »
Length:166
Mass (Da):18,275
Checksum:i30FFF157B8C66DE2
GO
Isoform 31 Publication (identifier: Q7Z7D3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-87: GRHSITVTTV...GLVHEFKEGK → EVSVWLSAMK...WGGWNPELHF
     88-282: Missing.

Show »
Length:87
Mass (Da):9,875
Checksum:i1006690A861AB006
GO
Isoform 4 (identifier: Q7Z7D3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:187
Mass (Da):20,743
Checksum:i9AED6155AEED4E63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29F → L in ABI16083 (Ref. 10) Curated1
Sequence conflicti54L → Q in BAB15349 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0454231 – 95Missing in isoform 4. 2 PublicationsAdd BLAST95
Alternative sequenceiVSP_05284133 – 148Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_05284233 – 87GRHSI…FKEGK → EVSVWLSAMKGWCRSSKASL SIDLCFLNFRETLHHSHYCR LSWEHWGGWNPELHF in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_05284388 – 282Missing in isoform 3. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280972 mRNA. Translation: AAP37283.1.
AY346100 mRNA. Translation: AAQ24206.1.
DQ103757 mRNA. Translation: AAZ17406.1.
AY442303 mRNA. Translation: AAS13400.1.
AY358352 mRNA. Translation: AAQ88718.1.
AK026071 mRNA. Translation: BAB15349.1.
AK303466 mRNA. Translation: BAH13967.1.
AL391476 Genomic DNA. Translation: CAI12739.1.
CH471122 Genomic DNA. Translation: EAW56672.1.
CH471122 Genomic DNA. Translation: EAW56673.1.
BC065717 mRNA. Translation: AAH65717.1.
BC074729 mRNA. Translation: AAH74729.1.
DQ836392 mRNA. Translation: ABI16083.1.
CCDSiCCDS58019.1. [Q7Z7D3-4]
CCDS58020.1. [Q7Z7D3-2]
CCDS894.1. [Q7Z7D3-1]
RefSeqiNP_001240778.1. NM_001253849.1. [Q7Z7D3-4]
NP_001240779.1. NM_001253850.1. [Q7Z7D3-2]
NP_078902.2. NM_024626.3. [Q7Z7D3-1]
UniGeneiHs.546434.

Genome annotation databases

EnsembliENST00000328189; ENSP00000328168; ENSG00000134258. [Q7Z7D3-2]
ENST00000369458; ENSP00000358470; ENSG00000134258. [Q7Z7D3-1]
ENST00000539893; ENSP00000444724; ENSG00000134258. [Q7Z7D3-4]
GeneIDi79679.
KEGGihsa:79679.
UCSCiuc001ehb.4. human. [Q7Z7D3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280972 mRNA. Translation: AAP37283.1.
AY346100 mRNA. Translation: AAQ24206.1.
DQ103757 mRNA. Translation: AAZ17406.1.
AY442303 mRNA. Translation: AAS13400.1.
AY358352 mRNA. Translation: AAQ88718.1.
AK026071 mRNA. Translation: BAB15349.1.
AK303466 mRNA. Translation: BAH13967.1.
AL391476 Genomic DNA. Translation: CAI12739.1.
CH471122 Genomic DNA. Translation: EAW56672.1.
CH471122 Genomic DNA. Translation: EAW56673.1.
BC065717 mRNA. Translation: AAH65717.1.
BC074729 mRNA. Translation: AAH74729.1.
DQ836392 mRNA. Translation: ABI16083.1.
CCDSiCCDS58019.1. [Q7Z7D3-4]
CCDS58020.1. [Q7Z7D3-2]
CCDS894.1. [Q7Z7D3-1]
RefSeqiNP_001240778.1. NM_001253849.1. [Q7Z7D3-4]
NP_001240779.1. NM_001253850.1. [Q7Z7D3-2]
NP_078902.2. NM_024626.3. [Q7Z7D3-1]
UniGeneiHs.546434.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GOSX-ray1.59A30-148[»]
ProteinModelPortaliQ7Z7D3.
SMRiQ7Z7D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122803. 1 interactor.
STRINGi9606.ENSP00000358470.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ7Z7D3.
PhosphoSitePlusiQ7Z7D3.

Polymorphism and mutation databases

BioMutaiVTCN1.
DMDMi74759262.

Proteomic databases

PaxDbiQ7Z7D3.
PeptideAtlasiQ7Z7D3.
PRIDEiQ7Z7D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328189; ENSP00000328168; ENSG00000134258. [Q7Z7D3-2]
ENST00000369458; ENSP00000358470; ENSG00000134258. [Q7Z7D3-1]
ENST00000539893; ENSP00000444724; ENSG00000134258. [Q7Z7D3-4]
GeneIDi79679.
KEGGihsa:79679.
UCSCiuc001ehb.4. human. [Q7Z7D3-1]

Organism-specific databases

CTDi79679.
DisGeNETi79679.
GeneCardsiVTCN1.
H-InvDBHIX0000935.
HGNCiHGNC:28873. VTCN1.
HPAiHPA054200.
MIMi608162. gene.
neXtProtiNX_Q7Z7D3.
OpenTargetsiENSG00000134258.
PharmGKBiPA142670611.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKB5. Eukaryota.
ENOG4111T2B. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ7Z7D3.
KOiK06747.
PhylomeDBiQ7Z7D3.
TreeFamiTF331083.

Miscellaneous databases

GeneWikiiVTCN1.
GenomeRNAii79679.
PROiQ7Z7D3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134258.
CleanExiHS_VTCN1.
ExpressionAtlasiQ7Z7D3. baseline and differential.
GenevisibleiQ7Z7D3. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVTCN1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7D3
Secondary accession number(s): Q0GN76
, Q45VN0, Q5WPZ3, Q6P097, Q9H6B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May serve as a predictive marker for renal cell carcinoma.1 Publication

Caution

The mouse ortholog has been shown to be a GPI-anchored protein but the Gly residue which is predicted to be the modified site in mouse and rat is not conserved in human.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.