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Protein

Stimulated by retinoic acid gene 8 protein homolog

Gene

STRA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, DNA replication, Meiosis, Oogenesis, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Stimulated by retinoic acid gene 8 protein homolog
Gene namesi
Name:STRA8Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30653. STRA8.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405043.

Polymorphism and mutation databases

BioMutaiSTRA8.
DMDMi74713759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Stimulated by retinoic acid gene 8 protein homologPRO_0000318114Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z7C7.
PRIDEiQ7Z7C7.

PTM databases

PhosphoSiteiQ7Z7C7.

Expressioni

Tissue specificityi

Expressed specifically in testis and fetal ovaries.2 Publications

Developmental stagei

Expression detected in fetal ovaries between wpf (weeks post-fertilization) 11 and 27; expression peaks at wpf 14.5 and is decreasing afterwards.1 Publication

Gene expression databases

BgeeiQ7Z7C7.
CleanExiHS_STRA8.

Organism-specific databases

HPAiHPA020385.

Interactioni

Subunit structurei

Interacts with XPO1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000275764.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili88 – 11225Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 556Nuclear localization signal (NLS)By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEEF. Eukaryota.
ENOG410ZG79. LUCA.
GeneTreeiENSGT00390000017181.
HOGENOMiHOG000154445.
HOVERGENiHBG095604.
InParanoidiQ7Z7C7.
OMAiLTASKWQ.
OrthoDBiEOG7M98GS.
PhylomeDBiQ7Z7C7.
TreeFamiTF335594.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z7C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIDVDKIL FFNQEIRLWQ LIMATPEENS NPHDRATPQL PAQLQELEHR
60 70 80 90 100
VARRRLSQAR HRATLAALFN NLRKTVYSQS DLIASKWQVL NKAKSHIPEL
110 120 130 140 150
EQTLDNLLKL KASFNLEDGH ASSLEEVKKE YASMYSGNDS FPQNGSSPWY
160 170 180 190 200
LNFYKQTMDL LTGSGIITPQ EAALPIVSAA ISHLWQNLSE ERKASLRQAW
210 220 230 240 250
AQKHRGPATL AEACREPACA EGSVKDSGVD SQGASCSLVS TPEEILFEDA
260 270 280 290 300
FDVASFLDKS EVPSTSSSSS VLASCNPENP EEKFQLYMQI INFFKGLSCA
310 320 330
NTQVKQEASF PVDEEMIMLQ CTETFDDEDL
Length:330
Mass (Da):36,908
Last modified:October 1, 2003 - v1
Checksum:i35DA813FADAA435C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513502 mRNA. Translation: AAP47163.1.
CH236950 Genomic DNA. Translation: EAL24061.1.
CH471070 Genomic DNA. Translation: EAW83846.1.
CCDSiCCDS5839.1.
RefSeqiNP_872295.1. NM_182489.1.
UniGeneiHs.592279.

Genome annotation databases

EnsembliENST00000275764; ENSP00000275764; ENSG00000146857.
GeneIDi346673.
KEGGihsa:346673.
UCSCiuc011kpx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513502 mRNA. Translation: AAP47163.1.
CH236950 Genomic DNA. Translation: EAL24061.1.
CH471070 Genomic DNA. Translation: EAW83846.1.
CCDSiCCDS5839.1.
RefSeqiNP_872295.1. NM_182489.1.
UniGeneiHs.592279.

3D structure databases

ProteinModelPortaliQ7Z7C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000275764.

PTM databases

PhosphoSiteiQ7Z7C7.

Polymorphism and mutation databases

BioMutaiSTRA8.
DMDMi74713759.

Proteomic databases

PaxDbiQ7Z7C7.
PRIDEiQ7Z7C7.

Protocols and materials databases

DNASUi346673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275764; ENSP00000275764; ENSG00000146857.
GeneIDi346673.
KEGGihsa:346673.
UCSCiuc011kpx.2. human.

Organism-specific databases

CTDi346673.
GeneCardsiSTRA8.
HGNCiHGNC:30653. STRA8.
HPAiHPA020385.
MIMi609987. gene.
neXtProtiNX_Q7Z7C7.
PharmGKBiPA162405043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEEF. Eukaryota.
ENOG410ZG79. LUCA.
GeneTreeiENSGT00390000017181.
HOGENOMiHOG000154445.
HOVERGENiHBG095604.
InParanoidiQ7Z7C7.
OMAiLTASKWQ.
OrthoDBiEOG7M98GS.
PhylomeDBiQ7Z7C7.
TreeFamiTF335594.

Miscellaneous databases

GenomeRNAii346673.
NextBioi99000.
PROiQ7Z7C7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z7C7.
CleanExiHS_STRA8.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8."
    Miyamoto T., Sengoku K., Takuma N., Hasuike S., Hayashi H., Yamauchi T., Yamashita T., Ishikawa M.
    J. Assist. Reprod. Genet. 19:531-535(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts."
    Abby E., Tourpin S., Ribeiro J., Daniel K., Messiaen S., Moison D., Guerquin J., Gaillard J.C., Armengaud J., Langa F., Toth A., Martini E., Livera G.
    Nat. Commun. 7:10324-10324(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSTRA8_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.