ID   DB128_HUMAN             Reviewed;          93 AA.
AC   Q7Z7B8; B2RU29;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=Beta-defensin 128;
DE   AltName: Full=Beta-defensin 28;
DE            Short=DEFB-28;
DE   AltName: Full=Defensin, beta 128;
DE   Flags: Precursor;
GN   Name=DEFB128; Synonyms=DEFB28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=12620395; DOI=10.1016/s0888-7543(02)00034-4;
RA   Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G.,
RA   Conejo-Garcia J.-R., Schreeb R., Motzkus D.;
RT   "Distribution of new human beta-defensin genes clustered on chromosome 20
RT   in functionally different segments of epididymis.";
RL   Genomics 81:175-183(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-27.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q7Z7B8; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-18310688, EBI-18304435;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF525930; AAP47223.1; -; mRNA.
DR   EMBL; AL360078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC140936; AAI40937.1; -; mRNA.
DR   CCDS; CCDS33430.1; -.
DR   RefSeq; NP_001032821.1; NM_001037732.2.
DR   AlphaFoldDB; Q7Z7B8; -.
DR   SMR; Q7Z7B8; -.
DR   BioGRID; 128852; 1.
DR   IntAct; Q7Z7B8; 1.
DR   STRING; 9606.ENSP00000335382; -.
DR   BioMuta; DEFB128; -.
DR   DMDM; 61212983; -.
DR   PaxDb; 9606-ENSP00000335382; -.
DR   PeptideAtlas; Q7Z7B8; -.
DR   Antibodypedia; 82036; 1 antibodies from 1 providers.
DR   DNASU; 245939; -.
DR   Ensembl; ENST00000334391.5; ENSP00000335382.4; ENSG00000185982.7.
DR   GeneID; 245939; -.
DR   KEGG; hsa:245939; -.
DR   MANE-Select; ENST00000334391.5; ENSP00000335382.4; NM_001037732.3; NP_001032821.1.
DR   UCSC; uc002wcz.2; human.
DR   AGR; HGNC:18106; -.
DR   CTD; 245939; -.
DR   DisGeNET; 245939; -.
DR   GeneCards; DEFB128; -.
DR   HGNC; HGNC:18106; DEFB128.
DR   HPA; ENSG00000185982; Tissue enriched (epididymis).
DR   neXtProt; NX_Q7Z7B8; -.
DR   OpenTargets; ENSG00000185982; -.
DR   PharmGKB; PA38502; -.
DR   VEuPathDB; HostDB:ENSG00000185982; -.
DR   eggNOG; ENOG502TM18; Eukaryota.
DR   GeneTree; ENSGT00530000064329; -.
DR   HOGENOM; CLU_2399087_0_0_1; -.
DR   InParanoid; Q7Z7B8; -.
DR   OMA; ISEMGCL; -.
DR   OrthoDB; 4735829at2759; -.
DR   PhylomeDB; Q7Z7B8; -.
DR   PathwayCommons; Q7Z7B8; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   SignaLink; Q7Z7B8; -.
DR   BioGRID-ORCS; 245939; 46 hits in 1099 CRISPR screens.
DR   GenomeRNAi; 245939; -.
DR   Pharos; Q7Z7B8; Tbio.
DR   PRO; PR:Q7Z7B8; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q7Z7B8; Protein.
DR   Bgee; ENSG00000185982; Expressed in granulocyte and 15 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR15001:SF5; BETA-DEFENSIN; 1.
DR   PANTHER; PTHR15001; BETA-DEFENSIN 123-RELATED; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..93
FT                   /note="Beta-defensin 128"
FT                   /id="PRO_0000007004"
FT   DISULFID        24..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..53
FT                   /evidence="ECO:0000250"
FT   VARIANT         27
FT                   /note="K -> N (in dbSNP:rs4813043)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_048866"
SQ   SEQUENCE   93 AA;  10650 MW;  8A0C1C72A876362D CRC64;
     MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK LCCANDEEEK
     KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV
//