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Protein

Beta-defensin 128

Gene

DEFB128

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

BioCyciZFISH:G66-33761-MONOMER.
ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 128
Alternative name(s):
Beta-defensin 28
Short name:
DEFB-28
Defensin, beta 128
Gene namesi
Name:DEFB128
Synonyms:DEFB28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18106. DEFB128.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185982.
PharmGKBiPA38502.

Polymorphism and mutation databases

BioMutaiDEFB128.
DMDMi61212983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000700419 – 93Beta-defensin 128Add BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 52By similarity
Disulfide bondi32 ↔ 46By similarity
Disulfide bondi36 ↔ 53By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z7B8.
PRIDEiQ7Z7B8.

Expressioni

Gene expression databases

BgeeiENSG00000185982.
CleanExiHS_DEFB128.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335382.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3FN. Eukaryota.
ENOG41113ZN. LUCA.
GeneTreeiENSGT00530000064329.
HOGENOMiHOG000112159.
HOVERGENiHBG051310.
InParanoidiQ7Z7B8.
OMAiNITGYCR.
OrthoDBiEOG091G14JC.
PhylomeDBiQ7Z7B8.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK
60 70 80 90
LCCANDEEEK KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV
Length:93
Mass (Da):10,650
Last modified:October 1, 2003 - v1
Checksum:i8A0C1C72A876362D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04886627K → N.1 PublicationCorresponds to variant rs4813043dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525930 mRNA. Translation: AAP47223.1.
AL360078 Genomic DNA. Translation: CAI15187.1.
BC140936 mRNA. Translation: AAI40937.1.
CCDSiCCDS33430.1.
RefSeqiNP_001032821.1. NM_001037732.2.
UniGeneiHs.516818.

Genome annotation databases

EnsembliENST00000334391; ENSP00000335382; ENSG00000185982.
GeneIDi245939.
KEGGihsa:245939.
UCSCiuc002wcz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525930 mRNA. Translation: AAP47223.1.
AL360078 Genomic DNA. Translation: CAI15187.1.
BC140936 mRNA. Translation: AAI40937.1.
CCDSiCCDS33430.1.
RefSeqiNP_001032821.1. NM_001037732.2.
UniGeneiHs.516818.

3D structure databases

ProteinModelPortaliQ7Z7B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335382.

Polymorphism and mutation databases

BioMutaiDEFB128.
DMDMi61212983.

Proteomic databases

PaxDbiQ7Z7B8.
PRIDEiQ7Z7B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334391; ENSP00000335382; ENSG00000185982.
GeneIDi245939.
KEGGihsa:245939.
UCSCiuc002wcz.2. human.

Organism-specific databases

CTDi245939.
GeneCardsiDEFB128.
HGNCiHGNC:18106. DEFB128.
neXtProtiNX_Q7Z7B8.
OpenTargetsiENSG00000185982.
PharmGKBiPA38502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3FN. Eukaryota.
ENOG41113ZN. LUCA.
GeneTreeiENSGT00530000064329.
HOGENOMiHOG000112159.
HOVERGENiHBG051310.
InParanoidiQ7Z7B8.
OMAiNITGYCR.
OrthoDBiEOG091G14JC.
PhylomeDBiQ7Z7B8.

Enzyme and pathway databases

BioCyciZFISH:G66-33761-MONOMER.
ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii245939.
PROiQ7Z7B8.

Gene expression databases

BgeeiENSG00000185982.
CleanExiHS_DEFB128.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiDB128_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7B8
Secondary accession number(s): B2RU29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.