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Q7Z7B8

- DB128_HUMAN

UniProt

Q7Z7B8 - DB128_HUMAN

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Protein

Beta-defensin 128

Gene

DEFB128

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 128
Alternative name(s):
Beta-defensin 28
Short name:
DEFB-28
Defensin, beta 128
Gene namesi
Name:DEFB128
Synonyms:DEFB28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:18106. DEFB128.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 9375Beta-defensin 128PRO_0000007004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 52By similarity
Disulfide bondi32 ↔ 46By similarity
Disulfide bondi36 ↔ 53By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z7B8.
PRIDEiQ7Z7B8.

Expressioni

Gene expression databases

BgeeiQ7Z7B8.
CleanExiHS_DEFB128.
GenevestigatoriQ7Z7B8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335382.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43617.
GeneTreeiENSGT00530000064329.
HOGENOMiHOG000112159.
HOVERGENiHBG051310.
InParanoidiQ7Z7B8.
OMAiKKCFNNV.
OrthoDBiEOG7K3TPT.
PhylomeDBiQ7Z7B8.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7B8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK
60 70 80 90
LCCANDEEEK KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV
Length:93
Mass (Da):10,650
Last modified:October 1, 2003 - v1
Checksum:i8A0C1C72A876362D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271K → N.1 Publication
Corresponds to variant rs4813043 [ dbSNP | Ensembl ].
VAR_048866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525930 mRNA. Translation: AAP47223.1.
AL360078 Genomic DNA. Translation: CAI15187.1.
BC140936 mRNA. Translation: AAI40937.1.
CCDSiCCDS33430.1.
RefSeqiNP_001032821.1. NM_001037732.1.
UniGeneiHs.516818.

Genome annotation databases

EnsembliENST00000334391; ENSP00000335382; ENSG00000185982.
GeneIDi245939.
KEGGihsa:245939.
UCSCiuc002wcz.1. human.

Polymorphism databases

DMDMi61212983.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525930 mRNA. Translation: AAP47223.1 .
AL360078 Genomic DNA. Translation: CAI15187.1 .
BC140936 mRNA. Translation: AAI40937.1 .
CCDSi CCDS33430.1.
RefSeqi NP_001032821.1. NM_001037732.1.
UniGenei Hs.516818.

3D structure databases

ProteinModelPortali Q7Z7B8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335382.

Polymorphism databases

DMDMi 61212983.

Proteomic databases

PaxDbi Q7Z7B8.
PRIDEi Q7Z7B8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334391 ; ENSP00000335382 ; ENSG00000185982 .
GeneIDi 245939.
KEGGi hsa:245939.
UCSCi uc002wcz.1. human.

Organism-specific databases

CTDi 245939.
GeneCardsi GC20M000168.
HGNCi HGNC:18106. DEFB128.
neXtProti NX_Q7Z7B8.
PharmGKBi PA38502.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43617.
GeneTreei ENSGT00530000064329.
HOGENOMi HOG000112159.
HOVERGENi HBG051310.
InParanoidi Q7Z7B8.
OMAi KKCFNNV.
OrthoDBi EOG7K3TPT.
PhylomeDBi Q7Z7B8.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii 245939.
NextBioi 91820.
PROi Q7Z7B8.

Gene expression databases

Bgeei Q7Z7B8.
CleanExi HS_DEFB128.
Genevestigatori Q7Z7B8.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
    Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
    Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27.

Entry informationi

Entry nameiDB128_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7B8
Secondary accession number(s): B2RU29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3