Q7Z7B8 (DB128_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 128

Alternative name(s):
Beta-defensin 28
Short name=DEFB-28
Defensin, beta 128

Gene names

Name:	DEFB128
Synonyms:	DEFB28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	93 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 93	75	Beta-defensin 128		PRO_0000007004
Amino acid modifications
	Disulfide bond	24 ↔ 52		By similarity
	Disulfide bond	32 ↔ 46		By similarity
	Disulfide bond	36 ↔ 53		By similarity
Natural variations
	Natural variant	27	1	K → N. Ref.3 Corresponds to variant rs4813043 [ dbSNP | Ensembl ].		VAR_048866

Sequences

	Sequence		Length	Mass (Da)
	Q7Z7B8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8A0C1C72A876362D	FASTA	93	10,650
	10 20 30 40 50 60 MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK LCCANDEEEK 70 80 90 KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis." Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D. Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF525930 mRNA. Translation: AAP47223.1. AL360078 Genomic DNA. Translation: CAI15187.1. BC140936 mRNA. Translation: AAI40937.1.
IPI	IPI00385523.
RefSeq	NP_001032821.1. NM_001037732.1.
UniGene	Hs.516818.
3D structure databases
ProteinModelPortal	Q7Z7B8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335382.
Polymorphism databases
DMDM	61212983.
Proteomic databases
PaxDb	Q7Z7B8.
PRIDE	Q7Z7B8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334391; ENSP00000335382; ENSG00000185982.
GeneID	245939.
KEGG	hsa:245939.
UCSC	uc002wcz.1. human.
Organism-specific databases
CTD	245939.
GeneCards	GC20M000117.
HGNC	HGNC:18106. DEFB128.
neXtProt	NX_Q7Z7B8.
PharmGKB	PA38502.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43617.
HOGENOM	HOG000112159.
HOVERGEN	HBG051310.
InParanoid	Q7Z7B8.
OMA	CRKKCKV.
OrthoDB	EOG46MBM8.
PhylomeDB	Q7Z7B8.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q7Z7B8.
CleanEx	HS_DEFB128.
Genevestigator	Q7Z7B8.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91820.

Entry information

Entry name

DB128_HUMAN

Accession

Primary (citable) accession number: Q7Z7B8
Secondary accession number(s): B2RU29

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.