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Protein

Beta-defensin 128

Gene

DEFB128

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 128
Alternative name(s):
Beta-defensin 28
Short name:
DEFB-28
Defensin, beta 128
Gene namesi
Name:DEFB128
Synonyms:DEFB28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18106. DEFB128.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38502.

Polymorphism and mutation databases

BioMutaiDEFB128.
DMDMi61212983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 9375Beta-defensin 128PRO_0000007004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 52By similarity
Disulfide bondi32 ↔ 46By similarity
Disulfide bondi36 ↔ 53By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z7B8.
PRIDEiQ7Z7B8.

Expressioni

Gene expression databases

BgeeiQ7Z7B8.
CleanExiHS_DEFB128.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335382.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43617.
GeneTreeiENSGT00530000064329.
HOGENOMiHOG000112159.
HOVERGENiHBG051310.
InParanoidiQ7Z7B8.
OMAiEIGCLSG.
OrthoDBiEOG7K3TPT.
PhylomeDBiQ7Z7B8.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK
60 70 80 90
LCCANDEEEK KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV
Length:93
Mass (Da):10,650
Last modified:October 1, 2003 - v1
Checksum:i8A0C1C72A876362D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271K → N.1 Publication
Corresponds to variant rs4813043 [ dbSNP | Ensembl ].
VAR_048866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525930 mRNA. Translation: AAP47223.1.
AL360078 Genomic DNA. Translation: CAI15187.1.
BC140936 mRNA. Translation: AAI40937.1.
CCDSiCCDS33430.1.
RefSeqiNP_001032821.1. NM_001037732.2.
UniGeneiHs.516818.

Genome annotation databases

EnsembliENST00000334391; ENSP00000335382; ENSG00000185982.
GeneIDi245939.
KEGGihsa:245939.
UCSCiuc002wcz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525930 mRNA. Translation: AAP47223.1.
AL360078 Genomic DNA. Translation: CAI15187.1.
BC140936 mRNA. Translation: AAI40937.1.
CCDSiCCDS33430.1.
RefSeqiNP_001032821.1. NM_001037732.2.
UniGeneiHs.516818.

3D structure databases

ProteinModelPortaliQ7Z7B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335382.

Polymorphism and mutation databases

BioMutaiDEFB128.
DMDMi61212983.

Proteomic databases

PaxDbiQ7Z7B8.
PRIDEiQ7Z7B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334391; ENSP00000335382; ENSG00000185982.
GeneIDi245939.
KEGGihsa:245939.
UCSCiuc002wcz.1. human.

Organism-specific databases

CTDi245939.
GeneCardsiGC20M000168.
HGNCiHGNC:18106. DEFB128.
neXtProtiNX_Q7Z7B8.
PharmGKBiPA38502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43617.
GeneTreeiENSGT00530000064329.
HOGENOMiHOG000112159.
HOVERGENiHBG051310.
InParanoidiQ7Z7B8.
OMAiEIGCLSG.
OrthoDBiEOG7K3TPT.
PhylomeDBiQ7Z7B8.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii245939.
NextBioi91820.
PROiQ7Z7B8.

Gene expression databases

BgeeiQ7Z7B8.
CleanExiHS_DEFB128.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
    Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
    Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27.

Entry informationi

Entry nameiDB128_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7B8
Secondary accession number(s): B2RU29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.