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Q7Z7B8

- DB128_HUMAN

UniProt

Q7Z7B8 - DB128_HUMAN

Protein

Beta-defensin 128

Gene

DEFB128

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 128
    Alternative name(s):
    Beta-defensin 28
    Short name:
    DEFB-28
    Defensin, beta 128
    Gene namesi
    Name:DEFB128
    Synonyms:DEFB28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:18106. DEFB128.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 9375Beta-defensin 128PRO_0000007004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 52By similarity
    Disulfide bondi32 ↔ 46By similarity
    Disulfide bondi36 ↔ 53By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ7Z7B8.
    PRIDEiQ7Z7B8.

    Expressioni

    Gene expression databases

    BgeeiQ7Z7B8.
    CleanExiHS_DEFB128.
    GenevestigatoriQ7Z7B8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7B8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43617.
    HOGENOMiHOG000112159.
    HOVERGENiHBG051310.
    InParanoidiQ7Z7B8.
    OMAiKKCFNNV.
    OrthoDBiEOG7K3TPT.
    PhylomeDBiQ7Z7B8.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z7B8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK   50
    LCCANDEEEK KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV 93
    Length:93
    Mass (Da):10,650
    Last modified:October 1, 2003 - v1
    Checksum:i8A0C1C72A876362D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271K → N.1 Publication
    Corresponds to variant rs4813043 [ dbSNP | Ensembl ].
    VAR_048866

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF525930 mRNA. Translation: AAP47223.1.
    AL360078 Genomic DNA. Translation: CAI15187.1.
    BC140936 mRNA. Translation: AAI40937.1.
    CCDSiCCDS33430.1.
    RefSeqiNP_001032821.1. NM_001037732.1.
    UniGeneiHs.516818.

    Genome annotation databases

    EnsembliENST00000334391; ENSP00000335382; ENSG00000185982.
    GeneIDi245939.
    KEGGihsa:245939.
    UCSCiuc002wcz.1. human.

    Polymorphism databases

    DMDMi61212983.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF525930 mRNA. Translation: AAP47223.1 .
    AL360078 Genomic DNA. Translation: CAI15187.1 .
    BC140936 mRNA. Translation: AAI40937.1 .
    CCDSi CCDS33430.1.
    RefSeqi NP_001032821.1. NM_001037732.1.
    UniGenei Hs.516818.

    3D structure databases

    ProteinModelPortali Q7Z7B8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335382.

    Polymorphism databases

    DMDMi 61212983.

    Proteomic databases

    PaxDbi Q7Z7B8.
    PRIDEi Q7Z7B8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334391 ; ENSP00000335382 ; ENSG00000185982 .
    GeneIDi 245939.
    KEGGi hsa:245939.
    UCSCi uc002wcz.1. human.

    Organism-specific databases

    CTDi 245939.
    GeneCardsi GC20M000117.
    HGNCi HGNC:18106. DEFB128.
    neXtProti NX_Q7Z7B8.
    PharmGKBi PA38502.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43617.
    HOGENOMi HOG000112159.
    HOVERGENi HBG051310.
    InParanoidi Q7Z7B8.
    OMAi KKCFNNV.
    OrthoDBi EOG7K3TPT.
    PhylomeDBi Q7Z7B8.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 91820.
    PROi Q7Z7B8.

    Gene expression databases

    Bgeei Q7Z7B8.
    CleanExi HS_DEFB128.
    Genevestigatori Q7Z7B8.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
      Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
      Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27.

    Entry informationi

    Entry nameiDB128_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7B8
    Secondary accession number(s): B2RU29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3