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Protein

Beta-defensin 132

Gene

DEFB132

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 132
Alternative name(s):
Beta-defensin 32
Short name:
BD-32
Short name:
DEFB-32
Defensin HEL-75
Defensin, beta 132
Gene namesi
Name:DEFB132
Synonyms:DEFB32
ORF Names:UNQ827/PRO1754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:33806. DEFB132.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383557.

Polymorphism and mutation databases

BioMutaiDEFB132.
DMDMi61212742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 9573Beta-defensin 132PRO_0000007007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z7B7.
PeptideAtlasiQ7Z7B7.
PRIDEiQ7Z7B7.

Expressioni

Gene expression databases

BgeeiENSG00000186458.
CleanExiHS_DEFB132.
GenevisibleiQ7Z7B7. HS.

Organism-specific databases

HPAiHPA046399.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371813.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JH6I. Eukaryota.
ENOG41114VH. LUCA.
GeneTreeiENSGT00390000013860.
HOGENOMiHOG000246960.
HOVERGENiHBG081411.
InParanoidiQ7Z7B7.
OMAiGETALFM.
OrthoDBiEOG091G10TG.
PhylomeDBiQ7Z7B7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLLLVLAA LGFLTQVIPA SAGGSKCVSN TPGYCRTCCH WGETALFMCN
60 70 80 90
ASRKCCISYS FLPKPDLPQL IGNHWQSRRR NTQRKDKKQQ TTVTS
Length:95
Mass (Da):10,610
Last modified:October 1, 2003 - v1
Checksum:iDEFE657F7DA7A6DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525932 mRNA. Translation: AAP47225.1.
AY621329 mRNA. Translation: AAT51868.1.
AY358708 mRNA. Translation: AAQ89071.1.
EF426755 mRNA. Translation: ABR09864.1.
AL034548 Genomic DNA. Translation: CAI19174.1.
BC137292 mRNA. Translation: AAI37293.1.
BC137293 mRNA. Translation: AAI37294.1.
CCDSiCCDS12993.1.
RefSeqiNP_997352.1. NM_207469.2.
UniGeneiHs.516819.

Genome annotation databases

EnsembliENST00000382376; ENSP00000371813; ENSG00000186458.
GeneIDi400830.
KEGGihsa:400830.
UCSCiuc002wdb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525932 mRNA. Translation: AAP47225.1.
AY621329 mRNA. Translation: AAT51868.1.
AY358708 mRNA. Translation: AAQ89071.1.
EF426755 mRNA. Translation: ABR09864.1.
AL034548 Genomic DNA. Translation: CAI19174.1.
BC137292 mRNA. Translation: AAI37293.1.
BC137293 mRNA. Translation: AAI37294.1.
CCDSiCCDS12993.1.
RefSeqiNP_997352.1. NM_207469.2.
UniGeneiHs.516819.

3D structure databases

ProteinModelPortaliQ7Z7B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371813.

Polymorphism and mutation databases

BioMutaiDEFB132.
DMDMi61212742.

Proteomic databases

PaxDbiQ7Z7B7.
PeptideAtlasiQ7Z7B7.
PRIDEiQ7Z7B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382376; ENSP00000371813; ENSG00000186458.
GeneIDi400830.
KEGGihsa:400830.
UCSCiuc002wdb.4. human.

Organism-specific databases

CTDi400830.
GeneCardsiDEFB132.
HGNCiHGNC:33806. DEFB132.
HPAiHPA046399.
neXtProtiNX_Q7Z7B7.
PharmGKBiPA162383557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH6I. Eukaryota.
ENOG41114VH. LUCA.
GeneTreeiENSGT00390000013860.
HOGENOMiHOG000246960.
HOVERGENiHBG081411.
InParanoidiQ7Z7B7.
OMAiGETALFM.
OrthoDBiEOG091G10TG.
PhylomeDBiQ7Z7B7.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii400830.
PROiQ7Z7B7.

Gene expression databases

BgeeiENSG00000186458.
CleanExiHS_DEFB132.
GenevisibleiQ7Z7B7. HS.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDB132_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7B7
Secondary accession number(s): B2RP72, Q4QY40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (Ref. 2) DEFB133.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.