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Q7Z7B1 (PIGW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol-glycan biosynthesis class W protein
Short name=PIG-W
EC=2.3.-.-
Gene names
Name:PIGW
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins By similarity.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PIGW family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Phosphatidylinositol-glycan biosynthesis class W protein
PRO_0000246282

Regions

Topological domain1 – 2121Lumenal Potential
Transmembrane22 – 4221Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane306 – 32621Helical; Potential
Transmembrane339 – 35921Helical; Potential
Transmembrane371 – 39121Helical; Potential
Transmembrane449 – 46921Helical; Potential
Transmembrane474 – 49421Helical; Potential

Amino acid modifications

Glycosylation151N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1261N → D in BAC04413. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7Z7B1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 6CACD6EFD154DDE2

FASTA50456,882
        10         20         30         40         50         60 
MSEKQMKEAF VSNLNGTTVL EITQGLCFPA FCILCRGFLI IFSQYLCSFS PTWKTRFLTD 

        70         80         90        100        110        120 
FVVLIVPMVA TLTIWASFIL LELLGVIIFG AGLLYQIYRR RTCYARLPFL KILEKFLNIS 

       130        140        150        160        170        180 
LESEYNPAIS CFRVITSAFT AIAILAVDFP LFPRRFAKTE LYGTGAMDFG VGGFVFGSAM 

       190        200        210        220        230        240 
VCLEVRRRKY MEGSKLHYFT NSLYSVWPLV FLGIGRLAII KSIGYQEHLT EYGVHWNFFF 

       250        260        270        280        290        300 
TIIVVKLITP LLLIIFPLNK SWIIALGITV LYQLALDFTS LKRLILYGTD GSGTRVGLLN 

       310        320        330        340        350        360 
ANREGIISTL GYVAIHMAGV QTGLYMHKNR SHIKDLIKVA CFLLLAAISL FISLYVVQVN 

       370        380        390        400        410        420 
VEAVSRRMAN LAFCIWIVAS SLILLSSLLL GDIILSFAKF LIKGALVPCS WKLIQSPVTN 

       430        440        450        460        470        480 
KKHSESLVPE AERMEPSLCL ITALNRKQLI FFLLSNITTG LINLMVDTLH SSTLWALFVV 

       490        500 
NLYMFSNCLI VYVLYLQDKT VQFW

« Hide

References

« Hide 'large scale' references
[1]"PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor."
Murakami Y., Siripanyapinyo U., Hong Y., Kang J.Y., Ishihara S., Nakakuma H., Maeda Y., Kinoshita T.
Mol. Biol. Cell 14:4285-4295(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB097818 mRNA. Translation: BAC77021.1.
AK094752 mRNA. Translation: BAC04413.1.
IPIIPI00167713.
RefSeqNP_848612.2. NM_178517.3.
UniGeneHs.378885.

3D structure databases

ProteinModelPortalQ7Z7B1.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000332313.

PTM databases

PhosphoSiteQ7Z7B1.

Polymorphism databases

DMDM74713752.

Proteomic databases

PaxDbQ7Z7B1.
PRIDEQ7Z7B1.

Protocols and materials databases

DNASU284098.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328396; ENSP00000332313; ENSG00000184886.
ENST00000561548; ENSP00000455647; ENSG00000261300.
ENST00000592983; ENSP00000468778; ENSG00000184886.
GeneID284098.
KEGGhsa:284098.
UCSCuc002hmy.1. human.

Organism-specific databases

CTD284098.
GeneCardsGC17P034890.
H-InvDBHIX0019575.
HGNCHGNC:23213. PIGW.
HPAHPA023499.
MIM610275. gene.
neXtProtNX_Q7Z7B1.
PharmGKBPA134894412.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5062.
HOGENOMHOG000204712.
HOVERGENHBG079452.
InParanoidQ7Z7B1.
KOK05283.
OMAPIFPRRF.
PhylomeDBQ7Z7B1.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.
UniPathwayUPA00196.

Gene expression databases

ArrayExpressQ7Z7B1.
BgeeQ7Z7B1.
CleanExHS_PIGW.
GenevestigatorQ7Z7B1.
GermOnlineENSG00000184886. Homo sapiens.

Family and domain databases

InterProIPR009447. GWT1.
[Graphical view]
PANTHERPTHR20661. PTHR20661. 1 hit.
PfamPF06423. GWT1. 1 hit.
[Graphical view]
PIRSFPIRSF017321. GWT1. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPIGW. human.
GenomeRNAi284098.
NextBio94531.
SOURCESearch...

Entry information

Entry namePIGW_HUMAN
AccessionPrimary (citable) accession number: Q7Z7B1
Secondary accession number(s): Q8N9G3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents