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Protein

PX domain-containing protein kinase-like protein

Gene

PXK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.1 PublicationBy similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • phosphatidylinositol binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

  • inflammatory response Source: UniProtKB
  • modulation of chemical synaptic transmission Source: UniProtKB
  • negative regulation of ATPase activity Source: UniProtKB
  • negative regulation of ion transport Source: UniProtKB

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiQ7Z7A4

Names & Taxonomyi

Protein namesi
Recommended name:
PX domain-containing protein kinase-like protein
Alternative name(s):
Modulator of Na,K-ATPase
Short name:
MONaKA
Gene namesi
Name:PXKImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168297.15
HGNCiHGNC:23326 PXK
MIMi611450 gene
neXtProtiNX_Q7Z7A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54R → Q: No effect on subcellular location. 1 Publication1
Mutagenesisi56Y → A: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication1
Mutagenesisi92R → L: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication1

Organism-specific databases

DisGeNETi54899
OpenTargetsiENSG00000168297
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA134899496

Polymorphism and mutation databases

BioMutaiPXK
DMDMi74759261

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865921 – 578PX domain-containing protein kinase-like proteinAdd BLAST578

Proteomic databases

EPDiQ7Z7A4
MaxQBiQ7Z7A4
PaxDbiQ7Z7A4
PeptideAtlasiQ7Z7A4
PRIDEiQ7Z7A4

PTM databases

iPTMnetiQ7Z7A4
PhosphoSitePlusiQ7Z7A4

Expressioni

Tissue specificityi

Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.1 Publication

Gene expression databases

BgeeiENSG00000168297
ExpressionAtlasiQ7Z7A4 baseline and differential
GenevisibleiQ7Z7A4 HS

Organism-specific databases

HPAiHPA024068

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120245, 15 interactors
IntActiQ7Z7A4, 4 interactors
STRINGi9606.ENSP00000348472

Structurei

3D structure databases

ProteinModelPortaliQ7Z7A4
SMRiQ7Z7A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 126PXPROSITE-ProRule annotationAdd BLAST113
Domaini88 – 481Protein kinasePROSITE-ProRule annotationAdd BLAST394
Domaini548 – 567WH2PROSITE-ProRule annotationAdd BLAST20

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IF7B Eukaryota
ENOG410Z20X LUCA
GeneTreeiENSGT00390000017669
HOVERGENiHBG061245
InParanoidiQ7Z7A4
KOiK17543
OMAiTCDHSAP
OrthoDBiEOG091G09MA
PhylomeDBiQ7Z7A4
TreeFamiTF324116

Family and domain databases

CDDicd06871 PX_MONaKA, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR037903 MONaKA_PX
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
IPR003124 WH2_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00787 PX, 1 hit
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit
PS51082 WH2, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q7Z7A4-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication, v11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW
60 70 80 90 100
QIVRRYSDFD LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL
110 120 130 140 150
NVITTNHILS NCELVKKFLD PNNYSANYTE IALQQVSMFF RSEPKWEVVE
160 170 180 190 200
PLKDIGWRIR KKYFLMKIKN QPKERLVLSW ADLGPDKYLS DKDFQCLIKL
210 220 230 240 250
LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK AKPKDPFLKK
260 270 280 290 300
YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
310 320 330 340 350
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP
360 370 380 390 400
PDSVPVDSFP PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL
410 420 430 440 450
LTTSEKPQFK IPTKLKEALR IAKECIEKRL IEEQKQIHQH RRLTRAQSHH
460 470 480 490 500
GSEEERKKRK ILARKKSKRS ALENSEEHSA KYSNSNNSAG SGASSPLTSP
510 520 530 540 550
SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS SQAVNGMSRG
560 570
ALLSSIQNFQ KGTLRKAKTC DHSAPKIG
Length:578
Mass (Da):64,950
Last modified:October 1, 2003 - v1
Checksum:i73523CFC3731FFC8
GO
Isoform 21 Publication (identifier: Q7Z7A4-2) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     510-515: GISALP → VEHAPF
     516-578: Missing.

Show »
Length:515
Mass (Da):58,732
Checksum:i8115EBC6A5157C97
GO
Isoform 31 Publication (identifier: Q7Z7A4-3) [UniParc]FASTAAdd to basket
Also known as: v31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: Missing.

Show »
Length:352
Mass (Da):38,875
Checksum:iDE5F73819ABBB77C
GO
Isoform 4Curated (identifier: Q7Z7A4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:561
Mass (Da):62,891
Checksum:i615A342917403DCD
GO
Isoform 51 Publication (identifier: Q7Z7A4-5) [UniParc]FASTAAdd to basket
Also known as: v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Show »
Length:441
Mass (Da):49,491
Checksum:iF1D219D8C6988D86
GO
Isoform 61 Publication (identifier: Q7Z7A4-6) [UniParc]FASTAAdd to basket
Also known as: v21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     35-67: Missing.

Show »
Length:545
Mass (Da):60,956
Checksum:iA1F5BED8AEAFF293
GO
Isoform 71 Publication (identifier: Q7Z7A4-7) [UniParc]FASTAAdd to basket
Also known as: v51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:495
Mass (Da):55,762
Checksum:iE5BA2969CBC9E57D
GO

Sequence cautioni

The sequence AAH14479 differs from that shown. Reason: Erroneous termination at position 451. Translated as Gly.Curated
The sequence BAA91097 differs from that shown. Reason: Frameshift at position 569.Curated
The sequence BAD18536 differs from that shown. Reason: Frameshift at position 510.Curated
The sequence BAD92925 differs from that shown. Reason: Frameshift at position 147.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42R → G in AAK94455 (Ref. 3) Curated1
Sequence conflicti42R → G in BAA91097 (PubMed:14702039).Curated1
Sequence conflicti459R → K in AAR98521 (PubMed:16142408).Curated1
Sequence conflicti489Missing in BAD18536 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041362426I → V1 PublicationCorresponds to variant dbSNP:rs55973253Ensembl.1
Natural variantiVAR_041363481K → R2 PublicationsCorresponds to variant dbSNP:rs56384862Ensembl.1
Natural variantiVAR_033911525A → V. Corresponds to variant dbSNP:rs34579268Ensembl.1
Natural variantiVAR_033912535A → V. Corresponds to variant dbSNP:rs34579268Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0519071 – 226Missing in isoform 3. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_0519081 – 137Missing in isoform 5. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_0519091 – 83Missing in isoform 7. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_05191035 – 67Missing in isoform 6. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_05191135 – 51Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_051912510 – 515GISALP → VEHAPF in isoform 2. 3 Publications6
Alternative sequenceiVSP_051913516 – 578Missing in isoform 2. 3 PublicationsAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ124707 mRNA Translation: AAZ38821.1
DQ124708 mRNA Translation: AAZ38822.1
AY437879 mRNA Translation: AAR98521.1
AY847222 mRNA Translation: AAX73354.1
AY847220 mRNA Translation: AAX73352.1
AY847221 mRNA Translation: AAX73353.1
AF399753 mRNA Translation: AAK94455.1
AY274811 mRNA Translation: AAP42076.1
AB209688 mRNA Translation: BAD92925.1 Frameshift.
AK000342 mRNA Translation: BAA91097.1 Frameshift.
AK131385 mRNA Translation: BAD18536.1 Frameshift.
BC008943 mRNA Translation: AAH08943.1
BC014479 mRNA Translation: AAH14479.1 Sequence problems.
CCDSiCCDS2889.1 [Q7Z7A4-1]
CCDS74952.1 [Q7Z7A4-2]
RefSeqiNP_001276024.1, NM_001289095.1
NP_001276025.1, NM_001289096.1 [Q7Z7A4-6]
NP_001276027.1, NM_001289098.1 [Q7Z7A4-2]
NP_001276028.1, NM_001289099.1 [Q7Z7A4-7]
NP_001276029.1, NM_001289100.1
NP_001276030.1, NM_001289101.1 [Q7Z7A4-5]
NP_060241.2, NM_017771.4 [Q7Z7A4-1]
XP_016862160.1, XM_017006671.1
XP_016862164.1, XM_017006675.1
XP_016862175.1, XM_017006686.1
UniGeneiHs.190544

Genome annotation databases

EnsembliENST00000356151; ENSP00000348472; ENSG00000168297 [Q7Z7A4-1]
ENST00000383716; ENSP00000373222; ENSG00000168297 [Q7Z7A4-2]
ENST00000484288; ENSP00000417915; ENSG00000168297 [Q7Z7A4-2]
GeneIDi54899
KEGGihsa:54899
UCSCiuc003djx.2 human [Q7Z7A4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPXK_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7A4
Secondary accession number(s): Q3BCH4
, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health