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Q7Z7A4

- PXK_HUMAN

UniProt

Q7Z7A4 - PXK_HUMAN

Protein

PX domain-containing protein kinase-like protein

Gene

PXK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.By similarity1 Publication

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: InterPro
    2. protein C-terminus binding Source: UniProtKB
    3. transferase activity, transferring phosphorus-containing groups Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: UniProtKB
    2. negative regulation of ATPase activity Source: Ensembl
    3. negative regulation of ion transport Source: Ensembl
    4. regulation of synaptic transmission Source: UniProtKB

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiQ7Z7A4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PX domain-containing protein kinase-like protein
    Alternative name(s):
    Modulator of Na,K-ATPase
    Short name:
    MONaKA
    Gene namesi
    Name:PXKImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:23326. PXK.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Also associates with the plasma membrane. Isoform 3 is present throughout the cell.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. microtubule organizing center Source: HPA
    3. nucleus Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541R → Q: No effect on subcellular location. 1 Publication
    Mutagenesisi56 – 561Y → A: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication
    Mutagenesisi92 – 921R → L: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication

    Organism-specific databases

    Orphaneti536. Systemic lupus erythematosus.
    PharmGKBiPA134899496.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 578578PX domain-containing protein kinase-like proteinPRO_0000086592Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z7A4.
    PaxDbiQ7Z7A4.
    PRIDEiQ7Z7A4.

    PTM databases

    PhosphoSiteiQ7Z7A4.

    Expressioni

    Tissue specificityi

    Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z7A4.
    BgeeiQ7Z7A4.
    GenevestigatoriQ7Z7A4.

    Organism-specific databases

    HPAiHPA024068.

    Interactioni

    Protein-protein interaction databases

    BioGridi120245. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7A4.
    SMRiQ7Z7A4. Positions 28-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 126113PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini88 – 481394Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini548 – 56720WH2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 1 WH2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG71043.
    HOVERGENiHBG061245.
    InParanoidiQ7Z7A4.
    KOiK17543.
    OMAiPQAVNGV.
    OrthoDBiEOG7FFMRQ.
    PhylomeDBiQ7Z7A4.
    TreeFamiTF324116.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000719. Prot_kinase_dom.
    IPR003124. WH2_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00787. PX. 1 hit.
    PF02205. WH2. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50195. PX. 1 hit.
    PS51082. WH2. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q7Z7A4-1) [UniParc]FASTAAdd to Basket

    Also known as: Long1 Publication

    , v11 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW    50
    QIVRRYSDFD LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL 100
    NVITTNHILS NCELVKKFLD PNNYSANYTE IALQQVSMFF RSEPKWEVVE 150
    PLKDIGWRIR KKYFLMKIKN QPKERLVLSW ADLGPDKYLS DKDFQCLIKL 200
    LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK AKPKDPFLKK 250
    YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT 300
    CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP 350
    PDSVPVDSFP PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL 400
    LTTSEKPQFK IPTKLKEALR IAKECIEKRL IEEQKQIHQH RRLTRAQSHH 450
    GSEEERKKRK ILARKKSKRS ALENSEEHSA KYSNSNNSAG SGASSPLTSP 500
    SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS SQAVNGMSRG 550
    ALLSSIQNFQ KGTLRKAKTC DHSAPKIG 578
    Length:578
    Mass (Da):64,950
    Last modified:October 1, 2003 - v1
    Checksum:i73523CFC3731FFC8
    GO
    Isoform 21 Publication (identifier: Q7Z7A4-2) [UniParc]FASTAAdd to Basket

    Also known as: Short1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         510-515: GISALP → VEHAPF
         516-578: Missing.

    Show »
    Length:515
    Mass (Da):58,732
    Checksum:i8115EBC6A5157C97
    GO
    Isoform 31 Publication (identifier: Q7Z7A4-3) [UniParc]FASTAAdd to Basket

    Also known as: v31 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-226: Missing.

    Show »
    Length:352
    Mass (Da):38,875
    Checksum:iDE5F73819ABBB77C
    GO
    Isoform 4Curated (identifier: Q7Z7A4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-51: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:561
    Mass (Da):62,891
    Checksum:i615A342917403DCD
    GO
    Isoform 51 Publication (identifier: Q7Z7A4-5) [UniParc]FASTAAdd to Basket

    Also known as: v41 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-137: Missing.

    Show »
    Length:441
    Mass (Da):49,491
    Checksum:iF1D219D8C6988D86
    GO
    Isoform 61 Publication (identifier: Q7Z7A4-6) [UniParc]FASTAAdd to Basket

    Also known as: v21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         35-67: Missing.

    Show »
    Length:545
    Mass (Da):60,956
    Checksum:iA1F5BED8AEAFF293
    GO
    Isoform 71 Publication (identifier: Q7Z7A4-7) [UniParc]FASTAAdd to Basket

    Also known as: v51 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: Missing.

    Show »
    Length:495
    Mass (Da):55,762
    Checksum:iE5BA2969CBC9E57D
    GO

    Sequence cautioni

    The sequence BAA91097.1 differs from that shown. Reason: Frameshift at position 569.
    The sequence BAD18536.1 differs from that shown. Reason: Frameshift at position 510.
    The sequence BAD92925.1 differs from that shown. Reason: Frameshift at position 147.
    The sequence AAH14479.1 differs from that shown. Reason: Erroneous termination at position 451. Translated as Gly.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421R → G in AAK94455. 1 PublicationCurated
    Sequence conflicti42 – 421R → G in BAA91097. (PubMed:14702039)Curated
    Sequence conflicti459 – 4591R → K in AAR98521. (PubMed:16142408)Curated
    Sequence conflicti489 – 4891Missing in BAD18536. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti426 – 4261I → V.1 Publication
    Corresponds to variant rs55973253 [ dbSNP | Ensembl ].
    VAR_041362
    Natural varianti481 – 4811K → R.2 Publications
    Corresponds to variant rs56384862 [ dbSNP | Ensembl ].
    VAR_041363
    Natural varianti525 – 5251A → V.
    Corresponds to variant rs34579268 [ dbSNP | Ensembl ].
    VAR_033911
    Natural varianti535 – 5351A → V.
    Corresponds to variant rs34579268 [ dbSNP | Ensembl ].
    VAR_033912

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 226226Missing in isoform 3. 1 PublicationVSP_051907Add
    BLAST
    Alternative sequencei1 – 137137Missing in isoform 5. 1 PublicationVSP_051908Add
    BLAST
    Alternative sequencei1 – 8383Missing in isoform 7. 1 PublicationVSP_051909Add
    BLAST
    Alternative sequencei35 – 6733Missing in isoform 6. 1 PublicationVSP_051910Add
    BLAST
    Alternative sequencei35 – 5117Missing in isoform 4. 1 PublicationVSP_051911Add
    BLAST
    Alternative sequencei510 – 5156GISALP → VEHAPF in isoform 2. 3 PublicationsVSP_051912
    Alternative sequencei516 – 57863Missing in isoform 2. 3 PublicationsVSP_051913Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ124707 mRNA. Translation: AAZ38821.1.
    DQ124708 mRNA. Translation: AAZ38822.1.
    AY437879 mRNA. Translation: AAR98521.1.
    AY847222 mRNA. Translation: AAX73354.1.
    AY847220 mRNA. Translation: AAX73352.1.
    AY847221 mRNA. Translation: AAX73353.1.
    AF399753 mRNA. Translation: AAK94455.1.
    AY274811 mRNA. Translation: AAP42076.1.
    AB209688 mRNA. Translation: BAD92925.1. Frameshift.
    AK000342 mRNA. Translation: BAA91097.1. Frameshift.
    AK131385 mRNA. Translation: BAD18536.1. Frameshift.
    BC008943 mRNA. Translation: AAH08943.1.
    BC014479 mRNA. Translation: AAH14479.1. Sequence problems.
    CCDSiCCDS2889.1. [Q7Z7A4-1]
    RefSeqiNP_001276024.1. NM_001289095.1.
    NP_001276025.1. NM_001289096.1. [Q7Z7A4-6]
    NP_001276027.1. NM_001289098.1. [Q7Z7A4-2]
    NP_001276028.1. NM_001289099.1. [Q7Z7A4-7]
    NP_001276029.1. NM_001289100.1.
    NP_001276030.1. NM_001289101.1. [Q7Z7A4-5]
    NP_060241.2. NM_017771.4. [Q7Z7A4-1]
    UniGeneiHs.190544.

    Genome annotation databases

    EnsembliENST00000302779; ENSP00000305045; ENSG00000168297. [Q7Z7A4-4]
    ENST00000356151; ENSP00000348472; ENSG00000168297. [Q7Z7A4-1]
    ENST00000383716; ENSP00000373222; ENSG00000168297. [Q7Z7A4-6]
    ENST00000479241; ENSP00000419049; ENSG00000168297.
    ENST00000484288; ENSP00000417915; ENSG00000168297. [Q7Z7A4-2]
    GeneIDi54899.
    KEGGihsa:54899.
    UCSCiuc003djx.1. human. [Q7Z7A4-2]
    uc003djz.1. human. [Q7Z7A4-1]
    uc010hnj.1. human. [Q7Z7A4-6]

    Polymorphism databases

    DMDMi74759261.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ124707 mRNA. Translation: AAZ38821.1 .
    DQ124708 mRNA. Translation: AAZ38822.1 .
    AY437879 mRNA. Translation: AAR98521.1 .
    AY847222 mRNA. Translation: AAX73354.1 .
    AY847220 mRNA. Translation: AAX73352.1 .
    AY847221 mRNA. Translation: AAX73353.1 .
    AF399753 mRNA. Translation: AAK94455.1 .
    AY274811 mRNA. Translation: AAP42076.1 .
    AB209688 mRNA. Translation: BAD92925.1 . Frameshift.
    AK000342 mRNA. Translation: BAA91097.1 . Frameshift.
    AK131385 mRNA. Translation: BAD18536.1 . Frameshift.
    BC008943 mRNA. Translation: AAH08943.1 .
    BC014479 mRNA. Translation: AAH14479.1 . Sequence problems.
    CCDSi CCDS2889.1. [Q7Z7A4-1 ]
    RefSeqi NP_001276024.1. NM_001289095.1.
    NP_001276025.1. NM_001289096.1. [Q7Z7A4-6 ]
    NP_001276027.1. NM_001289098.1. [Q7Z7A4-2 ]
    NP_001276028.1. NM_001289099.1. [Q7Z7A4-7 ]
    NP_001276029.1. NM_001289100.1.
    NP_001276030.1. NM_001289101.1. [Q7Z7A4-5 ]
    NP_060241.2. NM_017771.4. [Q7Z7A4-1 ]
    UniGenei Hs.190544.

    3D structure databases

    ProteinModelPortali Q7Z7A4.
    SMRi Q7Z7A4. Positions 28-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120245. 6 interactions.

    PTM databases

    PhosphoSitei Q7Z7A4.

    Polymorphism databases

    DMDMi 74759261.

    Proteomic databases

    MaxQBi Q7Z7A4.
    PaxDbi Q7Z7A4.
    PRIDEi Q7Z7A4.

    Protocols and materials databases

    DNASUi 54899.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302779 ; ENSP00000305045 ; ENSG00000168297 . [Q7Z7A4-4 ]
    ENST00000356151 ; ENSP00000348472 ; ENSG00000168297 . [Q7Z7A4-1 ]
    ENST00000383716 ; ENSP00000373222 ; ENSG00000168297 . [Q7Z7A4-6 ]
    ENST00000479241 ; ENSP00000419049 ; ENSG00000168297 .
    ENST00000484288 ; ENSP00000417915 ; ENSG00000168297 . [Q7Z7A4-2 ]
    GeneIDi 54899.
    KEGGi hsa:54899.
    UCSCi uc003djx.1. human. [Q7Z7A4-2 ]
    uc003djz.1. human. [Q7Z7A4-1 ]
    uc010hnj.1. human. [Q7Z7A4-6 ]

    Organism-specific databases

    CTDi 54899.
    GeneCardsi GC03P058318.
    H-InvDB HIX0020846.
    HGNCi HGNC:23326. PXK.
    HPAi HPA024068.
    MIMi 611450. gene.
    neXtProti NX_Q7Z7A4.
    Orphaneti 536. Systemic lupus erythematosus.
    PharmGKBi PA134899496.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71043.
    HOVERGENi HBG061245.
    InParanoidi Q7Z7A4.
    KOi K17543.
    OMAi PQAVNGV.
    OrthoDBi EOG7FFMRQ.
    PhylomeDBi Q7Z7A4.
    TreeFami TF324116.

    Enzyme and pathway databases

    SignaLinki Q7Z7A4.

    Miscellaneous databases

    ChiTaRSi PXK. human.
    GenomeRNAii 54899.
    NextBioi 57920.
    PROi Q7Z7A4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z7A4.
    Bgeei Q7Z7A4.
    Genevestigatori Q7Z7A4.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000719. Prot_kinase_dom.
    IPR003124. WH2_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00787. PX. 1 hit.
    PF02205. WH2. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50195. PX. 1 hit.
    PS51082. WH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MONaKA, a novel modulator of the plasma membrane Na,K-ATPase."
      Mao H., Ferguson T.S., Cibulsky S.M., Holmqvist M., Ding C., Fei H., Levitan I.B.
      J. Neurosci. 25:7934-7943(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain1 Publication.
    2. "Expression pattern and subcellular localization of five splice isoforms of human PXK."
      Zou X., Qiu G., Chen C., Wu M., Hu Y., Zheng H., Li X., Gu S., Ji C., Mao Y.
      Int. J. Mol. Med. 16:701-707(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6 AND 7), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-54; TYR-56 AND ARG-92, VARIANT ARG-481.
      Tissue: Fetal brain1 Publication.
    3. Hong W.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. Shan Y.X., Yu L.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: BrainImported.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Caudate nucleusImported and HepatomaImported.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-461 (ISOFORMS 1/2).
      Tissue: B-cellImported and KidneyImported.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-426 AND ARG-481.

    Entry informationi

    Entry nameiPXK_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7A4
    Secondary accession number(s): Q3BCH4
    , Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3