Q7Z7A4 (PXK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PX domain-containing protein kinase-like protein

Alternative name(s):
Modulator of Na,K-ATPase
Short name=MONaKA

Gene names

Name:

PXK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Ref.2 UniProtKB Q8BX57
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein. Note: Also associates with the plasma membrane. Isoform 3 is present throughout the cell. Ref.2
Tissue specificity	Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated. Ref.2
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Contains 1 protein kinase domain. Contains 1 PX (phox homology) domain. Contains 1 WH2 domain.
Sequence caution	The sequence AAH14479.1 differs from that shown. Reason: Erroneous termination at position 451. Translated as Gly. The sequence BAA91097.1 differs from that shown. Reason: Frameshift at position 569. The sequence BAD18536.1 differs from that shown. Reason: Frameshift at position 510. The sequence BAD92925.1 differs from that shown. Reason: Frameshift at position 147.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from mutant phenotype PubMed 18204446. Source: UniProtKB negative regulation of ATPase activity Inferred from electronic annotation. Source: Compara negative regulation of ion transport Inferred from electronic annotation. Source: Compara regulation of synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay Ref.2. Source: UniProtKB nucleus Inferred from direct assay Ref.2. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Molecular_function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro protein C-terminus binding Inferred from sequence or structural similarity Ref.1. Source: UniProtKB transferase activity, transferring phosphorus-containing groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q7Z7A4-1)

Also known as: Long; v1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q7Z7A4-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     510-515: GISALP → VEHAPF
     516-578: Missing.

Isoform 3 Ref.2 (identifier: Q7Z7A4-3)

Also known as: v3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: Missing.

Isoform 4 (identifier: Q7Z7A4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Note: No experimental confirmation available.

Isoform 5 Ref.2 (identifier: Q7Z7A4-5)

Also known as: v4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Isoform 6 Ref.2 (identifier: Q7Z7A4-6)

Also known as: v2;

The sequence of this isoform differs from the canonical sequence as follows:
     35-67: Missing.

Isoform 7 Ref.2 (identifier: Q7Z7A4-7)

Also known as: v5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 578	578	PX domain-containing protein kinase-like protein		PRO_0000086592
Regions
	Domain	14 – 126	113	PX
	Domain	88 – 481	394	Protein kinase
	Domain	548 – 567	20	WH2
Natural variations
	Alternative sequence	1 – 226	226	Missing in isoform 3. Ref.2		VSP_051907
	Alternative sequence	1 – 137	137	Missing in isoform 5. Ref.2		VSP_051908
	Alternative sequence	1 – 83	83	Missing in isoform 7. Ref.2		VSP_051909
	Alternative sequence	35 – 67	33	Missing in isoform 6. Ref.2		VSP_051910
	Alternative sequence	35 – 51	17	Missing in isoform 4.		VSP_051911
	Alternative sequence	510 – 515	6	GISALP → VEHAPF in isoform 2. Ref.1		VSP_051912
	Alternative sequence	516 – 578	63	Missing in isoform 2. Ref.1		VSP_051913
	Natural variant	426	1	I → V. Ref.9 Corresponds to variant rs55973253 [ dbSNP | Ensembl ].		VAR_041362
	Natural variant	481	1	K → R. Ref.2 Ref.9 Corresponds to variant rs56384862 [ dbSNP | Ensembl ].		VAR_041363
	Natural variant	525	1	A → V. Corresponds to variant rs34579268 [ dbSNP | Ensembl ].		VAR_033911
	Natural variant	535	1	A → V. Corresponds to variant rs34579268 [ dbSNP | Ensembl ].		VAR_033912
Experimental info
	Mutagenesis	54	1	R → Q: No effect on subcellular location. Ref.2
	Mutagenesis	56	1	Y → A: Results in redistribution of protein from cytoplasm throughout entire cell. Ref.2
	Mutagenesis	92	1	R → L: Results in redistribution of protein from cytoplasm throughout entire cell. Ref.2
	Sequence conflict	42	1	R → G in AAK94455. Ref.3
	Sequence conflict	42	1	R → G in BAA91097. Ref.6
	Sequence conflict	459	1	R → K in AAR98521. Ref.2
	Sequence conflict	489	1	Missing in BAD18536. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) (v1) [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 73523CFC3731FFC8	FASTA	578	64,950
	10 20 30 40 50 60 MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD 70 80 90 100 110 120 LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD 130 140 150 160 170 180 PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW 190 200 210 220 230 240 ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK 250 260 270 280 290 300 AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT 310 320 330 340 350 360 CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP 370 380 390 400 410 420 PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR 430 440 450 460 470 480 IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA 490 500 510 520 530 540 KYSNSNNSAG SGASSPLTSP SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS 550 560 570 SQAVNGMSRG ALLSSIQNFQ KGTLRKAKTC DHSAPKIG
	Isoform 2 (Short) [UniParc]. Checksum: 8115EBC6A5157C97	FASTA	515	58,732
	10 20 30 40 50 60 MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QIVRRYSDFD 70 80 90 100 110 120 LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL NVITTNHILS NCELVKKFLD 130 140 150 160 170 180 PNNYSANYTE IALQQVSMFF RSEPKWEVVE PLKDIGWRIR KKYFLMKIKN QPKERLVLSW 190 200 210 220 230 240 ADLGPDKYLS DKDFQCLIKL LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK 250 260 270 280 290 300 AKPKDPFLKK YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT 310 320 330 340 350 360 CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP PDSVPVDSFP 370 380 390 400 410 420 PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL LTTSEKPQFK IPTKLKEALR 430 440 450 460 470 480 IAKECIEKRL IEEQKQIHQH RRLTRAQSHH GSEEERKKRK ILARKKSKRS ALENSEEHSA 490 500 510 KYSNSNNSAG SGASSPLTSP SSPTPPSTSV EHAPF
	Isoform 3 (v3) [UniParc]. Checksum: DE5F73819ABBB77C	FASTA	352	38,875
	10 20 30 40 50 60 MFNEKGTLKD LIYKAKPKDP FLKKYCNPKK IQGLELQQIK TYGRQILEVL KFLHDKGFPY 70 80 90 100 110 120 GHLHASNVML DGDTCRLLDL ENSLLGLPSF YRSYFSQFRK INTLESVDVH CFGHLLYEMT 130 140 150 160 170 180 YGRPPDSVPV DSFPPAPSMA VVAVLESTLS CEACKNGMPT ISRLLQMPLF SDVLLTTSEK 190 200 210 220 230 240 PQFKIPTKLK EALRIAKECI EKRLIEEQKQ IHQHRRLTRA QSHHGSEEER KKRKILARKK 250 260 270 280 290 300 SKRSALENSE EHSAKYSNSN NSAGSGASSP LTSPSSPTPP STSGISALPP PPPPPPPPAA 310 320 330 340 350 PLPPASTEAP AQLSSQAVNG MSRGALLSSI QNFQKGTLRK AKTCDHSAPK IG
	Isoform 4 [UniParc]. Checksum: 615A342917403DCD	FASTA	561	62,891
	10 20 30 40 50 60 MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTIVRRYS DFDLLNNSLQ IAGLSLPLPP 70 80 90 100 110 120 KKLIGNMDRE FIAERQKGLQ NYLNVITTNH ILSNCELVKK FLDPNNYSAN YTEIALQQVS 130 140 150 160 170 180 MFFRSEPKWE VVEPLKDIGW RIRKKYFLMK IKNQPKERLV LSWADLGPDK YLSDKDFQCL 190 200 210 220 230 240 IKLLPSCLHP YIYRVTFATA NESSALLIRM FNEKGTLKDL IYKAKPKDPF LKKYCNPKKI 250 260 270 280 290 300 QGLELQQIKT YGRQILEVLK FLHDKGFPYG HLHASNVMLD GDTCRLLDLE NSLLGLPSFY 310 320 330 340 350 360 RSYFSQFRKI NTLESVDVHC FGHLLYEMTY GRPPDSVPVD SFPPAPSMAV VAVLESTLSC 370 380 390 400 410 420 EACKNGMPTI SRLLQMPLFS DVLLTTSEKP QFKIPTKLKE ALRIAKECIE KRLIEEQKQI 430 440 450 460 470 480 HQHRRLTRAQ SHHGSEEERK KRKILARKKS KRSALENSEE HSAKYSNSNN SAGSGASSPL 490 500 510 520 530 540 TSPSSPTPPS TSGISALPPP PPPPPPPAAP LPPASTEAPA QLSSQAVNGM SRGALLSSIQ 550 560 NFQKGTLRKA KTCDHSAPKI G
	Isoform 5 (v4) [UniParc]. Checksum: F1D219D8C6988D86	FASTA	441	49,491
	10 20 30 40 50 60 MFFRSEPKWE VVEPLKDIGW RIRKKYFLMK IKNQPKERLV LSWADLGPDK YLSDKDFQCL 70 80 90 100 110 120 IKLLPSCLHP YIYRVTFATA NESSALLIRM FNEKGTLKDL IYKAKPKDPF LKKYCNPKKI 130 140 150 160 170 180 QGLELQQIKT YGRQILEVLK FLHDKGFPYG HLHASNVMLD GDTCRLLDLE NSLLGLPSFY 190 200 210 220 230 240 RSYFSQFRKI NTLESVDVHC FGHLLYEMTY GRPPDSVPVD SFPPAPSMAV VAVLESTLSC 250 260 270 280 290 300 EACKNGMPTI SRLLQMPLFS DVLLTTSEKP QFKIPTKLKE ALRIAKECIE KRLIEEQKQI 310 320 330 340 350 360 HQHRRLTRAQ SHHGSEEERK KRKILARKKS KRSALENSEE HSAKYSNSNN SAGSGASSPL 370 380 390 400 410 420 TSPSSPTPPS TSGISALPPP PPPPPPPAAP LPPASTEAPA QLSSQAVNGM SRGALLSSIQ 430 440 NFQKGTLRKA KTCDHSAPKI G
	Isoform 6 (v2) [UniParc]. Checksum: A1F5BED8AEAFF293	FASTA	545	60,956
	10 20 30 40 50 60 MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTIAGLSL PLPPKKLIGN MDREFIAERQ 70 80 90 100 110 120 KGLQNYLNVI TTNHILSNCE LVKKFLDPNN YSANYTEIAL QQVSMFFRSE PKWEVVEPLK 130 140 150 160 170 180 DIGWRIRKKY FLMKIKNQPK ERLVLSWADL GPDKYLSDKD FQCLIKLLPS CLHPYIYRVT 190 200 210 220 230 240 FATANESSAL LIRMFNEKGT LKDLIYKAKP KDPFLKKYCN PKKIQGLELQ QIKTYGRQIL 250 260 270 280 290 300 EVLKFLHDKG FPYGHLHASN VMLDGDTCRL LDLENSLLGL PSFYRSYFSQ FRKINTLESV 310 320 330 340 350 360 DVHCFGHLLY EMTYGRPPDS VPVDSFPPAP SMAVVAVLES TLSCEACKNG MPTISRLLQM 370 380 390 400 410 420 PLFSDVLLTT SEKPQFKIPT KLKEALRIAK ECIEKRLIEE QKQIHQHRRL TRAQSHHGSE 430 440 450 460 470 480 EERKKRKILA RKKSKRSALE NSEEHSAKYS NSNNSAGSGA SSPLTSPSSP TPPSTSGISA 490 500 510 520 530 540 LPPPPPPPPP PAAPLPPAST EAPAQLSSQA VNGMSRGALL SSIQNFQKGT LRKAKTCDHS APKIG
	Isoform 7 (v5) [UniParc]. Checksum: E5BA2969CBC9E57D	FASTA	495	55,762
	10 20 30 40 50 60 MDREFIAERQ KGLQNYLNVI TTNHILSNCE LVKKFLDPNN YSANYTEIAL QQVSMFFRSE 70 80 90 100 110 120 PKWEVVEPLK DIGWRIRKKY FLMKIKNQPK ERLVLSWADL GPDKYLSDKD FQCLIKLLPS 130 140 150 160 170 180 CLHPYIYRVT FATANESSAL LIRMFNEKGT LKDLIYKAKP KDPFLKKYCN PKKIQGLELQ 190 200 210 220 230 240 QIKTYGRQIL EVLKFLHDKG FPYGHLHASN VMLDGDTCRL LDLENSLLGL PSFYRSYFSQ 250 260 270 280 290 300 FRKINTLESV DVHCFGHLLY EMTYGRPPDS VPVDSFPPAP SMAVVAVLES TLSCEACKNG 310 320 330 340 350 360 MPTISRLLQM PLFSDVLLTT SEKPQFKIPT KLKEALRIAK ECIEKRLIEE QKQIHQHRRL 370 380 390 400 410 420 TRAQSHHGSE EERKKRKILA RKKSKRSALE NSEEHSAKYS NSNNSAGSGA SSPLTSPSSP 430 440 450 460 470 480 TPPSTSGISA LPPPPPPPPP PAAPLPPAST EAPAQLSSQA VNGMSRGALL SSIQNFQKGT 490 LRKAKTCDHS APKIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MONaKA, a novel modulator of the plasma membrane Na,K-ATPase." Mao H., Ferguson T.S., Cibulsky S.M., Holmqvist M., Ding C., Fei H., Levitan I.B. J. Neurosci. 25:7934-7943(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"Expression pattern and subcellular localization of five splice isoforms of human PXK." Zou X., Qiu G., Chen C., Wu M., Hu Y., Zheng H., Li X., Gu S., Ji C., Mao Y. Int. J. Mol. Med. 16:701-707(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6 AND 7), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-54; TYR-56 AND ARG-92, VARIANT ARG-481. Tissue: Fetal brain.
[3]	Hong W. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	Shan Y.X., Yu L. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Caudate nucleus and Hepatoma.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-461 (ISOFORMS 1/2). Tissue: B-cell and Kidney.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[9]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-426 AND ARG-481.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ124707 mRNA. Translation: AAZ38821.1. DQ124708 mRNA. Translation: AAZ38822.1. AY437879 mRNA. Translation: AAR98521.1. AY847222 mRNA. Translation: AAX73354.1. AY847220 mRNA. Translation: AAX73352.1. AY847221 mRNA. Translation: AAX73353.1. AF399753 mRNA. Translation: AAK94455.1. AY274811 mRNA. Translation: AAP42076.1. AB209688 mRNA. Translation: BAD92925.1. Frameshift. AK000342 mRNA. Translation: BAA91097.1. Frameshift. AK131385 mRNA. Translation: BAD18536.1. Frameshift. BC008943 mRNA. Translation: AAH08943.1. BC014479 mRNA. Translation: AAH14479.1. Sequence problems.
IPI	IPI00479912. IPI00556666. IPI00654715. IPI00655529. IPI00655607. IPI00655666. IPI00656013.
RefSeq	NP_060241.2. NM_017771.3.
UniGene	Hs.190544.
3D structure databases
ProteinModelPortal	Q7Z7A4.
ModBase	Search...
PTM databases
PhosphoSite	Q7Z7A4.
Polymorphism databases
DMDM	74759261.
Proteomic databases
PaxDb	Q7Z7A4.
PRIDE	Q7Z7A4.
Protocols and materials databases
DNASU	54899.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302779; ENSP00000305045; ENSG00000168297. ENST00000356151; ENSP00000348472; ENSG00000168297. ENST00000383716; ENSP00000373222; ENSG00000168297. ENST00000479241; ENSP00000419049; ENSG00000168297. ENST00000484288; ENSP00000417915; ENSG00000168297. ENST00000536660; ENSP00000438356; ENSG00000168297.
GeneID	54899.
KEGG	hsa:54899.
UCSC	uc003djx.1. human. uc003djz.1. human. uc003dkc.1. human. uc010hnj.1. human.
Organism-specific databases
CTD	54899.
GeneCards	GC03P058318.
H-InvDB	HIX0020846.
HGNC	HGNC:23326. PXK.
HPA	HPA024068.
MIM	611450. gene.
neXtProt	NX_Q7Z7A4.
PharmGKB	PA134899496.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG71043.
HOVERGEN	HBG061245.
InParanoid	Q7Z7A4.
OMA	HGSEEEK.
OrthoDB	EOG40GCQT.
Gene expression databases
ArrayExpress	Q7Z7A4.
Bgee	Q7Z7A4.
Genevestigator	Q7Z7A4.
GermOnline	ENSG00000168297. Homo sapiens.
Family and domain databases
Gene3D	3.30.1520.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR001683. Phox. IPR000719. Prot_kinase_cat_dom. IPR003124. WH2_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00787. PX. 1 hit. PF02205. WH2. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF64268. PX. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50195. PX. 1 hit. PS51082. WH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PXK. human.
GenomeRNAi	54899.
NextBio	57920.
SOURCE	Search...

Entry information

Entry name

PXK_HUMAN

Accession

Primary (citable) accession number: Q7Z7A4
Secondary accession number(s): Q3BCH4 , Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.