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Protein

PX domain-containing protein kinase-like protein

Gene

PXK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.1 PublicationBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB
  2. protein C-terminus binding Source: UniProtKB
  3. transferase activity, transferring phosphorus-containing groups Source: InterPro

GO - Biological processi

  1. inflammatory response Source: UniProtKB
  2. negative regulation of ATPase activity Source: UniProtKB
  3. negative regulation of ion transport Source: UniProtKB
  4. regulation of synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiQ7Z7A4.

Names & Taxonomyi

Protein namesi
Recommended name:
PX domain-containing protein kinase-like protein
Alternative name(s):
Modulator of Na,K-ATPase
Short name:
MONaKA
Gene namesi
Name:PXKImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23326. PXK.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Also associates with the plasma membrane. Isoform 3 is present throughout the cell.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. microtubule organizing center Source: HPA
  3. nucleus Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541R → Q: No effect on subcellular location. 1 Publication
Mutagenesisi56 – 561Y → A: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication
Mutagenesisi92 – 921R → L: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication

Organism-specific databases

Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA134899496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578PX domain-containing protein kinase-like proteinPRO_0000086592Add
BLAST

Proteomic databases

MaxQBiQ7Z7A4.
PaxDbiQ7Z7A4.
PRIDEiQ7Z7A4.

PTM databases

PhosphoSiteiQ7Z7A4.

Expressioni

Tissue specificityi

Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.1 Publication

Gene expression databases

BgeeiQ7Z7A4.
ExpressionAtlasiQ7Z7A4. baseline and differential.
GenevestigatoriQ7Z7A4.

Organism-specific databases

HPAiHPA024068.

Interactioni

Protein-protein interaction databases

BioGridi120245. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7A4.
SMRiQ7Z7A4. Positions 28-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 126113PXPROSITE-ProRule annotationAdd
BLAST
Domaini88 – 481394Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini548 – 56720WH2PROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG71043.
GeneTreeiENSGT00390000017669.
HOVERGENiHBG061245.
InParanoidiQ7Z7A4.
KOiK17543.
OMAiPQAVNGV.
OrthoDBiEOG7FFMRQ.
PhylomeDBiQ7Z7A4.
TreeFamiTF324116.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
IPR003124. WH2_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q7Z7A4-1) [UniParc]FASTAAdd to basket

Also known as: Long1 Publication

, v11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW
60 70 80 90 100
QIVRRYSDFD LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL
110 120 130 140 150
NVITTNHILS NCELVKKFLD PNNYSANYTE IALQQVSMFF RSEPKWEVVE
160 170 180 190 200
PLKDIGWRIR KKYFLMKIKN QPKERLVLSW ADLGPDKYLS DKDFQCLIKL
210 220 230 240 250
LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK AKPKDPFLKK
260 270 280 290 300
YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
310 320 330 340 350
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP
360 370 380 390 400
PDSVPVDSFP PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL
410 420 430 440 450
LTTSEKPQFK IPTKLKEALR IAKECIEKRL IEEQKQIHQH RRLTRAQSHH
460 470 480 490 500
GSEEERKKRK ILARKKSKRS ALENSEEHSA KYSNSNNSAG SGASSPLTSP
510 520 530 540 550
SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS SQAVNGMSRG
560 570
ALLSSIQNFQ KGTLRKAKTC DHSAPKIG
Length:578
Mass (Da):64,950
Last modified:September 30, 2003 - v1
Checksum:i73523CFC3731FFC8
GO
Isoform 21 Publication (identifier: Q7Z7A4-2) [UniParc]FASTAAdd to basket

Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     510-515: GISALP → VEHAPF
     516-578: Missing.

Show »
Length:515
Mass (Da):58,732
Checksum:i8115EBC6A5157C97
GO
Isoform 31 Publication (identifier: Q7Z7A4-3) [UniParc]FASTAAdd to basket

Also known as: v31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: Missing.

Show »
Length:352
Mass (Da):38,875
Checksum:iDE5F73819ABBB77C
GO
Isoform 4Curated (identifier: Q7Z7A4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:561
Mass (Da):62,891
Checksum:i615A342917403DCD
GO
Isoform 51 Publication (identifier: Q7Z7A4-5) [UniParc]FASTAAdd to basket

Also known as: v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Show »
Length:441
Mass (Da):49,491
Checksum:iF1D219D8C6988D86
GO
Isoform 61 Publication (identifier: Q7Z7A4-6) [UniParc]FASTAAdd to basket

Also known as: v21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     35-67: Missing.

Show »
Length:545
Mass (Da):60,956
Checksum:iA1F5BED8AEAFF293
GO
Isoform 71 Publication (identifier: Q7Z7A4-7) [UniParc]FASTAAdd to basket

Also known as: v51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:495
Mass (Da):55,762
Checksum:iE5BA2969CBC9E57D
GO

Sequence cautioni

The sequence AAH14479.1 differs from that shown. Reason: Erroneous termination at position 451. Translated as Gly.Curated
The sequence BAA91097.1 differs from that shown. Reason: Frameshift at position 569. Curated
The sequence BAD18536.1 differs from that shown. Reason: Frameshift at position 510. Curated
The sequence BAD92925.1 differs from that shown. Reason: Frameshift at position 147. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421R → G in AAK94455 (Ref. 3) Curated
Sequence conflicti42 – 421R → G in BAA91097 (PubMed:14702039).Curated
Sequence conflicti459 – 4591R → K in AAR98521 (PubMed:16142408).Curated
Sequence conflicti489 – 4891Missing in BAD18536 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti426 – 4261I → V.1 Publication
Corresponds to variant rs55973253 [ dbSNP | Ensembl ].
VAR_041362
Natural varianti481 – 4811K → R.2 Publications
Corresponds to variant rs56384862 [ dbSNP | Ensembl ].
VAR_041363
Natural varianti525 – 5251A → V.
Corresponds to variant rs34579268 [ dbSNP | Ensembl ].
VAR_033911
Natural varianti535 – 5351A → V.
Corresponds to variant rs34579268 [ dbSNP | Ensembl ].
VAR_033912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 226226Missing in isoform 3. 1 PublicationVSP_051907Add
BLAST
Alternative sequencei1 – 137137Missing in isoform 5. 1 PublicationVSP_051908Add
BLAST
Alternative sequencei1 – 8383Missing in isoform 7. 1 PublicationVSP_051909Add
BLAST
Alternative sequencei35 – 6733Missing in isoform 6. 1 PublicationVSP_051910Add
BLAST
Alternative sequencei35 – 5117Missing in isoform 4. 1 PublicationVSP_051911Add
BLAST
Alternative sequencei510 – 5156GISALP → VEHAPF in isoform 2. 3 PublicationsVSP_051912
Alternative sequencei516 – 57863Missing in isoform 2. 3 PublicationsVSP_051913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ124707 mRNA. Translation: AAZ38821.1.
DQ124708 mRNA. Translation: AAZ38822.1.
AY437879 mRNA. Translation: AAR98521.1.
AY847222 mRNA. Translation: AAX73354.1.
AY847220 mRNA. Translation: AAX73352.1.
AY847221 mRNA. Translation: AAX73353.1.
AF399753 mRNA. Translation: AAK94455.1.
AY274811 mRNA. Translation: AAP42076.1.
AB209688 mRNA. Translation: BAD92925.1. Frameshift.
AK000342 mRNA. Translation: BAA91097.1. Frameshift.
AK131385 mRNA. Translation: BAD18536.1. Frameshift.
BC008943 mRNA. Translation: AAH08943.1.
BC014479 mRNA. Translation: AAH14479.1. Sequence problems.
CCDSiCCDS2889.1. [Q7Z7A4-1]
CCDS74952.1. [Q7Z7A4-2]
RefSeqiNP_001276024.1. NM_001289095.1.
NP_001276025.1. NM_001289096.1. [Q7Z7A4-6]
NP_001276027.1. NM_001289098.1. [Q7Z7A4-2]
NP_001276028.1. NM_001289099.1. [Q7Z7A4-7]
NP_001276029.1. NM_001289100.1.
NP_001276030.1. NM_001289101.1. [Q7Z7A4-5]
NP_060241.2. NM_017771.4. [Q7Z7A4-1]
UniGeneiHs.190544.

Genome annotation databases

EnsembliENST00000356151; ENSP00000348472; ENSG00000168297. [Q7Z7A4-1]
ENST00000383716; ENSP00000373222; ENSG00000168297. [Q7Z7A4-2]
ENST00000484288; ENSP00000417915; ENSG00000168297. [Q7Z7A4-2]
GeneIDi54899.
KEGGihsa:54899.
UCSCiuc003djx.1. human. [Q7Z7A4-2]
uc003djz.1. human. [Q7Z7A4-1]
uc010hnj.1. human. [Q7Z7A4-6]

Polymorphism databases

DMDMi74759261.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ124707 mRNA. Translation: AAZ38821.1.
DQ124708 mRNA. Translation: AAZ38822.1.
AY437879 mRNA. Translation: AAR98521.1.
AY847222 mRNA. Translation: AAX73354.1.
AY847220 mRNA. Translation: AAX73352.1.
AY847221 mRNA. Translation: AAX73353.1.
AF399753 mRNA. Translation: AAK94455.1.
AY274811 mRNA. Translation: AAP42076.1.
AB209688 mRNA. Translation: BAD92925.1. Frameshift.
AK000342 mRNA. Translation: BAA91097.1. Frameshift.
AK131385 mRNA. Translation: BAD18536.1. Frameshift.
BC008943 mRNA. Translation: AAH08943.1.
BC014479 mRNA. Translation: AAH14479.1. Sequence problems.
CCDSiCCDS2889.1. [Q7Z7A4-1]
CCDS74952.1. [Q7Z7A4-2]
RefSeqiNP_001276024.1. NM_001289095.1.
NP_001276025.1. NM_001289096.1. [Q7Z7A4-6]
NP_001276027.1. NM_001289098.1. [Q7Z7A4-2]
NP_001276028.1. NM_001289099.1. [Q7Z7A4-7]
NP_001276029.1. NM_001289100.1.
NP_001276030.1. NM_001289101.1. [Q7Z7A4-5]
NP_060241.2. NM_017771.4. [Q7Z7A4-1]
UniGeneiHs.190544.

3D structure databases

ProteinModelPortaliQ7Z7A4.
SMRiQ7Z7A4. Positions 28-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120245. 6 interactions.

PTM databases

PhosphoSiteiQ7Z7A4.

Polymorphism databases

DMDMi74759261.

Proteomic databases

MaxQBiQ7Z7A4.
PaxDbiQ7Z7A4.
PRIDEiQ7Z7A4.

Protocols and materials databases

DNASUi54899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356151; ENSP00000348472; ENSG00000168297. [Q7Z7A4-1]
ENST00000383716; ENSP00000373222; ENSG00000168297. [Q7Z7A4-2]
ENST00000484288; ENSP00000417915; ENSG00000168297. [Q7Z7A4-2]
GeneIDi54899.
KEGGihsa:54899.
UCSCiuc003djx.1. human. [Q7Z7A4-2]
uc003djz.1. human. [Q7Z7A4-1]
uc010hnj.1. human. [Q7Z7A4-6]

Organism-specific databases

CTDi54899.
GeneCardsiGC03P058318.
H-InvDBHIX0020846.
HGNCiHGNC:23326. PXK.
HPAiHPA024068.
MIMi611450. gene.
neXtProtiNX_Q7Z7A4.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA134899496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG71043.
GeneTreeiENSGT00390000017669.
HOVERGENiHBG061245.
InParanoidiQ7Z7A4.
KOiK17543.
OMAiPQAVNGV.
OrthoDBiEOG7FFMRQ.
PhylomeDBiQ7Z7A4.
TreeFamiTF324116.

Enzyme and pathway databases

SignaLinkiQ7Z7A4.

Miscellaneous databases

ChiTaRSiPXK. human.
GenomeRNAii54899.
NextBioi57920.
PROiQ7Z7A4.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z7A4.
ExpressionAtlasiQ7Z7A4. baseline and differential.
GenevestigatoriQ7Z7A4.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
IPR003124. WH2_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MONaKA, a novel modulator of the plasma membrane Na,K-ATPase."
    Mao H., Ferguson T.S., Cibulsky S.M., Holmqvist M., Ding C., Fei H., Levitan I.B.
    J. Neurosci. 25:7934-7943(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain1 Publication.
  2. "Expression pattern and subcellular localization of five splice isoforms of human PXK."
    Zou X., Qiu G., Chen C., Wu M., Hu Y., Zheng H., Li X., Gu S., Ji C., Mao Y.
    Int. J. Mol. Med. 16:701-707(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6 AND 7), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-54; TYR-56 AND ARG-92, VARIANT ARG-481.
    Tissue: Fetal brain1 Publication.
  3. Hong W.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. Shan Y.X., Yu L.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: BrainImported.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Caudate nucleusImported and HepatomaImported.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-461 (ISOFORMS 1/2).
    Tissue: B-cellImported and KidneyImported.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-426 AND ARG-481.

Entry informationi

Entry nameiPXK_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7A4
Secondary accession number(s): Q3BCH4
, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2005
Last sequence update: September 30, 2003
Last modified: March 3, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.