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Q7Z7A1

- CNTRL_HUMAN

UniProt

Q7Z7A1 - CNTRL_HUMAN

Protein

Centriolin

Gene

CNTRL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei2139 – 21402Breakpoint for translocation to form CEP110-FGFR1

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G2/M transition of mitotic cell cycle Source: Reactome
    3. mitotic cell cycle Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.
    REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centriolin
    Alternative name(s):
    Centrosomal protein 1
    Centrosomal protein of 110 kDa
    Short name:
    Cep110
    Gene namesi
    Name:CNTRL
    Synonyms:CEP1, CEP110
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:1858. CNTRL.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 3 Publications
    Note: During cytokinesis, localizes to a ring-like structure at the central midbody.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: HPA
    3. cytosol Source: Reactome
    4. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

    Organism-specific databases

    PharmGKBiPA26414.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23252325CentriolinPRO_0000323675Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z7A1.
    PaxDbiQ7Z7A1.
    PRIDEiQ7Z7A1.

    PTM databases

    PhosphoSiteiQ7Z7A1.

    Expressioni

    Tissue specificityi

    Highly expressed in testis and trachea.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z7A1.
    BgeeiQ7Z7A1.
    CleanExiHS_CEP110.
    GenevestigatoriQ7Z7A1.

    Organism-specific databases

    HPAiHPA020468.
    HPA020480.
    HPA051583.

    Interactioni

    Subunit structurei

    Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex.2 Publications

    Protein-protein interaction databases

    BioGridi116248. 4 interactions.
    DIPiDIP-47280N.
    IntActiQ7Z7A1. 18 interactions.
    MINTiMINT-4988988.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7A1.
    SMRiQ7Z7A1. Positions 74-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati126 – 14722LRR 1Add
    BLAST
    Repeati148 – 16922LRR 2Add
    BLAST
    Repeati170 – 19122LRR 3Add
    BLAST
    Repeati194 – 21522LRR 4Add
    BLAST
    Domaini228 – 26639LRRCTAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1948 – 2118171Required for centrosome localizationAdd
    BLAST
    Regioni1985 – 2325341Sufficient for interaction with HOOK2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili267 – 34377Sequence AnalysisAdd
    BLAST
    Coiled coili435 – 799365Sequence AnalysisAdd
    BLAST
    Coiled coili851 – 1101251Sequence AnalysisAdd
    BLAST
    Coiled coili1317 – 2255939Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi956 – 9594Poly-Lys
    Compositional biasi1147 – 11504Poly-Pro
    Compositional biasi1236 – 130772Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 4 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated

    Keywords - Domaini

    Coiled coil, Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG145909.
    HOVERGENiHBG101203.
    InParanoidiQ7Z7A1.
    KOiK16770.
    OMAiDESPYIG.
    OrthoDBiEOG7NSB1F.
    PhylomeDBiQ7Z7A1.
    TreeFamiTF101135.

    Family and domain databases

    InterProiIPR028640. CEP110.
    IPR001611. Leu-rich_rpt.
    [Graphical view]
    PANTHERiPTHR18877. PTHR18877. 1 hit.
    PROSITEiPS51450. LRR. 5 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z7A1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG     50
    QWCEQVEIAD ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI 100
    KSLNLSLSKD GGKKFKYIEN LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR 150
    ELNLSYNKIS KIEGIENMCN LQKLNLAGNE IEHIPVWLGK KLKSLRVLNL 200
    KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT IFHLRSLESL 250
    EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI 300
    KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY 350
    ELEQELAFYK IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT 400
    ESYIIDSAQA VQIKKMEPDE QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ 450
    TRLSELHDEI EKAEQQILRA TEEFKQLEEA IQLKKISEAG KDLLYKQLSG 500
    RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI DSLDSKDPKH 550
    SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT 600
    EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL 650
    QRLTEVEQER DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD 700
    LSAYEAELEA RLNLRDAEAN QLKEELEKVT RLTQLEQSAL QAELEKERQA 750
    LKNALGKAQF SEEKEQENSE LHAKLKHLQD DNNLLKQQLK DFQNHLNHVV 800
    DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL ADLQKQFSEI 850
    LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF 900
    DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ 950
    LRELEKKKKL EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ 1000
    LKSLHGTVMK INQERAEELQ EAERFSRKAA QAARDLTRAE AEIELLQNLL 1050
    RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL NETMERQRTE IARLQNVLDL 1100
    TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR GYWYFMPPPP 1150
    SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW 1200
    VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL 1250
    PDGSPVPQGM ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PMVYGPPPPN 1300
    FSIPFIPMGV LHCNVPEHHN LENEVSRLED IMQHLKSKKR EERWMRASKR 1350
    QSEKEMEELH HNIDDLLQEK KSLECEVEEL HRTVQKRQQQ KDFIDGNVES 1400
    LMTELEIEKS LKHHEDIVDE IECIEKTLLK RRSELREADR LLAEAESELS 1450
    CTKEKTKNAV EKFTDAKRSL LQTESDAEEL ERRAQETAVN LVKADQQLRS 1500
    LQADAKDLEQ HKIKQEEILK EINKIVAAKD SDFQCLSKKK EKLTEELQKL 1550
    QKDIEMAERN EDHHLQVLKE SEVLLQAKRA ELEKLKSQVT SQQQEMAVLD 1600
    RQLGHKKEEL HLLQGSMVQA KADLQEALRL GETEVTEKCN HIREVKSLLE 1650
    ELSFQKGELN VQISERKTQL TLIKQEIEKE EENLQVVLRQ MSKHKTELKN 1700
    ILDMLQLENH ELQGLKLQHD QRVSELEKTQ VAVLEEKLEL ENLQQISQQQ 1750
    KGEIEWQKQL LERDKREIER MTAESRALQS CVECLSKEKE DLQEKCDIWE 1800
    KKLAQTKRVL AAAEENSKME QSNLEKLELN VRKLQQELDQ LNRDKLSLHN 1850
    DISAMQQQLQ EKREAVNSLQ EELANVQDHL NLAKQDLLHT TKHQDVLLSE 1900
    QTRLQKDISE WANRFEDCQK EEETKQQQLQ VLQNEIEENK LKLVQQEMMF 1950
    QRLQKERESE ESKLETSKVT LKEQQHQLEK ELTDQKSKLD QVLSKVLAAE 2000
    ERVRTLQEEE RWCESLEKTL SQTKRQLSER EQQLVEKSGE LLALQKEADS 2050
    MRADFSLLRN QFLTERKKAE KQVASLKEAL KIQRSQLEKN LLEQKQENSC 2100
    IQKEMATIEL VAQDNHERAR RLMKELNQMQ YEYTELKKQM ANQKDLERRQ 2150
    MEISDAMRTL KSEVKDEIRT SLKNLNQFLP ELPADLEAIL ERNENLEGEL 2200
    ESLKENLPFT MNEGPFEEKL NFSQVHIMDE HWRGEALREK LRHREDRLKA 2250
    QLRHCMSKQA EVLIKGKRQT EGTLHSLRRQ VDALGELVTS TSADSASSPS 2300
    LSQLESSLTE DSQLGQNQEK NASAR 2325
    Length:2,325
    Mass (Da):268,886
    Last modified:March 18, 2008 - v2
    Checksum:i93DD4CA08B5BD4AF
    GO
    Isoform 2 (identifier: Q7Z7A1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-552: Missing.

    Show »
    Length:1,773
    Mass (Da):205,172
    Checksum:iF430B910E219D5E2
    GO
    Isoform 3 (identifier: Q7Z7A1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1331: Missing.

    Show »
    Length:994
    Mass (Da):116,799
    Checksum:iBFE7F893259BA73D
    GO
    Isoform 4 (identifier: Q7Z7A1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1818: Missing.
         1962-1986: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:482
    Mass (Da):56,587
    Checksum:i1B4867D4FEAFE023
    GO
    Isoform 5 (identifier: Q7Z7A1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1291-1296: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,319
    Mass (Da):268,241
    Checksum:i5C9924F8D58B852A
    GO

    Sequence cautioni

    The sequence AAH02932.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH89415.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH02932.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1389 – 13891Q → R in AAC32373. (PubMed:10688839)Curated
    Sequence conflicti1699 – 16991K → Q in AAC32373. (PubMed:10688839)Curated
    Sequence conflicti1828 – 18281E → D in AAC32373. (PubMed:10688839)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561V → I.1 Publication
    Corresponds to variant rs10818503 [ dbSNP | Ensembl ].
    VAR_039559
    Natural varianti216 – 2161P → L.
    Corresponds to variant rs10818504 [ dbSNP | Ensembl ].
    VAR_039560
    Natural varianti889 – 8891A → T.
    Corresponds to variant rs17292952 [ dbSNP | Ensembl ].
    VAR_039561
    Natural varianti1146 – 11461M → V.
    Corresponds to variant rs35342437 [ dbSNP | Ensembl ].
    VAR_061622

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 18181818Missing in isoform 4. 1 PublicationVSP_032046Add
    BLAST
    Alternative sequencei1 – 13311331Missing in isoform 3. 1 PublicationVSP_032047Add
    BLAST
    Alternative sequencei1 – 552552Missing in isoform 2. 1 PublicationVSP_032048Add
    BLAST
    Alternative sequencei1291 – 12966Missing in isoform 5. 1 PublicationVSP_032049
    Alternative sequencei1962 – 198625Missing in isoform 4. 1 PublicationVSP_032050Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083322 mRNA. Translation: AAC32373.1.
    AF513978 mRNA. Translation: AAP43846.1.
    BX640927 mRNA. Translation: CAE45965.1.
    AL137068 Genomic DNA. Translation: CAI12358.1.
    AL137068 Genomic DNA. Translation: CAM13285.1.
    BC002932 mRNA. Translation: AAH02932.1. Sequence problems.
    BC089415 mRNA. Translation: AAH89415.1. Sequence problems.
    BC137286 mRNA. Translation: AAI37287.1.
    AY651261 mRNA. Translation: AAX35689.1.
    AK074079 mRNA. Translation: BAB84905.1.
    CCDSiCCDS35118.1. [Q7Z7A1-1]
    RefSeqiNP_008949.4. NM_007018.4. [Q7Z7A1-1]
    XP_005251736.1. XM_005251679.2. [Q7Z7A1-1]
    UniGeneiHs.653263.

    Genome annotation databases

    EnsembliENST00000238341; ENSP00000238341; ENSG00000119397. [Q7Z7A1-1]
    ENST00000373850; ENSP00000362956; ENSG00000119397. [Q7Z7A1-2]
    ENST00000373855; ENSP00000362962; ENSG00000119397. [Q7Z7A1-1]
    GeneIDi11064.
    KEGGihsa:11064.
    UCSCiuc004bkx.1. human. [Q7Z7A1-1]
    uc004blb.1. human. [Q7Z7A1-3]
    uc010mvp.1. human. [Q7Z7A1-4]

    Polymorphism databases

    DMDMi172045911.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083322 mRNA. Translation: AAC32373.1 .
    AF513978 mRNA. Translation: AAP43846.1 .
    BX640927 mRNA. Translation: CAE45965.1 .
    AL137068 Genomic DNA. Translation: CAI12358.1 .
    AL137068 Genomic DNA. Translation: CAM13285.1 .
    BC002932 mRNA. Translation: AAH02932.1 . Sequence problems.
    BC089415 mRNA. Translation: AAH89415.1 . Sequence problems.
    BC137286 mRNA. Translation: AAI37287.1 .
    AY651261 mRNA. Translation: AAX35689.1 .
    AK074079 mRNA. Translation: BAB84905.1 .
    CCDSi CCDS35118.1. [Q7Z7A1-1 ]
    RefSeqi NP_008949.4. NM_007018.4. [Q7Z7A1-1 ]
    XP_005251736.1. XM_005251679.2. [Q7Z7A1-1 ]
    UniGenei Hs.653263.

    3D structure databases

    ProteinModelPortali Q7Z7A1.
    SMRi Q7Z7A1. Positions 74-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116248. 4 interactions.
    DIPi DIP-47280N.
    IntActi Q7Z7A1. 18 interactions.
    MINTi MINT-4988988.

    PTM databases

    PhosphoSitei Q7Z7A1.

    Polymorphism databases

    DMDMi 172045911.

    Proteomic databases

    MaxQBi Q7Z7A1.
    PaxDbi Q7Z7A1.
    PRIDEi Q7Z7A1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000238341 ; ENSP00000238341 ; ENSG00000119397 . [Q7Z7A1-1 ]
    ENST00000373850 ; ENSP00000362956 ; ENSG00000119397 . [Q7Z7A1-2 ]
    ENST00000373855 ; ENSP00000362962 ; ENSG00000119397 . [Q7Z7A1-1 ]
    GeneIDi 11064.
    KEGGi hsa:11064.
    UCSCi uc004bkx.1. human. [Q7Z7A1-1 ]
    uc004blb.1. human. [Q7Z7A1-3 ]
    uc010mvp.1. human. [Q7Z7A1-4 ]

    Organism-specific databases

    CTDi 11064.
    GeneCardsi GC09P123839.
    H-InvDB HIX0008344.
    HGNCi HGNC:1858. CNTRL.
    HPAi HPA020468.
    HPA020480.
    HPA051583.
    MIMi 605496. gene.
    neXtProti NX_Q7Z7A1.
    PharmGKBi PA26414.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145909.
    HOVERGENi HBG101203.
    InParanoidi Q7Z7A1.
    KOi K16770.
    OMAi DESPYIG.
    OrthoDBi EOG7NSB1F.
    PhylomeDBi Q7Z7A1.
    TreeFami TF101135.

    Enzyme and pathway databases

    Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.
    REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    ChiTaRSi CNTRL. human.
    GeneWikii CNTRL.
    GenomeRNAii 11064.
    NextBioi 42047.
    PROi Q7Z7A1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z7A1.
    Bgeei Q7Z7A1.
    CleanExi HS_CEP110.
    Genevestigatori Q7Z7A1.

    Family and domain databases

    InterProi IPR028640. CEP110.
    IPR001611. Leu-rich_rpt.
    [Graphical view ]
    PANTHERi PTHR18877. PTHR18877. 1 hit.
    PROSITEi PS51450. LRR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)."
      Guasch G., Mack G.J., Popovici C., Dastugue N., Birnbaum D., Rattner J.B., Pebusque M.-J.
      Blood 95:1788-1796(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH FGFR1, SUBCELLULAR LOCATION.
    2. "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase."
      Gromley A., Jurczyk A., Sillibourne J., Halilovic E., Mogensen M., Groisman I., Blomberg M., Doxsey S.J.
      J. Cell Biol. 161:535-545(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-56, SUBCELLULAR LOCATION, FUNCTION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Liver.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1513 (ISOFORM 2).
      Tissue: Lymph and Placenta.
    6. "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
      Guinn B.-A., Bland E.A., Lodi U., Liggins A.P., Tobal K., Petters S., Wells J.W., Banham A.H., Mufti G.J.
      Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-1677 (ISOFORM 1).
    7. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 527-2325 (ISOFORM 5).
      Tissue: Spleen.
    8. "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation."
      Ou Y.Y., Mack G.J., Zhang M., Rattner J.B.
      J. Cell Sci. 115:1825-1835(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission."
      Gromley A., Yeaman C., Rosa J., Redick S., Chen C.-T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J.
      Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EXOC6 AND SNAPIN.
    10. "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function."
      Szebenyi G., Hall B., Yu R., Hashim A.I., Kraemer H.
      Traffic 8:32-46(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOOK2.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCNTRL_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7A1
    Secondary accession number(s): A2A2Y1
    , B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q8TEP3, Q9Y489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3