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Q7Z7A1

- CNTRL_HUMAN

UniProt

Q7Z7A1 - CNTRL_HUMAN

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Protein
Centriolin
Gene
CNTRL, CEP1, CEP110
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2139 – 21402Breakpoint for translocation to form CEP110-FGFR1

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. cell division Source: UniProtKB-KW
  3. mitotic cell cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centriolin
Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name:
Cep110
Gene namesi
Name:CNTRL
Synonyms:CEP1, CEP110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1858. CNTRL.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: During cytokinesis, localizes to a ring-like structure at the central midbody.3 Publications

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

Organism-specific databases

PharmGKBiPA26414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23252325Centriolin
PRO_0000323675Add
BLAST

Proteomic databases

MaxQBiQ7Z7A1.
PaxDbiQ7Z7A1.
PRIDEiQ7Z7A1.

PTM databases

PhosphoSiteiQ7Z7A1.

Expressioni

Tissue specificityi

Highly expressed in testis and trachea.1 Publication

Gene expression databases

ArrayExpressiQ7Z7A1.
BgeeiQ7Z7A1.
CleanExiHS_CEP110.
GenevestigatoriQ7Z7A1.

Organism-specific databases

HPAiHPA020468.
HPA020480.
HPA051583.

Interactioni

Subunit structurei

Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex.2 Publications

Protein-protein interaction databases

BioGridi116248. 4 interactions.
DIPiDIP-47280N.
IntActiQ7Z7A1. 17 interactions.
MINTiMINT-4988988.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7A1.
SMRiQ7Z7A1. Positions 74-279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 14722LRR 1
Add
BLAST
Repeati148 – 16922LRR 2
Add
BLAST
Repeati170 – 19122LRR 3
Add
BLAST
Repeati194 – 21522LRR 4
Add
BLAST
Domaini228 – 26639LRRCT
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1948 – 2118171Required for centrosome localization
Add
BLAST
Regioni1985 – 2325341Sufficient for interaction with HOOK2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili267 – 34377 Reviewed prediction
Add
BLAST
Coiled coili435 – 799365 Reviewed prediction
Add
BLAST
Coiled coili851 – 1101251 Reviewed prediction
Add
BLAST
Coiled coili1317 – 2255939 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi956 – 9594Poly-Lys
Compositional biasi1147 – 11504Poly-Pro
Compositional biasi1236 – 130772Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG145909.
HOVERGENiHBG101203.
InParanoidiQ7Z7A1.
KOiK16770.
OMAiDESPYIG.
OrthoDBiEOG7NSB1F.
PhylomeDBiQ7Z7A1.
TreeFamiTF101135.

Family and domain databases

InterProiIPR028640. CEP110.
IPR001611. Leu-rich_rpt.
[Graphical view]
PANTHERiPTHR18877. PTHR18877. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z7A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG     50
QWCEQVEIAD ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI 100
KSLNLSLSKD GGKKFKYIEN LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR 150
ELNLSYNKIS KIEGIENMCN LQKLNLAGNE IEHIPVWLGK KLKSLRVLNL 200
KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT IFHLRSLESL 250
EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI 300
KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY 350
ELEQELAFYK IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT 400
ESYIIDSAQA VQIKKMEPDE QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ 450
TRLSELHDEI EKAEQQILRA TEEFKQLEEA IQLKKISEAG KDLLYKQLSG 500
RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI DSLDSKDPKH 550
SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT 600
EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL 650
QRLTEVEQER DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD 700
LSAYEAELEA RLNLRDAEAN QLKEELEKVT RLTQLEQSAL QAELEKERQA 750
LKNALGKAQF SEEKEQENSE LHAKLKHLQD DNNLLKQQLK DFQNHLNHVV 800
DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL ADLQKQFSEI 850
LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF 900
DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ 950
LRELEKKKKL EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ 1000
LKSLHGTVMK INQERAEELQ EAERFSRKAA QAARDLTRAE AEIELLQNLL 1050
RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL NETMERQRTE IARLQNVLDL 1100
TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR GYWYFMPPPP 1150
SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW 1200
VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL 1250
PDGSPVPQGM ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PMVYGPPPPN 1300
FSIPFIPMGV LHCNVPEHHN LENEVSRLED IMQHLKSKKR EERWMRASKR 1350
QSEKEMEELH HNIDDLLQEK KSLECEVEEL HRTVQKRQQQ KDFIDGNVES 1400
LMTELEIEKS LKHHEDIVDE IECIEKTLLK RRSELREADR LLAEAESELS 1450
CTKEKTKNAV EKFTDAKRSL LQTESDAEEL ERRAQETAVN LVKADQQLRS 1500
LQADAKDLEQ HKIKQEEILK EINKIVAAKD SDFQCLSKKK EKLTEELQKL 1550
QKDIEMAERN EDHHLQVLKE SEVLLQAKRA ELEKLKSQVT SQQQEMAVLD 1600
RQLGHKKEEL HLLQGSMVQA KADLQEALRL GETEVTEKCN HIREVKSLLE 1650
ELSFQKGELN VQISERKTQL TLIKQEIEKE EENLQVVLRQ MSKHKTELKN 1700
ILDMLQLENH ELQGLKLQHD QRVSELEKTQ VAVLEEKLEL ENLQQISQQQ 1750
KGEIEWQKQL LERDKREIER MTAESRALQS CVECLSKEKE DLQEKCDIWE 1800
KKLAQTKRVL AAAEENSKME QSNLEKLELN VRKLQQELDQ LNRDKLSLHN 1850
DISAMQQQLQ EKREAVNSLQ EELANVQDHL NLAKQDLLHT TKHQDVLLSE 1900
QTRLQKDISE WANRFEDCQK EEETKQQQLQ VLQNEIEENK LKLVQQEMMF 1950
QRLQKERESE ESKLETSKVT LKEQQHQLEK ELTDQKSKLD QVLSKVLAAE 2000
ERVRTLQEEE RWCESLEKTL SQTKRQLSER EQQLVEKSGE LLALQKEADS 2050
MRADFSLLRN QFLTERKKAE KQVASLKEAL KIQRSQLEKN LLEQKQENSC 2100
IQKEMATIEL VAQDNHERAR RLMKELNQMQ YEYTELKKQM ANQKDLERRQ 2150
MEISDAMRTL KSEVKDEIRT SLKNLNQFLP ELPADLEAIL ERNENLEGEL 2200
ESLKENLPFT MNEGPFEEKL NFSQVHIMDE HWRGEALREK LRHREDRLKA 2250
QLRHCMSKQA EVLIKGKRQT EGTLHSLRRQ VDALGELVTS TSADSASSPS 2300
LSQLESSLTE DSQLGQNQEK NASAR 2325
Length:2,325
Mass (Da):268,886
Last modified:March 18, 2008 - v2
Checksum:i93DD4CA08B5BD4AF
GO
Isoform 2 (identifier: Q7Z7A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.

Show »
Length:1,773
Mass (Da):205,172
Checksum:iF430B910E219D5E2
GO
Isoform 3 (identifier: Q7Z7A1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1331: Missing.

Show »
Length:994
Mass (Da):116,799
Checksum:iBFE7F893259BA73D
GO
Isoform 4 (identifier: Q7Z7A1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1818: Missing.
     1962-1986: Missing.

Note: No experimental confirmation available.

Show »
Length:482
Mass (Da):56,587
Checksum:i1B4867D4FEAFE023
GO
Isoform 5 (identifier: Q7Z7A1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1296: Missing.

Note: No experimental confirmation available.

Show »
Length:2,319
Mass (Da):268,241
Checksum:i5C9924F8D58B852A
GO

Sequence cautioni

The sequence AAH02932.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH89415.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH02932.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561V → I.1 Publication
Corresponds to variant rs10818503 [ dbSNP | Ensembl ].
VAR_039559
Natural varianti216 – 2161P → L.
Corresponds to variant rs10818504 [ dbSNP | Ensembl ].
VAR_039560
Natural varianti889 – 8891A → T.
Corresponds to variant rs17292952 [ dbSNP | Ensembl ].
VAR_039561
Natural varianti1146 – 11461M → V.
Corresponds to variant rs35342437 [ dbSNP | Ensembl ].
VAR_061622

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18181818Missing in isoform 4.
VSP_032046Add
BLAST
Alternative sequencei1 – 13311331Missing in isoform 3.
VSP_032047Add
BLAST
Alternative sequencei1 – 552552Missing in isoform 2.
VSP_032048Add
BLAST
Alternative sequencei1291 – 12966Missing in isoform 5.
VSP_032049
Alternative sequencei1962 – 198625Missing in isoform 4.
VSP_032050Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1389 – 13891Q → R in AAC32373. 1 Publication
Sequence conflicti1699 – 16991K → Q in AAC32373. 1 Publication
Sequence conflicti1828 – 18281E → D in AAC32373. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083322 mRNA. Translation: AAC32373.1.
AF513978 mRNA. Translation: AAP43846.1.
BX640927 mRNA. Translation: CAE45965.1.
AL137068 Genomic DNA. Translation: CAI12358.1.
AL137068 Genomic DNA. Translation: CAM13285.1.
BC002932 mRNA. Translation: AAH02932.1. Sequence problems.
BC089415 mRNA. Translation: AAH89415.1. Sequence problems.
BC137286 mRNA. Translation: AAI37287.1.
AY651261 mRNA. Translation: AAX35689.1.
AK074079 mRNA. Translation: BAB84905.1.
CCDSiCCDS35118.1. [Q7Z7A1-1]
RefSeqiNP_008949.4. NM_007018.4. [Q7Z7A1-1]
XP_005251736.1. XM_005251679.2. [Q7Z7A1-1]
UniGeneiHs.653263.

Genome annotation databases

EnsembliENST00000238341; ENSP00000238341; ENSG00000119397. [Q7Z7A1-1]
ENST00000373850; ENSP00000362956; ENSG00000119397. [Q7Z7A1-2]
ENST00000373855; ENSP00000362962; ENSG00000119397. [Q7Z7A1-1]
GeneIDi11064.
KEGGihsa:11064.
UCSCiuc004bkx.1. human. [Q7Z7A1-1]
uc004blb.1. human. [Q7Z7A1-3]
uc010mvp.1. human. [Q7Z7A1-4]

Polymorphism databases

DMDMi172045911.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083322 mRNA. Translation: AAC32373.1 .
AF513978 mRNA. Translation: AAP43846.1 .
BX640927 mRNA. Translation: CAE45965.1 .
AL137068 Genomic DNA. Translation: CAI12358.1 .
AL137068 Genomic DNA. Translation: CAM13285.1 .
BC002932 mRNA. Translation: AAH02932.1 . Sequence problems.
BC089415 mRNA. Translation: AAH89415.1 . Sequence problems.
BC137286 mRNA. Translation: AAI37287.1 .
AY651261 mRNA. Translation: AAX35689.1 .
AK074079 mRNA. Translation: BAB84905.1 .
CCDSi CCDS35118.1. [Q7Z7A1-1 ]
RefSeqi NP_008949.4. NM_007018.4. [Q7Z7A1-1 ]
XP_005251736.1. XM_005251679.2. [Q7Z7A1-1 ]
UniGenei Hs.653263.

3D structure databases

ProteinModelPortali Q7Z7A1.
SMRi Q7Z7A1. Positions 74-279.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116248. 4 interactions.
DIPi DIP-47280N.
IntActi Q7Z7A1. 17 interactions.
MINTi MINT-4988988.

PTM databases

PhosphoSitei Q7Z7A1.

Polymorphism databases

DMDMi 172045911.

Proteomic databases

MaxQBi Q7Z7A1.
PaxDbi Q7Z7A1.
PRIDEi Q7Z7A1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238341 ; ENSP00000238341 ; ENSG00000119397 . [Q7Z7A1-1 ]
ENST00000373850 ; ENSP00000362956 ; ENSG00000119397 . [Q7Z7A1-2 ]
ENST00000373855 ; ENSP00000362962 ; ENSG00000119397 . [Q7Z7A1-1 ]
GeneIDi 11064.
KEGGi hsa:11064.
UCSCi uc004bkx.1. human. [Q7Z7A1-1 ]
uc004blb.1. human. [Q7Z7A1-3 ]
uc010mvp.1. human. [Q7Z7A1-4 ]

Organism-specific databases

CTDi 11064.
GeneCardsi GC09P123839.
H-InvDBi HIX0008344.
HGNCi HGNC:1858. CNTRL.
HPAi HPA020468.
HPA020480.
HPA051583.
MIMi 605496. gene.
neXtProti NX_Q7Z7A1.
PharmGKBi PA26414.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145909.
HOVERGENi HBG101203.
InParanoidi Q7Z7A1.
KOi K16770.
OMAi DESPYIG.
OrthoDBi EOG7NSB1F.
PhylomeDBi Q7Z7A1.
TreeFami TF101135.

Enzyme and pathway databases

Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

ChiTaRSi CNTRL. human.
GeneWikii CNTRL.
GenomeRNAii 11064.
NextBioi 42047.
PROi Q7Z7A1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7Z7A1.
Bgeei Q7Z7A1.
CleanExi HS_CEP110.
Genevestigatori Q7Z7A1.

Family and domain databases

InterProi IPR028640. CEP110.
IPR001611. Leu-rich_rpt.
[Graphical view ]
PANTHERi PTHR18877. PTHR18877. 1 hit.
PROSITEi PS51450. LRR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)."
    Guasch G., Mack G.J., Popovici C., Dastugue N., Birnbaum D., Rattner J.B., Pebusque M.-J.
    Blood 95:1788-1796(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH FGFR1, SUBCELLULAR LOCATION.
  2. "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase."
    Gromley A., Jurczyk A., Sillibourne J., Halilovic E., Mogensen M., Groisman I., Blomberg M., Doxsey S.J.
    J. Cell Biol. 161:535-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-56, SUBCELLULAR LOCATION, FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Liver.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1513 (ISOFORM 2).
    Tissue: Lymph and Placenta.
  6. "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
    Guinn B.-A., Bland E.A., Lodi U., Liggins A.P., Tobal K., Petters S., Wells J.W., Banham A.H., Mufti G.J.
    Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-1677 (ISOFORM 1).
  7. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 527-2325 (ISOFORM 5).
    Tissue: Spleen.
  8. "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation."
    Ou Y.Y., Mack G.J., Zhang M., Rattner J.B.
    J. Cell Sci. 115:1825-1835(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission."
    Gromley A., Yeaman C., Rosa J., Redick S., Chen C.-T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J.
    Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EXOC6 AND SNAPIN.
  10. "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function."
    Szebenyi G., Hall B., Yu R., Hashim A.I., Kraemer H.
    Traffic 8:32-46(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOOK2.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCNTRL_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7A1
Secondary accession number(s): A2A2Y1
, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q8TEP3, Q9Y489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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