Q7Z7A1 (CNTRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Centriolin

Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name=Cep110

Gene names

Name:	CNTRL
Synonyms:	CEP1, CEP110

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2325 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. Ref.2 Ref.9
Subunit structure	Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex. Ref.9 Ref.10
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Note: During cytokinesis, localizes to a ring-like structure at the central midbody. Ref.1 Ref.2 Ref.8
Tissue specificity	Highly expressed in testis and trachea. Ref.1
Involvement in disease	A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
Sequence similarities	Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.
Sequence caution	The sequence AAH02932.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH02932.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH89415.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Coiled coil Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G2/M transition of mitotic cell cycle Traceable author statement. Source: Reactome cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB cytosol Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z7A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z7A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.

Isoform 3 (identifier: Q7Z7A1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1331: Missing.

Isoform 4 (identifier: Q7Z7A1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1818: Missing.
     1962-1986: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q7Z7A1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1296: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2325	2325	Centriolin		PRO_0000323675
Regions
	Repeat	126 – 147	22	LRR 1
	Repeat	148 – 169	22	LRR 2
	Repeat	170 – 191	22	LRR 3
	Repeat	194 – 215	22	LRR 4
	Domain	228 – 266	39	LRRCT
	Region	1948 – 2118	171	Required for centrosome localization
	Region	1985 – 2325	341	Sufficient for interaction with HOOK2
	Coiled coil	267 – 343	77	Potential
	Coiled coil	435 – 799	365	Potential
	Coiled coil	851 – 1101	251	Potential
	Coiled coil	1317 – 2255	939	Potential
	Compositional bias	956 – 959	4	Poly-Lys
	Compositional bias	1147 – 1150	4	Poly-Pro
	Compositional bias	1236 – 1307	72	Pro-rich
Sites
	Site	2139 – 2140	2	Breakpoint for translocation to form CEP110-FGFR1
Natural variations
	Alternative sequence	1 – 1818	1818	Missing in isoform 4.		VSP_032046
	Alternative sequence	1 – 1331	1331	Missing in isoform 3.		VSP_032047
	Alternative sequence	1 – 552	552	Missing in isoform 2.		VSP_032048
	Alternative sequence	1291 – 1296	6	Missing in isoform 5.		VSP_032049
	Alternative sequence	1962 – 1986	25	Missing in isoform 4.		VSP_032050
	Natural variant	56	1	V → I. Ref.2 Corresponds to variant rs10818503 [ dbSNP | Ensembl ].		VAR_039559
	Natural variant	216	1	P → L. Corresponds to variant rs10818504 [ dbSNP | Ensembl ].		VAR_039560
	Natural variant	889	1	A → T. Corresponds to variant rs17292952 [ dbSNP | Ensembl ].		VAR_039561
	Natural variant	1146	1	M → V. Corresponds to variant rs35342437 [ dbSNP | Ensembl ].		VAR_061622
Experimental info
	Sequence conflict	1389	1	Q → R in AAC32373. Ref.1
	Sequence conflict	1699	1	K → Q in AAC32373. Ref.1
	Sequence conflict	1828	1	E → D in AAC32373. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 93DD4CA08B5BD4AF	FASTA	2,325	268,886
	10 20 30 40 50 60 MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG QWCEQVEIAD 70 80 90 100 110 120 ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI KSLNLSLSKD GGKKFKYIEN 130 140 150 160 170 180 LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR ELNLSYNKIS KIEGIENMCN LQKLNLAGNE 190 200 210 220 230 240 IEHIPVWLGK KLKSLRVLNL KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT 250 260 270 280 290 300 IFHLRSLESL EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI 310 320 330 340 350 360 KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY ELEQELAFYK 370 380 390 400 410 420 IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT ESYIIDSAQA VQIKKMEPDE 430 440 450 460 470 480 QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ TRLSELHDEI EKAEQQILRA TEEFKQLEEA 490 500 510 520 530 540 IQLKKISEAG KDLLYKQLSG RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI 550 560 570 580 590 600 DSLDSKDPKH SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT 610 620 630 640 650 660 EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL QRLTEVEQER 670 680 690 700 710 720 DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD LSAYEAELEA RLNLRDAEAN 730 740 750 760 770 780 QLKEELEKVT RLTQLEQSAL QAELEKERQA LKNALGKAQF SEEKEQENSE LHAKLKHLQD 790 800 810 820 830 840 DNNLLKQQLK DFQNHLNHVV DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL 850 860 870 880 890 900 ADLQKQFSEI LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF 910 920 930 940 950 960 DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ LRELEKKKKL 970 980 990 1000 1010 1020 EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ LKSLHGTVMK INQERAEELQ 1030 1040 1050 1060 1070 1080 EAERFSRKAA QAARDLTRAE AEIELLQNLL RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL 1090 1100 1110 1120 1130 1140 NETMERQRTE IARLQNVLDL TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR 1150 1160 1170 1180 1190 1200 GYWYFMPPPP SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW 1210 1220 1230 1240 1250 1260 VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL PDGSPVPQGM 1270 1280 1290 1300 1310 1320 ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PMVYGPPPPN FSIPFIPMGV LHCNVPEHHN 1330 1340 1350 1360 1370 1380 LENEVSRLED IMQHLKSKKR EERWMRASKR QSEKEMEELH HNIDDLLQEK KSLECEVEEL 1390 1400 1410 1420 1430 1440 HRTVQKRQQQ KDFIDGNVES LMTELEIEKS LKHHEDIVDE IECIEKTLLK RRSELREADR 1450 1460 1470 1480 1490 1500 LLAEAESELS CTKEKTKNAV EKFTDAKRSL LQTESDAEEL ERRAQETAVN LVKADQQLRS 1510 1520 1530 1540 1550 1560 LQADAKDLEQ HKIKQEEILK EINKIVAAKD SDFQCLSKKK EKLTEELQKL QKDIEMAERN 1570 1580 1590 1600 1610 1620 EDHHLQVLKE SEVLLQAKRA ELEKLKSQVT SQQQEMAVLD RQLGHKKEEL HLLQGSMVQA 1630 1640 1650 1660 1670 1680 KADLQEALRL GETEVTEKCN HIREVKSLLE ELSFQKGELN VQISERKTQL TLIKQEIEKE 1690 1700 1710 1720 1730 1740 EENLQVVLRQ MSKHKTELKN ILDMLQLENH ELQGLKLQHD QRVSELEKTQ VAVLEEKLEL 1750 1760 1770 1780 1790 1800 ENLQQISQQQ KGEIEWQKQL LERDKREIER MTAESRALQS CVECLSKEKE DLQEKCDIWE 1810 1820 1830 1840 1850 1860 KKLAQTKRVL AAAEENSKME QSNLEKLELN VRKLQQELDQ LNRDKLSLHN DISAMQQQLQ 1870 1880 1890 1900 1910 1920 EKREAVNSLQ EELANVQDHL NLAKQDLLHT TKHQDVLLSE QTRLQKDISE WANRFEDCQK 1930 1940 1950 1960 1970 1980 EEETKQQQLQ VLQNEIEENK LKLVQQEMMF QRLQKERESE ESKLETSKVT LKEQQHQLEK 1990 2000 2010 2020 2030 2040 ELTDQKSKLD QVLSKVLAAE ERVRTLQEEE RWCESLEKTL SQTKRQLSER EQQLVEKSGE 2050 2060 2070 2080 2090 2100 LLALQKEADS MRADFSLLRN QFLTERKKAE KQVASLKEAL KIQRSQLEKN LLEQKQENSC 2110 2120 2130 2140 2150 2160 IQKEMATIEL VAQDNHERAR RLMKELNQMQ YEYTELKKQM ANQKDLERRQ MEISDAMRTL 2170 2180 2190 2200 2210 2220 KSEVKDEIRT SLKNLNQFLP ELPADLEAIL ERNENLEGEL ESLKENLPFT MNEGPFEEKL 2230 2240 2250 2260 2270 2280 NFSQVHIMDE HWRGEALREK LRHREDRLKA QLRHCMSKQA EVLIKGKRQT EGTLHSLRRQ 2290 2300 2310 2320 VDALGELVTS TSADSASSPS LSQLESSLTE DSQLGQNQEK NASAR
	Isoform 2 [UniParc]. Checksum: F430B910E219D5E2	FASTA	1,773	205,172
	10 20 30 40 50 60 MKAQKSGKEQ QLDIMNKQYQ QLESRLDEIL SRIAKETEEI KDLEEQLTEG QIAANEALKK 70 80 90 100 110 120 DLEGVISGLQ EYLGTIKGQA TQAQNECRKL RDEKETLLQR LTEVEQERDQ LEIVAMDAEN 130 140 150 160 170 180 MRKELAELES ALQEQHEVNA SLQQTQGDLS AYEAELEARL NLRDAEANQL KEELEKVTRL 190 200 210 220 230 240 TQLEQSALQA ELEKERQALK NALGKAQFSE EKEQENSELH AKLKHLQDDN NLLKQQLKDF 250 260 270 280 290 300 QNHLNHVVDG LVRPEEVAAR VDELRRKLKL GTGEMNIHSP SDVLGKSLAD LQKQFSEILA 310 320 330 340 350 360 RSKWERDEAQ VRERKLQEEM ALQQEKLATG QEEFRQACER ALEARMNFDK RQHEARIQQM 370 380 390 400 410 420 ENEIHYLQEN LKSMEEIQGL TDLQLQEADE EKERILAQLR ELEKKKKLED AKSQEQVFGL 430 440 450 460 470 480 DKELKKLKKA VATSDKLATA ELTIAKDQLK SLHGTVMKIN QERAEELQEA ERFSRKAAQA 490 500 510 520 530 540 ARDLTRAEAE IELLQNLLRQ KGEQFRLEME KTGVGTGANS QVLEIEKLNE TMERQRTEIA 550 560 570 580 590 600 RLQNVLDLTG SDNKGGFENV LEEIAELRRE VSYQNDYISS MADPFKRRGY WYFMPPPPSS 610 620 630 640 650 660 KVSSHSSQAT KDSGVGLKYS ASTPVRKPRP GQQDGKEGSQ PPPASGYWVY SPIRSGLHKL 670 680 690 700 710 720 FPSRDADSGG DSQEESELDD QEEPPFVPPP GYMMYTVLPD GSPVPQGMAL YAPPPPLPNN 730 740 750 760 770 780 SRPLTPGTVV YGPPPAGAPM VYGPPPPNFS IPFIPMGVLH CNVPEHHNLE NEVSRLEDIM 790 800 810 820 830 840 QHLKSKKREE RWMRASKRQS EKEMEELHHN IDDLLQEKKS LECEVEELHR TVQKRQQQKD 850 860 870 880 890 900 FIDGNVESLM TELEIEKSLK HHEDIVDEIE CIEKTLLKRR SELREADRLL AEAESELSCT 910 920 930 940 950 960 KEKTKNAVEK FTDAKRSLLQ TESDAEELER RAQETAVNLV KADQQLRSLQ ADAKDLEQHK 970 980 990 1000 1010 1020 IKQEEILKEI NKIVAAKDSD FQCLSKKKEK LTEELQKLQK DIEMAERNED HHLQVLKESE 1030 1040 1050 1060 1070 1080 VLLQAKRAEL EKLKSQVTSQ QQEMAVLDRQ LGHKKEELHL LQGSMVQAKA DLQEALRLGE 1090 1100 1110 1120 1130 1140 TEVTEKCNHI REVKSLLEEL SFQKGELNVQ ISERKTQLTL IKQEIEKEEE NLQVVLRQMS 1150 1160 1170 1180 1190 1200 KHKTELKNIL DMLQLENHEL QGLKLQHDQR VSELEKTQVA VLEEKLELEN LQQISQQQKG 1210 1220 1230 1240 1250 1260 EIEWQKQLLE RDKREIERMT AESRALQSCV ECLSKEKEDL QEKCDIWEKK LAQTKRVLAA 1270 1280 1290 1300 1310 1320 AEENSKMEQS NLEKLELNVR KLQQELDQLN RDKLSLHNDI SAMQQQLQEK REAVNSLQEE 1330 1340 1350 1360 1370 1380 LANVQDHLNL AKQDLLHTTK HQDVLLSEQT RLQKDISEWA NRFEDCQKEE ETKQQQLQVL 1390 1400 1410 1420 1430 1440 QNEIEENKLK LVQQEMMFQR LQKERESEES KLETSKVTLK EQQHQLEKEL TDQKSKLDQV 1450 1460 1470 1480 1490 1500 LSKVLAAEER VRTLQEEERW CESLEKTLSQ TKRQLSEREQ QLVEKSGELL ALQKEADSMR 1510 1520 1530 1540 1550 1560 ADFSLLRNQF LTERKKAEKQ VASLKEALKI QRSQLEKNLL EQKQENSCIQ KEMATIELVA 1570 1580 1590 1600 1610 1620 QDNHERARRL MKELNQMQYE YTELKKQMAN QKDLERRQME ISDAMRTLKS EVKDEIRTSL 1630 1640 1650 1660 1670 1680 KNLNQFLPEL PADLEAILER NENLEGELES LKENLPFTMN EGPFEEKLNF SQVHIMDEHW 1690 1700 1710 1720 1730 1740 RGEALREKLR HREDRLKAQL RHCMSKQAEV LIKGKRQTEG TLHSLRRQVD ALGELVTSTS 1750 1760 1770 ADSASSPSLS QLESSLTEDS QLGQNQEKNA SAR
	Isoform 3 [UniParc]. Checksum: BFE7F893259BA73D	FASTA	994	116,799
	10 20 30 40 50 60 MQHLKSKKRE ERWMRASKRQ SEKEMEELHH NIDDLLQEKK SLECEVEELH RTVQKRQQQK 70 80 90 100 110 120 DFIDGNVESL MTELEIEKSL KHHEDIVDEI ECIEKTLLKR RSELREADRL LAEAESELSC 130 140 150 160 170 180 TKEKTKNAVE KFTDAKRSLL QTESDAEELE RRAQETAVNL VKADQQLRSL QADAKDLEQH 190 200 210 220 230 240 KIKQEEILKE INKIVAAKDS DFQCLSKKKE KLTEELQKLQ KDIEMAERNE DHHLQVLKES 250 260 270 280 290 300 EVLLQAKRAE LEKLKSQVTS QQQEMAVLDR QLGHKKEELH LLQGSMVQAK ADLQEALRLG 310 320 330 340 350 360 ETEVTEKCNH IREVKSLLEE LSFQKGELNV QISERKTQLT LIKQEIEKEE ENLQVVLRQM 370 380 390 400 410 420 SKHKTELKNI LDMLQLENHE LQGLKLQHDQ RVSELEKTQV AVLEEKLELE NLQQISQQQK 430 440 450 460 470 480 GEIEWQKQLL ERDKREIERM TAESRALQSC VECLSKEKED LQEKCDIWEK KLAQTKRVLA 490 500 510 520 530 540 AAEENSKMEQ SNLEKLELNV RKLQQELDQL NRDKLSLHND ISAMQQQLQE KREAVNSLQE 550 560 570 580 590 600 ELANVQDHLN LAKQDLLHTT KHQDVLLSEQ TRLQKDISEW ANRFEDCQKE EETKQQQLQV 610 620 630 640 650 660 LQNEIEENKL KLVQQEMMFQ RLQKERESEE SKLETSKVTL KEQQHQLEKE LTDQKSKLDQ 670 680 690 700 710 720 VLSKVLAAEE RVRTLQEEER WCESLEKTLS QTKRQLSERE QQLVEKSGEL LALQKEADSM 730 740 750 760 770 780 RADFSLLRNQ FLTERKKAEK QVASLKEALK IQRSQLEKNL LEQKQENSCI QKEMATIELV 790 800 810 820 830 840 AQDNHERARR LMKELNQMQY EYTELKKQMA NQKDLERRQM EISDAMRTLK SEVKDEIRTS 850 860 870 880 890 900 LKNLNQFLPE LPADLEAILE RNENLEGELE SLKENLPFTM NEGPFEEKLN FSQVHIMDEH 910 920 930 940 950 960 WRGEALREKL RHREDRLKAQ LRHCMSKQAE VLIKGKRQTE GTLHSLRRQV DALGELVTST 970 980 990 SADSASSPSL SQLESSLTED SQLGQNQEKN ASAR
	Isoform 4 [UniParc]. Checksum: 1B4867D4FEAFE023	FASTA	482	56,587
	10 20 30 40 50 60 MEQSNLEKLE LNVRKLQQEL DQLNRDKLSL HNDISAMQQQ LQEKREAVNS LQEELANVQD 70 80 90 100 110 120 HLNLAKQDLL HTTKHQDVLL SEQTRLQKDI SEWANRFEDC QKEEETKQQQ LQVLQNEIEE 130 140 150 160 170 180 NKLKLVQQEM MFQRLQKERE SEESKLDQVL SKVLAAEERV RTLQEEERWC ESLEKTLSQT 190 200 210 220 230 240 KRQLSEREQQ LVEKSGELLA LQKEADSMRA DFSLLRNQFL TERKKAEKQV ASLKEALKIQ 250 260 270 280 290 300 RSQLEKNLLE QKQENSCIQK EMATIELVAQ DNHERARRLM KELNQMQYEY TELKKQMANQ 310 320 330 340 350 360 KDLERRQMEI SDAMRTLKSE VKDEIRTSLK NLNQFLPELP ADLEAILERN ENLEGELESL 370 380 390 400 410 420 KENLPFTMNE GPFEEKLNFS QVHIMDEHWR GEALREKLRH REDRLKAQLR HCMSKQAEVL 430 440 450 460 470 480 IKGKRQTEGT LHSLRRQVDA LGELVTSTSA DSASSPSLSQ LESSLTEDSQ LGQNQEKNAS AR
	Isoform 5 [UniParc]. Checksum: 5C9924F8D58B852A	FASTA	2,319	268,241
	10 20 30 40 50 60 MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG QWCEQVEIAD 70 80 90 100 110 120 ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI KSLNLSLSKD GGKKFKYIEN 130 140 150 160 170 180 LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR ELNLSYNKIS KIEGIENMCN LQKLNLAGNE 190 200 210 220 230 240 IEHIPVWLGK KLKSLRVLNL KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT 250 260 270 280 290 300 IFHLRSLESL EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI 310 320 330 340 350 360 KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY ELEQELAFYK 370 380 390 400 410 420 IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT ESYIIDSAQA VQIKKMEPDE 430 440 450 460 470 480 QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ TRLSELHDEI EKAEQQILRA TEEFKQLEEA 490 500 510 520 530 540 IQLKKISEAG KDLLYKQLSG RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI 550 560 570 580 590 600 DSLDSKDPKH SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT 610 620 630 640 650 660 EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL QRLTEVEQER 670 680 690 700 710 720 DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD LSAYEAELEA RLNLRDAEAN 730 740 750 760 770 780 QLKEELEKVT RLTQLEQSAL QAELEKERQA LKNALGKAQF SEEKEQENSE LHAKLKHLQD 790 800 810 820 830 840 DNNLLKQQLK DFQNHLNHVV DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL 850 860 870 880 890 900 ADLQKQFSEI LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF 910 920 930 940 950 960 DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ LRELEKKKKL 970 980 990 1000 1010 1020 EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ LKSLHGTVMK INQERAEELQ 1030 1040 1050 1060 1070 1080 EAERFSRKAA QAARDLTRAE AEIELLQNLL RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL 1090 1100 1110 1120 1130 1140 NETMERQRTE IARLQNVLDL TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR 1150 1160 1170 1180 1190 1200 GYWYFMPPPP SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW 1210 1220 1230 1240 1250 1260 VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL PDGSPVPQGM 1270 1280 1290 1300 1310 1320 ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PPPNFSIPFI PMGVLHCNVP EHHNLENEVS 1330 1340 1350 1360 1370 1380 RLEDIMQHLK SKKREERWMR ASKRQSEKEM EELHHNIDDL LQEKKSLECE VEELHRTVQK 1390 1400 1410 1420 1430 1440 RQQQKDFIDG NVESLMTELE IEKSLKHHED IVDEIECIEK TLLKRRSELR EADRLLAEAE 1450 1460 1470 1480 1490 1500 SELSCTKEKT KNAVEKFTDA KRSLLQTESD AEELERRAQE TAVNLVKADQ QLRSLQADAK 1510 1520 1530 1540 1550 1560 DLEQHKIKQE EILKEINKIV AAKDSDFQCL SKKKEKLTEE LQKLQKDIEM AERNEDHHLQ 1570 1580 1590 1600 1610 1620 VLKESEVLLQ AKRAELEKLK SQVTSQQQEM AVLDRQLGHK KEELHLLQGS MVQAKADLQE 1630 1640 1650 1660 1670 1680 ALRLGETEVT EKCNHIREVK SLLEELSFQK GELNVQISER KTQLTLIKQE IEKEEENLQV 1690 1700 1710 1720 1730 1740 VLRQMSKHKT ELKNILDMLQ LENHELQGLK LQHDQRVSEL EKTQVAVLEE KLELENLQQI 1750 1760 1770 1780 1790 1800 SQQQKGEIEW QKQLLERDKR EIERMTAESR ALQSCVECLS KEKEDLQEKC DIWEKKLAQT 1810 1820 1830 1840 1850 1860 KRVLAAAEEN SKMEQSNLEK LELNVRKLQQ ELDQLNRDKL SLHNDISAMQ QQLQEKREAV 1870 1880 1890 1900 1910 1920 NSLQEELANV QDHLNLAKQD LLHTTKHQDV LLSEQTRLQK DISEWANRFE DCQKEEETKQ 1930 1940 1950 1960 1970 1980 QQLQVLQNEI EENKLKLVQQ EMMFQRLQKE RESEESKLET SKVTLKEQQH QLEKELTDQK 1990 2000 2010 2020 2030 2040 SKLDQVLSKV LAAEERVRTL QEEERWCESL EKTLSQTKRQ LSEREQQLVE KSGELLALQK 2050 2060 2070 2080 2090 2100 EADSMRADFS LLRNQFLTER KKAEKQVASL KEALKIQRSQ LEKNLLEQKQ ENSCIQKEMA 2110 2120 2130 2140 2150 2160 TIELVAQDNH ERARRLMKEL NQMQYEYTEL KKQMANQKDL ERRQMEISDA MRTLKSEVKD 2170 2180 2190 2200 2210 2220 EIRTSLKNLN QFLPELPADL EAILERNENL EGELESLKEN LPFTMNEGPF EEKLNFSQVH 2230 2240 2250 2260 2270 2280 IMDEHWRGEA LREKLRHRED RLKAQLRHCM SKQAEVLIKG KRQTEGTLHS LRRQVDALGE 2290 2300 2310 LVTSTSADSA SSPSLSQLES SLTEDSQLGQ NQEKNASAR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)." Guasch G., Mack G.J., Popovici C., Dastugue N., Birnbaum D., Rattner J.B., Pebusque M.-J. Blood 95:1788-1796(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH FGFR1, SUBCELLULAR LOCATION.
[2]	"A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase." Gromley A., Jurczyk A., Sillibourne J., Halilovic E., Mogensen M., Groisman I., Blomberg M., Doxsey S.J. J. Cell Biol. 161:535-545(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-56, SUBCELLULAR LOCATION, FUNCTION.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Liver.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1513 (ISOFORM 2). Tissue: Lymph and Placenta.
[6]	"Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia." Guinn B.-A., Bland E.A., Lodi U., Liggins A.P., Tobal K., Petters S., Wells J.W., Banham A.H., Mufti G.J. Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-1677 (ISOFORM 1).
[7]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 527-2325 (ISOFORM 5). Tissue: Spleen.
[8]	"CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation." Ou Y.Y., Mack G.J., Zhang M., Rattner J.B. J. Cell Sci. 115:1825-1835(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission." Gromley A., Yeaman C., Rosa J., Redick S., Chen C.-T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J. Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH EXOC6 AND SNAPIN.
[10]	"Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function." Szebenyi G., Hall B., Yu R., Hashim A.I., Kraemer H. Traffic 8:32-46(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HOOK2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF083322 mRNA. Translation: AAC32373.1. AF513978 mRNA. Translation: AAP43846.1. BX640927 mRNA. Translation: CAE45965.1. AL137068 Genomic DNA. Translation: CAI12358.1. AL137068 Genomic DNA. Translation: CAM13285.1. BC002932 mRNA. Translation: AAH02932.1. Sequence problems. BC089415 mRNA. Translation: AAH89415.1. Sequence problems. BC137286 mRNA. Translation: AAI37287.1. AY651261 mRNA. Translation: AAX35689.1. AK074079 mRNA. Translation: BAB84905.1.
IPI	IPI00376383. IPI00643703. IPI00657962. IPI00887632. IPI00888387.
RefSeq	NP_008949.4. NM_007018.4.
UniGene	Hs.653263.
3D structure databases
HSSP	HSSP built from PDB template 1FOS based on UniProtKB P01100.
ProteinModelPortal	Q7Z7A1.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47280N.
IntAct	Q7Z7A1. 17 interactions.
PTM databases
PhosphoSite	Q7Z7A1.
Polymorphism databases
DMDM	172045911.
Proteomic databases
PaxDb	Q7Z7A1.
PRIDE	Q7Z7A1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000238341; ENSP00000238341; ENSG00000119397. ENST00000373850; ENSP00000362956; ENSG00000119397. ENST00000373855; ENSP00000362962; ENSG00000119397.
GeneID	11064.
KEGG	hsa:11064.
UCSC	uc004bkx.1. human. uc004blb.1. human.
Organism-specific databases
CTD	11064.
GeneCards	GC09P123839.
H-InvDB	HIX0008344.
HGNC	HGNC:1858. CNTRL.
HPA	HPA020468. HPA020480. HPA051583.
MIM	605496. gene.
neXtProt	NX_Q7Z7A1.
PharmGKB	PA26414.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145909.
HOVERGEN	HBG101203.
InParanoid	Q7Z7A1.
KO	K16770.
OMA	DESPYIG.
OrthoDB	EOG48WC13.
PhylomeDB	Q7Z7A1.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle. REACT_116125. Disease.
Gene expression databases
ArrayExpress	Q7Z7A1.
Bgee	Q7Z7A1.
CleanEx	HS_CEP110.
Genevestigator	Q7Z7A1.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. [Graphical view]
PROSITE	PS51450. LRR. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CNTRL. human.
GenomeRNAi	11064.
NextBio	42047.
SOURCE	Search...

Entry information

Entry name

CNTRL_HUMAN

Accession

Primary (citable) accession number: Q7Z7A1
Secondary accession number(s): A2A2Y1 , B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q8TEP3, Q9Y489

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.