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Q7Z7A1

- CNTRL_HUMAN

UniProt

Q7Z7A1 - CNTRL_HUMAN

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Protein

Centriolin

Gene

CNTRL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2139 – 21402Breakpoint for translocation to form CEP110-FGFR1

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: Reactome
  3. mitotic cell cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centriolin
Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name:
Cep110
Gene namesi
Name:CNTRL
Synonyms:CEP1, CEP110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1858. CNTRL.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 3 Publications
Note: During cytokinesis, localizes to a ring-like structure at the central midbody.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
  4. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

Organism-specific databases

PharmGKBiPA26414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23252325CentriolinPRO_0000323675Add
BLAST

Proteomic databases

MaxQBiQ7Z7A1.
PaxDbiQ7Z7A1.
PRIDEiQ7Z7A1.

PTM databases

PhosphoSiteiQ7Z7A1.

Expressioni

Tissue specificityi

Highly expressed in testis and trachea.1 Publication

Gene expression databases

BgeeiQ7Z7A1.
CleanExiHS_CEP110.
ExpressionAtlasiQ7Z7A1. baseline and differential.
GenevestigatoriQ7Z7A1.

Organism-specific databases

HPAiHPA020468.
HPA020480.
HPA051583.

Interactioni

Subunit structurei

Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex.2 Publications

Protein-protein interaction databases

BioGridi116248. 4 interactions.
DIPiDIP-47280N.
IntActiQ7Z7A1. 18 interactions.
MINTiMINT-4988988.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7A1.
SMRiQ7Z7A1. Positions 90-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 14722LRR 1Add
BLAST
Repeati148 – 16922LRR 2Add
BLAST
Repeati170 – 19122LRR 3Add
BLAST
Repeati194 – 21522LRR 4Add
BLAST
Domaini228 – 26639LRRCTAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1948 – 2118171Required for centrosome localizationAdd
BLAST
Regioni1985 – 2325341Sufficient for interaction with HOOK2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili267 – 34377Sequence AnalysisAdd
BLAST
Coiled coili435 – 799365Sequence AnalysisAdd
BLAST
Coiled coili851 – 1101251Sequence AnalysisAdd
BLAST
Coiled coili1317 – 2255939Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi956 – 9594Poly-Lys
Compositional biasi1147 – 11504Poly-Pro
Compositional biasi1236 – 130772Pro-richAdd
BLAST

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG145909.
GeneTreeiENSGT00730000110223.
HOVERGENiHBG101203.
InParanoidiQ7Z7A1.
KOiK16770.
OMAiDESPYIG.
OrthoDBiEOG7NSB1F.
PhylomeDBiQ7Z7A1.
TreeFamiTF101135.

Family and domain databases

InterProiIPR028640. CEP110.
IPR001611. Leu-rich_rpt.
[Graphical view]
PANTHERiPTHR18877. PTHR18877. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z7A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG
60 70 80 90 100
QWCEQVEIAD ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI
110 120 130 140 150
KSLNLSLSKD GGKKFKYIEN LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR
160 170 180 190 200
ELNLSYNKIS KIEGIENMCN LQKLNLAGNE IEHIPVWLGK KLKSLRVLNL
210 220 230 240 250
KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT IFHLRSLESL
260 270 280 290 300
EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI
310 320 330 340 350
KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY
360 370 380 390 400
ELEQELAFYK IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT
410 420 430 440 450
ESYIIDSAQA VQIKKMEPDE QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ
460 470 480 490 500
TRLSELHDEI EKAEQQILRA TEEFKQLEEA IQLKKISEAG KDLLYKQLSG
510 520 530 540 550
RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI DSLDSKDPKH
560 570 580 590 600
SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT
610 620 630 640 650
EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL
660 670 680 690 700
QRLTEVEQER DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD
710 720 730 740 750
LSAYEAELEA RLNLRDAEAN QLKEELEKVT RLTQLEQSAL QAELEKERQA
760 770 780 790 800
LKNALGKAQF SEEKEQENSE LHAKLKHLQD DNNLLKQQLK DFQNHLNHVV
810 820 830 840 850
DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL ADLQKQFSEI
860 870 880 890 900
LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF
910 920 930 940 950
DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ
960 970 980 990 1000
LRELEKKKKL EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ
1010 1020 1030 1040 1050
LKSLHGTVMK INQERAEELQ EAERFSRKAA QAARDLTRAE AEIELLQNLL
1060 1070 1080 1090 1100
RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL NETMERQRTE IARLQNVLDL
1110 1120 1130 1140 1150
TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR GYWYFMPPPP
1160 1170 1180 1190 1200
SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW
1210 1220 1230 1240 1250
VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL
1260 1270 1280 1290 1300
PDGSPVPQGM ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PMVYGPPPPN
1310 1320 1330 1340 1350
FSIPFIPMGV LHCNVPEHHN LENEVSRLED IMQHLKSKKR EERWMRASKR
1360 1370 1380 1390 1400
QSEKEMEELH HNIDDLLQEK KSLECEVEEL HRTVQKRQQQ KDFIDGNVES
1410 1420 1430 1440 1450
LMTELEIEKS LKHHEDIVDE IECIEKTLLK RRSELREADR LLAEAESELS
1460 1470 1480 1490 1500
CTKEKTKNAV EKFTDAKRSL LQTESDAEEL ERRAQETAVN LVKADQQLRS
1510 1520 1530 1540 1550
LQADAKDLEQ HKIKQEEILK EINKIVAAKD SDFQCLSKKK EKLTEELQKL
1560 1570 1580 1590 1600
QKDIEMAERN EDHHLQVLKE SEVLLQAKRA ELEKLKSQVT SQQQEMAVLD
1610 1620 1630 1640 1650
RQLGHKKEEL HLLQGSMVQA KADLQEALRL GETEVTEKCN HIREVKSLLE
1660 1670 1680 1690 1700
ELSFQKGELN VQISERKTQL TLIKQEIEKE EENLQVVLRQ MSKHKTELKN
1710 1720 1730 1740 1750
ILDMLQLENH ELQGLKLQHD QRVSELEKTQ VAVLEEKLEL ENLQQISQQQ
1760 1770 1780 1790 1800
KGEIEWQKQL LERDKREIER MTAESRALQS CVECLSKEKE DLQEKCDIWE
1810 1820 1830 1840 1850
KKLAQTKRVL AAAEENSKME QSNLEKLELN VRKLQQELDQ LNRDKLSLHN
1860 1870 1880 1890 1900
DISAMQQQLQ EKREAVNSLQ EELANVQDHL NLAKQDLLHT TKHQDVLLSE
1910 1920 1930 1940 1950
QTRLQKDISE WANRFEDCQK EEETKQQQLQ VLQNEIEENK LKLVQQEMMF
1960 1970 1980 1990 2000
QRLQKERESE ESKLETSKVT LKEQQHQLEK ELTDQKSKLD QVLSKVLAAE
2010 2020 2030 2040 2050
ERVRTLQEEE RWCESLEKTL SQTKRQLSER EQQLVEKSGE LLALQKEADS
2060 2070 2080 2090 2100
MRADFSLLRN QFLTERKKAE KQVASLKEAL KIQRSQLEKN LLEQKQENSC
2110 2120 2130 2140 2150
IQKEMATIEL VAQDNHERAR RLMKELNQMQ YEYTELKKQM ANQKDLERRQ
2160 2170 2180 2190 2200
MEISDAMRTL KSEVKDEIRT SLKNLNQFLP ELPADLEAIL ERNENLEGEL
2210 2220 2230 2240 2250
ESLKENLPFT MNEGPFEEKL NFSQVHIMDE HWRGEALREK LRHREDRLKA
2260 2270 2280 2290 2300
QLRHCMSKQA EVLIKGKRQT EGTLHSLRRQ VDALGELVTS TSADSASSPS
2310 2320
LSQLESSLTE DSQLGQNQEK NASAR
Length:2,325
Mass (Da):268,886
Last modified:March 18, 2008 - v2
Checksum:i93DD4CA08B5BD4AF
GO
Isoform 2 (identifier: Q7Z7A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.

Show »
Length:1,773
Mass (Da):205,172
Checksum:iF430B910E219D5E2
GO
Isoform 3 (identifier: Q7Z7A1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1331: Missing.

Show »
Length:994
Mass (Da):116,799
Checksum:iBFE7F893259BA73D
GO
Isoform 4 (identifier: Q7Z7A1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1818: Missing.
     1962-1986: Missing.

Note: No experimental confirmation available.

Show »
Length:482
Mass (Da):56,587
Checksum:i1B4867D4FEAFE023
GO
Isoform 5 (identifier: Q7Z7A1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1296: Missing.

Note: No experimental confirmation available.

Show »
Length:2,319
Mass (Da):268,241
Checksum:i5C9924F8D58B852A
GO

Sequence cautioni

The sequence AAH02932.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH02932.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH89415.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1389 – 13891Q → R in AAC32373. (PubMed:10688839)Curated
Sequence conflicti1699 – 16991K → Q in AAC32373. (PubMed:10688839)Curated
Sequence conflicti1828 – 18281E → D in AAC32373. (PubMed:10688839)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561V → I.1 Publication
Corresponds to variant rs10818503 [ dbSNP | Ensembl ].
VAR_039559
Natural varianti216 – 2161P → L.
Corresponds to variant rs10818504 [ dbSNP | Ensembl ].
VAR_039560
Natural varianti889 – 8891A → T.
Corresponds to variant rs17292952 [ dbSNP | Ensembl ].
VAR_039561
Natural varianti1146 – 11461M → V.
Corresponds to variant rs35342437 [ dbSNP | Ensembl ].
VAR_061622

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18181818Missing in isoform 4. 1 PublicationVSP_032046Add
BLAST
Alternative sequencei1 – 13311331Missing in isoform 3. 1 PublicationVSP_032047Add
BLAST
Alternative sequencei1 – 552552Missing in isoform 2. 1 PublicationVSP_032048Add
BLAST
Alternative sequencei1291 – 12966Missing in isoform 5. 1 PublicationVSP_032049
Alternative sequencei1962 – 198625Missing in isoform 4. 1 PublicationVSP_032050Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083322 mRNA. Translation: AAC32373.1.
AF513978 mRNA. Translation: AAP43846.1.
BX640927 mRNA. Translation: CAE45965.1.
AL137068 Genomic DNA. Translation: CAI12358.1.
AL137068 Genomic DNA. Translation: CAM13285.1.
BC002932 mRNA. Translation: AAH02932.1. Sequence problems.
BC089415 mRNA. Translation: AAH89415.1. Sequence problems.
BC137286 mRNA. Translation: AAI37287.1.
AY651261 mRNA. Translation: AAX35689.1.
AK074079 mRNA. Translation: BAB84905.1.
CCDSiCCDS35118.1. [Q7Z7A1-1]
RefSeqiNP_008949.4. NM_007018.4. [Q7Z7A1-1]
XP_005251736.1. XM_005251679.2. [Q7Z7A1-1]
UniGeneiHs.653263.

Genome annotation databases

EnsembliENST00000238341; ENSP00000238341; ENSG00000119397. [Q7Z7A1-1]
ENST00000373850; ENSP00000362956; ENSG00000119397. [Q7Z7A1-2]
ENST00000373855; ENSP00000362962; ENSG00000119397. [Q7Z7A1-1]
ENST00000613863; ENSP00000481072; ENSG00000119397. [Q7Z7A1-4]
GeneIDi11064.
KEGGihsa:11064.
UCSCiuc004bkx.1. human. [Q7Z7A1-1]
uc004blb.1. human. [Q7Z7A1-3]
uc010mvp.1. human. [Q7Z7A1-4]

Polymorphism databases

DMDMi172045911.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083322 mRNA. Translation: AAC32373.1 .
AF513978 mRNA. Translation: AAP43846.1 .
BX640927 mRNA. Translation: CAE45965.1 .
AL137068 Genomic DNA. Translation: CAI12358.1 .
AL137068 Genomic DNA. Translation: CAM13285.1 .
BC002932 mRNA. Translation: AAH02932.1 . Sequence problems.
BC089415 mRNA. Translation: AAH89415.1 . Sequence problems.
BC137286 mRNA. Translation: AAI37287.1 .
AY651261 mRNA. Translation: AAX35689.1 .
AK074079 mRNA. Translation: BAB84905.1 .
CCDSi CCDS35118.1. [Q7Z7A1-1 ]
RefSeqi NP_008949.4. NM_007018.4. [Q7Z7A1-1 ]
XP_005251736.1. XM_005251679.2. [Q7Z7A1-1 ]
UniGenei Hs.653263.

3D structure databases

ProteinModelPortali Q7Z7A1.
SMRi Q7Z7A1. Positions 90-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116248. 4 interactions.
DIPi DIP-47280N.
IntActi Q7Z7A1. 18 interactions.
MINTi MINT-4988988.

PTM databases

PhosphoSitei Q7Z7A1.

Polymorphism databases

DMDMi 172045911.

Proteomic databases

MaxQBi Q7Z7A1.
PaxDbi Q7Z7A1.
PRIDEi Q7Z7A1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238341 ; ENSP00000238341 ; ENSG00000119397 . [Q7Z7A1-1 ]
ENST00000373850 ; ENSP00000362956 ; ENSG00000119397 . [Q7Z7A1-2 ]
ENST00000373855 ; ENSP00000362962 ; ENSG00000119397 . [Q7Z7A1-1 ]
ENST00000613863 ; ENSP00000481072 ; ENSG00000119397 . [Q7Z7A1-4 ]
GeneIDi 11064.
KEGGi hsa:11064.
UCSCi uc004bkx.1. human. [Q7Z7A1-1 ]
uc004blb.1. human. [Q7Z7A1-3 ]
uc010mvp.1. human. [Q7Z7A1-4 ]

Organism-specific databases

CTDi 11064.
GeneCardsi GC09P123839.
H-InvDB HIX0008344.
HGNCi HGNC:1858. CNTRL.
HPAi HPA020468.
HPA020480.
HPA051583.
MIMi 605496. gene.
neXtProti NX_Q7Z7A1.
PharmGKBi PA26414.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145909.
GeneTreei ENSGT00730000110223.
HOVERGENi HBG101203.
InParanoidi Q7Z7A1.
KOi K16770.
OMAi DESPYIG.
OrthoDBi EOG7NSB1F.
PhylomeDBi Q7Z7A1.
TreeFami TF101135.

Enzyme and pathway databases

Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

ChiTaRSi CNTRL. human.
GeneWikii CNTRL.
GenomeRNAii 11064.
NextBioi 42047.
PROi Q7Z7A1.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z7A1.
CleanExi HS_CEP110.
ExpressionAtlasi Q7Z7A1. baseline and differential.
Genevestigatori Q7Z7A1.

Family and domain databases

InterProi IPR028640. CEP110.
IPR001611. Leu-rich_rpt.
[Graphical view ]
PANTHERi PTHR18877. PTHR18877. 1 hit.
PROSITEi PS51450. LRR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)."
    Guasch G., Mack G.J., Popovici C., Dastugue N., Birnbaum D., Rattner J.B., Pebusque M.-J.
    Blood 95:1788-1796(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH FGFR1, SUBCELLULAR LOCATION.
  2. "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase."
    Gromley A., Jurczyk A., Sillibourne J., Halilovic E., Mogensen M., Groisman I., Blomberg M., Doxsey S.J.
    J. Cell Biol. 161:535-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-56, SUBCELLULAR LOCATION, FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Liver.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1513 (ISOFORM 2).
    Tissue: Lymph and Placenta.
  6. "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
    Guinn B.-A., Bland E.A., Lodi U., Liggins A.P., Tobal K., Petters S., Wells J.W., Banham A.H., Mufti G.J.
    Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-1677 (ISOFORM 1).
  7. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 527-2325 (ISOFORM 5).
    Tissue: Spleen.
  8. "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation."
    Ou Y.Y., Mack G.J., Zhang M., Rattner J.B.
    J. Cell Sci. 115:1825-1835(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission."
    Gromley A., Yeaman C., Rosa J., Redick S., Chen C.-T., Mirabelle S., Guha M., Sillibourne J., Doxsey S.J.
    Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EXOC6 AND SNAPIN.
  10. "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function."
    Szebenyi G., Hall B., Yu R., Hashim A.I., Kraemer H.
    Traffic 8:32-46(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOOK2.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCNTRL_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7A1
Secondary accession number(s): A2A2Y1
, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q8TEP3, Q9Y489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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