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Q7Z794 (K2C1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cytoskeletal 1b
Alternative name(s):
Cytokeratin-1B
Short name=CK-1B
Keratin-77
Short name=K77
Type-II keratin Kb39
Gene names
Name:KRT77
Synonyms:KRT1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length578 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed exclusively in skin. Ref.1

Post-translational modification

Undergoes deimination of some arginine residues (citrullination) By similarity. UniProtKB Q6IFZ6

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Sequence caution

The sequence DAA00402.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMCitrullination
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 578578Keratin, type II cytoskeletal 1b
PRO_0000063711

Regions

Region1 – 163163Head
Region164 – 474311Rod
Region164 – 20037Coil 1A
Region201 – 21919Linker 1
Region220 – 31192Coil 1B
Region312 – 33524Linker 12
Region336 – 474139Coil 2
Region475 – 578104Tail

Sites

Site4181Stutter

Natural variations

Natural variant101A → T.
Corresponds to variant rs17118224 [ dbSNP | Ensembl ].
VAR_056022

Experimental info

Sequence conflict3361D → N in CAD91892. Ref.1
Sequence conflict5331R → G in CAD91892. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z794 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 232F92351DF0FDCA

FASTA57861,901
        10         20         30         40         50         60 
MSHQFSSQSA FSSMSRRVYS TSSSAGSGGG SPAVGSVCYA RGRCGGGGYG IHGRGFGSRS 

        70         80         90        100        110        120 
LYNLGGSRSI SINLMGRSTS GFCQGGGVGG FGGGRGFGVG STGAGGFGGG GFGGAGFGTS 

       130        140        150        160        170        180 
NFGLGGFGPY CPPGGIQEVT INQSLLEPLH LEVDPEIQRI KTQEREQIMV LNNKFASFID 

       190        200        210        220        230        240 
KVRFLEQQNQ VLQTKWELLQ QVNTSTGTNN LEPLLENYIG DLRRQVDLLS AEQMRQNAEV 

       250        260        270        280        290        300 
RSMQDVVEDY KSKYEDEINK RTGSENDFVV LKKDVDAAYV SKVDLESRVD TLTGEVNFLK 

       310        320        330        340        350        360 
YLFLTELSQV QTHISDTNVI LSMDNNRSLD LDSIIDAVRT QYELIAQRSK DEAEALYQTK 

       370        380        390        400        410        420 
YQELQITAGR HGDDLKNSKM EIAELNRTVQ RLQAEISNVK KQIEQMQSLI SDAEERGEQA 

       430        440        450        460        470        480 
LQDAWQKLQD LEEALQQSKE ELARLLRDYQ AMLGVKLSLD VEIATYRQLL EGEESRMSGE 

       490        500        510        520        530        540 
LQSHVSISVQ NSQVSVNGGA GGGGSYGSGG YGGGSGGGYG GGRSYRGGGA RGRSGGGYGS 

       550        560        570 
GCGGGGGSYG GSGRSGRGSS RVQIIQTSTN TSHRRILE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Skin.
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18."
Hesse M., Magin T.M., Weber K.
J. Cell Sci. 114:2569-2575(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ564104 mRNA. Translation: CAD91892.1.
AC055716 Genomic DNA. No translation available.
BK000975 Genomic DNA. Translation: DAA00402.1. Sequence problems.
RefSeqNP_778253.2. NM_175078.2.
UniGeneHs.334989.

3D structure databases

ProteinModelPortalQ7Z794.
SMRQ7Z794. Positions 161-302, 330-472.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131903. 10 interactions.
IntActQ7Z794. 4 interactions.
STRING9606.ENSP00000342710.

PTM databases

PhosphoSiteQ7Z794.

Polymorphism databases

DMDM308153590.

Proteomic databases

PaxDbQ7Z794.
PRIDEQ7Z794.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341809; ENSP00000342710; ENSG00000189182.
GeneID374454.
KEGGhsa:374454.
UCSCuc001saw.3. human.

Organism-specific databases

CTD374454.
GeneCardsGC12M053083.
H-InvDBHIX0036740.
HGNCHGNC:20411. KRT77.
HPAHPA045934.
MIM611158. gene.
neXtProtNX_Q7Z794.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146126.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidQ7Z794.
KOK07605.
OMANTSHRRI.
OrthoDBEOG7FV3Q8.
PhylomeDBQ7Z794.
TreeFamTF317854.

Gene expression databases

ArrayExpressQ7Z794.
BgeeQ7Z794.
CleanExHS_KRT77.
GenevestigatorQ7Z794.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
SMARTSM00150. SPEC. 1 hit.
[Graphical view]
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi374454.
NextBio100191.
PROQ7Z794.
SOURCESearch...

Entry information

Entry nameK2C1B_HUMAN
AccessionPrimary (citable) accession number: Q7Z794
Secondary accession number(s): Q7RTS8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 5, 2010
Last modified: February 19, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM