ID   S35E3_HUMAN             Reviewed;         313 AA.
AC   Q7Z769; A8K0T0; Q0P5Y5; Q9P0V1;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   24-JAN-2024, entry version 131.
DE   RecName: Full=Solute carrier family 35 member E3;
DE   AltName: Full=Bladder cancer-overexpressed gene 1 protein;
GN   Name=SLC35E3; Synonyms=BLOV1; ORFNames=UNQ3043/PRO9859;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Luscombe M.J., Knowles M.A.;
RT   "A novel gene which is overexpressed in advanced bladder cancer.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Pancreas, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q7Z769; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-13389236, EBI-10827839;
CC       Q7Z769; P27449: ATP6V0C; NbExp=3; IntAct=EBI-13389236, EBI-721179;
CC       Q7Z769; Q92843: BCL2L2; NbExp=3; IntAct=EBI-13389236, EBI-707714;
CC       Q7Z769; Q13323: BIK; NbExp=3; IntAct=EBI-13389236, EBI-700794;
CC       Q7Z769; Q12982: BNIP2; NbExp=3; IntAct=EBI-13389236, EBI-752094;
CC       Q7Z769; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-13389236, EBI-12003442;
CC       Q7Z769; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-13389236, EBI-10267100;
CC       Q7Z769; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-13389236, EBI-18304435;
CC       Q7Z769; O15552: FFAR2; NbExp=3; IntAct=EBI-13389236, EBI-2833872;
CC       Q7Z769; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-13389236, EBI-713304;
CC       Q7Z769; O00258: GET1; NbExp=3; IntAct=EBI-13389236, EBI-18908258;
CC       Q7Z769; O00155: GPR25; NbExp=3; IntAct=EBI-13389236, EBI-10178951;
CC       Q7Z769; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-13389236, EBI-12133176;
CC       Q7Z769; P60201-2: PLP1; NbExp=3; IntAct=EBI-13389236, EBI-12188331;
CC       Q7Z769; Q99942: RNF5; NbExp=3; IntAct=EBI-13389236, EBI-348482;
CC       Q7Z769; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-13389236, EBI-8636004;
CC       Q7Z769; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-13389236, EBI-9679163;
CC       Q7Z769; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-13389236, EBI-3907610;
CC       Q7Z769; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-13389236, EBI-742688;
CC       Q7Z769; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-13389236, EBI-17280858;
CC       Q7Z769; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-13389236, EBI-8638294;
CC       Q7Z769; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-13389236, EBI-8642211;
CC       Q7Z769; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-13389236, EBI-2852148;
CC       Q7Z769; P49638: TTPA; NbExp=3; IntAct=EBI-13389236, EBI-10210710;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF73127.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF148713; AAF73127.1; ALT_FRAME; mRNA.
DR   EMBL; AY358943; AAQ89302.1; -; mRNA.
DR   EMBL; AK289645; BAF82334.1; -; mRNA.
DR   EMBL; CH471054; EAW97196.1; -; Genomic_DNA.
DR   EMBL; BC008412; AAH08412.1; -; mRNA.
DR   EMBL; BC021103; AAH21103.1; -; mRNA.
DR   EMBL; BC030504; AAH30504.1; -; mRNA.
DR   EMBL; BC049192; AAH49192.1; -; mRNA.
DR   CCDS; CCDS41808.1; -.
DR   RefSeq; NP_061126.2; NM_018656.2.
DR   AlphaFoldDB; Q7Z769; -.
DR   SMR; Q7Z769; -.
DR   BioGRID; 120688; 25.
DR   IntAct; Q7Z769; 24.
DR   STRING; 9606.ENSP00000381089; -.
DR   TCDB; 2.A.7.9.15; the drug/metabolite transporter (dmt) superfamily.
DR   iPTMnet; Q7Z769; -.
DR   PhosphoSitePlus; Q7Z769; -.
DR   BioMuta; SLC35E3; -.
DR   DMDM; 74738870; -.
DR   EPD; Q7Z769; -.
DR   MassIVE; Q7Z769; -.
DR   PaxDb; 9606-ENSP00000381089; -.
DR   PeptideAtlas; Q7Z769; -.
DR   ProteomicsDB; 69488; -.
DR   Antibodypedia; 59245; 23 antibodies from 8 providers.
DR   DNASU; 55508; -.
DR   Ensembl; ENST00000398004.4; ENSP00000381089.2; ENSG00000175782.11.
DR   GeneID; 55508; -.
DR   KEGG; hsa:55508; -.
DR   MANE-Select; ENST00000398004.4; ENSP00000381089.2; NM_018656.5; NP_061126.2.
DR   UCSC; uc001suh.4; human.
DR   AGR; HGNC:20864; -.
DR   CTD; 55508; -.
DR   DisGeNET; 55508; -.
DR   GeneCards; SLC35E3; -.
DR   HGNC; HGNC:20864; SLC35E3.
DR   HPA; ENSG00000175782; Low tissue specificity.
DR   MIM; 620355; gene.
DR   neXtProt; NX_Q7Z769; -.
DR   OpenTargets; ENSG00000175782; -.
DR   PharmGKB; PA128394684; -.
DR   VEuPathDB; HostDB:ENSG00000175782; -.
DR   eggNOG; KOG1441; Eukaryota.
DR   GeneTree; ENSGT00730000111164; -.
DR   HOGENOM; CLU_048347_3_2_1; -.
DR   InParanoid; Q7Z769; -.
DR   OMA; QGLGMLC; -.
DR   OrthoDB; 315937at2759; -.
DR   PhylomeDB; Q7Z769; -.
DR   TreeFam; TF329429; -.
DR   PathwayCommons; Q7Z769; -.
DR   SignaLink; Q7Z769; -.
DR   BioGRID-ORCS; 55508; 14 hits in 1151 CRISPR screens.
DR   ChiTaRS; SLC35E3; human.
DR   GenomeRNAi; 55508; -.
DR   Pharos; Q7Z769; Tdark.
DR   PRO; PR:Q7Z769; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q7Z769; Protein.
DR   Bgee; ENSG00000175782; Expressed in endothelial cell and 186 other cell types or tissues.
DR   ExpressionAtlas; Q7Z769; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0005338; F:nucleotide-sugar transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   PANTHER; PTHR11132; SOLUTE CARRIER FAMILY 35; 1.
DR   PANTHER; PTHR11132:SF250; SOLUTE CARRIER FAMILY 35 MEMBER E3; 1.
DR   Pfam; PF03151; TPT; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
DR   Genevisible; Q7Z769; HS.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Solute carrier family 35 member E3"
FT                   /id="PRO_0000297899"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        61
FT                   /note="C -> S (in Ref. 5; AAH49192)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        264
FT                   /note="T -> A (in Ref. 1; AAF73127)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        283
FT                   /note="G -> D (in Ref. 1; AAF73127)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  35066 MW;  275821E8A9CBE263 CRC64;
     MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH FVVTWLGLYI
     CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI GTYQLAKAMT TPVIIAIQTF
     CYQKTFSTRI QLTLIPITLG VILNSYYDVK FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL
     QVNSMQLLYY QAPMSSAMLL VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS
     IYWIIGNTSP VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS
     EQEGSRSKLA QRP
//