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Q7Z769 (S35E3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member E3
Alternative name(s):
Bladder cancer-overexpressed gene 1 protein
Gene names
Name:SLC35E3
Synonyms:BLOV1
ORF Names:UNQ3043/PRO9859
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative transporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TPT transporter family. SLC35E subfamily.

Sequence caution

The sequence AAF73127.1 differs from that shown. Reason: Frameshift at positions 4, 16 and 40.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Solute carrier family 35 member E3
PRO_0000297899

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane126 – 14318Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane187 – 20620Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane275 – 29521Helical; Potential
Compositional bias77 – 826Poly-Leu

Experimental info

Sequence conflict611C → S in AAH49192. Ref.5
Sequence conflict2641T → A in AAF73127. Ref.1
Sequence conflict2831G → D in AAF73127. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z769 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 275821E8A9CBE263

FASTA31335,066
        10         20         30         40         50         60 
MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH FVVTWLGLYI 

        70         80         90        100        110        120 
CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI GTYQLAKAMT TPVIIAIQTF 

       130        140        150        160        170        180 
CYQKTFSTRI QLTLIPITLG VILNSYYDVK FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL 

       190        200        210        220        230        240 
QVNSMQLLYY QAPMSSAMLL VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS 

       250        260        270        280        290        300 
IYWIIGNTSP VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS 

       310 
EQEGSRSKLA QRP 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene which is overexpressed in advanced bladder cancer."
Luscombe M.J., Knowles M.A.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Pancreas and Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF148713 mRNA. Translation: AAF73127.1. Frameshift.
AY358943 mRNA. Translation: AAQ89302.1.
AK289645 mRNA. Translation: BAF82334.1.
CH471054 Genomic DNA. Translation: EAW97196.1.
BC008412 mRNA. Translation: AAH08412.1.
BC021103 mRNA. Translation: AAH21103.1.
BC030504 mRNA. Translation: AAH30504.1.
BC049192 mRNA. Translation: AAH49192.1.
RefSeqNP_061126.2. NM_018656.2.
UniGeneHs.506011.

3D structure databases

ProteinModelPortalQ7Z769.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120688. 2 interactions.
STRING9606.ENSP00000381089.

Protein family/group databases

TCDB2.A.7.9.15. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ7Z769.

Polymorphism databases

DMDM74738870.

Proteomic databases

PRIDEQ7Z769.

Protocols and materials databases

DNASU55508.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398004; ENSP00000381089; ENSG00000175782.
GeneID55508.
KEGGhsa:55508.
UCSCuc001suh.3. human.

Organism-specific databases

CTD55508.
GeneCardsGC12P069139.
HGNCHGNC:20864. SLC35E3.
HPAHPA049403.
neXtProtNX_Q7Z769.
PharmGKBPA128394684.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG323583.
HOGENOMHOG000242404.
HOVERGENHBG059041.
KOK15285.
OMACYQKTFS.
OrthoDBEOG7D2FFW.
PhylomeDBQ7Z769.
TreeFamTF329429.

Gene expression databases

ArrayExpressQ7Z769.
BgeeQ7Z769.
CleanExHS_SLC35E3.
GenevestigatorQ7Z769.

Family and domain databases

InterProIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC35E3. human.
GenomeRNAi55508.
NextBio59911.
PROQ7Z769.

Entry information

Entry nameS35E3_HUMAN
AccessionPrimary (citable) accession number: Q7Z769
Secondary accession number(s): A8K0T0, Q0P5Y5, Q9P0V1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM