Q7Z769 (S35E3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member E3

Alternative name(s):
Bladder cancer-overexpressed gene 1 protein

Gene names

Name:	SLC35E3
Synonyms:	BLOV1
ORF Names:	UNQ3043/PRO9859

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative transporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TPT transporter family. SLC35E subfamily.
Sequence caution	The sequence AAF73127.1 differs from that shown. Reason: Frameshift at positions 4, 16 and 40.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Solute carrier family 35 member E3		PRO_0000297899
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	126 – 143	18	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	187 – 206	20	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	252 – 272	21	Helical; Potential
	Transmembrane	275 – 295	21	Helical; Potential
	Compositional bias	77 – 82	6	Poly-Leu
Experimental info
	Sequence conflict	61	1	C → S in AAH49192. Ref.5
	Sequence conflict	264	1	T → A in AAF73127. Ref.1
	Sequence conflict	283	1	G → D in AAF73127. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z769 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 275821E8A9CBE263	FASTA	313	35,066
	10 20 30 40 50 60 MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH FVVTWLGLYI 70 80 90 100 110 120 CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI GTYQLAKAMT TPVIIAIQTF 130 140 150 160 170 180 CYQKTFSTRI QLTLIPITLG VILNSYYDVK FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL 190 200 210 220 230 240 QVNSMQLLYY QAPMSSAMLL VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS 250 260 270 280 290 300 IYWIIGNTSP VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS 310 EQEGSRSKLA QRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene which is overexpressed in advanced bladder cancer." Luscombe M.J., Knowles M.A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Pancreas and Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF148713 mRNA. Translation: AAF73127.1. Frameshift. AY358943 mRNA. Translation: AAQ89302.1. AK289645 mRNA. Translation: BAF82334.1. CH471054 Genomic DNA. Translation: EAW97196.1. BC008412 mRNA. Translation: AAH08412.1. BC021103 mRNA. Translation: AAH21103.1. BC030504 mRNA. Translation: AAH30504.1. BC049192 mRNA. Translation: AAH49192.1.
IPI	IPI00032873.
RefSeq	NP_061126.2. NM_018656.2.
UniGene	Hs.506011.
3D structure databases
ProteinModelPortal	Q7Z769.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381089.
PTM databases
PhosphoSite	Q7Z769.
Polymorphism databases
DMDM	74738870.
Proteomic databases
PRIDE	Q7Z769.
Protocols and materials databases
DNASU	55508.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398004; ENSP00000381089; ENSG00000175782.
GeneID	55508.
KEGG	hsa:55508.
UCSC	uc001suh.3. human.
Organism-specific databases
CTD	55508.
GeneCards	GC12P069139.
HGNC	HGNC:20864. SLC35E3.
neXtProt	NX_Q7Z769.
PharmGKB	PA128394684.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG323583.
HOGENOM	HOG000242404.
HOVERGEN	HBG059041.
KO	K15285.
OMA	YQKSFST.
Gene expression databases
ArrayExpress	Q7Z769.
Bgee	Q7Z769.
CleanEx	HS_SLC35E3.
Genevestigator	Q7Z769.
Family and domain databases
InterPro	IPR004853. DUF250. [Graphical view]
Pfam	PF03151. TPT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC35E3. human.
GenomeRNAi	55508.
NextBio	59911.

Entry information

Entry name

S35E3_HUMAN

Accession

Primary (citable) accession number: Q7Z769
Secondary accession number(s): A8K0T0, Q0P5Y5, Q9P0V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.