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Protein

Solute carrier family 35 member E3

Gene

SLC35E3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.7.9.15. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E3
Alternative name(s):
Bladder cancer-overexpressed gene 1 protein
Gene namesi
Name:SLC35E3
Synonyms:BLOV1
ORF Names:UNQ3043/PRO9859
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:20864. SLC35E3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14318HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20620HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence AnalysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394684.

Polymorphism and mutation databases

BioMutaiSLC35E3.
DMDMi74738870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Solute carrier family 35 member E3PRO_0000297899Add
BLAST

Proteomic databases

PRIDEiQ7Z769.

PTM databases

PhosphoSiteiQ7Z769.

Expressioni

Gene expression databases

BgeeiQ7Z769.
CleanExiHS_SLC35E3.
ExpressionAtlasiQ7Z769. baseline and differential.
GenevisibleiQ7Z769. HS.

Organism-specific databases

HPAiHPA049403.

Interactioni

Protein-protein interaction databases

BioGridi120688. 1 interaction.
STRINGi9606.ENSP00000381089.

Structurei

3D structure databases

ProteinModelPortaliQ7Z769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 826Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323583.
GeneTreeiENSGT00730000111164.
HOGENOMiHOG000242404.
HOVERGENiHBG059041.
InParanoidiQ7Z769.
KOiK15285.
OMAiYICQKLD.
OrthoDBiEOG7D2FFW.
PhylomeDBiQ7Z769.
TreeFamiTF329429.

Family and domain databases

InterProiIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH
60 70 80 90 100
FVVTWLGLYI CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI
110 120 130 140 150
GTYQLAKAMT TPVIIAIQTF CYQKTFSTRI QLTLIPITLG VILNSYYDVK
160 170 180 190 200
FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL QVNSMQLLYY QAPMSSAMLL
210 220 230 240 250
VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS IYWIIGNTSP
260 270 280 290 300
VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS
310
EQEGSRSKLA QRP
Length:313
Mass (Da):35,066
Last modified:October 1, 2003 - v1
Checksum:i275821E8A9CBE263
GO

Sequence cautioni

The sequence AAF73127.1 differs from that shown. Reason: Frameshift at positions 4, 16 and 40. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611C → S in AAH49192 (PubMed:15489334).Curated
Sequence conflicti264 – 2641T → A in AAF73127 (Ref. 1) Curated
Sequence conflicti283 – 2831G → D in AAF73127 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148713 mRNA. Translation: AAF73127.1. Frameshift.
AY358943 mRNA. Translation: AAQ89302.1.
AK289645 mRNA. Translation: BAF82334.1.
CH471054 Genomic DNA. Translation: EAW97196.1.
BC008412 mRNA. Translation: AAH08412.1.
BC021103 mRNA. Translation: AAH21103.1.
BC030504 mRNA. Translation: AAH30504.1.
BC049192 mRNA. Translation: AAH49192.1.
CCDSiCCDS41808.1.
RefSeqiNP_061126.2. NM_018656.2.
UniGeneiHs.506011.

Genome annotation databases

EnsembliENST00000398004; ENSP00000381089; ENSG00000175782.
GeneIDi55508.
KEGGihsa:55508.
UCSCiuc001suh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148713 mRNA. Translation: AAF73127.1. Frameshift.
AY358943 mRNA. Translation: AAQ89302.1.
AK289645 mRNA. Translation: BAF82334.1.
CH471054 Genomic DNA. Translation: EAW97196.1.
BC008412 mRNA. Translation: AAH08412.1.
BC021103 mRNA. Translation: AAH21103.1.
BC030504 mRNA. Translation: AAH30504.1.
BC049192 mRNA. Translation: AAH49192.1.
CCDSiCCDS41808.1.
RefSeqiNP_061126.2. NM_018656.2.
UniGeneiHs.506011.

3D structure databases

ProteinModelPortaliQ7Z769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120688. 1 interaction.
STRINGi9606.ENSP00000381089.

Protein family/group databases

TCDBi2.A.7.9.15. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ7Z769.

Polymorphism and mutation databases

BioMutaiSLC35E3.
DMDMi74738870.

Proteomic databases

PRIDEiQ7Z769.

Protocols and materials databases

DNASUi55508.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398004; ENSP00000381089; ENSG00000175782.
GeneIDi55508.
KEGGihsa:55508.
UCSCiuc001suh.3. human.

Organism-specific databases

CTDi55508.
GeneCardsiGC12P069139.
HGNCiHGNC:20864. SLC35E3.
HPAiHPA049403.
neXtProtiNX_Q7Z769.
PharmGKBiPA128394684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG323583.
GeneTreeiENSGT00730000111164.
HOGENOMiHOG000242404.
HOVERGENiHBG059041.
InParanoidiQ7Z769.
KOiK15285.
OMAiYICQKLD.
OrthoDBiEOG7D2FFW.
PhylomeDBiQ7Z769.
TreeFamiTF329429.

Miscellaneous databases

ChiTaRSiSLC35E3. human.
GenomeRNAii55508.
NextBioi59911.
PROiQ7Z769.

Gene expression databases

BgeeiQ7Z769.
CleanExiHS_SLC35E3.
ExpressionAtlasiQ7Z769. baseline and differential.
GenevisibleiQ7Z769. HS.

Family and domain databases

InterProiIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene which is overexpressed in advanced bladder cancer."
    Luscombe M.J., Knowles M.A.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Pancreas and Placenta.

Entry informationi

Entry nameiS35E3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z769
Secondary accession number(s): A8K0T0, Q0P5Y5, Q9P0V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.