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Q7Z769

- S35E3_HUMAN

UniProt

Q7Z769 - S35E3_HUMAN

Protein

Solute carrier family 35 member E3

Gene

SLC35E3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Putative transporter.By similarity

    Protein family/group databases

    TCDBi2.A.7.9.15. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member E3
    Alternative name(s):
    Bladder cancer-overexpressed gene 1 protein
    Gene namesi
    Name:SLC35E3
    Synonyms:BLOV1
    ORF Names:UNQ3043/PRO9859
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:20864. SLC35E3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394684.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Solute carrier family 35 member E3PRO_0000297899Add
    BLAST

    Proteomic databases

    PRIDEiQ7Z769.

    PTM databases

    PhosphoSiteiQ7Z769.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z769.
    BgeeiQ7Z769.
    CleanExiHS_SLC35E3.
    GenevestigatoriQ7Z769.

    Organism-specific databases

    HPAiHPA049403.

    Interactioni

    Protein-protein interaction databases

    BioGridi120688. 2 interactions.
    STRINGi9606.ENSP00000381089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z769.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi77 – 826Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323583.
    HOGENOMiHOG000242404.
    HOVERGENiHBG059041.
    KOiK15285.
    OMAiDVKFNVL.
    OrthoDBiEOG7D2FFW.
    PhylomeDBiQ7Z769.
    TreeFamiTF329429.

    Family and domain databases

    InterProiIPR004853. Tpt_PEP_trans_dom.
    [Graphical view]
    PfamiPF03151. TPT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z769-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH    50
    FVVTWLGLYI CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI 100
    GTYQLAKAMT TPVIIAIQTF CYQKTFSTRI QLTLIPITLG VILNSYYDVK 150
    FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL QVNSMQLLYY QAPMSSAMLL 200
    VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS IYWIIGNTSP 250
    VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS 300
    EQEGSRSKLA QRP 313
    Length:313
    Mass (Da):35,066
    Last modified:October 1, 2003 - v1
    Checksum:i275821E8A9CBE263
    GO

    Sequence cautioni

    The sequence AAF73127.1 differs from that shown. Reason: Frameshift at positions 4, 16 and 40.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611C → S in AAH49192. (PubMed:15489334)Curated
    Sequence conflicti264 – 2641T → A in AAF73127. 1 PublicationCurated
    Sequence conflicti283 – 2831G → D in AAF73127. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148713 mRNA. Translation: AAF73127.1. Frameshift.
    AY358943 mRNA. Translation: AAQ89302.1.
    AK289645 mRNA. Translation: BAF82334.1.
    CH471054 Genomic DNA. Translation: EAW97196.1.
    BC008412 mRNA. Translation: AAH08412.1.
    BC021103 mRNA. Translation: AAH21103.1.
    BC030504 mRNA. Translation: AAH30504.1.
    BC049192 mRNA. Translation: AAH49192.1.
    CCDSiCCDS41808.1.
    RefSeqiNP_061126.2. NM_018656.2.
    UniGeneiHs.506011.

    Genome annotation databases

    EnsembliENST00000398004; ENSP00000381089; ENSG00000175782.
    GeneIDi55508.
    KEGGihsa:55508.
    UCSCiuc001suh.3. human.

    Polymorphism databases

    DMDMi74738870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148713 mRNA. Translation: AAF73127.1 . Frameshift.
    AY358943 mRNA. Translation: AAQ89302.1 .
    AK289645 mRNA. Translation: BAF82334.1 .
    CH471054 Genomic DNA. Translation: EAW97196.1 .
    BC008412 mRNA. Translation: AAH08412.1 .
    BC021103 mRNA. Translation: AAH21103.1 .
    BC030504 mRNA. Translation: AAH30504.1 .
    BC049192 mRNA. Translation: AAH49192.1 .
    CCDSi CCDS41808.1.
    RefSeqi NP_061126.2. NM_018656.2.
    UniGenei Hs.506011.

    3D structure databases

    ProteinModelPortali Q7Z769.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120688. 2 interactions.
    STRINGi 9606.ENSP00000381089.

    Protein family/group databases

    TCDBi 2.A.7.9.15. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q7Z769.

    Polymorphism databases

    DMDMi 74738870.

    Proteomic databases

    PRIDEi Q7Z769.

    Protocols and materials databases

    DNASUi 55508.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398004 ; ENSP00000381089 ; ENSG00000175782 .
    GeneIDi 55508.
    KEGGi hsa:55508.
    UCSCi uc001suh.3. human.

    Organism-specific databases

    CTDi 55508.
    GeneCardsi GC12P069139.
    HGNCi HGNC:20864. SLC35E3.
    HPAi HPA049403.
    neXtProti NX_Q7Z769.
    PharmGKBi PA128394684.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323583.
    HOGENOMi HOG000242404.
    HOVERGENi HBG059041.
    KOi K15285.
    OMAi DVKFNVL.
    OrthoDBi EOG7D2FFW.
    PhylomeDBi Q7Z769.
    TreeFami TF329429.

    Miscellaneous databases

    ChiTaRSi SLC35E3. human.
    GenomeRNAii 55508.
    NextBioi 59911.
    PROi Q7Z769.

    Gene expression databases

    ArrayExpressi Q7Z769.
    Bgeei Q7Z769.
    CleanExi HS_SLC35E3.
    Genevestigatori Q7Z769.

    Family and domain databases

    InterProi IPR004853. Tpt_PEP_trans_dom.
    [Graphical view ]
    Pfami PF03151. TPT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene which is overexpressed in advanced bladder cancer."
      Luscombe M.J., Knowles M.A.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Pancreas and Placenta.

    Entry informationi

    Entry nameiS35E3_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z769
    Secondary accession number(s): A8K0T0, Q0P5Y5, Q9P0V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3