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Protein

Maestro heat-like repeat-containing protein family member 2B

Gene

MROH2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 2B
Alternative name(s):
HEAT repeat-containing protein 7B2
Gene namesi
Name:MROH2B
Synonyms:HEATR7B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26857. MROH2B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720440.

Polymorphism and mutation databases

BioMutaiMROH2B.
DMDMi296453066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15851585Maestro heat-like repeat-containing protein family member 2BPRO_0000332243Add
BLAST

Proteomic databases

PaxDbiQ7Z745.
PRIDEiQ7Z745.

PTM databases

iPTMnetiQ7Z745.
PhosphoSiteiQ7Z745.

Expressioni

Gene expression databases

BgeeiQ7Z745.
ExpressionAtlasiQ7Z745. baseline and differential.
GenevisibleiQ7Z745. HS.

Organism-specific databases

HPAiHPA059457.

Interactioni

Protein-protein interaction databases

BioGridi126362. 1 interaction.
STRINGi9606.ENSP00000382476.

Structurei

3D structure databases

ProteinModelPortaliQ7Z745.
SMRiQ7Z745. Positions 931-956, 1267-1372, 1388-1415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6538HEAT 1Add
BLAST
Repeati228 – 26336HEAT 2Add
BLAST
Repeati272 – 30938HEAT 3Add
BLAST
Repeati310 – 34637HEAT 4Add
BLAST
Repeati405 – 44541HEAT 5Add
BLAST
Repeati531 – 56939HEAT 6Add
BLAST
Repeati572 – 61140HEAT 7Add
BLAST
Repeati662 – 69938HEAT 8Add
BLAST
Repeati777 – 81943HEAT 9Add
BLAST
Repeati964 – 100138HEAT 10Add
BLAST
Repeati1021 – 105939HEAT 11Add
BLAST
Repeati1112 – 115140HEAT 12Add
BLAST
Repeati1157 – 119539HEAT 13Add
BLAST
Repeati1258 – 129538HEAT 14Add
BLAST
Repeati1363 – 140240HEAT 15Add
BLAST

Sequence similaritiesi

Contains 15 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2032. Eukaryota.
ENOG410XQE8. LUCA.
GeneTreeiENSGT00840000129723.
HOGENOMiHOG000168416.
HOVERGENiHBG108702.
InParanoidiQ7Z745.
OMAiYYASKDM.
PhylomeDBiQ7Z745.
TreeFamiTF315201.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z745-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLSTEESIE MFGDINLTLG MLNKEDIVNK EDIYSHLTSV IQNTDILDDA
60 70 80 90 100
IVQRLIYYAS KDMRDNNMLR EIRMLAGEVL VSLAAHDFNS VMYEVQSNFR
110 120 130 140 150
ILELPDEFVV LALAELATSY VSQSIPFMMM TLLTMQTMLR LAEDERMKGT
160 170 180 190 200
FCIALEKFSK AIYKYVNHWR DFPYPRLDAN RLSDKIFMLF WYIMEKWAPL
210 220 230 240 250
ASPMQTLSIV KAHGPTVSLL LHREDFRGYA LGQVPWLLNQ YKDKEIDFHV
260 270 280 290 300
TQSLKQILTA AVLYDIGLPR SLRRSIFINL LQQICRAPEP PVKENEMKAS
310 320 330 340 350
SCFLILAHSN PGELMEFFDE QVRSNNEAIR VGILTLLRLA VNADEPRLRD
360 370 380 390 400
HIISIERTVK IVMGDLSTKV RNSVLLLIQT MCEKSYIEAR EGWPLIDYVF
410 420 430 440 450
SQFATLNRNL EKPVKTNFHE NEKEEESVRE TSLEVLKTLD PLVIGMPQVL
460 470 480 490 500
WPRILTFVVP AEYTEALEPL FSIIRILIMA EEKKQHSAKE STALVVSTGA
510 520 530 540 550
VKLPSPQQLL ARLLVISMPA SLGELRGAGA IGLLKILPEI IHPKLVDLWK
560 570 580 590 600
TRLPELLQPL EGKNISTVLW ETMLLQLLKE SLWKISDVAW TIQLTQDFKQ
610 620 630 640 650
QMGSYSNNST EKKFLWKALG TTLACCQDSD FVNSQIKEFL TAPNQLGDQR
660 670 680 690 700
QGITSILGYC AENHLDIVLK VLKTFQNQEK FFMNRCKSLF SGKKSLTKTD
710 720 730 740 750
VMVIYGAVAL HAPKKQLLSR LNQDIISQVL SLHGQCSQVL GMSVMNKDMD
760 770 780 790 800
LQMSFTRSIT EIGIAVQDAE DQGFQFSYKE MLIGYMLDFI RDEPLDSLAS
810 820 830 840 850
PIRWKALIAI RYLSKLKPQL SLQDHLNILE ENIRRLLPLP PLENLKSEGQ
860 870 880 890 900
TDKDKEHIQF LYERSMDALG KLLKTMMWDN VNAEDCQEMF NLLQMWLVSQ
910 920 930 940 950
KEWERERAFQ ITAKVLTNDI EAPENFKIGS LLGLLAPHSC DTLPTIRQAA
960 970 980 990 1000
ASSTIGLFYI KGIHLEVERL QGLQEGLESD DVQVQIKISS KIAKIVSKFI
1010 1020 1030 1040 1050
PNEEILMFLE EMLDGLESLN PTCTKACGIW MITVLKQQGA ALEDQLLEIL
1060 1070 1080 1090 1100
GTIYHHMPVL RQKEESFQFI LEAISQIASF HMDTVVVNLL QKPLPFDRDT
1110 1120 1130 1140 1150
KTLWKALAEK PASSGKLLQA LIDKLETELE DDIARVEAIS VACAMYEVIS
1160 1170 1180 1190 1200
MGTSVTGLYP ELFTLLLKLV SCTLGQKMLT CPWSHRRHVM QQGEQQQIPD
1210 1220 1230 1240 1250
PCRLSTATLK CLQAQAMREG LAKESDEGDN LWTLLSSPST HHIGVCSLAR
1260 1270 1280 1290 1300
SMAVWQHGVI LDIMEQLLSS LTSSSENYRI TGAAFFSELM KEPILWKHGN
1310 1320 1330 1340 1350
LRNVLILMDQ SAWDSNATLR QMAIRGLGNT ASGAPHKVKK HKQLMLESII
1360 1370 1380 1390 1400
RGLYHLARTE VVCESLKALK KILELLTDRD VSFYFKEIVL QTRTFFEDEQ
1410 1420 1430 1440 1450
DDVRLTAIFL FEDLAPLTGR RWKIFFAEEI KKSLISFLLH LWDPNPKIGV
1460 1470 1480 1490 1500
ACRDVLMVCI PFLGLQELYG VLDRLLDQDL PRARDFYRQF CVKLAKKNQE
1510 1520 1530 1540 1550
ILWILHTHSF TFFTSTWEVI RSAAVKLTDA VVLNLTSQYV ELLDREQLTT
1560 1570 1580
RLQALRQDPC ISVQRAAEAA LQTLLRRCKE TSIPL
Length:1,585
Mass (Da):180,781
Last modified:May 18, 2010 - v3
Checksum:iA57EF4E9DC182FAD
GO
Isoform 2 (identifier: Q7Z745-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.

Note: No experimental confirmation available.
Show »
Length:1,289
Mass (Da):146,438
Checksum:iCD1E87E04BB82DDD
GO

Sequence cautioni

The sequence AAP97306.1 differs from that shown. Reason: Frameshift at positions 1063 and 1080. Curated
The sequence BAC05103.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti624 – 6241A → V in CAH18199 (PubMed:17974005).Curated
Sequence conflicti897 – 8971L → P in BAC05103 (PubMed:14702039).Curated
Sequence conflicti1059 – 10591V → L in AAP97306 (Ref. 5) Curated
Sequence conflicti1072 – 10721E → D in AAP97306 (Ref. 5) Curated
Sequence conflicti1424 – 14241I → T in CAH18199 (PubMed:17974005).Curated
Sequence conflicti1424 – 14241I → T in AAP97306 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111M → V.1 Publication
Corresponds to variant rs13174484 [ dbSNP | Ensembl ].
VAR_042983
Natural varianti191 – 1911W → R.1 Publication
Corresponds to variant rs865093 [ dbSNP | Ensembl ].
VAR_042984
Natural varianti263 – 2631L → I.
Corresponds to variant rs10045243 [ dbSNP | Ensembl ].
VAR_042985
Natural varianti468 – 4681E → V.
Corresponds to variant rs17198125 [ dbSNP | Ensembl ].
VAR_042986
Natural varianti496 – 4961V → I.2 Publications
Corresponds to variant rs325864 [ dbSNP | Ensembl ].
VAR_042987
Natural varianti526 – 5261R → H.2 Publications
Corresponds to variant rs13173930 [ dbSNP | Ensembl ].
VAR_042988
Natural varianti617 – 6171K → N.1 Publication
Corresponds to variant rs17854768 [ dbSNP | Ensembl ].
VAR_042989
Natural varianti648 – 6481D → V.
Corresponds to variant rs16870720 [ dbSNP | Ensembl ].
VAR_042990
Natural varianti781 – 7811M → V.
Corresponds to variant rs10067611 [ dbSNP | Ensembl ].
VAR_042991
Natural varianti918 – 9181N → K.
Corresponds to variant rs10054110 [ dbSNP | Ensembl ].
VAR_042992
Natural varianti1179 – 11791L → P.4 Publications
Corresponds to variant rs2271704 [ dbSNP | Ensembl ].
VAR_042993

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 296296Missing in isoform 2. 1 PublicationVSP_033361Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749346 mRNA. Translation: CAH18199.1.
AC114967 Genomic DNA. No translation available.
BC052962 mRNA. Translation: AAH52962.1.
AK097562 mRNA. Translation: BAC05103.1. Different initiation.
AF432068 mRNA. Translation: AAP97306.1. Frameshift.
CCDSiCCDS47202.1. [Q7Z745-1]
RefSeqiNP_775760.3. NM_173489.4. [Q7Z745-1]
UniGeneiHs.97714.

Genome annotation databases

EnsembliENST00000399564; ENSP00000382476; ENSG00000171495. [Q7Z745-1]
GeneIDi133558.
KEGGihsa:133558.
UCSCiuc003jmj.5. human. [Q7Z745-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749346 mRNA. Translation: CAH18199.1.
AC114967 Genomic DNA. No translation available.
BC052962 mRNA. Translation: AAH52962.1.
AK097562 mRNA. Translation: BAC05103.1. Different initiation.
AF432068 mRNA. Translation: AAP97306.1. Frameshift.
CCDSiCCDS47202.1. [Q7Z745-1]
RefSeqiNP_775760.3. NM_173489.4. [Q7Z745-1]
UniGeneiHs.97714.

3D structure databases

ProteinModelPortaliQ7Z745.
SMRiQ7Z745. Positions 931-956, 1267-1372, 1388-1415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126362. 1 interaction.
STRINGi9606.ENSP00000382476.

PTM databases

iPTMnetiQ7Z745.
PhosphoSiteiQ7Z745.

Polymorphism and mutation databases

BioMutaiMROH2B.
DMDMi296453066.

Proteomic databases

PaxDbiQ7Z745.
PRIDEiQ7Z745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399564; ENSP00000382476; ENSG00000171495. [Q7Z745-1]
GeneIDi133558.
KEGGihsa:133558.
UCSCiuc003jmj.5. human. [Q7Z745-1]

Organism-specific databases

CTDi133558.
GeneCardsiMROH2B.
H-InvDBHIX0004834.
HGNCiHGNC:26857. MROH2B.
HPAiHPA059457.
neXtProtiNX_Q7Z745.
PharmGKBiPA164720440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2032. Eukaryota.
ENOG410XQE8. LUCA.
GeneTreeiENSGT00840000129723.
HOGENOMiHOG000168416.
HOVERGENiHBG108702.
InParanoidiQ7Z745.
OMAiYYASKDM.
PhylomeDBiQ7Z745.
TreeFamiTF315201.

Miscellaneous databases

GenomeRNAii133558.
PROiQ7Z745.

Gene expression databases

BgeeiQ7Z745.
ExpressionAtlasiQ7Z745. baseline and differential.
GenevisibleiQ7Z745. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-496; HIS-526 AND PRO-1179.
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-11; ARG-191; ILE-496; HIS-526; ASN-617 AND PRO-1179.
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 823-1585 (ISOFORM 1), VARIANT PRO-1179.
    Tissue: Testis.
  5. Guo J.H., Yu L.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1049-1585 (ISOFORM 1), VARIANT PRO-1179.

Entry informationi

Entry nameiMRO2B_HUMAN
AccessioniPrimary (citable) accession number: Q7Z745
Secondary accession number(s): Q68DM1, Q7Z4U4, Q8N7X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.