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Q7Z739

- YTHD3_HUMAN

UniProt

Q7Z739 - YTHD3_HUMAN

Protein

YTH domain-containing family protein 3

Gene

YTHDF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.2 Publications

    GO - Molecular functioni

    1. N6-methyladenosine-containing RNA binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    YTH domain-containing family protein 3
    Gene namesi
    Name:YTHDF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:26465. YTHDF3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134976395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 585584YTH domain-containing family protein 3PRO_0000230991Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei23 – 231Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z739.
    PaxDbiQ7Z739.
    PRIDEiQ7Z739.

    PTM databases

    PhosphoSiteiQ7Z739.

    Miscellaneous databases

    PMAP-CutDBQ7Z739.

    Expressioni

    Gene expression databases

    CleanExiHS_YTHDF3.
    GenevestigatoriQ7Z739.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    gagP045912EBI-2849837,EBI-6179727From a different organism.

    Protein-protein interaction databases

    BioGridi128997. 9 interactions.
    IntActiQ7Z739. 3 interactions.
    MINTiMINT-5005374.
    STRINGi9606.ENSP00000398476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z739.
    SMRiQ7Z739. Positions 417-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini416 – 550135YTHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 YTH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276347.
    HOVERGENiHBG060315.
    InParanoidiQ7Z739.
    PhylomeDBiQ7Z739.

    Family and domain databases

    InterProiIPR007275. YTH_domain.
    [Graphical view]
    PfamiPF04146. YTH. 1 hit.
    [Graphical view]
    PROSITEiPS50882. YTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATSVDQRP KGQGNKVSVQ NGSIHQKDAV NDDDFEPYLS SQTNQSNSYP    50
    PMSDPYMPSY YAPSIGFPYS LGEAAWSTAG DQPMPYLTTY GQMSNGEHHY 100
    IPDGVFSQPG ALGNTPPFLG QHGFNFFPGN ADFSTWGTSG SQGQSTQSSA 150
    YSSSYGYPPS SLGRAITDGQ AGFGNDTLSK VPGISSIEQG MTGLKIGGDL 200
    TAAVTKTVGT ALSSSGMTSI ATNSVPPVSS AAPKPTSWAA IARKPAKPQP 250
    KLKPKGNVGI GGSAVPPPPI KHNMNIGTWD EKGSVVKAPP TQPVLPPQTI 300
    IQQPQPLIQP PPLVQSQLPQ QQPQPPQPQQ QQGPQPQAQP HQVQPQQQQL 350
    QNRWVAPRNR GAGFNQNNGA GSENFGLGVV PVSASPSSVE VHPVLEKLKA 400
    INNYNPKDFD WNLKNGRVFI IKSYSEDDIH RSIKYSIWCS TEHGNKRLDA 450
    AYRSLNGKGP LYLLFSVNGS GHFCGVAEMK SVVDYNAYAG VWSQDKWKGK 500
    FEVKWIFVKD VPNNQLRHIR LENNDNKPVT NSRDTQEVPL EKAKQVLKII 550
    ATFKHTTSIF DDFAHYEKRQ EEEEAMRRER NRNKQ 585
    Length:585
    Mass (Da):63,861
    Last modified:October 1, 2003 - v1
    Checksum:iC7021FE48DEA441E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391S → R in CAH56224. (PubMed:17974005)Curated
    Sequence conflicti381 – 3811P → S in CAH56224. (PubMed:17974005)Curated
    Sequence conflicti532 – 5321S → P in CAH56480. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127574 mRNA. Translation: BAG54526.1.
    AL832005 mRNA. Translation: CAH56224.1.
    BX537996 mRNA. Translation: CAH56480.1.
    CH471068 Genomic DNA. Translation: EAW86867.1.
    BC052970 mRNA. Translation: AAH52970.1.
    RefSeqiNP_001264742.1. NM_001277813.1.
    NP_001264743.1. NM_001277814.1.
    NP_001264744.1. NM_001277815.1.
    NP_001264745.1. NM_001277816.1.
    NP_001264746.1. NM_001277817.1.
    NP_001264747.1. NM_001277818.1.
    NP_689971.4. NM_152758.5.
    UniGeneiHs.491861.

    Genome annotation databases

    GeneIDi253943.
    KEGGihsa:253943.
    UCSCiuc003xuy.4. human.

    Polymorphism databases

    DMDMi74738853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127574 mRNA. Translation: BAG54526.1 .
    AL832005 mRNA. Translation: CAH56224.1 .
    BX537996 mRNA. Translation: CAH56480.1 .
    CH471068 Genomic DNA. Translation: EAW86867.1 .
    BC052970 mRNA. Translation: AAH52970.1 .
    RefSeqi NP_001264742.1. NM_001277813.1.
    NP_001264743.1. NM_001277814.1.
    NP_001264744.1. NM_001277815.1.
    NP_001264745.1. NM_001277816.1.
    NP_001264746.1. NM_001277817.1.
    NP_001264747.1. NM_001277818.1.
    NP_689971.4. NM_152758.5.
    UniGenei Hs.491861.

    3D structure databases

    ProteinModelPortali Q7Z739.
    SMRi Q7Z739. Positions 417-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128997. 9 interactions.
    IntActi Q7Z739. 3 interactions.
    MINTi MINT-5005374.
    STRINGi 9606.ENSP00000398476.

    PTM databases

    PhosphoSitei Q7Z739.

    Polymorphism databases

    DMDMi 74738853.

    Proteomic databases

    MaxQBi Q7Z739.
    PaxDbi Q7Z739.
    PRIDEi Q7Z739.

    Protocols and materials databases

    DNASUi 253943.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 253943.
    KEGGi hsa:253943.
    UCSCi uc003xuy.4. human.

    Organism-specific databases

    CTDi 253943.
    GeneCardsi GC08P064081.
    HGNCi HGNC:26465. YTHDF3.
    neXtProti NX_Q7Z739.
    PharmGKBi PA134976395.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276347.
    HOVERGENi HBG060315.
    InParanoidi Q7Z739.
    PhylomeDBi Q7Z739.

    Miscellaneous databases

    GeneWikii YTHDF3.
    GenomeRNAii 253943.
    NextBioi 92198.
    PMAP-CutDB Q7Z739.
    PROi Q7Z739.

    Gene expression databases

    CleanExi HS_YTHDF3.
    Genevestigatori Q7Z739.

    Family and domain databases

    InterProi IPR007275. YTH_domain.
    [Graphical view ]
    Pfami PF04146. YTH. 1 hit.
    [Graphical view ]
    PROSITEi PS50882. YTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle and Spinal cord.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 256-271; 408-414 AND 534-542, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: RNA-BINDING, FUNCTION.
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "N-methyladenosine-dependent regulation of messenger RNA stability."
      Wang X., Lu Z., Gomez A., Hon G.C., Yue Y., Han D., Fu Y., Parisien M., Dai Q., Jia G., Ren B., Pan T., He C.
      Nature 505:117-120(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA-BINDING, FUNCTION.

    Entry informationi

    Entry nameiYTHD3_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z739
    Secondary accession number(s): B3KXL4, Q63Z37, Q659A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3