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Q7Z739

- YTHD3_HUMAN

UniProt

Q7Z739 - YTHD3_HUMAN

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Protein
YTH domain-containing family protein 3
Gene
YTHDF3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.2 Publications

GO - Molecular functioni

  1. N6-methyladenosine-containing RNA binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: IntAct
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
YTH domain-containing family protein 3
Gene namesi
Name:YTHDF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:26465. YTHDF3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 585584YTH domain-containing family protein 3
PRO_0000230991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei23 – 231Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ7Z739.
PaxDbiQ7Z739.
PRIDEiQ7Z739.

PTM databases

PhosphoSiteiQ7Z739.

Miscellaneous databases

PMAP-CutDBQ7Z739.

Expressioni

Gene expression databases

CleanExiHS_YTHDF3.
GenevestigatoriQ7Z739.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gagP045912EBI-2849837,EBI-6179727From a different organism.

Protein-protein interaction databases

BioGridi128997. 9 interactions.
IntActiQ7Z739. 3 interactions.
MINTiMINT-5005374.
STRINGi9606.ENSP00000398476.

Structurei

3D structure databases

ProteinModelPortaliQ7Z739.
SMRiQ7Z739. Positions 417-549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini416 – 550135YTH
Add
BLAST

Sequence similaritiesi

Contains 1 YTH domain.

Phylogenomic databases

eggNOGiNOG276347.
HOVERGENiHBG060315.
InParanoidiQ7Z739.
PhylomeDBiQ7Z739.

Family and domain databases

InterProiIPR007275. YTH_domain.
[Graphical view]
PfamiPF04146. YTH. 1 hit.
[Graphical view]
PROSITEiPS50882. YTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z739-1 [UniParc]FASTAAdd to Basket

« Hide

MSATSVDQRP KGQGNKVSVQ NGSIHQKDAV NDDDFEPYLS SQTNQSNSYP    50
PMSDPYMPSY YAPSIGFPYS LGEAAWSTAG DQPMPYLTTY GQMSNGEHHY 100
IPDGVFSQPG ALGNTPPFLG QHGFNFFPGN ADFSTWGTSG SQGQSTQSSA 150
YSSSYGYPPS SLGRAITDGQ AGFGNDTLSK VPGISSIEQG MTGLKIGGDL 200
TAAVTKTVGT ALSSSGMTSI ATNSVPPVSS AAPKPTSWAA IARKPAKPQP 250
KLKPKGNVGI GGSAVPPPPI KHNMNIGTWD EKGSVVKAPP TQPVLPPQTI 300
IQQPQPLIQP PPLVQSQLPQ QQPQPPQPQQ QQGPQPQAQP HQVQPQQQQL 350
QNRWVAPRNR GAGFNQNNGA GSENFGLGVV PVSASPSSVE VHPVLEKLKA 400
INNYNPKDFD WNLKNGRVFI IKSYSEDDIH RSIKYSIWCS TEHGNKRLDA 450
AYRSLNGKGP LYLLFSVNGS GHFCGVAEMK SVVDYNAYAG VWSQDKWKGK 500
FEVKWIFVKD VPNNQLRHIR LENNDNKPVT NSRDTQEVPL EKAKQVLKII 550
ATFKHTTSIF DDFAHYEKRQ EEEEAMRRER NRNKQ 585
Length:585
Mass (Da):63,861
Last modified:October 1, 2003 - v1
Checksum:iC7021FE48DEA441E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391S → R in CAH56224. 1 Publication
Sequence conflicti381 – 3811P → S in CAH56224. 1 Publication
Sequence conflicti532 – 5321S → P in CAH56480. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127574 mRNA. Translation: BAG54526.1.
AL832005 mRNA. Translation: CAH56224.1.
BX537996 mRNA. Translation: CAH56480.1.
CH471068 Genomic DNA. Translation: EAW86867.1.
BC052970 mRNA. Translation: AAH52970.1.
RefSeqiNP_001264742.1. NM_001277813.1.
NP_001264743.1. NM_001277814.1.
NP_001264744.1. NM_001277815.1.
NP_001264745.1. NM_001277816.1.
NP_001264746.1. NM_001277817.1.
NP_001264747.1. NM_001277818.1.
NP_689971.4. NM_152758.5.
UniGeneiHs.491861.

Genome annotation databases

GeneIDi253943.
KEGGihsa:253943.
UCSCiuc003xuy.4. human.

Polymorphism databases

DMDMi74738853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127574 mRNA. Translation: BAG54526.1 .
AL832005 mRNA. Translation: CAH56224.1 .
BX537996 mRNA. Translation: CAH56480.1 .
CH471068 Genomic DNA. Translation: EAW86867.1 .
BC052970 mRNA. Translation: AAH52970.1 .
RefSeqi NP_001264742.1. NM_001277813.1.
NP_001264743.1. NM_001277814.1.
NP_001264744.1. NM_001277815.1.
NP_001264745.1. NM_001277816.1.
NP_001264746.1. NM_001277817.1.
NP_001264747.1. NM_001277818.1.
NP_689971.4. NM_152758.5.
UniGenei Hs.491861.

3D structure databases

ProteinModelPortali Q7Z739.
SMRi Q7Z739. Positions 417-549.
ModBasei Search...

Protein-protein interaction databases

BioGridi 128997. 9 interactions.
IntActi Q7Z739. 3 interactions.
MINTi MINT-5005374.
STRINGi 9606.ENSP00000398476.

PTM databases

PhosphoSitei Q7Z739.

Polymorphism databases

DMDMi 74738853.

Proteomic databases

MaxQBi Q7Z739.
PaxDbi Q7Z739.
PRIDEi Q7Z739.

Protocols and materials databases

DNASUi 253943.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 253943.
KEGGi hsa:253943.
UCSCi uc003xuy.4. human.

Organism-specific databases

CTDi 253943.
GeneCardsi GC08P064081.
HGNCi HGNC:26465. YTHDF3.
neXtProti NX_Q7Z739.
PharmGKBi PA134976395.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276347.
HOVERGENi HBG060315.
InParanoidi Q7Z739.
PhylomeDBi Q7Z739.

Miscellaneous databases

GeneWikii YTHDF3.
GenomeRNAii 253943.
NextBioi 92198.
PMAP-CutDB Q7Z739.
PROi Q7Z739.

Gene expression databases

CleanExi HS_YTHDF3.
Genevestigatori Q7Z739.

Family and domain databases

InterProi IPR007275. YTH_domain.
[Graphical view ]
Pfami PF04146. YTH. 1 hit.
[Graphical view ]
PROSITEi PS50882. YTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle and Spinal cord.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Bienvenut W.V., Vousden K.H., Lukashchuk N.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 256-271; 408-414 AND 534-542, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: RNA-BINDING, FUNCTION.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "N-methyladenosine-dependent regulation of messenger RNA stability."
    Wang X., Lu Z., Gomez A., Hon G.C., Yue Y., Han D., Fu Y., Parisien M., Dai Q., Jia G., Ren B., Pan T., He C.
    Nature 505:117-120(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING, FUNCTION.

Entry informationi

Entry nameiYTHD3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z739
Secondary accession number(s): B3KXL4, Q63Z37, Q659A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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