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Protein
Submitted name:

PRKCA protein

Gene

PRKCA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
PRKCA proteinImported
Gene namesi
Name:PRKCAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ7Z727.
PRIDEiQ7Z727.

Expressioni

Gene expression databases

BgeeiQ7Z727.
GenevisibleiQ7Z727. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000408695.

Chemistry

BindingDBiQ7Z727.

Structurei

3D structure databases

ProteinModelPortaliQ7Z727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 15851Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini173 – 22351Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini244 – 33289C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
HOVERGENiHBG108317.
KOiK02677.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q7Z727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASQRLRLPLP LRAAPARLSP APAAPPRRDL GHRPAPRARG RPEPAPLPRR
60 70 80 90 100
PRPPGPPRPQ LPGGGKRWLG GTMADVFPGN DSTASQDVAN RFARKGALRQ
110 120 130 140 150
KNVHEVKDHK FIARFFKQPT FCSHCTDFIW GFGKQGFQCQ VCCFVVHKRC
160 170 180 190 200
HEFVTFSCPG ADKGPDTDDP RSKHKFKIHT YGSPTFCDHC GSLLYGLIHQ
210 220 230 240 250
GMKCDTCDMN VHKQCVINVP SLCGMDHTEK RGRIYLKAEV ADEKLHVTVR
260 270 280 290 300
DAKNLIPMDP NGLSDPYVKL KLIPDPKNES KQKTKTIRST LNPQWNESFT
310 320 330 340 350
FKLKPSDKDR RLSVEIWDWD RTTRNDFMGS LSFGVSELMK MPASGWYKLL
360 370 380
NQEEGEYYNV PIPEGDEEGN MELRQKFEWR
Length:380
Mass (Da):43,185
Last modified:October 1, 2003 - v1
Checksum:iBDFBD8C8EC489604
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053321 mRNA. Translation: AAH53321.1.
RefSeqiNP_002728.1. NM_002737.2.
UniGeneiHs.531704.
Hs.708867.

Genome annotation databases

GeneIDi5578.
KEGGihsa:5578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053321 mRNA. Translation: AAH53321.1.
RefSeqiNP_002728.1. NM_002737.2.
UniGeneiHs.531704.
Hs.708867.

3D structure databases

ProteinModelPortaliQ7Z727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000408695.

Chemistry

BindingDBiQ7Z727.

Proteomic databases

PaxDbiQ7Z727.
PRIDEiQ7Z727.

Protocols and materials databases

DNASUi5578.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5578.
KEGGihsa:5578.

Organism-specific databases

CTDi5578.

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
HOVERGENiHBG108317.
KOiK02677.

Miscellaneous databases

ChiTaRSiPRKCA. human.
GenomeRNAii5578.
NextBioi21628.

Gene expression databases

BgeeiQ7Z727.
GenevisibleiQ7Z727. HS.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.

Entry informationi

Entry nameiQ7Z727_HUMAN
AccessioniPrimary (citable) accession number: Q7Z727
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: March 16, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.