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Protein

Importin subunit alpha

Gene

KPNA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport

Enzyme and pathway databases

SignaLinkiQ7Z726

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alphaUniRule annotation
Gene namesi
Name:KPNA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30186

PTM / Processingi

Proteomic databases

PeptideAtlasiQ7Z726
PRIDEiQ7Z726

Expressioni

Gene expression databases

GenevisibleiQ7Z726 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP50Q9UKX73EBI-10323362,EBI-2371082

Protein-protein interaction databases

IntActiQ7Z726, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ7Z726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60IBBInterPro annotationAdd BLAST60
Repeati119 – 162ARMPROSITE-ProRule annotationAdd BLAST44
Repeati162 – 190ARMPROSITE-ProRule annotationAdd BLAST29
Repeati251 – 293ARMPROSITE-ProRule annotationAdd BLAST43
Repeati293 – 335ARMPROSITE-ProRule annotationAdd BLAST43
Repeati335 – 377ARMPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 107Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the importin alpha family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
HOVERGENiHBG001846

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 8 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 5 hits
PS51214 IBB, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR
60 70 80 90 100
RNVSSFPDDA TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA
110 120 130 140 150
RKLLSREKQP PIDNIIRAGL IPKFVSFLGR TDCSPIQFES AWALTNIASG
160 170 180 190 200
TSEQTKAVVD GGAIPAFISL LASPHAHISE QAVWALGNIA GDGSVFRDLV
210 220 230 240 250
IKYGAVDPLL ALLAVPEMSS LACGYLRNLT WTLSNLCRNK NPAPPIDAVE
260 270 280 290 300
QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV KTGVVPQLVK
310 320 330 340 350
LLGASELPIV TPALRAIGNI VTGTDEQTQV VIDAGALAVF PSLLTNPKTN
360 370 380 390 400
IQKEATWTMS NITAGRQDQI QQVVNHGLVP FLVSVLSKAD FKTQKEAVWA
410 420 430 440 450
VTNYTSGGTV EQIVYLVHCG IIEPLMNLLT AKDTKIILVI LDAISNIFQA
460 470 480 490 500
AEKLGETEKL SIMIEECGGL DKIEALQNHE NESVYKASLS LIEKYFSVEE
510 520
EEDQNVVPET TSEGYTFQVQ DGAPGTFNF
Length:529
Mass (Da):57,876
Last modified:October 1, 2003 - v1
Checksum:i45490F04304DBEED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053343 mRNA Translation: AAH53343.1
UniGeneiHs.594238

Similar proteinsi

Entry informationi

Entry nameiQ7Z726_HUMAN
AccessioniPrimary (citable) accession number: Q7Z726
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health