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Protein

Importin subunit alpha

Gene

KPNA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport

Enzyme and pathway databases

SignaLinkiQ7Z726.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alphaUniRule annotation
Gene namesi
Name:KPNA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30186.

PTM / Processingi

Proteomic databases

PaxDbiQ7Z726.
PeptideAtlasiQ7Z726.
PRIDEiQ7Z726.

Expressioni

Gene expression databases

GenevisibleiQ7Z726. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP50Q9UKX73EBI-10323362,EBI-2371082

Protein-protein interaction databases

IntActiQ7Z726. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ7Z726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60IBBInterPro annotationAdd BLAST60
Repeati119 – 162ARMPROSITE-ProRule annotationAdd BLAST44
Repeati162 – 190ARMPROSITE-ProRule annotationAdd BLAST29
Repeati251 – 293ARMPROSITE-ProRule annotationAdd BLAST43
Repeati293 – 335ARMPROSITE-ProRule annotationAdd BLAST43
Repeati335 – 377ARMPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the importin alpha family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
HOVERGENiHBG001846.

Family and domain databases

Gene3Di1.20.5.690. 1 hit.
1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
PfamiView protein in Pfam
PF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiView protein in SMART
SM00185. ARM. 8 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 5 hits.
PS51214. IBB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR
60 70 80 90 100
RNVSSFPDDA TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA
110 120 130 140 150
RKLLSREKQP PIDNIIRAGL IPKFVSFLGR TDCSPIQFES AWALTNIASG
160 170 180 190 200
TSEQTKAVVD GGAIPAFISL LASPHAHISE QAVWALGNIA GDGSVFRDLV
210 220 230 240 250
IKYGAVDPLL ALLAVPEMSS LACGYLRNLT WTLSNLCRNK NPAPPIDAVE
260 270 280 290 300
QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV KTGVVPQLVK
310 320 330 340 350
LLGASELPIV TPALRAIGNI VTGTDEQTQV VIDAGALAVF PSLLTNPKTN
360 370 380 390 400
IQKEATWTMS NITAGRQDQI QQVVNHGLVP FLVSVLSKAD FKTQKEAVWA
410 420 430 440 450
VTNYTSGGTV EQIVYLVHCG IIEPLMNLLT AKDTKIILVI LDAISNIFQA
460 470 480 490 500
AEKLGETEKL SIMIEECGGL DKIEALQNHE NESVYKASLS LIEKYFSVEE
510 520
EEDQNVVPET TSEGYTFQVQ DGAPGTFNF
Length:529
Mass (Da):57,876
Last modified:October 1, 2003 - v1
Checksum:i45490F04304DBEED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053343 mRNA. Translation: AAH53343.1.
UniGeneiHs.594238.

Similar proteinsi

Entry informationi

Entry nameiQ7Z726_HUMAN
AccessioniPrimary (citable) accession number: Q7Z726
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.