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Protein

Ankyrin repeat domain-containing protein 37

Gene

ANKRD37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 37
Alternative name(s):
Low-density lipoprotein receptor-related protein 2-binding protein
Short name:
hLrp2bp
Gene namesi
Name:ANKRD37
Synonyms:LPR2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000186352.8.
HGNCiHGNC:29593. ANKRD37.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi353322.
OpenTargetsiENSG00000186352.
PharmGKBiPA142672604.

Polymorphism and mutation databases

BioMutaiANKRD37.
DMDMi74750211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443611 – 158Ankyrin repeat domain-containing protein 37Add BLAST158

Proteomic databases

PaxDbiQ7Z713.
PRIDEiQ7Z713.

PTM databases

iPTMnetiQ7Z713.
PhosphoSitePlusiQ7Z713.

Expressioni

Tissue specificityi

Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells.1 Publication

Gene expression databases

BgeeiENSG00000186352.
CleanExiHS_ANKRD37.
ExpressionAtlasiQ7Z713. baseline and differential.
GenevisibleiQ7Z713. HS.

Organism-specific databases

HPAiHPA036626.
HPA058127.

Interactioni

Protein-protein interaction databases

IntActiQ7Z713. 1 interactor.
STRINGi9606.ENSP00000335147.

Structurei

3D structure databases

ProteinModelPortaliQ7Z713.
SMRiQ7Z713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 25ANK 1Add BLAST25
Repeati30 – 59ANK 2Add BLAST30
Repeati63 – 92ANK 3Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063667.
HOVERGENiHBG080851.
InParanoidiQ7Z713.
OMAiCAKFLTT.
OrthoDBiEOG091G0SY6.
PhylomeDBiQ7Z713.
TreeFamiTF338463.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 3 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ
60 70 80 90 100
LQTGADLNQQ DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA
110 120 130 140 150
EDLAWSCGFP DCAKFLTTIK CMQTIKASEH PDRNDCVAVL RQKRSLGSVE

NTSGKRKC
Length:158
Mass (Da):16,872
Last modified:October 1, 2003 - v1
Checksum:iBD5DEB2D8C2E3D67
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048279152T → S. Corresponds to variant dbSNP:rs4317244Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296056 mRNA. Translation: AAP50252.1.
BC088376 mRNA. Translation: AAH88376.1.
CCDSiCCDS3841.1.
RefSeqiNP_859077.1. NM_181726.3.
UniGeneiHs.508154.

Genome annotation databases

EnsembliENST00000335174; ENSP00000335147; ENSG00000186352.
GeneIDi353322.
KEGGihsa:353322.
UCSCiuc003ixm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANR37_HUMAN
AccessioniPrimary (citable) accession number: Q7Z713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations