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Q7Z713 (ANR37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 37
Alternative name(s):
Low-density lipoprotein receptor-related protein 2-binding protein
Short name=hLrp2bp
Gene names
Name:ANKRD37
Synonyms:LPR2BP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus. Cytoplasm Ref.1.

Tissue specificity

Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells. Ref.1

Sequence similarities

Contains 3 ANK repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 158158Ankyrin repeat domain-containing protein 37
PRO_0000244361

Regions

Repeat1 – 2525ANK 1
Repeat30 – 5930ANK 2
Repeat63 – 9230ANK 3

Natural variations

Natural variant1521T → S.
Corresponds to variant rs4317244 [ dbSNP | Ensembl ].
VAR_048279

Sequences

Sequence LengthMass (Da)Tools
Q7Z713 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: BD5DEB2D8C2E3D67

FASTA15816,872
        10         20         30         40         50         60 
MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ LQTGADLNQQ 

        70         80         90        100        110        120 
DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA EDLAWSCGFP DCAKFLTTIK 

       130        140        150 
CMQTIKASEH PDRNDCVAVL RQKRSLGSVE NTSGKRKC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains."
Li J., Ji C., Zheng H., Fei X., Zheng M., Dai J., Gu S., Xie Y., Mao Y.
Cell. Mol. Biol. Lett. 10:185-193(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY296056 mRNA. Translation: AAP50252.1.
BC088376 mRNA. Translation: AAH88376.1.
RefSeqNP_859077.1. NM_181726.2.
UniGeneHs.508154.

3D structure databases

ProteinModelPortalQ7Z713.
SMRQ7Z713. Positions 1-152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131683. 2 interactions.
STRING9606.ENSP00000335147.

PTM databases

PhosphoSiteQ7Z713.

Polymorphism databases

DMDM74750211.

Proteomic databases

PaxDbQ7Z713.
PRIDEQ7Z713.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335174; ENSP00000335147; ENSG00000186352.
GeneID353322.
KEGGhsa:353322.
UCSCuc003ixm.3. human.

Organism-specific databases

CTD353322.
GeneCardsGC04P186317.
HGNCHGNC:29593. ANKRD37.
HPAHPA036626.
neXtProtNX_Q7Z713.
PharmGKBPA142672604.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG326407.
HOVERGENHBG080851.
InParanoidQ7Z713.
OMALTTIKCM.
PhylomeDBQ7Z713.
TreeFamTF338463.

Gene expression databases

ArrayExpressQ7Z713.
BgeeQ7Z713.
CleanExHS_ANKRD37.
GenevestigatorQ7Z713.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSANKRD37. human.
GenomeRNAi353322.
NextBio99772.
PROQ7Z713.

Entry information

Entry nameANR37_HUMAN
AccessionPrimary (citable) accession number: Q7Z713
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: March 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM