Q7Z713 (ANR37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 37

Alternative name(s):
Low-density lipoprotein receptor-related protein 2-binding protein
Short name=hLrp2bp

Gene names

Name:	ANKRD37
Synonyms:	LPR2BP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus. Cytoplasm Ref.1.
Tissue specificity	Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells. Ref.1
Sequence similarities	Contains 3 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Ankyrin repeat domain-containing protein 37		PRO_0000244361
Regions
	Repeat	1 – 25	25	ANK 1
	Repeat	30 – 59	30	ANK 2
	Repeat	63 – 92	30	ANK 3
Natural variations
	Natural variant	152	1	T → S. Corresponds to variant rs4317244 [ dbSNP | Ensembl ].		VAR_048279

Sequences

	Sequence		Length	Mass (Da)
	Q7Z713 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: BD5DEB2D8C2E3D67	FASTA	158	16,872
	10 20 30 40 50 60 MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ LQTGADLNQQ 70 80 90 100 110 120 DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA EDLAWSCGFP DCAKFLTTIK 130 140 150 CMQTIKASEH PDRNDCVAVL RQKRSLGSVE NTSGKRKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains." Li J., Ji C., Zheng H., Fei X., Zheng M., Dai J., Gu S., Xie Y., Mao Y. Cell. Mol. Biol. Lett. 10:185-193(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY296056 mRNA. Translation: AAP50252.1. BC088376 mRNA. Translation: AAH88376.1.
IPI	IPI00376353.
RefSeq	NP_859077.1. NM_181726.2.
UniGene	Hs.508154.
3D structure databases
ProteinModelPortal	Q7Z713.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335147.
PTM databases
PhosphoSite	Q7Z713.
Polymorphism databases
DMDM	74750211.
Proteomic databases
PaxDb	Q7Z713.
PRIDE	Q7Z713.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335174; ENSP00000335147; ENSG00000186352.
GeneID	353322.
KEGG	hsa:353322.
UCSC	uc003ixm.3. human.
Organism-specific databases
CTD	353322.
GeneCards	GC04P186317.
HGNC	HGNC:29593. ANKRD37.
HPA	HPA036626.
neXtProt	NX_Q7Z713.
PharmGKB	PA142672604.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG326407.
HOVERGEN	HBG080851.
InParanoid	Q7Z713.
OMA	LTTIKCM.
PhylomeDB	Q7Z713.
Gene expression databases
ArrayExpress	Q7Z713.
Bgee	Q7Z713.
CleanEx	HS_ANKRD37.
Genevestigator	Q7Z713.
GermOnline	ENSG00000186352. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANKRD37. human.
GenomeRNAi	353322.
NextBio	99772.

Entry information

Entry name

ANR37_HUMAN

Accession

Primary (citable) accession number: Q7Z713

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.