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Q7Z713

- ANR37_HUMAN

UniProt

Q7Z713 - ANR37_HUMAN

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Protein

Ankyrin repeat domain-containing protein 37

Gene

ANKRD37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 37
Alternative name(s):
Low-density lipoprotein receptor-related protein 2-binding protein
Short name:
hLrp2bp
Gene namesi
Name:ANKRD37
Synonyms:LPR2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:29593. ANKRD37.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Ankyrin repeat domain-containing protein 37PRO_0000244361Add
BLAST

Proteomic databases

PaxDbiQ7Z713.
PRIDEiQ7Z713.

PTM databases

PhosphoSiteiQ7Z713.

Expressioni

Tissue specificityi

Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells.1 Publication

Gene expression databases

BgeeiQ7Z713.
CleanExiHS_ANKRD37.
ExpressionAtlasiQ7Z713. baseline and differential.
GenevestigatoriQ7Z713.

Organism-specific databases

HPAiHPA036626.

Interactioni

Protein-protein interaction databases

BioGridi131683. 2 interactions.
STRINGi9606.ENSP00000335147.

Structurei

3D structure databases

ProteinModelPortaliQ7Z713.
SMRiQ7Z713. Positions 1-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 2525ANK 1Add
BLAST
Repeati30 – 5930ANK 2Add
BLAST
Repeati63 – 9230ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG326407.
GeneTreeiENSGT00530000063667.
HOVERGENiHBG080851.
InParanoidiQ7Z713.
OMAiMLLLDCN.
PhylomeDBiQ7Z713.
TreeFamiTF338463.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z713-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ
60 70 80 90 100
LQTGADLNQQ DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA
110 120 130 140 150
EDLAWSCGFP DCAKFLTTIK CMQTIKASEH PDRNDCVAVL RQKRSLGSVE

NTSGKRKC
Length:158
Mass (Da):16,872
Last modified:October 1, 2003 - v1
Checksum:iBD5DEB2D8C2E3D67
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521T → S.
Corresponds to variant rs4317244 [ dbSNP | Ensembl ].
VAR_048279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296056 mRNA. Translation: AAP50252.1.
BC088376 mRNA. Translation: AAH88376.1.
CCDSiCCDS3841.1.
RefSeqiNP_859077.1. NM_181726.2.
UniGeneiHs.508154.

Genome annotation databases

EnsembliENST00000335174; ENSP00000335147; ENSG00000186352.
GeneIDi353322.
KEGGihsa:353322.
UCSCiuc003ixm.3. human.

Polymorphism databases

DMDMi74750211.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296056 mRNA. Translation: AAP50252.1 .
BC088376 mRNA. Translation: AAH88376.1 .
CCDSi CCDS3841.1.
RefSeqi NP_859077.1. NM_181726.2.
UniGenei Hs.508154.

3D structure databases

ProteinModelPortali Q7Z713.
SMRi Q7Z713. Positions 1-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131683. 2 interactions.
STRINGi 9606.ENSP00000335147.

PTM databases

PhosphoSitei Q7Z713.

Polymorphism databases

DMDMi 74750211.

Proteomic databases

PaxDbi Q7Z713.
PRIDEi Q7Z713.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335174 ; ENSP00000335147 ; ENSG00000186352 .
GeneIDi 353322.
KEGGi hsa:353322.
UCSCi uc003ixm.3. human.

Organism-specific databases

CTDi 353322.
GeneCardsi GC04P186317.
HGNCi HGNC:29593. ANKRD37.
HPAi HPA036626.
neXtProti NX_Q7Z713.
PharmGKBi PA142672604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326407.
GeneTreei ENSGT00530000063667.
HOVERGENi HBG080851.
InParanoidi Q7Z713.
OMAi MLLLDCN.
PhylomeDBi Q7Z713.
TreeFami TF338463.

Miscellaneous databases

ChiTaRSi ANKRD37. human.
GenomeRNAii 353322.
NextBioi 99772.
PROi Q7Z713.

Gene expression databases

Bgeei Q7Z713.
CleanExi HS_ANKRD37.
ExpressionAtlasi Q7Z713. baseline and differential.
Genevestigatori Q7Z713.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains."
    Li J., Ji C., Zheng H., Fei X., Zheng M., Dai J., Gu S., Xie Y., Mao Y.
    Cell. Mol. Biol. Lett. 10:185-193(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiANR37_HUMAN
AccessioniPrimary (citable) accession number: Q7Z713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3