Reviewed, UniProtKB/Swiss-Prot Q7Z713 (ANR37_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 37
Alternative name(s):
    Low-density lipoprotein receptor-related protein 2-binding protein
      Short name=hLrp2bp

Gene names

Name:	ANKRD37
Synonyms:	LPR2BP

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus. Cytoplasm.
Tissue specificity	Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells. Ref.1
Sequence similarities	Contains 3 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Ankyrin repeat domain-containing protein 37		PRO_0000244361
Regions
	Repeat	1 – 25	25	ANK 1
	Repeat	30 – 59	30	ANK 2
	Repeat	63 – 92	30	ANK 3
Natural variations
	Natural variant	152	1	T → S: dbSNP rs4317244.		VAR_048279

Sequences

	Sequence		Length	Mass (Da)
	Q7Z713-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: BD5DEB2D8C2E3D67	FASTA	158	16,872
	10 20 30 40 50 60 MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ LQTGADLNQQ 70 80 90 100 110 120 DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA EDLAWSCGFP DCAKFLTTIK 130 140 150 CMQTIKASEH PDRNDCVAVL RQKRSLGSVE NTSGKRKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains." Li J., Ji C., Zheng H., Fei X., Zheng M., Dai J., Gu S., Xie Y., Mao Y. Cell. Mol. Biol. Lett. 10:185-193(2005) [PubMed: 15809689] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY296056 mRNA. Translation: AAP50252.1. BC088376 mRNA. Translation: AAH88376.1.
IPI	IPI00376353.
RefSeq	NP_859077.1.
UniGene	Hs.508154
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q7Z713.
Genome annotation databases
Ensembl	ENST00000335174; ENSP00000335147; ENSG00000186352; Homo sapiens. [Genome view]
GeneID	353322.
KEGG	hsa:353322.
UCSC	uc003ixm.1. human.
Organism-specific databases
CTD	353322.
GeneCards	GC04P186554.
HGNC	HGNC:29593. ANKRD37.
PharmGKB	PA142672604.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q7Z713.
HOVERGEN	Q7Z713.
OMA	DCNPEVD
OrthoDB	EOG93XXP5
Gene expression databases
ArrayExpress	Q7Z713.
Bgee	Q7Z713.
CleanEx	HS_ANKRD37.
Genevestigator	Q7Z713.
GermOnline	ENSG00000186352. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 3 hits. [Graphical view]
SMART	SM00248. ANK. 3 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	99772.

Entry information

Entry name

ANR37_HUMAN

Accession

Primary (citable) accession number: Q7Z713

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2003
Last modified:	November 24, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.