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Q7Z713

- ANR37_HUMAN

UniProt

Q7Z713 - ANR37_HUMAN

Protein

Ankyrin repeat domain-containing protein 37

Gene

ANKRD37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 37
    Alternative name(s):
    Low-density lipoprotein receptor-related protein 2-binding protein
    Short name:
    hLrp2bp
    Gene namesi
    Name:ANKRD37
    Synonyms:LPR2BP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:29593. ANKRD37.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 158158Ankyrin repeat domain-containing protein 37PRO_0000244361Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z713.
    PRIDEiQ7Z713.

    PTM databases

    PhosphoSiteiQ7Z713.

    Expressioni

    Tissue specificityi

    Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z713.
    BgeeiQ7Z713.
    CleanExiHS_ANKRD37.
    GenevestigatoriQ7Z713.

    Organism-specific databases

    HPAiHPA036626.

    Interactioni

    Protein-protein interaction databases

    BioGridi131683. 2 interactions.
    STRINGi9606.ENSP00000335147.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z713.
    SMRiQ7Z713. Positions 1-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 2525ANK 1Add
    BLAST
    Repeati30 – 5930ANK 2Add
    BLAST
    Repeati63 – 9230ANK 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG326407.
    HOVERGENiHBG080851.
    InParanoidiQ7Z713.
    OMAiMLLLDCN.
    PhylomeDBiQ7Z713.
    TreeFamiTF338463.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z713-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ    50
    LQTGADLNQQ DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA 100
    EDLAWSCGFP DCAKFLTTIK CMQTIKASEH PDRNDCVAVL RQKRSLGSVE 150
    NTSGKRKC 158
    Length:158
    Mass (Da):16,872
    Last modified:October 1, 2003 - v1
    Checksum:iBD5DEB2D8C2E3D67
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521T → S.
    Corresponds to variant rs4317244 [ dbSNP | Ensembl ].
    VAR_048279

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY296056 mRNA. Translation: AAP50252.1.
    BC088376 mRNA. Translation: AAH88376.1.
    CCDSiCCDS3841.1.
    RefSeqiNP_859077.1. NM_181726.2.
    UniGeneiHs.508154.

    Genome annotation databases

    EnsembliENST00000335174; ENSP00000335147; ENSG00000186352.
    GeneIDi353322.
    KEGGihsa:353322.
    UCSCiuc003ixm.3. human.

    Polymorphism databases

    DMDMi74750211.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY296056 mRNA. Translation: AAP50252.1 .
    BC088376 mRNA. Translation: AAH88376.1 .
    CCDSi CCDS3841.1.
    RefSeqi NP_859077.1. NM_181726.2.
    UniGenei Hs.508154.

    3D structure databases

    ProteinModelPortali Q7Z713.
    SMRi Q7Z713. Positions 1-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131683. 2 interactions.
    STRINGi 9606.ENSP00000335147.

    PTM databases

    PhosphoSitei Q7Z713.

    Polymorphism databases

    DMDMi 74750211.

    Proteomic databases

    PaxDbi Q7Z713.
    PRIDEi Q7Z713.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335174 ; ENSP00000335147 ; ENSG00000186352 .
    GeneIDi 353322.
    KEGGi hsa:353322.
    UCSCi uc003ixm.3. human.

    Organism-specific databases

    CTDi 353322.
    GeneCardsi GC04P186317.
    HGNCi HGNC:29593. ANKRD37.
    HPAi HPA036626.
    neXtProti NX_Q7Z713.
    PharmGKBi PA142672604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326407.
    HOVERGENi HBG080851.
    InParanoidi Q7Z713.
    OMAi MLLLDCN.
    PhylomeDBi Q7Z713.
    TreeFami TF338463.

    Miscellaneous databases

    ChiTaRSi ANKRD37. human.
    GenomeRNAii 353322.
    NextBioi 99772.
    PROi Q7Z713.

    Gene expression databases

    ArrayExpressi Q7Z713.
    Bgeei Q7Z713.
    CleanExi HS_ANKRD37.
    Genevestigatori Q7Z713.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains."
      Li J., Ji C., Zheng H., Fei X., Zheng M., Dai J., Gu S., Xie Y., Mao Y.
      Cell. Mol. Biol. Lett. 10:185-193(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiANR37_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z713
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3