Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z6Z6

- PLPL5_HUMAN

UniProt

Q7Z6Z6 - PLPL5_HUMAN

Protein

Patatin-like phospholipase domain-containing protein 5

Gene

PNPLA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Lipid hydrolase.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491By similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Patatin-like phospholipase domain-containing protein 5 (EC:3.1.1.-)
    Alternative name(s):
    GS2-like protein
    Gene namesi
    Name:PNPLA5
    Synonyms:GS2L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:24888. PNPLA5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869344.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Patatin-like phospholipase domain-containing protein 5PRO_0000292021Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z6Z6.
    PRIDEiQ7Z6Z6.

    Expressioni

    Tissue specificityi

    Expressed in brain and pituitary gland.1 Publication

    Developmental stagei

    No differential expression during adipocyte differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z6Z6.
    BgeeiQ7Z6Z6.
    CleanExiHS_PNPLA5.
    GenevestigatoriQ7Z6Z6.

    Organism-specific databases

    HPAiHPA050409.
    HPA054211.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000216177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z6Z6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 181170PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi47 – 515GXSXG

    Sequence similaritiesi

    Contains 1 patatin domain.Curated

    Phylogenomic databases

    eggNOGiNOG261571.
    HOGENOMiHOG000007467.
    HOVERGENiHBG007046.
    InParanoidiQ7Z6Z6.
    KOiK16814.
    OMAiCPSTITV.
    OrthoDBiEOG7J9VQR.
    PhylomeDBiQ7Z6Z6.
    TreeFamiTF314272.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view]
    PfamiPF01734. Patatin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z6Z6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFLEEEGRW NLSFSGAGYL GAHHVGATEC LRQRAPRLLQ GARRIYGSSS    50
    GALNAVSIVC GKSVDFCCSH LLGMVGQLER LSLSILHPAY APIEHVKQQL 100
    QDALPPDAHV LASQRLGISL TRWPDGRNFL VTDFATCDEL IQALVCTLYF 150
    PFYCGLIPPE FRGERYIDGA LSNNLPFADC PSTITVSPFH GTVDICPQST 200
    SPNLHELNVF NFSFQISTEN FFLGLICLIP PSLEVVADNC RQGYLDALRF 250
    LERRGLTKEP VLWTLVSKEP PAPADGNWDA GCDQRWKGGL SLNWKVPHVQ 300
    VKDVPNFEQL SPELEAALKK ACTRDPSRWA RFWHSGPGQV LTYLLLPCTL 350
    PFEYIYFRSR RLVVWLPDVP ADLWWMQGLL RNMALEVFSR TKAQLLGPIS 400
    PPATRVLETS PLQPQIAPHR EELGPTHQA 429
    Length:429
    Mass (Da):47,912
    Last modified:October 1, 2003 - v1
    Checksum:i6278FA8C7968BBC3
    GO
    Isoform 2 (identifier: Q7Z6Z6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         66-179: Missing.

    Show »
    Length:315
    Mass (Da):35,168
    Checksum:i76376B449E5178DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti319 – 3191K → E in BAC86866. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401L → F.
    Corresponds to variant rs2071883 [ dbSNP | Ensembl ].
    VAR_032932
    Natural varianti200 – 2001T → I.
    Corresponds to variant rs10428037 [ dbSNP | Ensembl ].
    VAR_032933
    Natural varianti286 – 2861W → R.1 Publication
    Corresponds to variant rs739231 [ dbSNP | Ensembl ].
    VAR_032934

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei66 – 179114Missing in isoform 2. 1 PublicationVSP_026373Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056648 mRNA. Translation: BAG51773.1.
    AK127172 mRNA. Translation: BAC86866.1.
    Z97055 Genomic DNA. Translation: CAB09789.1.
    Z97055 Genomic DNA. Translation: CAQ09929.1.
    CH471138 Genomic DNA. Translation: EAW73321.1.
    BC031820 mRNA. Translation: AAH31820.1.
    BC104839 mRNA. Translation: AAI04840.1.
    BC104843 mRNA. Translation: AAI04844.1.
    CCDSiCCDS14053.1. [Q7Z6Z6-1]
    CCDS54537.1. [Q7Z6Z6-2]
    RefSeqiNP_001171146.1. NM_001177675.1. [Q7Z6Z6-2]
    NP_620169.1. NM_138814.3. [Q7Z6Z6-1]
    UniGeneiHs.248086.

    Genome annotation databases

    EnsembliENST00000216177; ENSP00000216177; ENSG00000100341. [Q7Z6Z6-1]
    ENST00000381198; ENSP00000370595; ENSG00000100341. [Q7Z6Z6-2]
    ENST00000593866; ENSP00000471795; ENSG00000100341. [Q7Z6Z6-2]
    ENST00000597664; ENSP00000471069; ENSG00000100341. [Q7Z6Z6-1]
    GeneIDi150379.
    KEGGihsa:150379.
    UCSCiuc003beg.3. human. [Q7Z6Z6-1]
    uc003beh.3. human. [Q7Z6Z6-2]

    Polymorphism databases

    DMDMi74762442.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056648 mRNA. Translation: BAG51773.1 .
    AK127172 mRNA. Translation: BAC86866.1 .
    Z97055 Genomic DNA. Translation: CAB09789.1 .
    Z97055 Genomic DNA. Translation: CAQ09929.1 .
    CH471138 Genomic DNA. Translation: EAW73321.1 .
    BC031820 mRNA. Translation: AAH31820.1 .
    BC104839 mRNA. Translation: AAI04840.1 .
    BC104843 mRNA. Translation: AAI04844.1 .
    CCDSi CCDS14053.1. [Q7Z6Z6-1 ]
    CCDS54537.1. [Q7Z6Z6-2 ]
    RefSeqi NP_001171146.1. NM_001177675.1. [Q7Z6Z6-2 ]
    NP_620169.1. NM_138814.3. [Q7Z6Z6-1 ]
    UniGenei Hs.248086.

    3D structure databases

    ProteinModelPortali Q7Z6Z6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000216177.

    Polymorphism databases

    DMDMi 74762442.

    Proteomic databases

    PaxDbi Q7Z6Z6.
    PRIDEi Q7Z6Z6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216177 ; ENSP00000216177 ; ENSG00000100341 . [Q7Z6Z6-1 ]
    ENST00000381198 ; ENSP00000370595 ; ENSG00000100341 . [Q7Z6Z6-2 ]
    ENST00000593866 ; ENSP00000471795 ; ENSG00000100341 . [Q7Z6Z6-2 ]
    ENST00000597664 ; ENSP00000471069 ; ENSG00000100341 . [Q7Z6Z6-1 ]
    GeneIDi 150379.
    KEGGi hsa:150379.
    UCSCi uc003beg.3. human. [Q7Z6Z6-1 ]
    uc003beh.3. human. [Q7Z6Z6-2 ]

    Organism-specific databases

    CTDi 150379.
    GeneCardsi GC22M044275.
    HGNCi HGNC:24888. PNPLA5.
    HPAi HPA050409.
    HPA054211.
    MIMi 611589. gene.
    neXtProti NX_Q7Z6Z6.
    PharmGKBi PA134869344.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261571.
    HOGENOMi HOG000007467.
    HOVERGENi HBG007046.
    InParanoidi Q7Z6Z6.
    KOi K16814.
    OMAi CPSTITV.
    OrthoDBi EOG7J9VQR.
    PhylomeDBi Q7Z6Z6.
    TreeFami TF314272.

    Miscellaneous databases

    GenomeRNAii 150379.
    NextBioi 86433.
    PROi Q7Z6Z6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z6Z6.
    Bgeei Q7Z6Z6.
    CleanExi HS_PNPLA5.
    Genevestigatori Q7Z6Z6.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view ]
    Pfami PF01734. Patatin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-286.
      Tissue: Brain and Caudate nucleus.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Skin.
    5. "Characterization of the human patatin-like phospholipase family."
      Wilson P.A., Gardner S.D., Lambie N.M., Commans S.A., Crowther D.J.
      J. Lipid Res. 47:1940-1949(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPLPL5_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z6Z6
    Secondary accession number(s): B1AHL8, B3KPR1, Q6ZST0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3