Q7Z6Z6 (PLPL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Patatin-like phospholipase domain-containing protein 5
EC=3.1.1.-

Alternative name(s):
GS2-like protein

Gene names

Name:	PNPLA5
Synonyms:	GS2L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lipid hydrolase By similarity.
Tissue specificity	Expressed in brain and pituitary gland. Ref.5
Developmental stage	No differential expression during adipocyte differentiation. Ref.5
Sequence similarities	Contains 1 patatin domain.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6Z6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6Z6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     66-179: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Patatin-like phospholipase domain-containing protein 5		PRO_0000292021
Regions
	Domain	12 – 181	170	Patatin
	Motif	47 – 51	5	GXSXG
Sites
	Active site	49	1	By similarity
Natural variations
	Alternative sequence	66 – 179	114	Missing in isoform 2.		VSP_026373
	Natural variant	140	1	L → F. Corresponds to variant rs2071883 [ dbSNP | Ensembl ].		VAR_032932
	Natural variant	200	1	T → I. Corresponds to variant rs10428037 [ dbSNP | Ensembl ].		VAR_032933
	Natural variant	286	1	W → R. Ref.1 Corresponds to variant rs739231 [ dbSNP | Ensembl ].		VAR_032934
Experimental info
	Sequence conflict	319	1	K → E in BAC86866. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 6278FA8C7968BBC3	FASTA	429	47,912
	10 20 30 40 50 60 MGFLEEEGRW NLSFSGAGYL GAHHVGATEC LRQRAPRLLQ GARRIYGSSS GALNAVSIVC 70 80 90 100 110 120 GKSVDFCCSH LLGMVGQLER LSLSILHPAY APIEHVKQQL QDALPPDAHV LASQRLGISL 130 140 150 160 170 180 TRWPDGRNFL VTDFATCDEL IQALVCTLYF PFYCGLIPPE FRGERYIDGA LSNNLPFADC 190 200 210 220 230 240 PSTITVSPFH GTVDICPQST SPNLHELNVF NFSFQISTEN FFLGLICLIP PSLEVVADNC 250 260 270 280 290 300 RQGYLDALRF LERRGLTKEP VLWTLVSKEP PAPADGNWDA GCDQRWKGGL SLNWKVPHVQ 310 320 330 340 350 360 VKDVPNFEQL SPELEAALKK ACTRDPSRWA RFWHSGPGQV LTYLLLPCTL PFEYIYFRSR 370 380 390 400 410 420 RLVVWLPDVP ADLWWMQGLL RNMALEVFSR TKAQLLGPIS PPATRVLETS PLQPQIAPHR EELGPTHQA
	Isoform 2 [UniParc]. Checksum: 76376B449E5178DF	FASTA	315	35,168
	10 20 30 40 50 60 MGFLEEEGRW NLSFSGAGYL GAHHVGATEC LRQRAPRLLQ GARRIYGSSS GALNAVSIVC 70 80 90 100 110 120 GKSVDCPSTI TVSPFHGTVD ICPQSTSPNL HELNVFNFSF QISTENFFLG LICLIPPSLE 130 140 150 160 170 180 VVADNCRQGY LDALRFLERR GLTKEPVLWT LVSKEPPAPA DGNWDAGCDQ RWKGGLSLNW 190 200 210 220 230 240 KVPHVQVKDV PNFEQLSPEL EAALKKACTR DPSRWARFWH SGPGQVLTYL LLPCTLPFEY 250 260 270 280 290 300 IYFRSRRLVV WLPDVPADLW WMQGLLRNMA LEVFSRTKAQ LLGPISPPAT RVLETSPLQP 310 QIAPHREELG PTHQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-286. Tissue: Brain and Caudate nucleus.
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Skin.
[5]	"Characterization of the human patatin-like phospholipase family." Wilson P.A., Gardner S.D., Lambie N.M., Commans S.A., Crowther D.J. J. Lipid Res. 47:1940-1949(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056648 mRNA. Translation: BAG51773.1. AK127172 mRNA. Translation: BAC86866.1. Z97055 Genomic DNA. Translation: CAB09789.1. Z97055 Genomic DNA. Translation: CAQ09929.1. CH471138 Genomic DNA. Translation: EAW73321.1. BC031820 mRNA. Translation: AAH31820.1. BC104839 mRNA. Translation: AAI04840.1. BC104843 mRNA. Translation: AAI04844.1.
IPI	IPI00006356. IPI00444698.
RefSeq	NP_001171146.1. NM_001177675.1. NP_620169.1. NM_138814.3.
UniGene	Hs.248086.
3D structure databases
ProteinModelPortal	Q7Z6Z6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000216177.
Polymorphism databases
DMDM	74762442.
Proteomic databases
PaxDb	Q7Z6Z6.
PRIDE	Q7Z6Z6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216177; ENSP00000216177; ENSG00000100341. ENST00000381198; ENSP00000370595; ENSG00000100341. ENST00000593866; ENSP00000471795; ENSG00000100341. ENST00000597664; ENSP00000471069; ENSG00000100341.
GeneID	150379.
KEGG	hsa:150379.
UCSC	uc003beg.3. human. uc003beh.3. human.
Organism-specific databases
CTD	150379.
GeneCards	GC22M044275.
HGNC	HGNC:24888. PNPLA5.
HPA	HPA050409. HPA054211.
MIM	611589. gene.
neXtProt	NX_Q7Z6Z6.
PharmGKB	PA134869344.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261571.
HOGENOM	HOG000007467.
HOVERGEN	HBG007046.
InParanoid	Q7Z6Z6.
KO	K16814.
OMA	EVVADNC.
OrthoDB	EOG4DNF4C.
PhylomeDB	Q7Z6Z6.
Gene expression databases
ArrayExpress	Q7Z6Z6.
Bgee	Q7Z6Z6.
CleanEx	HS_PNPLA5.
Genevestigator	Q7Z6Z6.
Family and domain databases
InterPro	IPR016035. Acyl_Trfase/lysoPLipase. IPR002641. Patatin/PLipase_A2-rel. [Graphical view]
Pfam	PF01734. Patatin. 1 hit. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	150379.
NextBio	86433.
SOURCE	Search...

Entry information

Entry name

PLPL5_HUMAN

Accession

Primary (citable) accession number: Q7Z6Z6
Secondary accession number(s): B1AHL8, B3KPR1, Q6ZST0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.