ID   DNJB7_HUMAN             Reviewed;         309 AA.
AC   Q7Z6W7; Q2M220; Q5H904; Q8WYJ7;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   25-JAN-2012, entry version 68.
DE   RecName: Full=DnaJ homolog subfamily B member 7;
GN   Name=DNAJB7; Synonyms=HSC3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Xing Y., Yu L., Fu Q., Zhao Y., Bi A., Zhao S.;
RT   "Cloning a novel human gene, HSC3, which shows significant homology to
RT   murine MRJ.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=20057165; PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably acts as a co-chaperone (By similarity).
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AF085232; AAL40391.1; -; mRNA.
DR   EMBL; CR456468; CAG30354.1; -; mRNA.
DR   EMBL; Z98048; CAI20493.1; -; Genomic_DNA.
DR   EMBL; BC112135; AAI12136.1; -; mRNA.
DR   IPI; IPI00103726; -.
DR   RefSeq; NP_660157.1; NM_145174.1.
DR   UniGene; Hs.585042; -.
DR   ProteinModelPortal; Q7Z6W7; -.
DR   SMR; Q7Z6W7; 1-70.
DR   STRING; Q7Z6W7; -.
DR   PhosphoSite; Q7Z6W7; -.
DR   DMDM; 44887848; -.
DR   PRIDE; Q7Z6W7; -.
DR   Ensembl; ENST00000307221; ENSP00000307197; ENSG00000172404.
DR   GeneID; 150353; -.
DR   KEGG; hsa:150353; -.
DR   UCSC; uc003azj.1; human.
DR   CTD; 150353; -.
DR   GeneCards; GC22M041255; -.
DR   H-InvDB; HIX0203199; -.
DR   HGNC; HGNC:24986; DNAJB7.
DR   HPA; HPA000534; -.
DR   MIM; 611336; gene.
DR   neXtProt; NX_Q7Z6W7; -.
DR   PharmGKB; PA134961522; -.
DR   eggNOG; prNOG15836; -.
DR   GeneTree; ENSGT00600000084029; -.
DR   HOGENOM; HBG716471; -.
DR   HOVERGEN; HBG066998; -.
DR   InParanoid; Q7Z6W7; -.
DR   OMA; VALKWHP; -.
DR   OrthoDB; EOG47H5QG; -.
DR   PhylomeDB; Q7Z6W7; -.
DR   NextBio; 86410; -.
DR   ArrayExpress; Q7Z6W7; -.
DR   Bgee; Q7Z6W7; -.
DR   CleanEx; HS_DNAJB7; -.
DR   Genevestigator; Q7Z6W7; -.
DR   GermOnline; ENSG00000172404; Homo sapiens.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR018253; Heat_shock_DnaJ_CS.
DR   InterPro; IPR003095; Hsp_DnaJ.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   KO; K09513; -.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; DnaJ_N; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Complete proteome; Polymorphism; Reference proteome.
FT   CHAIN         1    309       DnaJ homolog subfamily B member 7.
FT                                /FTId=PRO_0000071027.
FT   DOMAIN        3     69       J.
FT   COMPBIAS    291    298       Poly-Lys.
FT   VARIANT      41     41       E -> A (in dbSNP:rs2269619).
FT                                /FTId=VAR_017779.
SQ   SEQUENCE   309 AA;  35434 MW;  64F0F8544CDB8984 CRC64;
     MVDYYEVLGL QRYASPEDIK KAYHKVALKW HPDKNPENKE EAERKFKEVA EAYEVLSNDE
     KRDIYDKYGT EGLNGGGSHF DDECEYGFTF HKPDDVFKEI FHERDPFSFH FFEDSLEDLL
     NRPGSSYGNR NRDAGYFFST ASEYPIFEKF SSYDTGYTSQ GSLGHEGLTS FSSLAFDNSG
     MDNYISVTTS DKIVNGRNIN TKKIIESDQE REAEDNGELT FFLVNSVANE EGFAKECSWR
     TQSFNNYSPN SHSSKHVSQY TFVDNDEGGI SWVTSNRDPP IFSAGVKEGG KRKKKKRKEV
     QKKSTKRNC
//