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Protein

DnaJ homolog subfamily B member 7

Gene

DNAJB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably acts as a co-chaperone.By similarity

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 7
Gene namesi
Name:DNAJB7
Synonyms:HSC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:24986. DNAJB7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961522.

Polymorphism and mutation databases

BioMutaiDNAJB7.
DMDMi44887848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309DnaJ homolog subfamily B member 7PRO_0000071027Add
BLAST

Proteomic databases

PaxDbiQ7Z6W7.
PeptideAtlasiQ7Z6W7.
PRIDEiQ7Z6W7.

PTM databases

iPTMnetiQ7Z6W7.
PhosphoSiteiQ7Z6W7.

Expressioni

Gene expression databases

BgeeiQ7Z6W7.
CleanExiHS_DNAJB7.
GenevisibleiQ7Z6W7. HS.

Organism-specific databases

HPAiHPA000534.

Interactioni

GO - Molecular functioni

  • chaperone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127284. 3 interactions.
IntActiQ7Z6W7. 1 interaction.
STRINGi9606.ENSP00000307197.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6W7.
SMRiQ7Z6W7. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6967JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi291 – 2988Poly-Lys

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiQ7Z6W7.
KOiK09513.
OMAiFSFHFFE.
OrthoDBiEOG7KSX9F.
PhylomeDBiQ7Z6W7.
TreeFamiTF105142.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z6W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYYEVLGL QRYASPEDIK KAYHKVALKW HPDKNPENKE EAERKFKEVA
60 70 80 90 100
EAYEVLSNDE KRDIYDKYGT EGLNGGGSHF DDECEYGFTF HKPDDVFKEI
110 120 130 140 150
FHERDPFSFH FFEDSLEDLL NRPGSSYGNR NRDAGYFFST ASEYPIFEKF
160 170 180 190 200
SSYDTGYTSQ GSLGHEGLTS FSSLAFDNSG MDNYISVTTS DKIVNGRNIN
210 220 230 240 250
TKKIIESDQE REAEDNGELT FFLVNSVANE EGFAKECSWR TQSFNNYSPN
260 270 280 290 300
SHSSKHVSQY TFVDNDEGGI SWVTSNRDPP IFSAGVKEGG KRKKKKRKEV

QKKSTKRNC
Length:309
Mass (Da):35,434
Last modified:March 1, 2004 - v2
Checksum:i64F0F8544CDB8984
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411E → A.
Corresponds to variant rs2269619 [ dbSNP | Ensembl ].
VAR_017779

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085232 mRNA. Translation: AAL40391.1.
CR456468 mRNA. Translation: CAG30354.1.
Z98048 Genomic DNA. Translation: CAI20493.1.
BC112135 mRNA. Translation: AAI12136.1.
CCDSiCCDS14008.1.
RefSeqiNP_660157.1. NM_145174.1.
UniGeneiHs.585042.

Genome annotation databases

EnsembliENST00000307221; ENSP00000307197; ENSG00000172404.
GeneIDi150353.
KEGGihsa:150353.
UCSCiuc003azj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085232 mRNA. Translation: AAL40391.1.
CR456468 mRNA. Translation: CAG30354.1.
Z98048 Genomic DNA. Translation: CAI20493.1.
BC112135 mRNA. Translation: AAI12136.1.
CCDSiCCDS14008.1.
RefSeqiNP_660157.1. NM_145174.1.
UniGeneiHs.585042.

3D structure databases

ProteinModelPortaliQ7Z6W7.
SMRiQ7Z6W7. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127284. 3 interactions.
IntActiQ7Z6W7. 1 interaction.
STRINGi9606.ENSP00000307197.

PTM databases

iPTMnetiQ7Z6W7.
PhosphoSiteiQ7Z6W7.

Polymorphism and mutation databases

BioMutaiDNAJB7.
DMDMi44887848.

Proteomic databases

PaxDbiQ7Z6W7.
PeptideAtlasiQ7Z6W7.
PRIDEiQ7Z6W7.

Protocols and materials databases

DNASUi150353.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307221; ENSP00000307197; ENSG00000172404.
GeneIDi150353.
KEGGihsa:150353.
UCSCiuc003azj.4. human.

Organism-specific databases

CTDi150353.
GeneCardsiDNAJB7.
HGNCiHGNC:24986. DNAJB7.
HPAiHPA000534.
MIMi611336. gene.
neXtProtiNX_Q7Z6W7.
PharmGKBiPA134961522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiQ7Z6W7.
KOiK09513.
OMAiFSFHFFE.
OrthoDBiEOG7KSX9F.
PhylomeDBiQ7Z6W7.
TreeFamiTF105142.

Miscellaneous databases

GenomeRNAii150353.
PROiQ7Z6W7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z6W7.
CleanExiHS_DNAJB7.
GenevisibleiQ7Z6W7. HS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning a novel human gene, HSC3, which shows significant homology to murine MRJ."
    Xing Y., Yu L., Fu Q., Zhao Y., Bi A., Zhao S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiDNJB7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6W7
Secondary accession number(s): Q2M220, Q5H904, Q8WYJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: July 6, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.