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Protein

Transmembrane and coiled-coil domain-containing protein 2

Gene

TMCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32841-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 2
Gene namesi
Name:TMCO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23312. TMCO2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188800.
PharmGKBiPA142670793.

Polymorphism and mutation databases

BioMutaiTMCO2.
DMDMi74750201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002494351 – 182Transmembrane and coiled-coil domain-containing protein 2Add BLAST182

Proteomic databases

PaxDbiQ7Z6W1.
PeptideAtlasiQ7Z6W1.
PRIDEiQ7Z6W1.

PTM databases

iPTMnetiQ7Z6W1.
PhosphoSitePlusiQ7Z6W1.

Expressioni

Gene expression databases

BgeeiENSG00000188800.
CleanExiHS_TMCO2.
ExpressionAtlasiQ7Z6W1. baseline and differential.
GenevisibleiQ7Z6W1. HS.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6W1.
SMRiQ7Z6W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 151Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 8Poly-Ser7

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JA7Q. Eukaryota.
ENOG4111526. LUCA.
GeneTreeiENSGT00390000001528.
HOGENOMiHOG000154635.
HOVERGENiHBG080208.
InParanoidiQ7Z6W1.
OMAiATKRDCS.
OrthoDBiEOG091G0VZZ.
PhylomeDBiQ7Z6W1.
TreeFamiTF337575.

Family and domain databases

InterProiIPR031697. TMCCDC2.
[Graphical view]
PfamiPF15844. TMCCDC2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z6W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSSSSSWD NLLESLSLST VWNWIQASFL GETSAPQQTS LGLLDNLAPA
60 70 80 90 100
VQIILRISFL ILLGIGIYAL WKRSIQSIQK TLLFVITLYK LYKKGSHIFE
110 120 130 140 150
ALLANPEGSG LRIQDNNNLF LSLGLQEKIL KKLKTVENKM KNLEGIIVAQ
160 170 180
KPATKRDCSS EPYCSCSDCQ SPLSTSGFTS PI
Length:182
Mass (Da):20,071
Last modified:October 1, 2003 - v1
Checksum:iCA0A64E52CBF8462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050341 Genomic DNA. Translation: CAB81609.1.
BC108666 mRNA. Translation: AAI08667.1.
CCDSiCCDS30684.1.
RefSeqiNP_001008740.1. NM_001008740.3.
UniGeneiHs.406265.

Genome annotation databases

EnsembliENST00000372766; ENSP00000361852; ENSG00000188800.
GeneIDi127391.
KEGGihsa:127391.
UCSCiuc001cfe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050341 Genomic DNA. Translation: CAB81609.1.
BC108666 mRNA. Translation: AAI08667.1.
CCDSiCCDS30684.1.
RefSeqiNP_001008740.1. NM_001008740.3.
UniGeneiHs.406265.

3D structure databases

ProteinModelPortaliQ7Z6W1.
SMRiQ7Z6W1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ7Z6W1.
PhosphoSitePlusiQ7Z6W1.

Polymorphism and mutation databases

BioMutaiTMCO2.
DMDMi74750201.

Proteomic databases

PaxDbiQ7Z6W1.
PeptideAtlasiQ7Z6W1.
PRIDEiQ7Z6W1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372766; ENSP00000361852; ENSG00000188800.
GeneIDi127391.
KEGGihsa:127391.
UCSCiuc001cfe.3. human.

Organism-specific databases

CTDi127391.
GeneCardsiTMCO2.
HGNCiHGNC:23312. TMCO2.
neXtProtiNX_Q7Z6W1.
OpenTargetsiENSG00000188800.
PharmGKBiPA142670793.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JA7Q. Eukaryota.
ENOG4111526. LUCA.
GeneTreeiENSGT00390000001528.
HOGENOMiHOG000154635.
HOVERGENiHBG080208.
InParanoidiQ7Z6W1.
OMAiATKRDCS.
OrthoDBiEOG091G0VZZ.
PhylomeDBiQ7Z6W1.
TreeFamiTF337575.

Enzyme and pathway databases

BioCyciZFISH:G66-32841-MONOMER.

Miscellaneous databases

GenomeRNAii127391.
PROiQ7Z6W1.

Gene expression databases

BgeeiENSG00000188800.
CleanExiHS_TMCO2.
ExpressionAtlasiQ7Z6W1. baseline and differential.
GenevisibleiQ7Z6W1. HS.

Family and domain databases

InterProiIPR031697. TMCCDC2.
[Graphical view]
PfamiPF15844. TMCCDC2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMCO2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.