Q7Z6V5 (ADAT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 68.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: tRNA-specific adenosine deaminase 2 EC=3.5.4.- Alternative name(s): Deaminase domain-containing protein 1 tRNA-specific adenosine-34 deaminase subunit ADAT2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 191 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Probably participates in deamination of adenosine-34 to inosine in many tRNAs By similarity. |
| Cofactor | Zinc By similarity. |
| Sequence similarities | Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily. |
| Sequence caution | The sequence AAH37955.2 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | tRNA processing |
| Coding sequence diversity | Alternative splicing |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q7Z6V5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q7Z6V5-2) The sequence of this isoform differs from the canonical sequence as follows: 1-47: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 191 | 191 | tRNA-specific adenosine deaminase 2 | PRO_0000287653 | |||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||
| Active site | 73 | 1 | Proton donor By similarity | ||||||||||||||||||||||||||
| Metal binding | 71 | 1 | Zinc; catalytic | ||||||||||||||||||||||||||
| Metal binding | 107 | 1 | Zinc; catalytic | ||||||||||||||||||||||||||
| Metal binding | 110 | 1 | Zinc; catalytic | ||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||
| Alternative sequence | 1 – 47 | 47 | Missing in isoform 2. | VSP_025582 | |||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||
| Helix | 20 – 38 | 19 | |||||||||||||||||||||||||||
| Beta strand | 47 – 50 | 4 | |||||||||||||||||||||||||||
| Helix | 62 – 65 | 4 | |||||||||||||||||||||||||||
| Helix | 72 – 86 | 15 | |||||||||||||||||||||||||||
| Helix | 91 – 95 | 5 | |||||||||||||||||||||||||||
| Beta strand | 98 – 101 | 4 | |||||||||||||||||||||||||||
| Helix | 108 – 117 | 10 | |||||||||||||||||||||||||||
| Beta strand | 121 – 123 | 3 | |||||||||||||||||||||||||||
| Beta strand | 153 – 155 | 3 | |||||||||||||||||||||||||||
| Helix | 160 – 170 | 11 | |||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||||||||
References
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AK126201 mRNA. Translation: BAG54295.1. BX538182 mRNA. Translation: CAD98054.1. AL031320 Genomic DNA. Translation: CAD92490.1. CH471051 Genomic DNA. Translation: EAW47868.1. BC037955 mRNA. Translation: AAH37955.2. Different initiation. | ||||||||||||
| IPI | IPI00217631. IPI00845439. | ||||||||||||
| RefSeq | NP_872309.2. NM_182503.2. | ||||||||||||
| UniGene | Hs.709561. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q7Z6V5. | ||||||||||||
| SMR | Q7Z6V5. Positions 18-173. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q7Z6V5. 1 interaction. | ||||||||||||
| STRING | Q7Z6V5. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 74750199. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q7Z6V5. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000237283; ENSP00000237283; ENSG00000189007. | ||||||||||||
| GeneID | 134637. | ||||||||||||
| KEGG | hsa:134637. | ||||||||||||
| UCSC | uc003qjj.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 134637. | ||||||||||||
| GeneCards | GC06M143789. | ||||||||||||
| H-InvDB | HIX0025050. | ||||||||||||
| HGNC | HGNC:21172. ADAT2. | ||||||||||||
| HPA | HPA035479. | ||||||||||||
| neXtProt | NX_Q7Z6V5. | ||||||||||||
| PharmGKB | PA162375592. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| GeneTree | ENSGT00390000000280. | ||||||||||||
| HOGENOM | HBG741046. | ||||||||||||
| HOVERGEN | HBG055246. | ||||||||||||
| InParanoid | Q7Z6V5. | ||||||||||||
| OMA | CRNERFG. | ||||||||||||
| OrthoDB | EOG4MW87C. | ||||||||||||
| PhylomeDB | Q7Z6V5. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q7Z6V5. | ||||||||||||
| Bgee | Q7Z6V5. | ||||||||||||
| CleanEx | HS_ADAT2. | ||||||||||||
| Genevestigator | Q7Z6V5. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR016193. Cytidine_deaminase-like. [Graphical view] | ||||||||||||
| KO | K15441. | ||||||||||||
| Pfam | PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF53927. Cytidine_deaminase-like. 1 hit. | ||||||||||||
| PROSITE | PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 83413. | ||||||||||||
Entry information
| Entry name | ADAT2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q7Z6V5 Secondary accession number(s): A6NL12 Q8IY39 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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