ID   Q7Z6S5_HUMAN            Unreviewed;       208 AA.
AC   Q7Z6S5;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 132.
DE   RecName: Full=TATA-box-binding protein {ECO:0000256|ARBA:ARBA00021962};
DE   AltName: Full=TATA sequence-binding protein {ECO:0000256|ARBA:ARBA00030739};
DE   AltName: Full=TATA-binding factor {ECO:0000256|ARBA:ARBA00042653};
DE   AltName: Full=TATA-box factor {ECO:0000256|ARBA:ARBA00033017};
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit {ECO:0000256|ARBA:ARBA00042691};
DE   Flags: Fragment;
GN   Name=TBP {ECO:0000313|Ensembl:ENSP00000400008.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400008.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400008.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000400008.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000256|ARBA:ARBA00005560}.
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DR   EMBL; AL031259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q7Z6S5; -.
DR   SMR; Q7Z6S5; -.
DR   MassIVE; Q7Z6S5; -.
DR   MaxQB; Q7Z6S5; -.
DR   PeptideAtlas; Q7Z6S5; -.
DR   ProteomicsDB; 69457; -.
DR   Antibodypedia; 4001; 709 antibodies from 45 providers.
DR   Ensembl; ENST00000421512.5; ENSP00000400008.1; ENSG00000112592.15.
DR   UCSC; uc063tbe.1; human.
DR   HGNC; HGNC:11588; TBP.
DR   VEuPathDB; HostDB:ENSG00000112592; -.
DR   GeneTree; ENSGT00940000157474; -.
DR   HOGENOM; CLU_060161_6_0_1; -.
DR   OMA; NMDQNNS; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000112592; Expressed in left testis and 153 other cell types or tissues.
DR   ExpressionAtlas; Q7Z6S5; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; TATA-BOX BINDING PROTEIN; 1.
DR   PANTHER; PTHR10126:SF20; TATA-BOX-BINDING PROTEIN; 1.
DR   Pfam; PF00352; TBP; 1.
DR   PRINTS; PR00686; TIFACTORIID.
DR   SUPFAM; SSF55945; TATA-box binding protein-like; 1.
PE   1: Evidence at protein level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:Q7Z6S5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          36..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..149
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         208
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000400008.1"
SQ   SEQUENCE   208 AA;  22921 MW;  95792234163A9618 CRC64;
     MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ
     QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQAVAAA AVQQSTSQQA TQGTSGQAPQ
     LFHSQTLTTA PLPGTTPLYP SPMTPMTPIT PATPASESSG IVPQLQNIVS TVNLGCKLDL
     KTIALRARNA EYNPKRFAAV IMRIREPR
//