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Protein

Ras-related protein Rab-44

Gene

RAB44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi543 – 550GTPBy similarity8
Nucleotide bindingi591 – 595GTPBy similarity5
Nucleotide bindingi649 – 652GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33812-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-44
Gene namesi
Name:RAB44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21068. RAB44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi317373517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330771 – 723Ras-related protein Rab-44Add BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi722S-geranylgeranyl cysteineBy similarity1
Lipidationi723S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ7Z6P3.
PeptideAtlasiQ7Z6P3.
PRIDEiQ7Z6P3.
TopDownProteomicsiQ7Z6P3.

PTM databases

iPTMnetiQ7Z6P3.
PhosphoSitePlusiQ7Z6P3.

Expressioni

Gene expression databases

BgeeiENSG00000255587.
ExpressionAtlasiQ7Z6P3. baseline and differential.

Organism-specific databases

HPAiHPA029767.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6P3.
SMRiQ7Z6P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 63Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 269Pro-richAdd BLAST136

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000090219.
HOVERGENiHBG108390.
InParanoidiQ7Z6P3.
PhylomeDBiQ7Z6P3.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z6P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDVLEAKER EVQRLAEGQR ELEAQLSHLR STHQEAASEN QQLQEAKRDL
60 70 80 90 100
AGRLEEVRGQ LQVTRGRLDA ARGRVSWQVE EKLRQVAAIP GLGFPGAGEK
110 120 130 140 150
TPDPQAASPE EAPLPGLFGD NDDWDQLLSN FGSPPHGALQ LCWSPPPTPR
160 170 180 190 200
ATSGPQTPRV VRQISISEPQ AFLFGQEPSS DPDGAPRTPP GVTFSAKDNK
210 220 230 240 250
GVDPHEQDIR AEQPVEPHDP DPNQEPGSTP EGRLLWGLSG SLVAPAFKVL
260 270 280 290 300
IPLEDGPPPP ANSPPPQAPA GSSKQIQASD PDDKGPGQRD ALQQDLHATG
310 320 330 340 350
SEPRLGTQRA RALTLGPAEP FQGLEFVGPV PTERLEQGQA GPAVQEGLPE
360 370 380 390 400
GLREAHGQVL GLGELSAFPH QELEEEPRSE EGKQEGRGGQ DLSSEQSEQS
410 420 430 440 450
VEAHGLETAH SELPQQDSLL VSLPSATPQA QVEAEGPTPG KSAPPRGSPP
460 470 480 490 500
RGAQPGAGAG PQEPTQTPPT MAEQEAQPRP SLTTAHAEEQ GPPHSREPRA
510 520 530 540 550
ESRLEDPGMD SREAGLTPSP GDPMAGGGPQ ANPDYLFHVI FLGDSNVGKT
560 570 580 590 600
SFLHLLHQNS FATGLTATVG VDFRVKTLLV DNKCFVLQLW DTAGQERYHS
610 620 630 640 650
MTRQLLRKAD GVVLMYDITS QESFAHVRYW LDCLQDAGSD GVVILLLGNK
660 670 680 690 700
MDCEEERQVS VEAGQQLAQE LGVYFGECSA ALGHNILEPV VNLARSLRMQ
710 720
EEGLKDSLVK VAPKRPPKRF GCC
Length:723
Mass (Da):77,638
Last modified:January 11, 2011 - v3
Checksum:i3793EBD708D1F430
GO

Sequence cautioni

The sequence CAD92808 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z85996 Genomic DNA. Translation: CAD92808.1. Sequence problems.
UniGeneiHs.485258.

Genome annotation databases

EnsembliENST00000229824; ENSP00000229824; ENSG00000255587.
UCSCiuc063oev.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z85996 Genomic DNA. Translation: CAD92808.1. Sequence problems.
UniGeneiHs.485258.

3D structure databases

ProteinModelPortaliQ7Z6P3.
SMRiQ7Z6P3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ7Z6P3.
PhosphoSitePlusiQ7Z6P3.

Polymorphism and mutation databases

DMDMi317373517.

Proteomic databases

EPDiQ7Z6P3.
PeptideAtlasiQ7Z6P3.
PRIDEiQ7Z6P3.
TopDownProteomicsiQ7Z6P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229824; ENSP00000229824; ENSG00000255587.
UCSCiuc063oev.1. human.

Organism-specific databases

GeneCardsiRAB44.
HGNCiHGNC:21068. RAB44.
HPAiHPA029767.
neXtProtiNX_Q7Z6P3.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000090219.
HOVERGENiHBG108390.
InParanoidiQ7Z6P3.
PhylomeDBiQ7Z6P3.
TreeFamiTF313199.

Enzyme and pathway databases

BioCyciZFISH:G66-33812-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ7Z6P3.

Gene expression databases

BgeeiENSG00000255587.
ExpressionAtlasiQ7Z6P3. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB44_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.