Q7Z6P3 (RAB44_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-44

Gene names

Name:

RAB44

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.
Sequence caution	The sequence CAD92808.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Ras-related protein Rab-44		PRO_0000333077
Regions
	Nucleotide binding	543 – 550	8	GTP By similarity
	Nucleotide binding	591 – 595	5	GTP By similarity
	Nucleotide binding	649 – 652	4	GTP By similarity
	Coiled coil	1 – 63	63	Potential
	Compositional bias	134 – 269	136	Pro-rich
Amino acid modifications
	Lipidation	722	1	S-geranylgeranyl cysteine By similarity
	Lipidation	723	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7Z6P3 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: 3793EBD708D1F430	FASTA	723	77,638
	10 20 30 40 50 60 MQDVLEAKER EVQRLAEGQR ELEAQLSHLR STHQEAASEN QQLQEAKRDL AGRLEEVRGQ 70 80 90 100 110 120 LQVTRGRLDA ARGRVSWQVE EKLRQVAAIP GLGFPGAGEK TPDPQAASPE EAPLPGLFGD 130 140 150 160 170 180 NDDWDQLLSN FGSPPHGALQ LCWSPPPTPR ATSGPQTPRV VRQISISEPQ AFLFGQEPSS 190 200 210 220 230 240 DPDGAPRTPP GVTFSAKDNK GVDPHEQDIR AEQPVEPHDP DPNQEPGSTP EGRLLWGLSG 250 260 270 280 290 300 SLVAPAFKVL IPLEDGPPPP ANSPPPQAPA GSSKQIQASD PDDKGPGQRD ALQQDLHATG 310 320 330 340 350 360 SEPRLGTQRA RALTLGPAEP FQGLEFVGPV PTERLEQGQA GPAVQEGLPE GLREAHGQVL 370 380 390 400 410 420 GLGELSAFPH QELEEEPRSE EGKQEGRGGQ DLSSEQSEQS VEAHGLETAH SELPQQDSLL 430 440 450 460 470 480 VSLPSATPQA QVEAEGPTPG KSAPPRGSPP RGAQPGAGAG PQEPTQTPPT MAEQEAQPRP 490 500 510 520 530 540 SLTTAHAEEQ GPPHSREPRA ESRLEDPGMD SREAGLTPSP GDPMAGGGPQ ANPDYLFHVI 550 560 570 580 590 600 FLGDSNVGKT SFLHLLHQNS FATGLTATVG VDFRVKTLLV DNKCFVLQLW DTAGQERYHS 610 620 630 640 650 660 MTRQLLRKAD GVVLMYDITS QESFAHVRYW LDCLQDAGSD GVVILLLGNK MDCEEERQVS 670 680 690 700 710 720 VEAGQQLAQE LGVYFGECSA ALGHNILEPV VNLARSLRMQ EEGLKDSLVK VAPKRPPKRF GCC

References

[1]

"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z85996 Genomic DNA. Translation: CAD92808.1. Sequence problems.
IPI	IPI00164150.
UniGene	Hs.485258. Hs.722748.
3D structure databases
HSSP	HSSP built from PDB template 2F7S based on UniProtKB O00194.
ProteinModelPortal	Q7Z6P3.
SMR	Q7Z6P3. Positions 536-699.
ModBase	Search...
PTM databases
PhosphoSite	Q7Z6P3.
Polymorphism databases
DMDM	189029597.
Proteomic databases
PRIDE	Q7Z6P3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000457893; ENSP00000397127; ENSG00000196624.
Organism-specific databases
GeneCards	GC06P036665.
HGNC	HGNC:21068. RAB44.
HPA	HPA029767.
neXtProt	NX_Q7Z6P3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18693.
GeneTree	ENSGT00600000084147.
HOGENOM	HBG506855.
HOVERGEN	HBG108390.
InParanoid	Q7Z6P3.
OMA	ARSLKMQ.
OrthoDB	EOG41JZDG.
Gene expression databases
Genevestigator	Q7Z6P3.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAB44_HUMAN

Accession

Primary (citable) accession number: Q7Z6P3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 11, 2011
Last modified:	December 14, 2011
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.