Reviewed, UniProtKB/Swiss-Prot Q7Z6P3 (RAB44_HUMAN)

Names and origin

Protein names

Recommended name:
    Ras-related protein Rab-44

Gene names

Name:

RAB44

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	721 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.
Sequence caution	The sequence CAD92808.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 721	721	Ras-related protein Rab-44		PRO_0000333077
Regions
	Nucleotide binding	542 – 549	8	GTP By similarity
	Nucleotide binding	590 – 594	5	GTP By similarity
	Nucleotide binding	647 – 650	4	GTP By similarity
	Coiled coil	1 – 62	62	Potential
	Compositional bias	133 – 268	136	Pro-rich
Amino acid modifications
	Lipidation	720	1	S-geranylgeranyl cysteine By similarity
	Lipidation	721	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7Z6P3-1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: BA4330FCD9A53F5B	FASTA	721	77,369
	10 20 30 40 50 60 MQDVLEAKER EVQRLAEGQR EEAQLSHLRS THQEAASENQ QLQEAKRDLA GRLEEVRGQL 70 80 90 100 110 120 QVTRGRLDAA RGRVSWQVEE KLRQVAAIPG LGFPGAGEKT PDPQAASPEE APLPGLFGDN 130 140 150 160 170 180 DDWDQLLSNF GSPPHGALQL CWSPPPTPRA TSGPQTPRVV RQISISEPQA FLFGQEPSSD 190 200 210 220 230 240 PDGAPRTPPG VTFSAKDNKG VDPHEQDIRA EQPVEPHDPD PNQEPGSTPE GRLLWGLSGS 250 260 270 280 290 300 LVAPAFKVLI PLEDGPPPPA NSPPPQAPAG SSKQIQASDP DDKGPGQRDA LQQDLHATGS 310 320 330 340 350 360 EPRLGTQRAR ALTLGPAEPF QGLEFVGPVP TERLEQGQAG PAVQEGLPEG LREAHGQVLG 370 380 390 400 410 420 LGELSAFPHQ ELEEEPRSEE GKQEGRGGQD LSSEQSEQSV EAHGLETAHS ELPQQDSLLV 430 440 450 460 470 480 SLPSATPQAQ VEAEGPTPGK SAPPRGSPPR GAQPGAGAGP QEPTQTPPTM AEQEAQPRPS 490 500 510 520 530 540 LTTAHAEEQG PPHSREPRAE SRLEDPGMDS REAGLTPSPG DPMAGGGPQA NPDYLFHVIF 550 560 570 580 590 600 LGDSNVGKTS FLHLLHQNSF ATGLTATVGV DFRVKTLLVD NKCFVLQLWD TAGQEYHSMT 610 620 630 640 650 660 RQLLRKADGV VLMYDITSQE SFAHVRYWLD CLQDAGSDGV VILLLGNKMD CEEERQVSVE 670 680 690 700 710 720 AGQQLAQELG VYFGECSAAL GHNILEPVVN LARSLRMQEE GLKDSLVKVA PKRPPKRFGC C

References

[1]

"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z85996 Genomic DNA. Translation: CAD92808.1. Sequence problems.
IPI	IPI00164150.
3D structure databases
HSSP	HSSP built from PDB template 1G16 based on UniProtKB P07560.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000112090. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC06P036779. GC06U900627.
HGNC	HGNC:21068. RAB44.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q7Z6P3.
HOVERGEN	Q7Z6P3.
Family and domain databases
InterPro	IPR003579. GTPase_Rab. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAB44_HUMAN

Accession

Primary (citable) accession number: Q7Z6P3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	June 16, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)