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Protein

Transcription termination factor 4, mitochondrial

Gene

MTERF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: InterPro
  • rRNA binding Source: MGI
  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6793080. rRNA modification in the mitochondrion.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 4, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 4
Short name:
MTERF4
mTERF domain-containing protein 2
Cleaved into the following chain:
Gene namesi
Name:MTERF4
Synonyms:MTERFD2
ORF Names:HSPC096
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28785. MTERF4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • mitochondrial large ribosomal subunit Source: MGI
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122085.
PharmGKBiPA142671310.

Polymorphism and mutation databases

BioMutaiMTERFD2.
DMDMi296439296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42Mitochondrion1 PublicationAdd BLAST42
ChainiPRO_000025546143 – 381Transcription termination factor 4, mitochondrialAdd BLAST339
ChainiPRO_000042434148 – 381mTERF domain-containing protein 2 processedAdd BLAST334

Post-translational modificationi

The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.1 Publication

Proteomic databases

EPDiQ7Z6M4.
MaxQBiQ7Z6M4.
PaxDbiQ7Z6M4.
PeptideAtlasiQ7Z6M4.
PRIDEiQ7Z6M4.

PTM databases

iPTMnetiQ7Z6M4.
PhosphoSitePlusiQ7Z6M4.

Expressioni

Gene expression databases

BgeeiENSG00000122085.
CleanExiHS_MTERFD2.
ExpressionAtlasiQ7Z6M4. baseline and differential.
GenevisibleiQ7Z6M4. HS.

Organism-specific databases

HPAiHPA027097.

Interactioni

Subunit structurei

Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.2 Publications

Protein-protein interaction databases

BioGridi126263. 10 interactors.
DIPiDIP-49918N.
IntActiQ7Z6M4. 4 interactors.
MINTiMINT-2878691.
STRINGi9606.ENSP00000241527.

Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi84 – 101Combined sources18
Helixi106 – 115Combined sources10
Turni123 – 125Combined sources3
Helixi126 – 134Combined sources9
Helixi140 – 146Combined sources7
Helixi149 – 152Combined sources4
Helixi156 – 169Combined sources14
Turni172 – 175Combined sources4
Helixi177 – 182Combined sources6
Helixi184 – 187Combined sources4
Helixi191 – 204Combined sources14
Helixi209 – 218Combined sources10
Helixi220 – 223Combined sources4
Helixi229 – 239Combined sources11
Helixi245 – 250Combined sources6
Helixi253 – 255Combined sources3
Helixi258 – 270Combined sources13
Beta strandi279 – 281Combined sources3
Helixi290 – 294Combined sources5
Helixi298 – 304Combined sources7
Helixi310 – 327Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FP9X-ray2.90B/E/G/H47-381[»]
4FZVX-ray2.00B122-330[»]
ProteinModelPortaliQ7Z6M4.
SMRiQ7Z6M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati142 – 172MTERF 11 PublicationAdd BLAST31
Repeati177 – 204MTERF 21 PublicationAdd BLAST28
Repeati209 – 239MTERF 31 PublicationAdd BLAST31
Repeati245 – 270MTERF 41 PublicationAdd BLAST26
Repeati290 – 318MTERF 51 PublicationAdd BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni310 – 327Dimerization with NSUN4Add BLAST18

Domaini

The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiENOG410IK50. Eukaryota.
ENOG410Y0Q1. LUCA.
GeneTreeiENSGT00460000041648.
HOGENOMiHOG000069984.
HOVERGENiHBG081990.
InParanoidiQ7Z6M4.
KOiK15032.
OMAiTEILHRC.
OrthoDBiEOG091G0DPS.
PhylomeDBiQ7Z6M4.
TreeFamiTF329452.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z6M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFGRQVLD WHRLIPLTWA CMARQTPHLG EQRRTTASLL RKLTTASNGG
60 70 80 90 100
VIEELSCVRS NNYVQEPECR RNLVQCLLEK QGTPVVQGSL ELERVMSSLL
110 120 130 140 150
DMGFSNAHIN ELLSVRRGAS LQQLLDIISE FILLGLNPEP VCVVLKKSPQ
160 170 180 190 200
LLKLPIMQMR KRSSYLQKLG LGEGKLKRVL YCCPEIFTMR QQDINDTVRL
210 220 230 240 250
LKEKCLFTVQ QVTKILHSCP SVLREDLGQL EYKFQYAYFR MGIKHPDIVK
260 270 280 290 300
SEYLQYSLTK IKQRHIYLER LGRYQTPDKK GQTQIPNPLL KDILRVSEAE
310 320 330 340 350
FLARTACTSV EEFQVFKKLL AREEEESESS TSDDKRASLD EDEDDDDEED
360 370 380
NDEDDNDEDD DDEDDDEAED NDEDEDDDEE E
Length:381
Mass (Da):43,958
Last modified:May 18, 2010 - v3
Checksum:i45592F93558EE190
GO

Sequence cautioni

The sequence AAF28919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27P → R in AAF28919 (Ref. 4) Curated1
Sequence conflicti251S → G in BAF84354 (PubMed:14702039).Curated1
Sequence conflicti307C → R in AAH53533 (PubMed:15489334).Curated1
Sequence conflicti312E → G in BAF84354 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02886545T → A.Corresponds to variant rs3796093dbSNPEnsembl.1
Natural variantiVAR_028866189M → T.Corresponds to variant rs2286323dbSNPEnsembl.1
Natural variantiVAR_028867339L → V.Corresponds to variant rs2240539dbSNPEnsembl.1
Natural variantiVAR_028868347D → E.Corresponds to variant rs10203977dbSNPEnsembl.1
Natural variantiVAR_028869378D → E.Corresponds to variant rs10167328dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291665 mRNA. Translation: BAF84354.1.
AC005237 Genomic DNA. No translation available.
BC053533 mRNA. Translation: AAH53533.2.
AF161359 mRNA. Translation: AAF28919.1. Different initiation.
CCDSiCCDS2544.1.
RefSeqiNP_872307.2. NM_182501.3.
XP_016858876.1. XM_017003387.1.
UniGeneiHs.159556.

Genome annotation databases

EnsembliENST00000241527; ENSP00000241527; ENSG00000122085.
ENST00000391980; ENSP00000375840; ENSG00000122085.
ENST00000614476; ENSP00000480378; ENSG00000122085.
GeneIDi130916.
KEGGihsa:130916.
UCSCiuc061uks.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291665 mRNA. Translation: BAF84354.1.
AC005237 Genomic DNA. No translation available.
BC053533 mRNA. Translation: AAH53533.2.
AF161359 mRNA. Translation: AAF28919.1. Different initiation.
CCDSiCCDS2544.1.
RefSeqiNP_872307.2. NM_182501.3.
XP_016858876.1. XM_017003387.1.
UniGeneiHs.159556.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FP9X-ray2.90B/E/G/H47-381[»]
4FZVX-ray2.00B122-330[»]
ProteinModelPortaliQ7Z6M4.
SMRiQ7Z6M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126263. 10 interactors.
DIPiDIP-49918N.
IntActiQ7Z6M4. 4 interactors.
MINTiMINT-2878691.
STRINGi9606.ENSP00000241527.

PTM databases

iPTMnetiQ7Z6M4.
PhosphoSitePlusiQ7Z6M4.

Polymorphism and mutation databases

BioMutaiMTERFD2.
DMDMi296439296.

Proteomic databases

EPDiQ7Z6M4.
MaxQBiQ7Z6M4.
PaxDbiQ7Z6M4.
PeptideAtlasiQ7Z6M4.
PRIDEiQ7Z6M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241527; ENSP00000241527; ENSG00000122085.
ENST00000391980; ENSP00000375840; ENSG00000122085.
ENST00000614476; ENSP00000480378; ENSG00000122085.
GeneIDi130916.
KEGGihsa:130916.
UCSCiuc061uks.1. human.

Organism-specific databases

CTDi130916.
GeneCardsiMTERF4.
H-InvDBHIX0002987.
HGNCiHGNC:28785. MTERF4.
HPAiHPA027097.
MIMi615393. gene.
neXtProtiNX_Q7Z6M4.
OpenTargetsiENSG00000122085.
PharmGKBiPA142671310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK50. Eukaryota.
ENOG410Y0Q1. LUCA.
GeneTreeiENSGT00460000041648.
HOGENOMiHOG000069984.
HOVERGENiHBG081990.
InParanoidiQ7Z6M4.
KOiK15032.
OMAiTEILHRC.
OrthoDBiEOG091G0DPS.
PhylomeDBiQ7Z6M4.
TreeFamiTF329452.

Enzyme and pathway databases

ReactomeiR-HSA-6793080. rRNA modification in the mitochondrion.

Miscellaneous databases

ChiTaRSiMTERFD2. human.
GenomeRNAii130916.
PROiQ7Z6M4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122085.
CleanExiHS_MTERFD2.
ExpressionAtlasiQ7Z6M4. baseline and differential.
GenevisibleiQ7Z6M4. HS.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6M4
Secondary accession number(s): A8K6K0, Q9P0E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.