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Protein

Transcription termination factor 4, mitochondrial

Gene

MTERF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: InterPro
  • rRNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 4, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 4
Short name:
MTERF4
mTERF domain-containing protein 2
Cleaved into the following chain:
Gene namesi
Name:MTERF4
Synonyms:MTERFD2
ORF Names:HSPC096
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28785. MTERF4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • mitochondrial large ribosomal subunit Source: MGI
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671310.

Polymorphism and mutation databases

BioMutaiMTERFD2.
DMDMi296439296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242Mitochondrion1 PublicationAdd
BLAST
Chaini43 – 381339Transcription termination factor 4, mitochondrialPRO_0000255461Add
BLAST
Chaini48 – 381334mTERF domain-containing protein 2 processedPRO_0000424341Add
BLAST

Post-translational modificationi

The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.1 Publication

Proteomic databases

EPDiQ7Z6M4.
MaxQBiQ7Z6M4.
PaxDbiQ7Z6M4.
PeptideAtlasiQ7Z6M4.
PRIDEiQ7Z6M4.

PTM databases

iPTMnetiQ7Z6M4.
PhosphoSiteiQ7Z6M4.

Expressioni

Gene expression databases

BgeeiENSG00000122085.
CleanExiHS_MTERFD2.
ExpressionAtlasiQ7Z6M4. baseline and differential.
GenevisibleiQ7Z6M4. HS.

Organism-specific databases

HPAiHPA027097.

Interactioni

Subunit structurei

Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.2 Publications

Protein-protein interaction databases

BioGridi126263. 10 interactions.
DIPiDIP-49918N.
IntActiQ7Z6M4. 3 interactions.
MINTiMINT-2878691.
STRINGi9606.ENSP00000241527.

Structurei

Secondary structure

1
381
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi84 – 10118Combined sources
Helixi106 – 11510Combined sources
Turni123 – 1253Combined sources
Helixi126 – 1349Combined sources
Helixi140 – 1467Combined sources
Helixi149 – 1524Combined sources
Helixi156 – 16914Combined sources
Turni172 – 1754Combined sources
Helixi177 – 1826Combined sources
Helixi184 – 1874Combined sources
Helixi191 – 20414Combined sources
Helixi209 – 21810Combined sources
Helixi220 – 2234Combined sources
Helixi229 – 23911Combined sources
Helixi245 – 2506Combined sources
Helixi253 – 2553Combined sources
Helixi258 – 27013Combined sources
Beta strandi279 – 2813Combined sources
Helixi290 – 2945Combined sources
Helixi298 – 3047Combined sources
Helixi310 – 32718Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FP9X-ray2.90B/E/G/H47-381[»]
4FZVX-ray2.00B122-330[»]
ProteinModelPortaliQ7Z6M4.
SMRiQ7Z6M4. Positions 83-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati142 – 17231MTERF 11 PublicationAdd
BLAST
Repeati177 – 20428MTERF 21 PublicationAdd
BLAST
Repeati209 – 23931MTERF 31 PublicationAdd
BLAST
Repeati245 – 27026MTERF 41 PublicationAdd
BLAST
Repeati290 – 31829MTERF 51 PublicationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni310 – 32718Dimerization with NSUN4Add
BLAST

Domaini

The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiENOG410IK50. Eukaryota.
ENOG410Y0Q1. LUCA.
GeneTreeiENSGT00460000041648.
HOGENOMiHOG000069984.
HOVERGENiHBG081990.
InParanoidiQ7Z6M4.
KOiK15032.
OMAiTEILHRC.
OrthoDBiEOG091G0DPS.
PhylomeDBiQ7Z6M4.
TreeFamiTF329452.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z6M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFGRQVLD WHRLIPLTWA CMARQTPHLG EQRRTTASLL RKLTTASNGG
60 70 80 90 100
VIEELSCVRS NNYVQEPECR RNLVQCLLEK QGTPVVQGSL ELERVMSSLL
110 120 130 140 150
DMGFSNAHIN ELLSVRRGAS LQQLLDIISE FILLGLNPEP VCVVLKKSPQ
160 170 180 190 200
LLKLPIMQMR KRSSYLQKLG LGEGKLKRVL YCCPEIFTMR QQDINDTVRL
210 220 230 240 250
LKEKCLFTVQ QVTKILHSCP SVLREDLGQL EYKFQYAYFR MGIKHPDIVK
260 270 280 290 300
SEYLQYSLTK IKQRHIYLER LGRYQTPDKK GQTQIPNPLL KDILRVSEAE
310 320 330 340 350
FLARTACTSV EEFQVFKKLL AREEEESESS TSDDKRASLD EDEDDDDEED
360 370 380
NDEDDNDEDD DDEDDDEAED NDEDEDDDEE E
Length:381
Mass (Da):43,958
Last modified:May 18, 2010 - v3
Checksum:i45592F93558EE190
GO

Sequence cautioni

The sequence AAF28919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271P → R in AAF28919 (Ref. 4) Curated
Sequence conflicti251 – 2511S → G in BAF84354 (PubMed:14702039).Curated
Sequence conflicti307 – 3071C → R in AAH53533 (PubMed:15489334).Curated
Sequence conflicti312 – 3121E → G in BAF84354 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451T → A.
Corresponds to variant rs3796093 [ dbSNP | Ensembl ].
VAR_028865
Natural varianti189 – 1891M → T.
Corresponds to variant rs2286323 [ dbSNP | Ensembl ].
VAR_028866
Natural varianti339 – 3391L → V.
Corresponds to variant rs2240539 [ dbSNP | Ensembl ].
VAR_028867
Natural varianti347 – 3471D → E.
Corresponds to variant rs10203977 [ dbSNP | Ensembl ].
VAR_028868
Natural varianti378 – 3781D → E.
Corresponds to variant rs10167328 [ dbSNP | Ensembl ].
VAR_028869

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291665 mRNA. Translation: BAF84354.1.
AC005237 Genomic DNA. No translation available.
BC053533 mRNA. Translation: AAH53533.2.
AF161359 mRNA. Translation: AAF28919.1. Different initiation.
CCDSiCCDS2544.1.
RefSeqiNP_872307.2. NM_182501.3.
XP_011508936.1. XM_011510634.2.
UniGeneiHs.159556.

Genome annotation databases

EnsembliENST00000241527; ENSP00000241527; ENSG00000122085.
ENST00000391980; ENSP00000375840; ENSG00000122085.
ENST00000614476; ENSP00000480378; ENSG00000122085.
GeneIDi130916.
KEGGihsa:130916.
UCSCiuc061uks.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291665 mRNA. Translation: BAF84354.1.
AC005237 Genomic DNA. No translation available.
BC053533 mRNA. Translation: AAH53533.2.
AF161359 mRNA. Translation: AAF28919.1. Different initiation.
CCDSiCCDS2544.1.
RefSeqiNP_872307.2. NM_182501.3.
XP_011508936.1. XM_011510634.2.
UniGeneiHs.159556.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FP9X-ray2.90B/E/G/H47-381[»]
4FZVX-ray2.00B122-330[»]
ProteinModelPortaliQ7Z6M4.
SMRiQ7Z6M4. Positions 83-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126263. 10 interactions.
DIPiDIP-49918N.
IntActiQ7Z6M4. 3 interactions.
MINTiMINT-2878691.
STRINGi9606.ENSP00000241527.

PTM databases

iPTMnetiQ7Z6M4.
PhosphoSiteiQ7Z6M4.

Polymorphism and mutation databases

BioMutaiMTERFD2.
DMDMi296439296.

Proteomic databases

EPDiQ7Z6M4.
MaxQBiQ7Z6M4.
PaxDbiQ7Z6M4.
PeptideAtlasiQ7Z6M4.
PRIDEiQ7Z6M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241527; ENSP00000241527; ENSG00000122085.
ENST00000391980; ENSP00000375840; ENSG00000122085.
ENST00000614476; ENSP00000480378; ENSG00000122085.
GeneIDi130916.
KEGGihsa:130916.
UCSCiuc061uks.1. human.

Organism-specific databases

CTDi130916.
GeneCardsiMTERF4.
H-InvDBHIX0002987.
HGNCiHGNC:28785. MTERF4.
HPAiHPA027097.
MIMi615393. gene.
neXtProtiNX_Q7Z6M4.
PharmGKBiPA142671310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK50. Eukaryota.
ENOG410Y0Q1. LUCA.
GeneTreeiENSGT00460000041648.
HOGENOMiHOG000069984.
HOVERGENiHBG081990.
InParanoidiQ7Z6M4.
KOiK15032.
OMAiTEILHRC.
OrthoDBiEOG091G0DPS.
PhylomeDBiQ7Z6M4.
TreeFamiTF329452.

Miscellaneous databases

ChiTaRSiMTERFD2. human.
GenomeRNAii130916.
PROiQ7Z6M4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122085.
CleanExiHS_MTERFD2.
ExpressionAtlasiQ7Z6M4. baseline and differential.
GenevisibleiQ7Z6M4. HS.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6M4
Secondary accession number(s): A8K6K0, Q9P0E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.