ID FBX33_HUMAN Reviewed; 555 AA. AC Q7Z6M2; Q6PIR2; Q86TR2; Q86YE0; DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 24-JAN-2024, entry version 148. DE RecName: Full=F-box only protein 33; GN Name=FBXO33; Synonyms=FBX33; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, Skin, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346. RC TISSUE=Placenta; RA Li W.B., Gruber C., Jessee J., Polayes D.; RT "Full-length cDNA libraries and normalization."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box CC protein) E3 ubiquitin-protein ligase complex which mediates the CC ubiquitination and subsequent proteasomal degradation of target CC proteins. Probably recognizes and binds to phosphorylated target CC proteins. Recognizes YBX1 (By similarity). {ECO:0000250}. CC -!- PATHWAY: Protein modification; protein ubiquitination. CC -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase CC complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts CC via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 CC and CUL1 (By similarity). {ECO:0000250}. CC -!- INTERACTION: CC Q7Z6M2; Q13616: CUL1; NbExp=2; IntAct=EBI-8555452, EBI-359390; CC Q7Z6M2; P63208: SKP1; NbExp=2; IntAct=EBI-8555452, EBI-307486; CC Q7Z6M2; P67809: YBX1; NbExp=6; IntAct=EBI-8555452, EBI-354065; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC030611; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC042535; AAH42535.1; -; mRNA. DR EMBL; BC053537; AAH53537.1; -; mRNA. DR EMBL; BC068566; AAH68566.1; -; mRNA. DR EMBL; BX248772; CAD66579.1; -; mRNA. DR CCDS; CCDS9677.1; -. DR RefSeq; NP_976046.1; NM_203301.3. DR AlphaFoldDB; Q7Z6M2; -. DR BioGRID; 129019; 20. DR IntAct; Q7Z6M2; 13. DR MINT; Q7Z6M2; -. DR STRING; 9606.ENSP00000298097; -. DR iPTMnet; Q7Z6M2; -. DR PhosphoSitePlus; Q7Z6M2; -. DR BioMuta; FBXO33; -. DR DMDM; 51315939; -. DR EPD; Q7Z6M2; -. DR jPOST; Q7Z6M2; -. DR MassIVE; Q7Z6M2; -. DR MaxQB; Q7Z6M2; -. DR PaxDb; 9606-ENSP00000298097; -. DR PeptideAtlas; Q7Z6M2; -. DR ProteomicsDB; 69446; -. DR Pumba; Q7Z6M2; -. DR Antibodypedia; 23412; 97 antibodies from 17 providers. DR DNASU; 254170; -. DR Ensembl; ENST00000298097.8; ENSP00000298097.7; ENSG00000165355.8. DR GeneID; 254170; -. DR KEGG; hsa:254170; -. DR MANE-Select; ENST00000298097.8; ENSP00000298097.7; NM_203301.4; NP_976046.1. DR UCSC; uc001wvk.4; human. DR AGR; HGNC:19833; -. DR CTD; 254170; -. DR DisGeNET; 254170; -. DR GeneCards; FBXO33; -. DR HGNC; HGNC:19833; FBXO33. DR HPA; ENSG00000165355; Tissue enhanced (bone). DR MIM; 609103; gene. DR neXtProt; NX_Q7Z6M2; -. DR OpenTargets; ENSG00000165355; -. DR PharmGKB; PA134861757; -. DR VEuPathDB; HostDB:ENSG00000165355; -. DR eggNOG; ENOG502QPU4; Eukaryota. DR GeneTree; ENSGT00390000017718; -. DR HOGENOM; CLU_042932_0_0_1; -. DR InParanoid; Q7Z6M2; -. DR OMA; APGMSVC; -. DR OrthoDB; 4175863at2759; -. DR PhylomeDB; Q7Z6M2; -. DR TreeFam; TF321665; -. DR PathwayCommons; Q7Z6M2; -. DR SignaLink; Q7Z6M2; -. DR SIGNOR; Q7Z6M2; -. DR UniPathway; UPA00143; -. DR BioGRID-ORCS; 254170; 12 hits in 1202 CRISPR screens. DR ChiTaRS; FBXO33; human. DR GenomeRNAi; 254170; -. DR Pharos; Q7Z6M2; Tdark. DR PRO; PR:Q7Z6M2; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; Q7Z6M2; Protein. DR Bgee; ENSG00000165355; Expressed in secondary oocyte and 188 other cell types or tissues. DR ExpressionAtlas; Q7Z6M2; baseline and differential. DR Genevisible; Q7Z6M2; HS. DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:InterPro. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central. DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro. DR CDD; cd22104; F-box_FBXO33; 1. DR Gene3D; 1.20.1280.50; -; 1. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1. DR InterPro; IPR036047; F-box-like_dom_sf. DR InterPro; IPR001810; F-box_dom. DR InterPro; IPR039940; FBXO33/FBX12. DR InterPro; IPR032675; LRR_dom_sf. DR PANTHER; PTHR20933; F-BOX ONLY PROTEIN 33; 1. DR PANTHER; PTHR20933:SF3; F-BOX ONLY PROTEIN 33; 1. DR Pfam; PF12937; F-box-like; 1. DR SMART; SM00256; FBOX; 1. DR SUPFAM; SSF81383; F-box domain; 1. DR PROSITE; PS50181; FBOX; 1. PE 1: Evidence at protein level; KW Reference proteome; Ubl conjugation pathway. FT CHAIN 1..555 FT /note="F-box only protein 33" FT /id="PRO_0000119925" FT DOMAIN 65..111 FT /note="F-box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080" SQ SEQUENCE 555 AA; 62630 MW; 457ABB301C592E32 CRC64; MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG AGSRRRGRMA LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE CLFYPALWPQ LRICLRVSPA EQPRLEFLMR KCGWFVRELR VEFAAENYLS GGGPGDGGGA DTGTGGEEVE ALQLSARWLE VLRTYLELVL CVLVSIRNNR NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ LFEEILSNSR QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS LDNMPNDEHW KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD SYITCVSGAI VDLISRQYDK FLTHFILMND VIDTSGFPDL SDNRNEDPLV LLAWRCTKLS LLAIHGYTVW AHNLIAIARL RGSDLKVLEV TEESIDFDQG ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP NRHFYREMQS FSEDI //