Q7Z6M2 (FBX33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box only protein 33

Gene names

Name:	FBXO33
Synonyms:	FBX33

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 By similarity.
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	F-box only protein 33		PRO_0000119925
Regions
	Domain	65 – 111	47	F-box
	Compositional bias	11 – 58	48	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	Q7Z6M2 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 457ABB301C592E32	FASTA	555	62,630
	10 20 30 40 50 60 MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG AGSRRRGRMA 70 80 90 100 110 120 LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE CLFYPALWPQ LRICLRVSPA 130 140 150 160 170 180 EQPRLEFLMR KCGWFVRELR VEFAAENYLS GGGPGDGGGA DTGTGGEEVE ALQLSARWLE 190 200 210 220 230 240 VLRTYLELVL CVLVSIRNNR NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ 250 260 270 280 290 300 LFEEILSNSR QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV 310 320 330 340 350 360 ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS LDNMPNDEHW 370 380 390 400 410 420 KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD SYITCVSGAI VDLISRQYDK 430 440 450 460 470 480 FLTHFILMND VIDTSGFPDL SDNRNEDPLV LLAWRCTKLS LLAIHGYTVW AHNLIAIARL 490 500 510 520 530 540 RGSDLKVLEV TEESIDFDQG ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP 550 NRHFYREMQS FSEDI

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Skin and Testis.
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC030611 mRNA. No translation available. BC042535 mRNA. Translation: AAH42535.1. BC053537 mRNA. Translation: AAH53537.1. BC068566 mRNA. Translation: AAH68566.1. BX248772 mRNA. Translation: CAD66579.1.
IPI	IPI00328603.
RefSeq	NP_976046.1. NM_203301.3.
UniGene	Hs.146632.
3D structure databases
ProteinModelPortal	Q7Z6M2.
SMR	Q7Z6M2. Positions 68-108, 248-322, 446-491.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2831379.
STRING	9606.ENSP00000298097.
PTM databases
PhosphoSite	Q7Z6M2.
Polymorphism databases
DMDM	51315939.
Proteomic databases
PaxDb	Q7Z6M2.
PRIDE	Q7Z6M2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298097; ENSP00000298097; ENSG00000165355.
GeneID	254170.
KEGG	hsa:254170.
UCSC	uc001wvk.3. human.
Organism-specific databases
CTD	254170.
GeneCards	GC14M039866.
HGNC	HGNC:19833. FBXO33.
HPA	HPA046657.
MIM	609103. gene.
neXtProt	NX_Q7Z6M2.
PharmGKB	PA134861757.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83241.
HOGENOM	HOG000072695.
HOVERGEN	HBG051575.
InParanoid	Q7Z6M2.
KO	K10310.
OMA	QLRWLSC.
OrthoDB	EOG4KWJSM.
PhylomeDB	Q7Z6M2.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q7Z6M2.
Bgee	Q7Z6M2.
CleanEx	HS_FBXO33.
Genevestigator	Q7Z6M2.
GermOnline	ENSG00000165355. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box_dom_cyclin-like. [Graphical view]
SMART	SM00256. FBOX. 1 hit. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FBXO33. human.
GenomeRNAi	254170.
NextBio	92275.
SOURCE	Search...

Entry information

Entry name

FBX33_HUMAN

Accession

Primary (citable) accession number: Q7Z6M2
Secondary accession number(s): Q6PIR2, Q86TR2, Q86YE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.