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Q7Z6M2 (FBX33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 33
Gene names
Name:FBXO33
Synonyms:FBX33
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 By similarity.

Sequence similarities

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 16797541. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

YBX1P678095EBI-8555452,EBI-354065

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555F-box only protein 33
PRO_0000119925

Regions

Domain65 – 11147F-box
Compositional bias11 – 5848Arg-rich

Sequences

Sequence LengthMass (Da)Tools
Q7Z6M2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 457ABB301C592E32

FASTA55562,630
        10         20         30         40         50         60 
MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG AGSRRRGRMA 

        70         80         90        100        110        120 
LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE CLFYPALWPQ LRICLRVSPA 

       130        140        150        160        170        180 
EQPRLEFLMR KCGWFVRELR VEFAAENYLS GGGPGDGGGA DTGTGGEEVE ALQLSARWLE 

       190        200        210        220        230        240 
VLRTYLELVL CVLVSIRNNR NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ 

       250        260        270        280        290        300 
LFEEILSNSR QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV 

       310        320        330        340        350        360 
ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS LDNMPNDEHW 

       370        380        390        400        410        420 
KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD SYITCVSGAI VDLISRQYDK 

       430        440        450        460        470        480 
FLTHFILMND VIDTSGFPDL SDNRNEDPLV LLAWRCTKLS LLAIHGYTVW AHNLIAIARL 

       490        500        510        520        530        540 
RGSDLKVLEV TEESIDFDQG ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP 

       550 
NRHFYREMQS FSEDI 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Skin and Testis.
[2]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346.
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC030611 mRNA. No translation available.
BC042535 mRNA. Translation: AAH42535.1.
BC053537 mRNA. Translation: AAH53537.1.
BC068566 mRNA. Translation: AAH68566.1.
BX248772 mRNA. Translation: CAD66579.1.
CCDSCCDS9677.1.
RefSeqNP_976046.1. NM_203301.3.
UniGeneHs.146632.

3D structure databases

ProteinModelPortalQ7Z6M2.
SMRQ7Z6M2. Positions 68-142, 303-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129019. 3 interactions.
IntActQ7Z6M2. 9 interactions.
MINTMINT-2831379.
STRING9606.ENSP00000298097.

PTM databases

PhosphoSiteQ7Z6M2.

Polymorphism databases

DMDM51315939.

Proteomic databases

MaxQBQ7Z6M2.
PaxDbQ7Z6M2.
PRIDEQ7Z6M2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298097; ENSP00000298097; ENSG00000165355.
GeneID254170.
KEGGhsa:254170.
UCSCuc001wvk.3. human.

Organism-specific databases

CTD254170.
GeneCardsGC14M039866.
HGNCHGNC:19833. FBXO33.
HPAHPA046657.
MIM609103. gene.
neXtProtNX_Q7Z6M2.
PharmGKBPA134861757.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83241.
HOGENOMHOG000072695.
HOVERGENHBG051575.
InParanoidQ7Z6M2.
KOK10310.
OMAQLRWLSC.
OrthoDBEOG7QZG98.
PhylomeDBQ7Z6M2.
TreeFamTF321665.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ7Z6M2.
BgeeQ7Z6M2.
CleanExHS_FBXO33.
GenevestigatorQ7Z6M2.

Family and domain databases

InterProIPR001810. F-box_dom.
[Graphical view]
PfamPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFBXO33. human.
GenomeRNAi254170.
NextBio92275.
PROQ7Z6M2.
SOURCESearch...

Entry information

Entry nameFBX33_HUMAN
AccessionPrimary (citable) accession number: Q7Z6M2
Secondary accession number(s): Q6PIR2, Q86TR2, Q86YE0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM