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Protein

F-box only protein 33

Gene

FBXO33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 33
Gene namesi
Name:FBXO33
Synonyms:FBX33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19833. FBXO33.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555F-box only protein 33PRO_0000119925Add
BLAST

Proteomic databases

MaxQBiQ7Z6M2.
PaxDbiQ7Z6M2.
PRIDEiQ7Z6M2.

PTM databases

PhosphoSiteiQ7Z6M2.

Expressioni

Gene expression databases

BgeeiQ7Z6M2.
CleanExiHS_FBXO33.
ExpressionAtlasiQ7Z6M2. baseline and differential.
GenevestigatoriQ7Z6M2.

Organism-specific databases

HPAiHPA046657.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
YBX1P678095EBI-8555452,EBI-354065

Protein-protein interaction databases

BioGridi129019. 3 interactions.
IntActiQ7Z6M2. 9 interactions.
MINTiMINT-2831379.
STRINGi9606.ENSP00000298097.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6M2.
SMRiQ7Z6M2. Positions 279-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 11147F-boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 5848Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG83241.
GeneTreeiENSGT00390000017718.
HOGENOMiHOG000072695.
HOVERGENiHBG051575.
InParanoidiQ7Z6M2.
KOiK10310.
OMAiQLRWLSC.
OrthoDBiEOG7QZG98.
PhylomeDBiQ7Z6M2.
TreeFamiTF321665.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z6M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG
60 70 80 90 100
AGSRRRGRMA LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE
110 120 130 140 150
CLFYPALWPQ LRICLRVSPA EQPRLEFLMR KCGWFVRELR VEFAAENYLS
160 170 180 190 200
GGGPGDGGGA DTGTGGEEVE ALQLSARWLE VLRTYLELVL CVLVSIRNNR
210 220 230 240 250
NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ LFEEILSNSR
260 270 280 290 300
QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV
310 320 330 340 350
ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS
360 370 380 390 400
LDNMPNDEHW KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD
410 420 430 440 450
SYITCVSGAI VDLISRQYDK FLTHFILMND VIDTSGFPDL SDNRNEDPLV
460 470 480 490 500
LLAWRCTKLS LLAIHGYTVW AHNLIAIARL RGSDLKVLEV TEESIDFDQG
510 520 530 540 550
ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP NRHFYREMQS

FSEDI
Length:555
Mass (Da):62,630
Last modified:October 1, 2003 - v1
Checksum:i457ABB301C592E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030611 mRNA. No translation available.
BC042535 mRNA. Translation: AAH42535.1.
BC053537 mRNA. Translation: AAH53537.1.
BC068566 mRNA. Translation: AAH68566.1.
BX248772 mRNA. Translation: CAD66579.1.
CCDSiCCDS9677.1.
RefSeqiNP_976046.1. NM_203301.3.
UniGeneiHs.146632.

Genome annotation databases

EnsembliENST00000298097; ENSP00000298097; ENSG00000165355.
GeneIDi254170.
KEGGihsa:254170.
UCSCiuc001wvk.3. human.

Polymorphism databases

DMDMi51315939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030611 mRNA. No translation available.
BC042535 mRNA. Translation: AAH42535.1.
BC053537 mRNA. Translation: AAH53537.1.
BC068566 mRNA. Translation: AAH68566.1.
BX248772 mRNA. Translation: CAD66579.1.
CCDSiCCDS9677.1.
RefSeqiNP_976046.1. NM_203301.3.
UniGeneiHs.146632.

3D structure databases

ProteinModelPortaliQ7Z6M2.
SMRiQ7Z6M2. Positions 279-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129019. 3 interactions.
IntActiQ7Z6M2. 9 interactions.
MINTiMINT-2831379.
STRINGi9606.ENSP00000298097.

PTM databases

PhosphoSiteiQ7Z6M2.

Polymorphism databases

DMDMi51315939.

Proteomic databases

MaxQBiQ7Z6M2.
PaxDbiQ7Z6M2.
PRIDEiQ7Z6M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298097; ENSP00000298097; ENSG00000165355.
GeneIDi254170.
KEGGihsa:254170.
UCSCiuc001wvk.3. human.

Organism-specific databases

CTDi254170.
GeneCardsiGC14M039866.
HGNCiHGNC:19833. FBXO33.
HPAiHPA046657.
MIMi609103. gene.
neXtProtiNX_Q7Z6M2.
PharmGKBiPA134861757.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG83241.
GeneTreeiENSGT00390000017718.
HOGENOMiHOG000072695.
HOVERGENiHBG051575.
InParanoidiQ7Z6M2.
KOiK10310.
OMAiQLRWLSC.
OrthoDBiEOG7QZG98.
PhylomeDBiQ7Z6M2.
TreeFamiTF321665.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiFBXO33. human.
GenomeRNAii254170.
NextBioi92275.
PROiQ7Z6M2.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z6M2.
CleanExiHS_FBXO33.
ExpressionAtlasiQ7Z6M2. baseline and differential.
GenevestigatoriQ7Z6M2.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Skin and Testis.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346.
    Tissue: Placenta.

Entry informationi

Entry nameiFBX33_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6M2
Secondary accession number(s): Q6PIR2, Q86TR2, Q86YE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.