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Q7Z6M2

- FBX33_HUMAN

UniProt

Q7Z6M2 - FBX33_HUMAN

Protein

F-box only protein 33

Gene

FBXO33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 33
    Gene namesi
    Name:FBXO33
    Synonyms:FBX33
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19833. FBXO33.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134861757.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555F-box only protein 33PRO_0000119925Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z6M2.
    PaxDbiQ7Z6M2.
    PRIDEiQ7Z6M2.

    PTM databases

    PhosphoSiteiQ7Z6M2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z6M2.
    BgeeiQ7Z6M2.
    CleanExiHS_FBXO33.
    GenevestigatoriQ7Z6M2.

    Organism-specific databases

    HPAiHPA046657.

    Interactioni

    Subunit structurei

    Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YBX1P678095EBI-8555452,EBI-354065

    Protein-protein interaction databases

    BioGridi129019. 3 interactions.
    IntActiQ7Z6M2. 9 interactions.
    MINTiMINT-2831379.
    STRINGi9606.ENSP00000298097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z6M2.
    SMRiQ7Z6M2. Positions 68-142, 303-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 11147F-boxPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 5848Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG83241.
    HOGENOMiHOG000072695.
    HOVERGENiHBG051575.
    InParanoidiQ7Z6M2.
    KOiK10310.
    OMAiQLRWLSC.
    OrthoDBiEOG7QZG98.
    PhylomeDBiQ7Z6M2.
    TreeFamiTF321665.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z6M2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG    50
    AGSRRRGRMA LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE 100
    CLFYPALWPQ LRICLRVSPA EQPRLEFLMR KCGWFVRELR VEFAAENYLS 150
    GGGPGDGGGA DTGTGGEEVE ALQLSARWLE VLRTYLELVL CVLVSIRNNR 200
    NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ LFEEILSNSR 250
    QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV 300
    ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS 350
    LDNMPNDEHW KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD 400
    SYITCVSGAI VDLISRQYDK FLTHFILMND VIDTSGFPDL SDNRNEDPLV 450
    LLAWRCTKLS LLAIHGYTVW AHNLIAIARL RGSDLKVLEV TEESIDFDQG 500
    ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP NRHFYREMQS 550
    FSEDI 555
    Length:555
    Mass (Da):62,630
    Last modified:October 1, 2003 - v1
    Checksum:i457ABB301C592E32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC030611 mRNA. No translation available.
    BC042535 mRNA. Translation: AAH42535.1.
    BC053537 mRNA. Translation: AAH53537.1.
    BC068566 mRNA. Translation: AAH68566.1.
    BX248772 mRNA. Translation: CAD66579.1.
    CCDSiCCDS9677.1.
    RefSeqiNP_976046.1. NM_203301.3.
    UniGeneiHs.146632.

    Genome annotation databases

    EnsembliENST00000298097; ENSP00000298097; ENSG00000165355.
    GeneIDi254170.
    KEGGihsa:254170.
    UCSCiuc001wvk.3. human.

    Polymorphism databases

    DMDMi51315939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC030611 mRNA. No translation available.
    BC042535 mRNA. Translation: AAH42535.1 .
    BC053537 mRNA. Translation: AAH53537.1 .
    BC068566 mRNA. Translation: AAH68566.1 .
    BX248772 mRNA. Translation: CAD66579.1 .
    CCDSi CCDS9677.1.
    RefSeqi NP_976046.1. NM_203301.3.
    UniGenei Hs.146632.

    3D structure databases

    ProteinModelPortali Q7Z6M2.
    SMRi Q7Z6M2. Positions 68-142, 303-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129019. 3 interactions.
    IntActi Q7Z6M2. 9 interactions.
    MINTi MINT-2831379.
    STRINGi 9606.ENSP00000298097.

    PTM databases

    PhosphoSitei Q7Z6M2.

    Polymorphism databases

    DMDMi 51315939.

    Proteomic databases

    MaxQBi Q7Z6M2.
    PaxDbi Q7Z6M2.
    PRIDEi Q7Z6M2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298097 ; ENSP00000298097 ; ENSG00000165355 .
    GeneIDi 254170.
    KEGGi hsa:254170.
    UCSCi uc001wvk.3. human.

    Organism-specific databases

    CTDi 254170.
    GeneCardsi GC14M039866.
    HGNCi HGNC:19833. FBXO33.
    HPAi HPA046657.
    MIMi 609103. gene.
    neXtProti NX_Q7Z6M2.
    PharmGKBi PA134861757.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83241.
    HOGENOMi HOG000072695.
    HOVERGENi HBG051575.
    InParanoidi Q7Z6M2.
    KOi K10310.
    OMAi QLRWLSC.
    OrthoDBi EOG7QZG98.
    PhylomeDBi Q7Z6M2.
    TreeFami TF321665.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi FBXO33. human.
    GenomeRNAii 254170.
    NextBioi 92275.
    PROi Q7Z6M2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z6M2.
    Bgeei Q7Z6M2.
    CleanExi HS_FBXO33.
    Genevestigatori Q7Z6M2.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Skin and Testis.
    2. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346.
      Tissue: Placenta.

    Entry informationi

    Entry nameiFBX33_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z6M2
    Secondary accession number(s): Q6PIR2, Q86TR2, Q86YE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3