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Q7Z6L1

- TCPR1_HUMAN

UniProt

Q7Z6L1 - TCPR1_HUMAN

Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

TECPR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.2 Publications

    GO - Molecular functioni

    1. phosphatidylinositol-3-phosphate binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagic vacuole fusion Source: UniProtKB
    2. autophagy Source: UniProtKB

    Keywords - Biological processi

    Autophagy

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tectonin beta-propeller repeat-containing protein 1
    Gene namesi
    Name:TECPR1
    Synonyms:KIAA1358
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:22214. TECPR1.

    Subcellular locationi

    Cytoplasmic vesicleautophagosome membrane. Lysosome membrane
    Note: Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

    GO - Cellular componenti

    1. autophagic vacuole membrane Source: UniProtKB
    2. cytoplasmic vesicle Source: UniProtKB-KW
    3. integral component of membrane Source: InterPro
    4. lysosomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164726436.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11651165Tectonin beta-propeller repeat-containing protein 1PRO_0000337060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei938 – 9381Phosphoserine1 Publication
    Modified residuei949 – 9491Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z6L1.
    PaxDbiQ7Z6L1.
    PRIDEiQ7Z6L1.

    PTM databases

    PhosphoSiteiQ7Z6L1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z6L1.
    BgeeiQ7Z6L1.
    GenevestigatoriQ7Z6L1.

    Organism-specific databases

    HPAiHPA021061.

    Interactioni

    Subunit structurei

    Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG3Q9NT623EBI-2946676,EBI-988094
    ATG5Q9H1Y06EBI-2946676,EBI-1047414

    Protein-protein interaction databases

    BioGridi117375. 9 interactions.
    IntActiQ7Z6L1. 11 interactions.
    STRINGi9606.ENSP00000404923.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z6L1.
    SMRiQ7Z6L1. Positions 64-170, 820-921.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati209 – 24032TECPR 1Add
    BLAST
    Repeati254 – 28532TECPR 2Add
    BLAST
    Repeati301 – 33232TECPR 3Add
    BLAST
    Repeati344 – 37633TECPR 4Add
    BLAST
    Domaini611 – 717107PHAdd
    BLAST
    Repeati729 – 75628TECPR 5Add
    BLAST
    Repeati953 – 98432TECPR 6Add
    BLAST
    Repeati998 – 102932TECPR 7Add
    BLAST
    Repeati1044 – 107532TECPR 8Add
    BLAST
    Repeati1087 – 112741TECPR 9Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi384 – 3918Poly-Ser

    Domaini

    The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P). While full-length protein is unable to bind PtdIns3P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns3P (PubMed:22342342).1 Publication

    Sequence similaritiesi

    Belongs to the TECPR1 family.Curated
    Contains 1 PH domain.Curated
    Contains 9 TECPR repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG328700.
    HOGENOMiHOG000007892.
    InParanoidiQ7Z6L1.
    KOiK17988.
    OMAiQYASDFP.
    OrthoDBiEOG7HXCQ5.
    PhylomeDBiQ7Z6L1.
    TreeFamiTF323648.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR006624. Beta-propeller_rpt_TECPR.
    IPR010482. Peroxin/Dysferlin.
    IPR006614. Peroxin/Ferlin.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF06462. Hyd_WA. 8 hits.
    PF06398. Pex24p. 2 hits.
    [Graphical view]
    SMARTiSM00694. DysFC. 2 hits.
    SM00693. DysFN. 2 hits.
    SM00233. PH. 1 hit.
    SM00706. TECPR. 11 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z6L1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC     50
    DNQVYVYVCA SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG 100
    LQHRPLDRVA LPSPHWEWES DWYVDENFGG EPTEKGGWTY AIDFPATYTK 150
    DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS KDDPKELPDP FNDLSVGGWE 200
    ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD TPGEVVQISC 250
    GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV 300
    SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG 350
    CEDRAVYFRQ GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG 400
    DEVRGSGESA PSDTDASSEV ERPGPGQILP AEPLDDSKNA TGNSASGLGA 450
    GRTAEDTVED ACPAEGSREA RPNTHPGPAP TPAELPWTNI DLKEAKKVPS 500
    HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG GCVVEACAMP 550
    RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY 600
    EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY 650
    YVVHEEKKYI HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA 700
    TEQDMNDWLA LLSLSCCESR KVQGRPSPQA IWSITCKGDI FVSEPSPDLE 750
    AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV VWGIGYDHTA WVYTGGYGGG 800
    CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL PTDRYMWSDA 850
    SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH 900
    GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG 950
    HSIALWAVSD KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV 1000
    WAVARDGSAF YRGSVYPSQP AGDCWYHIPS PPRQRLKQVS AGQTSVYALD 1050
    ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR VSVGPLDQVW VIANKVQGSH 1100
    SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA TRAPRSSSQE 1150
    QEPSAPPEAH GPVCC 1165
    Length:1,165
    Mass (Da):129,696
    Last modified:October 1, 2003 - v1
    Checksum:iD396F4128710062D
    GO
    Isoform 2 (identifier: Q7Z6L1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         557-557: A → AG

    Note: No experimental confirmation available.

    Show »
    Length:1,166
    Mass (Da):129,753
    Checksum:i514CB3EE46C887D6
    GO
    Isoform 3 (identifier: Q7Z6L1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.
         219-219: K → KVLCPCLASQ
         838-1165: RGLPTDRYMW...PPEAHGPVCC → SRDRISPCW

    Note: No experimental confirmation available.

    Show »
    Length:776
    Mass (Da):86,697
    Checksum:iCCBCAB81F92A970A
    GO
    Isoform 4 (identifier: Q7Z6L1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         556-556: Q → QA
         836-836: T → TS

    Note: No experimental confirmation available.

    Show »
    Length:1,167
    Mass (Da):129,854
    Checksum:i5E69B7980D8A5297
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161W → R in BAF85685. (PubMed:14702039)Curated
    Sequence conflicti151 – 1511D → Y in BAG51853. (PubMed:14702039)Curated
    Sequence conflicti464 – 4641A → T in BAF85685. (PubMed:14702039)Curated
    Sequence conflicti746 – 7461S → T in CAB55961. (PubMed:17974005)Curated
    Sequence conflicti953 – 9531I → T in BAF85685. (PubMed:14702039)Curated
    Sequence conflicti988 – 9881P → L in CAB55961. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti733 – 7331S → Y.
    Corresponds to variant rs35623371 [ dbSNP | Ensembl ].
    VAR_060190
    Natural varianti944 – 9441P → L.
    Corresponds to variant rs11762014 [ dbSNP | Ensembl ].
    VAR_062238

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979Missing in isoform 3. 1 PublicationVSP_042969Add
    BLAST
    Alternative sequencei219 – 2191K → KVLCPCLASQ in isoform 3. 1 PublicationVSP_042970
    Alternative sequencei556 – 5561Q → QA in isoform 4. CuratedVSP_042971
    Alternative sequencei557 – 5571A → AG in isoform 2. 1 PublicationVSP_033861
    Alternative sequencei836 – 8361T → TS in isoform 4. CuratedVSP_042972
    Alternative sequencei838 – 1165328RGLPT…GPVCC → SRDRISPCW in isoform 3. 1 PublicationVSP_042973Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057048 mRNA. Translation: BAG51853.1.
    AK292996 mRNA. Translation: BAF85685.1.
    AC091654 Genomic DNA. No translation available.
    CH236956 Genomic DNA. Translation: EAL23891.1.
    CH471091 Genomic DNA. Translation: EAW76717.1.
    BC012529 mRNA. Translation: AAH12529.2.
    BC053591 mRNA. Translation: AAH53591.1.
    AB037779 mRNA. Translation: BAA92596.1.
    AL117495 mRNA. Translation: CAB55961.2.
    CCDSiCCDS47648.1. [Q7Z6L1-1]
    PIRiT17271.
    RefSeqiNP_056210.1. NM_015395.2. [Q7Z6L1-1]
    XP_005250310.1. XM_005250253.2. [Q7Z6L1-1]
    UniGeneiHs.592281.

    Genome annotation databases

    EnsembliENST00000447648; ENSP00000404923; ENSG00000205356. [Q7Z6L1-1]
    GeneIDi25851.
    KEGGihsa:25851.
    UCSCiuc003upg.4. human. [Q7Z6L1-1]
    uc003uph.2. human. [Q7Z6L1-3]

    Polymorphism databases

    DMDMi74738829.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057048 mRNA. Translation: BAG51853.1 .
    AK292996 mRNA. Translation: BAF85685.1 .
    AC091654 Genomic DNA. No translation available.
    CH236956 Genomic DNA. Translation: EAL23891.1 .
    CH471091 Genomic DNA. Translation: EAW76717.1 .
    BC012529 mRNA. Translation: AAH12529.2 .
    BC053591 mRNA. Translation: AAH53591.1 .
    AB037779 mRNA. Translation: BAA92596.1 .
    AL117495 mRNA. Translation: CAB55961.2 .
    CCDSi CCDS47648.1. [Q7Z6L1-1 ]
    PIRi T17271.
    RefSeqi NP_056210.1. NM_015395.2. [Q7Z6L1-1 ]
    XP_005250310.1. XM_005250253.2. [Q7Z6L1-1 ]
    UniGenei Hs.592281.

    3D structure databases

    ProteinModelPortali Q7Z6L1.
    SMRi Q7Z6L1. Positions 64-170, 820-921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117375. 9 interactions.
    IntActi Q7Z6L1. 11 interactions.
    STRINGi 9606.ENSP00000404923.

    PTM databases

    PhosphoSitei Q7Z6L1.

    Polymorphism databases

    DMDMi 74738829.

    Proteomic databases

    MaxQBi Q7Z6L1.
    PaxDbi Q7Z6L1.
    PRIDEi Q7Z6L1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000447648 ; ENSP00000404923 ; ENSG00000205356 . [Q7Z6L1-1 ]
    GeneIDi 25851.
    KEGGi hsa:25851.
    UCSCi uc003upg.4. human. [Q7Z6L1-1 ]
    uc003uph.2. human. [Q7Z6L1-3 ]

    Organism-specific databases

    CTDi 25851.
    GeneCardsi GC07M097843.
    H-InvDB HIX0006878.
    HGNCi HGNC:22214. TECPR1.
    HPAi HPA021061.
    MIMi 614781. gene.
    neXtProti NX_Q7Z6L1.
    PharmGKBi PA164726436.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328700.
    HOGENOMi HOG000007892.
    InParanoidi Q7Z6L1.
    KOi K17988.
    OMAi QYASDFP.
    OrthoDBi EOG7HXCQ5.
    PhylomeDBi Q7Z6L1.
    TreeFami TF323648.

    Miscellaneous databases

    GenomeRNAii 25851.
    NextBioi 47193.
    PROi Q7Z6L1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z6L1.
    Bgeei Q7Z6L1.
    Genevestigatori Q7Z6L1.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR006624. Beta-propeller_rpt_TECPR.
    IPR010482. Peroxin/Dysferlin.
    IPR006614. Peroxin/Ferlin.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF06462. Hyd_WA. 8 hits.
    PF06398. Pex24p. 2 hits.
    [Graphical view ]
    SMARTi SM00694. DysFC. 2 hits.
    SM00693. DysFN. 2 hits.
    SM00233. PH. 1 hit.
    SM00706. TECPR. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Trachea.
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Placenta.
    6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1165 (ISOFORM 1).
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 418-1165 (ISOFORM 2).
      Tissue: Testis.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-938 AND SER-949, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE ATG5-ATG12 CONJUGATE, INTERACTION WITH ATG5 AND WIPI2.
    10. "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."
      Chen D., Fan W., Lu Y., Ding X., Chen S., Zhong Q.
      Mol. Cell 45:629-641(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE ATG5-ATG12 CONJUGATE, INTERACTION WITH ATG5, PTDINS(3)P-BINDING.

    Entry informationi

    Entry nameiTCPR1_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z6L1
    Secondary accession number(s): A8KAD1
    , B3KPZ1, C9J024, F5GX57, Q96EB0, Q9P2I9, Q9UFR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3