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Q7Z6L1

- TCPR1_HUMAN

UniProt

Q7Z6L1 - TCPR1_HUMAN

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Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

TECPR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.2 Publications

GO - Molecular functioni

  1. phosphatidylinositol-3-phosphate binding Source: UniProtKB

GO - Biological processi

  1. autophagic vacuole fusion Source: UniProtKB
  2. autophagy Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein 1
Gene namesi
Name:TECPR1
Synonyms:KIAA1358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22214. TECPR1.

Subcellular locationi

Cytoplasmic vesicleautophagosome membrane. Lysosome membrane
Note: Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

GO - Cellular componenti

  1. autophagic vacuole membrane Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. integral component of membrane Source: InterPro
  4. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11651165Tectonin beta-propeller repeat-containing protein 1PRO_0000337060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei938 – 9381Phosphoserine1 Publication
Modified residuei949 – 9491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z6L1.
PaxDbiQ7Z6L1.
PRIDEiQ7Z6L1.

PTM databases

PhosphoSiteiQ7Z6L1.

Expressioni

Gene expression databases

BgeeiQ7Z6L1.
ExpressionAtlasiQ7Z6L1. baseline and differential.
GenevestigatoriQ7Z6L1.

Organism-specific databases

HPAiHPA021061.

Interactioni

Subunit structurei

Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG3Q9NT623EBI-2946676,EBI-988094
ATG5Q9H1Y06EBI-2946676,EBI-1047414

Protein-protein interaction databases

BioGridi117375. 9 interactions.
IntActiQ7Z6L1. 11 interactions.
STRINGi9606.ENSP00000404923.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6L1.
SMRiQ7Z6L1. Positions 64-170, 820-921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati209 – 24032TECPR 1Add
BLAST
Repeati254 – 28532TECPR 2Add
BLAST
Repeati301 – 33232TECPR 3Add
BLAST
Repeati344 – 37633TECPR 4Add
BLAST
Domaini611 – 717107PHAdd
BLAST
Repeati729 – 75628TECPR 5Add
BLAST
Repeati953 – 98432TECPR 6Add
BLAST
Repeati998 – 102932TECPR 7Add
BLAST
Repeati1044 – 107532TECPR 8Add
BLAST
Repeati1087 – 112741TECPR 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 3918Poly-Ser

Domaini

The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P). While full-length protein is unable to bind PtdIns3P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns3P (PubMed:22342342).1 Publication

Sequence similaritiesi

Belongs to the TECPR1 family.Curated
Contains 1 PH domain.Curated
Contains 9 TECPR repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG328700.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ7Z6L1.
KOiK17988.
OMAiQYASDFP.
OrthoDBiEOG7HXCQ5.
PhylomeDBiQ7Z6L1.
TreeFamiTF323648.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin/Dysferlin.
IPR006614. Peroxin/Ferlin.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00233. PH. 1 hit.
SM00706. TECPR. 11 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z6L1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC
60 70 80 90 100
DNQVYVYVCA SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG
110 120 130 140 150
LQHRPLDRVA LPSPHWEWES DWYVDENFGG EPTEKGGWTY AIDFPATYTK
160 170 180 190 200
DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS KDDPKELPDP FNDLSVGGWE
210 220 230 240 250
ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD TPGEVVQISC
260 270 280 290 300
GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV
310 320 330 340 350
SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG
360 370 380 390 400
CEDRAVYFRQ GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG
410 420 430 440 450
DEVRGSGESA PSDTDASSEV ERPGPGQILP AEPLDDSKNA TGNSASGLGA
460 470 480 490 500
GRTAEDTVED ACPAEGSREA RPNTHPGPAP TPAELPWTNI DLKEAKKVPS
510 520 530 540 550
HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG GCVVEACAMP
560 570 580 590 600
RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
610 620 630 640 650
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY
660 670 680 690 700
YVVHEEKKYI HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA
710 720 730 740 750
TEQDMNDWLA LLSLSCCESR KVQGRPSPQA IWSITCKGDI FVSEPSPDLE
760 770 780 790 800
AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV VWGIGYDHTA WVYTGGYGGG
810 820 830 840 850
CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL PTDRYMWSDA
860 870 880 890 900
SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
910 920 930 940 950
GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG
960 970 980 990 1000
HSIALWAVSD KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV
1010 1020 1030 1040 1050
WAVARDGSAF YRGSVYPSQP AGDCWYHIPS PPRQRLKQVS AGQTSVYALD
1060 1070 1080 1090 1100
ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR VSVGPLDQVW VIANKVQGSH
1110 1120 1130 1140 1150
SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA TRAPRSSSQE
1160
QEPSAPPEAH GPVCC
Length:1,165
Mass (Da):129,696
Last modified:October 1, 2003 - v1
Checksum:iD396F4128710062D
GO
Isoform 2 (identifier: Q7Z6L1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-557: A → AG

Note: No experimental confirmation available.

Show »
Length:1,166
Mass (Da):129,753
Checksum:i514CB3EE46C887D6
GO
Isoform 3 (identifier: Q7Z6L1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     219-219: K → KVLCPCLASQ
     838-1165: RGLPTDRYMW...PPEAHGPVCC → SRDRISPCW

Note: No experimental confirmation available.

Show »
Length:776
Mass (Da):86,697
Checksum:iCCBCAB81F92A970A
GO
Isoform 4 (identifier: Q7Z6L1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     556-556: Q → QA
     836-836: T → TS

Note: No experimental confirmation available.

Show »
Length:1,167
Mass (Da):129,854
Checksum:i5E69B7980D8A5297
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161W → R in BAF85685. (PubMed:14702039)Curated
Sequence conflicti151 – 1511D → Y in BAG51853. (PubMed:14702039)Curated
Sequence conflicti464 – 4641A → T in BAF85685. (PubMed:14702039)Curated
Sequence conflicti746 – 7461S → T in CAB55961. (PubMed:17974005)Curated
Sequence conflicti953 – 9531I → T in BAF85685. (PubMed:14702039)Curated
Sequence conflicti988 – 9881P → L in CAB55961. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti733 – 7331S → Y.
Corresponds to variant rs35623371 [ dbSNP | Ensembl ].
VAR_060190
Natural varianti944 – 9441P → L.
Corresponds to variant rs11762014 [ dbSNP | Ensembl ].
VAR_062238

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979Missing in isoform 3. 1 PublicationVSP_042969Add
BLAST
Alternative sequencei219 – 2191K → KVLCPCLASQ in isoform 3. 1 PublicationVSP_042970
Alternative sequencei556 – 5561Q → QA in isoform 4. CuratedVSP_042971
Alternative sequencei557 – 5571A → AG in isoform 2. 1 PublicationVSP_033861
Alternative sequencei836 – 8361T → TS in isoform 4. CuratedVSP_042972
Alternative sequencei838 – 1165328RGLPT…GPVCC → SRDRISPCW in isoform 3. 1 PublicationVSP_042973Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057048 mRNA. Translation: BAG51853.1.
AK292996 mRNA. Translation: BAF85685.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23891.1.
CH471091 Genomic DNA. Translation: EAW76717.1.
BC012529 mRNA. Translation: AAH12529.2.
BC053591 mRNA. Translation: AAH53591.1.
AB037779 mRNA. Translation: BAA92596.1.
AL117495 mRNA. Translation: CAB55961.2.
CCDSiCCDS47648.1. [Q7Z6L1-1]
PIRiT17271.
RefSeqiNP_056210.1. NM_015395.2. [Q7Z6L1-1]
XP_005250310.1. XM_005250253.2. [Q7Z6L1-1]
UniGeneiHs.592281.

Genome annotation databases

EnsembliENST00000447648; ENSP00000404923; ENSG00000205356. [Q7Z6L1-1]
GeneIDi25851.
KEGGihsa:25851.
UCSCiuc003upg.4. human. [Q7Z6L1-1]
uc003uph.2. human. [Q7Z6L1-3]

Polymorphism databases

DMDMi74738829.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057048 mRNA. Translation: BAG51853.1 .
AK292996 mRNA. Translation: BAF85685.1 .
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23891.1 .
CH471091 Genomic DNA. Translation: EAW76717.1 .
BC012529 mRNA. Translation: AAH12529.2 .
BC053591 mRNA. Translation: AAH53591.1 .
AB037779 mRNA. Translation: BAA92596.1 .
AL117495 mRNA. Translation: CAB55961.2 .
CCDSi CCDS47648.1. [Q7Z6L1-1 ]
PIRi T17271.
RefSeqi NP_056210.1. NM_015395.2. [Q7Z6L1-1 ]
XP_005250310.1. XM_005250253.2. [Q7Z6L1-1 ]
UniGenei Hs.592281.

3D structure databases

ProteinModelPortali Q7Z6L1.
SMRi Q7Z6L1. Positions 64-170, 820-921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117375. 9 interactions.
IntActi Q7Z6L1. 11 interactions.
STRINGi 9606.ENSP00000404923.

PTM databases

PhosphoSitei Q7Z6L1.

Polymorphism databases

DMDMi 74738829.

Proteomic databases

MaxQBi Q7Z6L1.
PaxDbi Q7Z6L1.
PRIDEi Q7Z6L1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000447648 ; ENSP00000404923 ; ENSG00000205356 . [Q7Z6L1-1 ]
GeneIDi 25851.
KEGGi hsa:25851.
UCSCi uc003upg.4. human. [Q7Z6L1-1 ]
uc003uph.2. human. [Q7Z6L1-3 ]

Organism-specific databases

CTDi 25851.
GeneCardsi GC07M097843.
H-InvDB HIX0006878.
HGNCi HGNC:22214. TECPR1.
HPAi HPA021061.
MIMi 614781. gene.
neXtProti NX_Q7Z6L1.
PharmGKBi PA164726436.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328700.
GeneTreei ENSGT00510000047886.
HOGENOMi HOG000007892.
InParanoidi Q7Z6L1.
KOi K17988.
OMAi QYASDFP.
OrthoDBi EOG7HXCQ5.
PhylomeDBi Q7Z6L1.
TreeFami TF323648.

Miscellaneous databases

GenomeRNAii 25851.
NextBioi 47193.
PROi Q7Z6L1.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z6L1.
ExpressionAtlasi Q7Z6L1. baseline and differential.
Genevestigatori Q7Z6L1.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin/Dysferlin.
IPR006614. Peroxin/Ferlin.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view ]
SMARTi SM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00233. PH. 1 hit.
SM00706. TECPR. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Trachea.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Placenta.
  6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1165 (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 418-1165 (ISOFORM 2).
    Tissue: Testis.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-938 AND SER-949, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE ATG5-ATG12 CONJUGATE, INTERACTION WITH ATG5 AND WIPI2.
  10. "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."
    Chen D., Fan W., Lu Y., Ding X., Chen S., Zhong Q.
    Mol. Cell 45:629-641(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE ATG5-ATG12 CONJUGATE, INTERACTION WITH ATG5, PTDINS(3)P-BINDING.

Entry informationi

Entry nameiTCPR1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6L1
Secondary accession number(s): A8KAD1
, B3KPZ1, C9J024, F5GX57, Q96EB0, Q9P2I9, Q9UFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3