Q7Z6L1 (TCPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tectonin beta-propeller repeat-containing protein 1

Gene names

Name:	TECPR1
Synonyms:	KIAA1358

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Ref.9 Ref.10
Subunit structure	Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Ref.9 Ref.10
Subcellular location	Cytoplasmic vesicle › autophagosome membrane. Lysosome membrane. Note: Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes. Ref.9 Ref.10
Domain	The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P). While full-length protein is unable to bind PtdIns3P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns3P (Ref.10).
Sequence similarities	Belongs to the TECPR1 family. Contains 1 PH domain. Contains 9 TECPR repeats.

Ontologies

Keywords
Biological process	Autophagy
Cellular component	Cytoplasmic vesicle Lysosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagic vacuole fusion Inferred from mutant phenotype Ref.10. Source: UniProtKB
Cellular_component	autophagic vacuole membrane Inferred from direct assay Ref.9Ref.10. Source: UniProtKB cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: InterPro lysosomal membrane Inferred from direct assay Ref.10. Source: UniProtKB
Molecular_function	phosphatidylinositol-3-phosphate binding Inferred from direct assay Ref.10. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATG3	Q9NT62	3	EBI-2946676,EBI-988094
ATG5	Q9H1Y0	6	EBI-2946676,EBI-1047414

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6L1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6L1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     557-557: A → AG

Note: No experimental confirmation available.

Isoform 3 (identifier: Q7Z6L1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     219-219: K → KVLCPCLASQ
     838-1165: RGLPTDRYMW...PPEAHGPVCC → SRDRISPCW

Note: No experimental confirmation available.

Isoform 4 (identifier: Q7Z6L1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     556-556: Q → QA
     836-836: T → TS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1165	1165	Tectonin beta-propeller repeat-containing protein 1		PRO_0000337060
Regions
	Repeat	209 – 240	32	TECPR 1
	Repeat	254 – 285	32	TECPR 2
	Repeat	301 – 332	32	TECPR 3
	Repeat	344 – 376	33	TECPR 4
	Domain	611 – 717	107	PH
	Repeat	729 – 756	28	TECPR 5
	Repeat	953 – 984	32	TECPR 6
	Repeat	998 – 1029	32	TECPR 7
	Repeat	1044 – 1075	32	TECPR 8
	Repeat	1087 – 1127	41	TECPR 9
	Compositional bias	384 – 391	8	Poly-Ser
Amino acid modifications
	Modified residue	938	1	Phosphoserine Ref.8
	Modified residue	949	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 79	79	Missing in isoform 3.		VSP_042969
	Alternative sequence	219	1	K → KVLCPCLASQ in isoform 3.		VSP_042970
	Alternative sequence	556	1	Q → QA in isoform 4.		VSP_042971
	Alternative sequence	557	1	A → AG in isoform 2.		VSP_033861
	Alternative sequence	836	1	T → TS in isoform 4.		VSP_042972
	Alternative sequence	838 – 1165	328	RGLPT…GPVCC → SRDRISPCW in isoform 3.		VSP_042973
	Natural variant	733	1	S → Y. Corresponds to variant rs35623371 [ dbSNP | Ensembl ].		VAR_060190
	Natural variant	944	1	P → L. Corresponds to variant rs11762014 [ dbSNP | Ensembl ].		VAR_062238
Experimental info
	Sequence conflict	116	1	W → R in BAF85685. Ref.1
	Sequence conflict	151	1	D → Y in BAG51853. Ref.1
	Sequence conflict	464	1	A → T in BAF85685. Ref.1
	Sequence conflict	746	1	S → T in CAB55961. Ref.7
	Sequence conflict	953	1	I → T in BAF85685. Ref.1
	Sequence conflict	988	1	P → L in CAB55961. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: D396F4128710062D	FASTA	1,165	129,696
	10 20 30 40 50 60 MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA 70 80 90 100 110 120 SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG LQHRPLDRVA LPSPHWEWES 130 140 150 160 170 180 DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS 190 200 210 220 230 240 KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD 250 260 270 280 290 300 TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV 310 320 330 340 350 360 SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ 370 380 390 400 410 420 GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV 430 440 450 460 470 480 ERPGPGQILP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP 490 500 510 520 530 540 TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG 550 560 570 580 590 600 GCVVEACAMP RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY 610 620 630 640 650 660 EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY YVVHEEKKYI 670 680 690 700 710 720 HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR 730 740 750 760 770 780 KVQGRPSPQA IWSITCKGDI FVSEPSPDLE AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV 790 800 810 820 830 840 VWGIGYDHTA WVYTGGYGGG CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL 850 860 870 880 890 900 PTDRYMWSDA SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH 910 920 930 940 950 960 GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG HSIALWAVSD 970 980 990 1000 1010 1020 KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV WAVARDGSAF YRGSVYPSQP 1030 1040 1050 1060 1070 1080 AGDCWYHIPS PPRQRLKQVS AGQTSVYALD ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR 1090 1100 1110 1120 1130 1140 VSVGPLDQVW VIANKVQGSH SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA 1150 1160 TRAPRSSSQE QEPSAPPEAH GPVCC
	Isoform 2 [UniParc]. Checksum: 514CB3EE46C887D6	FASTA	1,166	129,753
	10 20 30 40 50 60 MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA 70 80 90 100 110 120 SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG LQHRPLDRVA LPSPHWEWES 130 140 150 160 170 180 DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS 190 200 210 220 230 240 KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD 250 260 270 280 290 300 TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV 310 320 330 340 350 360 SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ 370 380 390 400 410 420 GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV 430 440 450 460 470 480 ERPGPGQILP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP 490 500 510 520 530 540 TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG 550 560 570 580 590 600 GCVVEACAMP RWFTVQAGGL SSSVHMLSLS ITPAQTAAWR KQIFQQLTER TKRELENFRH 610 620 630 640 650 660 YEQAVEQSVW VKTGALQWWC DWKPHKWVDV RLALEQFTGH DGVRDSILFI YYVVHEEKKY 670 680 690 700 710 720 IHIFLNEVVA LVPVLNETKH SFALYTPERT RQRWPVRLAA ATEQDMNDWL ALLSLSCCES 730 740 750 760 770 780 RKVQGRPSPQ AIWSITCKGD IFVSEPSPDL EAHEHPLPCD QMFWRQMGGH LRMVEANSRG 790 800 810 820 830 840 VVWGIGYDHT AWVYTGGYGG GCFQGLASST SNIYTQSDVK CVHIYENQRW NPVTGYTSRG 850 860 870 880 890 900 LPTDRYMWSD ASGLQECTKA GTKPPSLQWA WVSDWFVDFS VPGGTDQEGW QYASDFPASY 910 920 930 940 950 960 HGSKTMKDFV RRRCWARKCK LVTSGPWLEV PPIALRDVSI IPESPGAEGS GHSIALWAVS 970 980 990 1000 1010 1020 DKGDVLCRLG VSELNPAGSS WLHVGTDQPF ASISIGACYQ VWAVARDGSA FYRGSVYPSQ 1030 1040 1050 1060 1070 1080 PAGDCWYHIP SPPRQRLKQV SAGQTSVYAL DENGNLWYRQ GITPSYPQGS SWEHVSNNVC 1090 1100 1110 1120 1130 1140 RVSVGPLDQV WVIANKVQGS HSLSRGTVCH RTGVQPHEPK GHGWDYGIGG GWDHISVRAN 1150 1160 ATRAPRSSSQ EQEPSAPPEA HGPVCC
	Isoform 3 [UniParc]. Checksum: CCBCAB81F92A970A	FASTA	776	86,697
	10 20 30 40 50 60 MGGFCEKLLL SDRWGWSDVS GLQHRPLDRV ALPSPHWEWE SDWYVDENFG GEPTEKGGWT 70 80 90 100 110 120 YAIDFPATYT KDKKWNSCVR RRKWIRYRRY KSRDIWAKIP SKDDPKELPD PFNDLSVGGW 130 140 150 160 170 180 EITEEPVGRL SVWAVSLQGK VLCPCLASQV WYREDVSHSN PEGSSWSLLD TPGEVVQISC 190 200 210 220 230 240 GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV SVVWAVTKDW 250 260 270 280 290 300 KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ GVTPSELSGK 310 320 330 340 350 360 TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV ERPGPGQILP 370 380 390 400 410 420 AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP TPAELPWTNI 430 440 450 460 470 480 DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG GCVVEACAMP 490 500 510 520 530 540 RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY EQAVEQSVWV 550 560 570 580 590 600 KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY YVVHEEKKYI HIFLNEVVAL 610 620 630 640 650 660 VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR KVQGRPSPQA 670 680 690 700 710 720 IWSITCKGDI FVSEPSPDLE AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV VWGIGYDHTA 730 740 750 760 770 WVYTGGYGGG CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSSRD RISPCW
	Isoform 4 [UniParc]. Checksum: 5E69B7980D8A5297	FASTA	1,167	129,854
	10 20 30 40 50 60 MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA 70 80 90 100 110 120 SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG LQHRPLDRVA LPSPHWEWES 130 140 150 160 170 180 DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS 190 200 210 220 230 240 KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD 250 260 270 280 290 300 TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV 310 320 330 340 350 360 SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ 370 380 390 400 410 420 GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV 430 440 450 460 470 480 ERPGPGQILP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP 490 500 510 520 530 540 TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG 550 560 570 580 590 600 GCVVEACAMP RWFTVQAAGL SSSVHMLSLS ITPAQTAAWR KQIFQQLTER TKRELENFRH 610 620 630 640 650 660 YEQAVEQSVW VKTGALQWWC DWKPHKWVDV RLALEQFTGH DGVRDSILFI YYVVHEEKKY 670 680 690 700 710 720 IHIFLNEVVA LVPVLNETKH SFALYTPERT RQRWPVRLAA ATEQDMNDWL ALLSLSCCES 730 740 750 760 770 780 RKVQGRPSPQ AIWSITCKGD IFVSEPSPDL EAHEHPLPCD QMFWRQMGGH LRMVEANSRG 790 800 810 820 830 840 VVWGIGYDHT AWVYTGGYGG GCFQGLASST SNIYTQSDVK CVHIYENQRW NPVTGYTSSR 850 860 870 880 890 900 GLPTDRYMWS DASGLQECTK AGTKPPSLQW AWVSDWFVDF SVPGGTDQEG WQYASDFPAS 910 920 930 940 950 960 YHGSKTMKDF VRRRCWARKC KLVTSGPWLE VPPIALRDVS IIPESPGAEG SGHSIALWAV 970 980 990 1000 1010 1020 SDKGDVLCRL GVSELNPAGS SWLHVGTDQP FASISIGACY QVWAVARDGS AFYRGSVYPS 1030 1040 1050 1060 1070 1080 QPAGDCWYHI PSPPRQRLKQ VSAGQTSVYA LDENGNLWYR QGITPSYPQG SSWEHVSNNV 1090 1100 1110 1120 1130 1140 CRVSVGPLDQ VWVIANKVQG SHSLSRGTVC HRTGVQPHEP KGHGWDYGIG GGWDHISVRA 1150 1160 NATRAPRSSS QEQEPSAPPE AHGPVCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Trachea.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye and Placenta.
[6]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1165 (ISOFORM 1). Tissue: Brain.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 418-1165 (ISOFORM 2). Tissue: Testis.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-938 AND SER-949, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens." Ogawa M., Yoshikawa Y., Kobayashi T., Mimuro H., Fukumatsu M., Kiga K., Piao Z., Ashida H., Yoshida M., Kakuta S., Koyama T., Goto Y., Nagatake T., Nagai S., Kiyono H., Kawalec M., Reichhart J.M., Sasakawa C. Cell Host Microbe 9:376-389(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE ATG5-ATG12 CONJUGATE, INTERACTION WITH ATG5 AND WIPI2.
[10]	"A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate." Chen D., Fan W., Lu Y., Ding X., Chen S., Zhong Q. Mol. Cell 45:629-641(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE ATG5-ATG12 CONJUGATE, INTERACTION WITH ATG5, PTDINS(3)P-BINDING.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057048 mRNA. Translation: BAG51853.1. AK292996 mRNA. Translation: BAF85685.1. AC091654 Genomic DNA. No translation available. CH236956 Genomic DNA. Translation: EAL23891.1. CH471091 Genomic DNA. Translation: EAW76717.1. BC012529 mRNA. Translation: AAH12529.2. BC053591 mRNA. Translation: AAH53591.1. AB037779 mRNA. Translation: BAA92596.1. AL117495 mRNA. Translation: CAB55961.2.
IPI	IPI00162199. IPI00893793. IPI00952913. IPI01015180.
PIR	T17271.
RefSeq	NP_056210.1. NM_015395.2.
UniGene	Hs.632303.
3D structure databases
ProteinModelPortal	Q7Z6L1.
SMR	Q7Z6L1. Positions 64-173, 820-923.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z6L1. 11 interactions.
STRING	9606.ENSP00000404923.
PTM databases
PhosphoSite	Q7Z6L1.
Polymorphism databases
DMDM	74738829.
Proteomic databases
PaxDb	Q7Z6L1.
PRIDE	Q7Z6L1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379795; ENSP00000369121; ENSG00000205356. ENST00000447648; ENSP00000404923; ENSG00000205356. ENST00000542604; ENSP00000441121; ENSG00000205356.
GeneID	25851.
KEGG	hsa:25851.
UCSC	uc003upg.3. human.
Organism-specific databases
CTD	25851.
GeneCards	GC07M097843.
H-InvDB	HIX0006878.
HGNC	HGNC:22214. TECPR1.
HPA	HPA021061.
MIM	614781. gene.
neXtProt	NX_Q7Z6L1.
PharmGKB	PA164726436.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG328700.
HOGENOM	HOG000007892.
InParanoid	Q7Z6L1.
OMA	QVWVIAN.
OrthoDB	EOG4ZPDTG.
Gene expression databases
ArrayExpress	Q7Z6L1.
Bgee	Q7Z6L1.
Genevestigator	Q7Z6L1.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR006624. Beta-propeller_rpt_TECPR. IPR010482. Peroxin/Dysferlin. IPR006614. Peroxin/Ferlin. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF06462. Hyd_WA. 8 hits. PF06398. Pex24p. 2 hits. [Graphical view]
SMART	SM00694. DysFC. 2 hits. SM00693. DysFN. 2 hits. SM00233. PH. 1 hit. SM00706. TECPR. 11 hits. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25851.
NextBio	47193.
SOURCE	Search...

Entry information

Entry name

TCPR1_HUMAN

Accession

Primary (citable) accession number: Q7Z6L1
Secondary accession number(s): A8KAD1 , B3KPZ1, C9J024, F5GX57, Q96EB0, Q9P2I9, Q9UFR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.