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Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

TECPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.2 Publications

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: UniProtKB

GO - Biological processi

  • autophagosome maturation Source: UniProtKB
  • autophagy Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein 1
Gene namesi
Name:TECPR1
Synonyms:KIAA1358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22214. TECPR1.

Subcellular locationi

GO - Cellular componenti

  • autophagosome membrane Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB-KW
  • integral component of membrane Source: InterPro
  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205356.
PharmGKBiPA164726436.

Polymorphism and mutation databases

DMDMi74738829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370601 – 1165Tectonin beta-propeller repeat-containing protein 1Add BLAST1165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei386PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei938PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z6L1.
MaxQBiQ7Z6L1.
PaxDbiQ7Z6L1.
PeptideAtlasiQ7Z6L1.
PRIDEiQ7Z6L1.

PTM databases

iPTMnetiQ7Z6L1.
PhosphoSitePlusiQ7Z6L1.

Expressioni

Gene expression databases

BgeeiENSG00000205356.
ExpressionAtlasiQ7Z6L1. baseline and differential.
GenevisibleiQ7Z6L1. HS.

Organism-specific databases

HPAiHPA021061.

Interactioni

Subunit structurei

Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG3Q9NT623EBI-2946676,EBI-988094
ATG5Q9H1Y08EBI-2946676,EBI-1047414

Protein-protein interaction databases

BioGridi117375. 9 interactors.
IntActiQ7Z6L1. 11 interactors.
STRINGi9606.ENSP00000404923.

Structurei

Secondary structure

11165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi577 – 594Combined sources18
Turni595 – 599Combined sources5
Beta strandi600 – 603Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TQ1X-ray1.80B573-610[»]
ProteinModelPortaliQ7Z6L1.
SMRiQ7Z6L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati209 – 240TECPR 1Add BLAST32
Repeati254 – 285TECPR 2Add BLAST32
Repeati301 – 332TECPR 3Add BLAST32
Repeati344 – 376TECPR 4Add BLAST33
Domaini611 – 717PHAdd BLAST107
Repeati729 – 756TECPR 5Add BLAST28
Repeati953 – 984TECPR 6Add BLAST32
Repeati998 – 1029TECPR 7Add BLAST32
Repeati1044 – 1075TECPR 8Add BLAST32
Repeati1087 – 1127TECPR 9Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi384 – 391Poly-Ser8

Domaini

The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P). While full-length protein is unable to bind PtdIns3P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns3P (PubMed:22342342).1 Publication

Sequence similaritiesi

Belongs to the TECPR1 family.Curated
Contains 1 PH domain.Curated
Contains 9 TECPR repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3669. Eukaryota.
ENOG410YE4N. LUCA.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ7Z6L1.
KOiK17988.
OMAiYLGLEFK.
OrthoDBiEOG091G00J5.
PhylomeDBiQ7Z6L1.
TreeFamiTF323648.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin.
IPR006614. Peroxin/Ferlin.
IPR011993. PH_dom-like.
IPR009091. RCC1/BLIP-II.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00706. TECPR. 11 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC
60 70 80 90 100
DNQVYVYVCA SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG
110 120 130 140 150
LQHRPLDRVA LPSPHWEWES DWYVDENFGG EPTEKGGWTY AIDFPATYTK
160 170 180 190 200
DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS KDDPKELPDP FNDLSVGGWE
210 220 230 240 250
ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD TPGEVVQISC
260 270 280 290 300
GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV
310 320 330 340 350
SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG
360 370 380 390 400
CEDRAVYFRQ GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG
410 420 430 440 450
DEVRGSGESA PSDTDASSEV ERPGPGQILP AEPLDDSKNA TGNSASGLGA
460 470 480 490 500
GRTAEDTVED ACPAEGSREA RPNTHPGPAP TPAELPWTNI DLKEAKKVPS
510 520 530 540 550
HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG GCVVEACAMP
560 570 580 590 600
RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
610 620 630 640 650
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY
660 670 680 690 700
YVVHEEKKYI HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA
710 720 730 740 750
TEQDMNDWLA LLSLSCCESR KVQGRPSPQA IWSITCKGDI FVSEPSPDLE
760 770 780 790 800
AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV VWGIGYDHTA WVYTGGYGGG
810 820 830 840 850
CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL PTDRYMWSDA
860 870 880 890 900
SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
910 920 930 940 950
GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG
960 970 980 990 1000
HSIALWAVSD KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV
1010 1020 1030 1040 1050
WAVARDGSAF YRGSVYPSQP AGDCWYHIPS PPRQRLKQVS AGQTSVYALD
1060 1070 1080 1090 1100
ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR VSVGPLDQVW VIANKVQGSH
1110 1120 1130 1140 1150
SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA TRAPRSSSQE
1160
QEPSAPPEAH GPVCC
Length:1,165
Mass (Da):129,696
Last modified:October 1, 2003 - v1
Checksum:iD396F4128710062D
GO
Isoform 2 (identifier: Q7Z6L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-557: A → AG

Note: No experimental confirmation available.
Show »
Length:1,166
Mass (Da):129,753
Checksum:i514CB3EE46C887D6
GO
Isoform 3 (identifier: Q7Z6L1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     219-219: K → KVLCPCLASQ
     838-1165: RGLPTDRYMW...PPEAHGPVCC → SRDRISPCW

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):86,697
Checksum:iCCBCAB81F92A970A
GO
Isoform 4 (identifier: Q7Z6L1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     556-556: Q → QA
     836-836: T → TS

Note: No experimental confirmation available.
Show »
Length:1,167
Mass (Da):129,854
Checksum:i5E69B7980D8A5297
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116W → R in BAF85685 (PubMed:14702039).Curated1
Sequence conflicti151D → Y in BAG51853 (PubMed:14702039).Curated1
Sequence conflicti464A → T in BAF85685 (PubMed:14702039).Curated1
Sequence conflicti746S → T in CAB55961 (PubMed:17974005).Curated1
Sequence conflicti953I → T in BAF85685 (PubMed:14702039).Curated1
Sequence conflicti988P → L in CAB55961 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060190733S → Y.Corresponds to variant rs35623371dbSNPEnsembl.1
Natural variantiVAR_062238944P → L.Corresponds to variant rs11762014dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0429691 – 79Missing in isoform 3. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_042970219K → KVLCPCLASQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_042971556Q → QA in isoform 4. Curated1
Alternative sequenceiVSP_033861557A → AG in isoform 2. 1 Publication1
Alternative sequenceiVSP_042972836T → TS in isoform 4. Curated1
Alternative sequenceiVSP_042973838 – 1165RGLPT…GPVCC → SRDRISPCW in isoform 3. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057048 mRNA. Translation: BAG51853.1.
AK292996 mRNA. Translation: BAF85685.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23891.1.
CH471091 Genomic DNA. Translation: EAW76717.1.
BC012529 mRNA. Translation: AAH12529.2.
BC053591 mRNA. Translation: AAH53591.1.
AB037779 mRNA. Translation: BAA92596.1.
AL117495 mRNA. Translation: CAB55961.2.
CCDSiCCDS47648.1. [Q7Z6L1-1]
PIRiT17271.
RefSeqiNP_056210.1. NM_015395.2. [Q7Z6L1-1]
XP_005250310.1. XM_005250253.3. [Q7Z6L1-1]
UniGeneiHs.592281.

Genome annotation databases

EnsembliENST00000447648; ENSP00000404923; ENSG00000205356. [Q7Z6L1-1]
GeneIDi25851.
KEGGihsa:25851.
UCSCiuc003upg.5. human. [Q7Z6L1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057048 mRNA. Translation: BAG51853.1.
AK292996 mRNA. Translation: BAF85685.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23891.1.
CH471091 Genomic DNA. Translation: EAW76717.1.
BC012529 mRNA. Translation: AAH12529.2.
BC053591 mRNA. Translation: AAH53591.1.
AB037779 mRNA. Translation: BAA92596.1.
AL117495 mRNA. Translation: CAB55961.2.
CCDSiCCDS47648.1. [Q7Z6L1-1]
PIRiT17271.
RefSeqiNP_056210.1. NM_015395.2. [Q7Z6L1-1]
XP_005250310.1. XM_005250253.3. [Q7Z6L1-1]
UniGeneiHs.592281.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TQ1X-ray1.80B573-610[»]
ProteinModelPortaliQ7Z6L1.
SMRiQ7Z6L1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117375. 9 interactors.
IntActiQ7Z6L1. 11 interactors.
STRINGi9606.ENSP00000404923.

PTM databases

iPTMnetiQ7Z6L1.
PhosphoSitePlusiQ7Z6L1.

Polymorphism and mutation databases

DMDMi74738829.

Proteomic databases

EPDiQ7Z6L1.
MaxQBiQ7Z6L1.
PaxDbiQ7Z6L1.
PeptideAtlasiQ7Z6L1.
PRIDEiQ7Z6L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447648; ENSP00000404923; ENSG00000205356. [Q7Z6L1-1]
GeneIDi25851.
KEGGihsa:25851.
UCSCiuc003upg.5. human. [Q7Z6L1-1]

Organism-specific databases

CTDi25851.
GeneCardsiTECPR1.
H-InvDBHIX0006878.
HGNCiHGNC:22214. TECPR1.
HPAiHPA021061.
MIMi614781. gene.
neXtProtiNX_Q7Z6L1.
OpenTargetsiENSG00000205356.
PharmGKBiPA164726436.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3669. Eukaryota.
ENOG410YE4N. LUCA.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ7Z6L1.
KOiK17988.
OMAiYLGLEFK.
OrthoDBiEOG091G00J5.
PhylomeDBiQ7Z6L1.
TreeFamiTF323648.

Enzyme and pathway databases

BioCyciZFISH:G66-31938-MONOMER.

Miscellaneous databases

GenomeRNAii25851.
PROiQ7Z6L1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205356.
ExpressionAtlasiQ7Z6L1. baseline and differential.
GenevisibleiQ7Z6L1. HS.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin.
IPR006614. Peroxin/Ferlin.
IPR011993. PH_dom-like.
IPR009091. RCC1/BLIP-II.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00706. TECPR. 11 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCPR1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6L1
Secondary accession number(s): A8KAD1
, B3KPZ1, C9J024, F5GX57, Q96EB0, Q9P2I9, Q9UFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.