##gff-version 3 Q7Z6L0 UniProtKB Chain 1 340 . . . ID=PRO_0000307745;Note=Proline-rich transmembrane protein 2 Q7Z6L0 UniProtKB Topological domain 1 268 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:E9PUL5,ECO:0000255 Q7Z6L0 UniProtKB Intramembrane 269 289 . . . Note=Helical;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:E9PUL5,ECO:0000255 Q7Z6L0 UniProtKB Topological domain 290 317 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:E9PUL5,ECO:0000255 Q7Z6L0 UniProtKB Transmembrane 318 338 . . . Note=Helical;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:E9PUL5,ECO:0000255 Q7Z6L0 UniProtKB Topological domain 339 340 . . . Note=Extracellular;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:E9PUL5,ECO:0000255 Q7Z6L0 UniProtKB Region 1 261 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z6L0 UniProtKB Compositional bias 74 105 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z6L0 UniProtKB Compositional bias 131 161 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z6L0 UniProtKB Compositional bias 197 211 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z6L0 UniProtKB Modified residue 28 28 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PUL5 Q7Z6L0 UniProtKB Modified residue 74 74 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PUL5 Q7Z6L0 UniProtKB Modified residue 238 238 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZFB6 Q7Z6L0 UniProtKB Modified residue 240 240 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PUL5 Q7Z6L0 UniProtKB Modified residue 248 248 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PUL5 Q7Z6L0 UniProtKB Modified residue 249 249 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:E9PUL5 Q7Z6L0 UniProtKB Alternative sequence 294 340 . . . ID=VSP_028814;Note=In isoform 3. SRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK->VSPMGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q7Z6L0 UniProtKB Alternative sequence 337 337 . . . ID=VSP_028815;Note=In isoform 2. G->GGEWGLGTGRGGMEGLARAALLTPAPALSCLSSLPLLCLSLSPPPPVCPSLSSPT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:16303743;Dbxref=PMID:14702039,PMID:16303743 Q7Z6L0 UniProtKB Natural variant 138 138 . . . ID=VAR_067010;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22101681;Dbxref=dbSNP:rs79182085,PMID:22101681 Q7Z6L0 UniProtKB Natural variant 147 147 . . . ID=VAR_067011;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22101681;Dbxref=dbSNP:rs79568162,PMID:22101681 Q7Z6L0 UniProtKB Natural variant 214 214 . . . ID=VAR_067012;Note=A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22101681;Dbxref=dbSNP:rs745594874,PMID:22101681 Q7Z6L0 UniProtKB Natural variant 215 215 . . . ID=VAR_067320;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22243967;Dbxref=dbSNP:rs200926711,PMID:22243967 Q7Z6L0 UniProtKB Natural variant 216 216 . . . ID=VAR_067321;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22243967;Dbxref=dbSNP:rs76335820,PMID:22243967 Q7Z6L0 UniProtKB Natural variant 237 237 . . . ID=VAR_067013;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22101681;Dbxref=dbSNP:rs199556853,PMID:22101681 Q7Z6L0 UniProtKB Natural variant 240 340 . . . ID=VAR_080269;Note=In ICCA%3B may be produced at very low levels due to a premature stop codon in the mRNA%2C that could lead to nonsense-mediated mRNA decay. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22832103;Dbxref=dbSNP:rs387907126,PMID:22832103 Q7Z6L0 UniProtKB Natural variant 245 245 . . . ID=VAR_067014;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22101681;Dbxref=dbSNP:rs754897123,PMID:22101681 Q7Z6L0 UniProtKB Natural variant 266 266 . . . ID=VAR_067322;Note=In EKD1. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22120146;Dbxref=dbSNP:rs387907128,PMID:22120146 Q7Z6L0 UniProtKB Natural variant 281 281 . . . ID=VAR_067323;Note=In EKD1. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22131361;Dbxref=PMID:22131361 Q7Z6L0 UniProtKB Natural variant 287 287 . . . ID=VAR_067324;Note=In EKD1%3B may affect subcellular location%2C becoming predominantly cytoplasmic%3B impairs interaction with GRIA1 and SNAP25. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22131361,ECO:0000269|PubMed:25915028;Dbxref=PMID:22131361,PMID:25915028 Q7Z6L0 UniProtKB Natural variant 305 305 . . . ID=VAR_067325;Note=In EKD1. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22209761;Dbxref=dbSNP:rs767799831,PMID:22209761 Q7Z6L0 UniProtKB Natural variant 308 308 . . . ID=VAR_067326;Note=In EKD1%3B no effect on location at the plasma membrane. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22131361,ECO:0000269|PubMed:27172900;Dbxref=dbSNP:rs932713001,PMID:22131361,PMID:27172900 Q7Z6L0 UniProtKB Natural variant 317 317 . . . ID=VAR_067327;Note=In ICCA. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22243967;Dbxref=dbSNP:rs387907125,PMID:22243967 Q7Z6L0 UniProtKB Natural variant 323 323 . . . ID=VAR_068426;Note=In BFIS2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22623405;Dbxref=PMID:22623405 Q7Z6L0 UniProtKB Sequence conflict 151 151 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q7Z6L0 UniProtKB Sequence conflict 214 214 . . . Note=A->AP;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q7Z6L0 UniProtKB Sequence conflict 275 275 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305