Q7Z6L0 (PRRT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline-rich transmembrane protein 2

Alternative name(s):
Dispanin subfamily B member 3
Short name=DSPB3

Gene names

Name:

PRRT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse By similarity Ref.6.
Involvement in disease	Episodic kinesigenic dyskinesia 1 (EKD1) [MIM:128200]: An autosomal dominant neurologic condition characterized by recurrent and brief attacks of abnormal involuntary movements, triggered by sudden voluntary movement. These attacks usually have onset during childhood or early adulthood and can involve dystonic postures, chorea, or athetosis. Note: The disease is caused by mutations affecting the gene represented in this entry. Disease-causing mutations that produce truncation of the C-terminus of the protein alter subcellular location, from plasma membrane to cytosplasm (Ref.6). Ref.6 Ref.9 Ref.11 Ref.13 Convulsions, familial infantile, with paroxysmal choreoathetosis (ICCA) [MIM:602066]: A syndrome characterized by clinical features of benign familial infantile seizures and episodic kinesigenic dyskinesia. Benign familial infantile seizures is a disorder characterized by afebrile seizures occurring during the first year of life, without neurologic sequelae. Paroxysmal choreoathetosis is a disorder of involuntary movements characterized by attacks that occur spontaneously or are induced by a variety of stimuli. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Seizures, benign familial infantile 2 (BFIS2) [MIM:605751]: An autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8 Ref.12
Sequence similarities	Belongs to the CD225/Dispanin family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Dystonia Epilepsy
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to biotic stimulus Inferred from electronic annotation. Source: InterPro
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6L0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6L0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     337-337: G → GGEWGLGTGRGGMEGLARAALLTPAPALSCLSSLPLLCLSLSPPPPVCPSLSSPT

Isoform 3 (identifier: Q7Z6L0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     294-340: SRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK → VSPMGP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Proline-rich transmembrane protein 2		PRO_0000307745
Regions
	Topological domain	1 – 268	268	Extracellular Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Topological domain	290 – 317	28	Cytoplasmic Potential
	Transmembrane	318 – 338	21	Helical; Potential
	Topological domain	339 – 340	2	Extracellular Potential
	Compositional bias	131 – 216	86	Pro-rich
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	294 – 340	47	SRNSL…LGVYK → VSPMGP in isoform 3.		VSP_028814
	Alternative sequence	337	1	G → GGEWGLGTGRGGMEGLARAA LLTPAPALSCLSSLPLLCLS LSPPPPVCPSLSSPT in isoform 2.		VSP_028815
	Natural variant	138	1	P → A. Ref.6 Corresponds to variant rs79182085 [ dbSNP | Ensembl ].		VAR_067010
	Natural variant	147	1	D → H. Ref.6 Corresponds to variant rs79568162 [ dbSNP | Ensembl ].		VAR_067011
	Natural variant	214	1	A → P. Ref.6		VAR_067012
	Natural variant	215	1	P → R. Ref.7 Corresponds to variant rs200926711 [ dbSNP | Ensembl ].		VAR_067320
	Natural variant	216	1	P → L. Ref.7 Corresponds to variant rs76335820 [ dbSNP | Ensembl ].		VAR_067321
	Natural variant	237	1	G → R. Ref.6 Corresponds to variant rs199556853 [ dbSNP | Ensembl ].		VAR_067013
	Natural variant	245	1	R → H. Ref.6		VAR_067014
	Natural variant	266	1	R → W in EKD1. Ref.11		VAR_067322
	Natural variant	281	1	W → R in EKD1. Ref.13		VAR_067323
	Natural variant	287	1	A → T in EKD1. Ref.13		VAR_067324
	Natural variant	305	1	G → R in EKD1. Ref.9		VAR_067325
	Natural variant	308	1	R → C in EKD1. Ref.13		VAR_067326
	Natural variant	317	1	S → N in ICCA. Ref.7		VAR_067327
	Natural variant	323	1	G → E in BFIS2. Ref.12		VAR_068426
Experimental info
	Sequence conflict	151	1	T → S in AAH11405. Ref.5
	Sequence conflict	214	1	A → AP in CAD38881. Ref.3
	Sequence conflict	275	1	S → P in CAD38881. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F4BBA6559F081E34	FASTA	340	34,945
	10 20 30 40 50 60 MAASSSEISE MKGVEESPKV PGEGPGHSEA ETGPPQVLAG VPDQPEAPQP GPNTTAAPVD 70 80 90 100 110 120 SGPKAGLAPE TTETPAGASE TAQATDLSLS PGGESKANCS PEDPCQETVS KPEVSKEATA 130 140 150 160 170 180 DQGSRLESAA PPEPAPEPAP QPDPRPDSQP TPKPALQPEL PTQEDPTPEI LSESVGEKQE 190 200 210 220 230 240 NGAVVPLQAG DGEEGPAPEP HSPPSKKSPP ANGAPPRVLQ QLVEEDRMRR AHSGHPGSPR 250 260 270 280 290 300 GSLSRHPSSQ LAGPGVEGGE GTQKPRDYII LAILSCFCPM WPVNIVAFAY AVMSRNSLQQ 310 320 330 340 GDVDGAQRLG RVAKLLSIVA LVGGVLIIIA SCVINLGVYK
	Isoform 2 [UniParc]. Checksum: A4E5CC372F517A63	FASTA	394	40,228
	10 20 30 40 50 60 MAASSSEISE MKGVEESPKV PGEGPGHSEA ETGPPQVLAG VPDQPEAPQP GPNTTAAPVD 70 80 90 100 110 120 SGPKAGLAPE TTETPAGASE TAQATDLSLS PGGESKANCS PEDPCQETVS KPEVSKEATA 130 140 150 160 170 180 DQGSRLESAA PPEPAPEPAP QPDPRPDSQP TPKPALQPEL PTQEDPTPEI LSESVGEKQE 190 200 210 220 230 240 NGAVVPLQAG DGEEGPAPEP HSPPSKKSPP ANGAPPRVLQ QLVEEDRMRR AHSGHPGSPR 250 260 270 280 290 300 GSLSRHPSSQ LAGPGVEGGE GTQKPRDYII LAILSCFCPM WPVNIVAFAY AVMSRNSLQQ 310 320 330 340 350 360 GDVDGAQRLG RVAKLLSIVA LVGGVLIIIA SCVINLGGEW GLGTGRGGME GLARAALLTP 370 380 390 APALSCLSSL PLLCLSLSPP PPVCPSLSSP TVYK
	Isoform 3 [UniParc]. Checksum: 9822B327E98D55C4	FASTA	299	30,653
	10 20 30 40 50 60 MAASSSEISE MKGVEESPKV PGEGPGHSEA ETGPPQVLAG VPDQPEAPQP GPNTTAAPVD 70 80 90 100 110 120 SGPKAGLAPE TTETPAGASE TAQATDLSLS PGGESKANCS PEDPCQETVS KPEVSKEATA 130 140 150 160 170 180 DQGSRLESAA PPEPAPEPAP QPDPRPDSQP TPKPALQPEL PTQEDPTPEI LSESVGEKQE 190 200 210 220 230 240 NGAVVPLQAG DGEEGPAPEP HSPPSKKSPP ANGAPPRVLQ QLVEEDRMRR AHSGHPGSPR 250 260 270 280 290 GSLSRHPSSQ LAGPGVEGGE GTQKPRDYII LAILSCFCPM WPVNIVAFAY AVMVSPMGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Teratocarcinoma and Testis.
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Eye.
[6]	"Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia." Chen W.J., Lin Y., Xiong Z.Q., Wei W., Ni W., Tan G.H., Guo S.L., He J., Chen Y.F., Zhang Q.J., Li H.F., Lin Y., Murong S.X., Xu J., Wang N., Wu Z.Y. Nat. Genet. 43:1252-1255(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN EKD1, SUBCELLULAR LOCATION, VARIANTS ALA-138; HIS-147; PRO-214; ARG-237 AND HIS-245.
[7]	"PRRT2 mutations cause benign familial infantile epilepsy and infantile convulsions with choreoathetosis syndrome." Heron S.E., Grinton B.E., Kivity S., Afawi Z., Zuberi S.M., Hughes J.N., Pridmore C., Hodgson B.L., Iona X., Sadleir L.G., Pelekanos J., Herlenius E., Goldberg-Stern H., Bassan H., Haan E., Korczyn A.D., Gardner A.E., Corbett M.A. , Gecz J., Thomas P.Q., Mulley J.C., Berkovic S.F., Scheffer I.E., Dibbens L.M. Am. J. Hum. Genet. 90:152-160(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN BFIS2, VARIANT ICCA ASN-317, VARIANTS ARG-215 AND LEU-216.
[8]	"Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions." Ono S., Yoshiura K.I., Kinoshita A., Kikuchi T., Nakane Y., Kato N., Sadamatsu M., Konishi T., Nagamitsu S., Matsuura M., Yasuda A., Komine M., Kanai K., Inoue T., Osamura T., Saito K., Hirose S., Koide H. , Tomita H., Ozawa H., Niikawa N., Kurotaki N. J. Hum. Genet. 57:338-341(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN BFIS2.
[9]	"Mutations in PRRT2 result in paroxysmal dyskinesias with marked variability in clinical expression." Liu Q., Qi Z., Wan X.H., Li J.Y., Shi L., Lu Q., Zhou X.Q., Qiao L., Wu L.W., Liu X.Q., Yang W., Liu Y., Cui L.Y., Zhang X. J. Med. Genet. 49:79-82(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EKD1 ARG-305.
[10]	"The dispanins: a novel gene family of ancient origin that contains 14 human members." Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B. PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY.
[11]	"Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias." Wang J.L., Cao L., Li X.H., Hu Z.M., Li J.D., Zhang J.G., Liang Y., San A., Li N., Chen S.Q., Guo J.F., Jiang H., Shen L., Zheng L., Mao X., Yan W.Q., Zhou Y., Shi Y.T. , Ai S.X., Dai M.Z., Zhang P., Xia K., Chen S.D., Tang B.S. Brain 134:3493-3501(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EKD1 TRP-266.
[12]	"PRRT2 Mutations are the major cause of benign familial infantile seizures." Schubert J., Paravidino R., Becker F., Berger A., Bebek N., Bianchi A., Brockmann K., Capovilla G., Bernardina B.D., Fukuyama Y., Hoffmann G.F., Jurkat-Rott K., Antonnen A.K., Kurlemann G., Lehesjoki A.E., Lehmann-Horn F., Mastrangelo M., Mause U. , Muller S., Neubauer B., Pust B., Rating D., Robbiano A., Ruf S., Schroeder C., Seidel A., Specchio N., Stephani U., Striano P., Teichler J., Turkdogan D., Vigevano F., Viri M., Bauer P., Zara F., Lerche H., Weber Y.G. Hum. Mutat. 33:1439-1443(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT BFIS2 GLU-323.
[13]	"Targeted genomic sequencing identifies PRRT2 mutations as a cause of paroxysmal kinesigenic choreoathetosis." Li J., Zhu X., Wang X., Sun W., Feng B., Du T., Sun B., Niu F., Wei H., Wu X., Dong L., Li L., Cai X., Wang Y., Liu Y. J. Med. Genet. 49:76-78(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS EKD1 ARG-281; THR-287 AND CYS-308.
+	Additional computationally mapped references.

Web resources

Proline-rich transmembrane protein 2 (PRRT2)

Leiden Open Variation Database (LOVD)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK092265 mRNA. Translation: BAC03843.1. AK074572 mRNA. Translation: BAC11067.1. AK292393 mRNA. Translation: BAF85082.1. AL834185 mRNA. Translation: CAD38881.1. CH471238 Genomic DNA. Translation: EAW79991.1. BC011405 mRNA. Translation: AAH11405.1. BC053594 mRNA. Translation: AAH53594.1.
IPI	IPI00328520. IPI00642382. IPI00718906.
RefSeq	NP_001243371.1. NM_001256442.1. NP_001243372.1. NM_001256443.1. NP_660282.2. NM_145239.2.
UniGene	Hs.655071.
3D structure databases
ProteinModelPortal	Q7Z6L0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z6L0. 1 interaction.
MINT	MINT-1420001.
STRING	9606.ENSP00000351608.
PTM databases
PhosphoSite	Q7Z6L0.
Polymorphism databases
DMDM	74738828.
Proteomic databases
PaxDb	Q7Z6L0.
PRIDE	Q7Z6L0.
Protocols and materials databases
DNASU	112476.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300797; ENSP00000300797; ENSG00000167371. ENST00000358758; ENSP00000351608; ENSG00000167371. ENST00000567659; ENSP00000456226; ENSG00000167371.
GeneID	112476.
KEGG	hsa:112476.
UCSC	uc002dud.2. human. uc002due.4. human. uc002duf.1. human.
Organism-specific databases
CTD	112476.
GeneCards	GC16P029823.
H-InvDB	HIX0012947.
HGNC	HGNC:30500. PRRT2.
HPA	HPA014447.
MIM	128200. phenotype. 602066. phenotype. 605751. phenotype. 614386. gene.
neXtProt	NX_Q7Z6L0.
Orphanet	306. Benign familial infantile seizures. 31709. ICCA syndrome. 98809. Paroxysmal kinesigenic dyskinesia.
PharmGKB	PA142671132.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG292287.
HOGENOM	HOG000115721.
HOVERGEN	HBG097184.
InParanoid	Q7Z6L0.
OMA	TQKPRDY.
OrthoDB	EOG4HHP3X.
PhylomeDB	Q7Z6L0.
Enzyme and pathway databases
SignaLink	Q7Z6L0.
Gene expression databases
ArrayExpress	Q7Z6L0.
Bgee	Q7Z6L0.
CleanEx	HS_PRRT2.
Genevestigator	Q7Z6L0.
Family and domain databases
InterPro	IPR007593. Interferon-induced_TM_protein. [Graphical view]
Pfam	PF04505. CD225. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	112476.
NextBio	78590.
SOURCE	Search...

Entry information

Entry name

PRRT2_HUMAN

Accession

Primary (citable) accession number: Q7Z6L0
Secondary accession number(s): A8K8M8 , Q8N2N8, Q8NAQ7, Q8ND36, Q96FA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 1, 2003
Last modified:	May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.