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Protein

Arpin

Gene

ARPIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.1 Publication

GO - Biological processi

  • directional locomotion Source: UniProtKB
  • negative regulation of actin nucleation Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of lamellipodium morphogenesis Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Arpin
Alternative name(s):
Arp2/3 inhibition protein
Gene namesi
Name:ARPIN
Synonyms:C15orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000242498.7
HGNCiHGNC:28782 ARPIN
MIMi615543 gene
neXtProtiNX_Q7Z6K5

Subcellular locationi

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

DisGeNETi348110
OpenTargetsiENSG00000242498
PharmGKBiPA142672274

Polymorphism and mutation databases

BioMutaiC15orf38
DMDMi74738824

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002442651 – 226ArpinAdd BLAST226

Proteomic databases

EPDiQ7Z6K5
MaxQBiQ7Z6K5
PaxDbiQ7Z6K5
PeptideAtlasiQ7Z6K5
PRIDEiQ7Z6K5
ProteomicsDBi69435
TopDownProteomicsiQ7Z6K5-1 [Q7Z6K5-1]

PTM databases

iPTMnetiQ7Z6K5
PhosphoSitePlusiQ7Z6K5

Expressioni

Gene expression databases

BgeeiENSG00000242498
CleanExiHS_C15orf38
ExpressionAtlasiQ7Z6K5 baseline and differential
GenevisibleiQ7Z6K5 HS

Organism-specific databases

HPAiHPA040513
HPA047173
HPA049270
HPA052278

Interactioni

Subunit structurei

Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131507, 12 interactors
1529312, 1 interactor
DIPiDIP-60587N
IntActiQ7Z6K5, 8 interactors
STRINGi9606.ENSP00000350075

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z68X-ray1.86E211-222[»]
ProteinModelPortaliQ7Z6K5
SMRiQ7Z6K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 226Necessary and sufficient for interaction with ARPC21 PublicationAdd BLAST16

Domaini

The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.1 Publication

Sequence similaritiesi

Belongs to the Arpin family.Curated

Phylogenomic databases

eggNOGiENOG410IGMB Eukaryota
ENOG4111JJD LUCA
GeneTreeiENSGT00530000064251
HOGENOMiHOG000111854
HOVERGENiHBG054275
InParanoidiQ7Z6K5
OMAiTHGRKER
OrthoDBiEOG091G0QZV
PhylomeDBiQ7Z6K5
TreeFamiTF300189

Family and domain databases

InterProiView protein in InterPro
IPR018889 Arpin
PANTHERiPTHR31199 PTHR31199, 1 hit
PfamiView protein in Pfam
PF10574 UPF0552, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRIYHDGAL RNKAVQSVRL PGAWDPAAHQ GGNGVLLEGE LIDVSRHSIL
60 70 80 90 100
DTHGRKERYY VLYIRPSHIH RRKFDAKGNE IEPNFSATRK VNTGFLMSSY
110 120 130 140 150
KVEAKGDTDR LTPEALKGLV NKPELLALTE SLTPDHTVAF WMPESEMEVM
160 170 180 190 200
ELELGAGVRL KTRGDGPFLD SLAKLEAGTV TKCNFTGDGK TGASWTDNIM
210 220
AQKCSKGAAA EIREQGDGAE DEEWDD
Length:226
Mass (Da):24,943
Last modified:October 1, 2003 - v1
Checksum:i80124CFFD6D6E455
GO
Isoform C15orf38-AP3S2 (identifier: Q7Z6K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: DD → PEEIQQQIVR...IKVPNLSQFV

Note: Based on a naturally occurring readthrough transcript which produces a C15orf38-AP3S2 fusion protein.
Show »
Length:394
Mass (Da):43,882
Checksum:iC6DC9DC6039C3C64
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047416225 – 226DD → PEEIQQQIVRETFHLVLKRD DNICNFLEGGSLIGGSDYKL IYRHYATLYFVFCVDSSESE LGILDLIQVFVETLDKCFEN VCELDLIFHMDKVHYILQEV VMGGMVLETNMNEIVAQIEA QNRLEKSEGGLSAAPARAVS AVKNINLPEIPRNINIGDLN IKVPNLSQFV in isoform C15orf38-AP3S2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000495 mRNA No translation available.
AC018988 Genomic DNA No translation available.
AC027176 Genomic DNA No translation available.
BC053602 mRNA Translation: AAH53602.1
CCDSiCCDS42080.1 [Q7Z6K5-1]
RefSeqiNP_001269309.1, NM_001282380.1
NP_872422.1, NM_182616.3 [Q7Z6K5-1]
UniGeneiHs.6734
Hs.744890

Genome annotation databases

EnsembliENST00000357484; ENSP00000350075; ENSG00000242498 [Q7Z6K5-1]
GeneIDi348110
KEGGihsa:348110
UCSCiuc002bou.4 human [Q7Z6K5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARPIN_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6K5
Secondary accession number(s): E2QRD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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