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Protein

Notch-regulated ankyrin repeat-containing protein

Gene

NRARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).By similarity1 Publication2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

BioCyciZFISH:G66-32129-MONOMER.
SIGNORiQ7Z6K4.

Names & Taxonomyi

Protein namesi
Recommended name:
Notch-regulated ankyrin repeat-containing protein
Gene namesi
Name:NRARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:33843. NRARP.

Pathology & Biotechi

Organism-specific databases

DisGeNETi441478.
OpenTargetsiENSG00000198435.
PharmGKBiPA164724205.

Polymorphism and mutation databases

BioMutaiNRARP.
DMDMi74750170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003250791 – 114Notch-regulated ankyrin repeat-containing proteinAdd BLAST114

Proteomic databases

PaxDbiQ7Z6K4.
PeptideAtlasiQ7Z6K4.
PRIDEiQ7Z6K4.

Expressioni

Inductioni

In endothelial cells by Notch signaling.1 Publication

Gene expression databases

BgeeiENSG00000198435.
CleanExiHS_NRARP.
GenevisibleiQ7Z6K4. HS.

Organism-specific databases

HPAiHPA025729.

Interactioni

Subunit structurei

Interacts with LEF1.By similarity

Protein-protein interaction databases

BioGridi137507. 1 interactor.
IntActiQ7Z6K4. 2 interactors.
STRINGi9606.ENSP00000349041.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6K4.
SMRiQ7Z6K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 79ANK 1Add BLAST30
Repeati83 – 112ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the NRARP family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00800000124147.
HOGENOMiHOG000082661.
HOVERGENiHBG097373.
InParanoidiQ7Z6K4.
OMAiKYAGSGR.
OrthoDBiEOG091G0WZR.
PhylomeDBiQ7Z6K4.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z6K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAELSTCS APQTQRIFQE AVRKGNTQEL QSLLQNMTNC EFNVNSFGPE
60 70 80 90 100
GQTALHQSVI DGNLELVKLL VKFGADIRLA NRDGWSALHI AAFGGHQDIV
110
LYLITKAKYA ASGR
Length:114
Mass (Da):12,492
Last modified:October 1, 2003 - v1
Checksum:iC8B84B648DB47F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255925 Genomic DNA. Translation: CAX15142.1.
BC053618 mRNA. Translation: AAH53618.1.
CCDSiCCDS35188.1.
RefSeqiNP_001004354.1. NM_001004354.2.
UniGeneiHs.535075.
Hs.732282.

Genome annotation databases

EnsembliENST00000356628; ENSP00000349041; ENSG00000198435.
GeneIDi441478.
KEGGihsa:441478.
UCSCiuc004cmo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255925 Genomic DNA. Translation: CAX15142.1.
BC053618 mRNA. Translation: AAH53618.1.
CCDSiCCDS35188.1.
RefSeqiNP_001004354.1. NM_001004354.2.
UniGeneiHs.535075.
Hs.732282.

3D structure databases

ProteinModelPortaliQ7Z6K4.
SMRiQ7Z6K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137507. 1 interactor.
IntActiQ7Z6K4. 2 interactors.
STRINGi9606.ENSP00000349041.

Polymorphism and mutation databases

BioMutaiNRARP.
DMDMi74750170.

Proteomic databases

PaxDbiQ7Z6K4.
PeptideAtlasiQ7Z6K4.
PRIDEiQ7Z6K4.

Protocols and materials databases

DNASUi441478.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356628; ENSP00000349041; ENSG00000198435.
GeneIDi441478.
KEGGihsa:441478.
UCSCiuc004cmo.3. human.

Organism-specific databases

CTDi441478.
DisGeNETi441478.
GeneCardsiNRARP.
HGNCiHGNC:33843. NRARP.
HPAiHPA025729.
neXtProtiNX_Q7Z6K4.
OpenTargetsiENSG00000198435.
PharmGKBiPA164724205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0505. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00800000124147.
HOGENOMiHOG000082661.
HOVERGENiHBG097373.
InParanoidiQ7Z6K4.
OMAiKYAGSGR.
OrthoDBiEOG091G0WZR.
PhylomeDBiQ7Z6K4.

Enzyme and pathway databases

BioCyciZFISH:G66-32129-MONOMER.
SIGNORiQ7Z6K4.

Miscellaneous databases

GenomeRNAii441478.
PROiQ7Z6K4.

Gene expression databases

BgeeiENSG00000198435.
CleanExiHS_NRARP.
GenevisibleiQ7Z6K4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRARP_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6K4
Secondary accession number(s): B8A4K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.