Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein prenyltransferase alpha subunit repeat-containing protein 1

Gene

PTAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein prenyltransferase alpha subunit repeat-containing protein 1
Gene namesi
Name:PTAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30449. PTAR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897041.

Polymorphism and mutation databases

BioMutaiPTAR1.
DMDMi167012004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 402401Protein prenyltransferase alpha subunit repeat-containing protein 1PRO_0000316843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z6K3.
MaxQBiQ7Z6K3.
PaxDbiQ7Z6K3.
PeptideAtlasiQ7Z6K3.
PRIDEiQ7Z6K3.

PTM databases

iPTMnetiQ7Z6K3.
PhosphoSiteiQ7Z6K3.

Expressioni

Gene expression databases

BgeeiQ7Z6K3.
CleanExiHS_PTAR1.
ExpressionAtlasiQ7Z6K3. baseline and differential.

Organism-specific databases

HPAiHPA021248.

Interactioni

Protein-protein interaction databases

BioGridi131995. 8 interactions.
IntActiQ7Z6K3. 5 interactions.
STRINGi9606.ENSP00000344299.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6K3.
SMRiQ7Z6K3. Positions 85-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati87 – 12034PFTA 1Add
BLAST
Repeati122 – 15534PFTA 2Add
BLAST
Repeati180 – 21334PFTA 3Add
BLAST
Repeati219 – 25234PFTA 4Add
BLAST
Repeati295 – 32834PFTA 5Add
BLAST

Sequence similaritiesi

Contains 5 PFTA repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGVZ. Eukaryota.
ENOG4110M6X. LUCA.
GeneTreeiENSGT00390000017892.
HOGENOMiHOG000115755.
HOVERGENiHBG108302.
InParanoidiQ7Z6K3.
KOiK14137.
OMAiRTRKQWL.
OrthoDBiEOG7HMS19.
PhylomeDBiQ7Z6K3.
TreeFamiTF324310.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 2 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z6K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETSEEVAV LVQRVVKDIT NAFRRNPHID EIGLIPCPEA RYNRSPIVLV
60 70 80 90 100
ENKLGVESWC VKFLLPYVHN KLLLYRTRKQ WLNRDELIDV TCTLLLLNPD
110 120 130 140 150
FTTAWNVRKE LILSGTLNPI KDLHLGKLAL TKFPKSPETW IHRRWVLQQL
160 170 180 190 200
IQETSLPSFV TKGNLGTIPT ERAQRLIQEE MEVCGEAAGR YPSNYNAWSH
210 220 230 240 250
RIWVLQHLAK LDVKILLDEL SSTKHWASMH VSDHSGFHYR QFLLKSLISQ
260 270 280 290 300
TVIDSSVMEQ NPLRSEPALV PPKDEEAAVS TEEPRINLPH LLEEEVEFST
310 320 330 340 350
DLIDSYPGHE TLWCHRRHIF YLQHHLNAGS QLSQAMEVDG LNDSSKQGYS
360 370 380 390 400
QETKRLKRTP VPDSLGLEME HRFIDQVLST CRNVEQARFA SAYRKWLVTL

SQ
Length:402
Mass (Da):46,405
Last modified:February 5, 2008 - v2
Checksum:iBCA832C2F9BEB99F
GO

Sequence cautioni

The sequence AAH53622.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI10944.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162412 Genomic DNA. Translation: CAI10944.1. Sequence problems.
AL162412 Genomic DNA. Translation: CAI10945.2.
BC053622 mRNA. Translation: AAH53622.1. Different initiation.
CCDSiCCDS47978.1.
RefSeqiNP_001093136.1. NM_001099666.1.
UniGeneiHs.744192.

Genome annotation databases

EnsembliENST00000340434; ENSP00000344299; ENSG00000188647.
GeneIDi375743.
KEGGihsa:375743.
UCSCiuc004ahj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162412 Genomic DNA. Translation: CAI10944.1. Sequence problems.
AL162412 Genomic DNA. Translation: CAI10945.2.
BC053622 mRNA. Translation: AAH53622.1. Different initiation.
CCDSiCCDS47978.1.
RefSeqiNP_001093136.1. NM_001099666.1.
UniGeneiHs.744192.

3D structure databases

ProteinModelPortaliQ7Z6K3.
SMRiQ7Z6K3. Positions 85-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131995. 8 interactions.
IntActiQ7Z6K3. 5 interactions.
STRINGi9606.ENSP00000344299.

PTM databases

iPTMnetiQ7Z6K3.
PhosphoSiteiQ7Z6K3.

Polymorphism and mutation databases

BioMutaiPTAR1.
DMDMi167012004.

Proteomic databases

EPDiQ7Z6K3.
MaxQBiQ7Z6K3.
PaxDbiQ7Z6K3.
PeptideAtlasiQ7Z6K3.
PRIDEiQ7Z6K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340434; ENSP00000344299; ENSG00000188647.
GeneIDi375743.
KEGGihsa:375743.
UCSCiuc004ahj.5. human.

Organism-specific databases

CTDi375743.
GeneCardsiPTAR1.
HGNCiHGNC:30449. PTAR1.
HPAiHPA021248.
neXtProtiNX_Q7Z6K3.
PharmGKBiPA134897041.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVZ. Eukaryota.
ENOG4110M6X. LUCA.
GeneTreeiENSGT00390000017892.
HOGENOMiHOG000115755.
HOVERGENiHBG108302.
InParanoidiQ7Z6K3.
KOiK14137.
OMAiRTRKQWL.
OrthoDBiEOG7HMS19.
PhylomeDBiQ7Z6K3.
TreeFamiTF324310.

Miscellaneous databases

ChiTaRSiPTAR1. human.
GenomeRNAii375743.
PROiQ7Z6K3.

Gene expression databases

BgeeiQ7Z6K3.
CleanExiHS_PTAR1.
ExpressionAtlasiQ7Z6K3. baseline and differential.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 2 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTAR1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6K3
Secondary accession number(s): Q5T7V5, Q5T7V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.