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Protein

THAP domain-containing protein 5

Gene

THAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8484THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protease binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. negative regulation of cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 5
Gene namesi
Name:THAP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:23188. THAP5.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleoplasm Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395THAP domain-containing protein 5PRO_0000333817Add
BLAST

Post-translational modificationi

Cleaved by HTRA2 during apoptosis.

Proteomic databases

PaxDbiQ7Z6K1.
PRIDEiQ7Z6K1.

PTM databases

PhosphoSiteiQ7Z6K1.

Expressioni

Tissue specificityi

Highly expressed in the heart. Also found in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ7Z6K1.
ExpressionAtlasiQ7Z6K1. baseline and differential.
GenevestigatoriQ7Z6K1.

Organism-specific databases

HPAiHPA043170.
HPA051488.

Interactioni

Subunit structurei

Interacts with HTRA2; under apoptotic conditions.1 Publication

Protein-protein interaction databases

BioGridi127964. 3 interactions.
IntActiQ7Z6K1. 2 interactions.
MINTiMINT-1198970.
STRINGi9606.ENSP00000400500.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6K1.
SMRiQ7Z6K1. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili348 – 38235Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi321 – 3244HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8484THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG41114.
GeneTreeiENSGT00780000121923.
HOGENOMiHOG000154564.
HOVERGENiHBG108566.
InParanoidiQ7Z6K1.
OMAiMPRYCAA.
OrthoDBiEOG7VDXPD.
PhylomeDBiQ7Z6K1.
TreeFamiTF335838.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z6K1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRYCAAICC KNRRGRNNKD RKLSFYPFPL HDKERLEKWL KNMKRDSWVP
60 70 80 90 100
SKYQFLCSDH FTPDSLDIRW GIRYLKQTAV PTIFSLPEDN QGKDPSKKKS
110 120 130 140 150
QKKNLEDEKE VCPKAKSEES FVLNETKKNI VNTDVPHQHP ELLHSSSLVK
160 170 180 190 200
PPAPKTGSIQ NNMLTLNLVK QHTGKPESTL ETSVNQDTGR GGFHTCFENL
210 220 230 240 250
NSTTITLTTS NSESIHQSLE TQEVLEVTTS HLANPNFTSN SMEIKSAQEN
260 270 280 290 300
PFLFSTINQT VEELNTNKES VIAIFVPAEN SKPSVNSFIS AQKETTEMED
310 320 330 340 350
TDIEDSLYKD VDYGTEVLQI EHSYCRQDIN KEHLWQKVSK LHSKITLLEL
360 370 380 390
KEQQTLGRLK SLEALIRQLK QENWLSEENV KIIENHFTTY EVTMI
Length:395
Mass (Da):45,416
Last modified:May 20, 2008 - v2
Checksum:i8AA3BE0E30DDB36A
GO
Isoform 2 (identifier: Q7Z6K1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:353
Mass (Da):40,237
Checksum:i5D82A93B5E7E2D5D
GO

Sequence cautioni

The sequence AAH53634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAL24383.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_033558Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24383.1. Sequence problems.
BC053634 mRNA. Translation: AAH53634.1. Different initiation.
CCDSiCCDS34734.2. [Q7Z6K1-2]
CCDS47687.1. [Q7Z6K1-1]
RefSeqiNP_001123947.1. NM_001130475.2. [Q7Z6K1-1]
NP_001274527.1. NM_001287598.1.
NP_001274528.1. NM_001287599.1.
NP_001274530.1. NM_001287601.1.
NP_872335.2. NM_182529.3. [Q7Z6K1-2]
UniGeneiHs.707689.

Genome annotation databases

EnsembliENST00000313516; ENSP00000322440; ENSG00000177683. [Q7Z6K1-2]
ENST00000415914; ENSP00000400500; ENSG00000177683. [Q7Z6K1-1]
GeneIDi168451.
KEGGihsa:168451.
UCSCiuc003vfl.3. human. [Q7Z6K1-1]

Polymorphism databases

DMDMi189029912.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24383.1. Sequence problems.
BC053634 mRNA. Translation: AAH53634.1. Different initiation.
CCDSiCCDS34734.2. [Q7Z6K1-2]
CCDS47687.1. [Q7Z6K1-1]
RefSeqiNP_001123947.1. NM_001130475.2. [Q7Z6K1-1]
NP_001274527.1. NM_001287598.1.
NP_001274528.1. NM_001287599.1.
NP_001274530.1. NM_001287601.1.
NP_872335.2. NM_182529.3. [Q7Z6K1-2]
UniGeneiHs.707689.

3D structure databases

ProteinModelPortaliQ7Z6K1.
SMRiQ7Z6K1. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127964. 3 interactions.
IntActiQ7Z6K1. 2 interactions.
MINTiMINT-1198970.
STRINGi9606.ENSP00000400500.

PTM databases

PhosphoSiteiQ7Z6K1.

Polymorphism databases

DMDMi189029912.

Proteomic databases

PaxDbiQ7Z6K1.
PRIDEiQ7Z6K1.

Protocols and materials databases

DNASUi168451.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313516; ENSP00000322440; ENSG00000177683. [Q7Z6K1-2]
ENST00000415914; ENSP00000400500; ENSG00000177683. [Q7Z6K1-1]
GeneIDi168451.
KEGGihsa:168451.
UCSCiuc003vfl.3. human. [Q7Z6K1-1]

Organism-specific databases

CTDi168451.
GeneCardsiGC07M108194.
H-InvDBHIX0201115.
HGNCiHGNC:23188. THAP5.
HPAiHPA043170.
HPA051488.
MIMi612534. gene.
neXtProtiNX_Q7Z6K1.
PharmGKBiPA134905837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41114.
GeneTreeiENSGT00780000121923.
HOGENOMiHOG000154564.
HOVERGENiHBG108566.
InParanoidiQ7Z6K1.
OMAiMPRYCAA.
OrthoDBiEOG7VDXPD.
PhylomeDBiQ7Z6K1.
TreeFamiTF335838.

Miscellaneous databases

GenomeRNAii168451.
NextBioi88741.
PROiQ7Z6K1.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z6K1.
ExpressionAtlasiQ7Z6K1. baseline and differential.
GenevestigatoriQ7Z6K1.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death."
    Balakrishnan M.P., Cilenti L., Mashak Z., Popat P., Alnemri E.S., Zervos A.S.
    Am. J. Physiol. 297:H643-H653(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION IN CELL CYCLE, INTERACTION WITH HTRA2, CLEAVAGE BY HTRA2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTHAP5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 4, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.