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Q7Z6K1 (THAP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
THAP domain-containing protein 5
Gene names
Name:THAP5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. Ref.3

Subunit structure

Interacts with HTRA2; under apoptotic conditions. Ref.3

Subcellular location

Nucleus Ref.3.

Tissue specificity

Highly expressed in the heart. Also found in brain and skeletal muscle. Ref.3

Post-translational modification

Cleaved by HTRA2 during apoptosis.

Sequence similarities

Contains 1 THAP-type zinc finger.

Sequence caution

The sequence AAH53634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence EAL24383.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of cell cycle

Inferred from mutant phenotype Ref.3. Source: UniProtKB

   Cellular_componentnucleus

Inferred from direct assay Ref.3. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protease binding

Inferred from physical interaction Ref.3. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z6K1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z6K1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395THAP domain-containing protein 5
PRO_0000333817

Regions

Zinc finger1 – 8484THAP-type
Coiled coil348 – 38235 Potential
Motif321 – 3244HCFC1-binding motif (HBM) By similarity

Natural variations

Alternative sequence1 – 4242Missing in isoform 2.
VSP_033558

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 8AA3BE0E30DDB36A

FASTA39545,416
        10         20         30         40         50         60 
MPRYCAAICC KNRRGRNNKD RKLSFYPFPL HDKERLEKWL KNMKRDSWVP SKYQFLCSDH 

        70         80         90        100        110        120 
FTPDSLDIRW GIRYLKQTAV PTIFSLPEDN QGKDPSKKKS QKKNLEDEKE VCPKAKSEES 

       130        140        150        160        170        180 
FVLNETKKNI VNTDVPHQHP ELLHSSSLVK PPAPKTGSIQ NNMLTLNLVK QHTGKPESTL 

       190        200        210        220        230        240 
ETSVNQDTGR GGFHTCFENL NSTTITLTTS NSESIHQSLE TQEVLEVTTS HLANPNFTSN 

       250        260        270        280        290        300 
SMEIKSAQEN PFLFSTINQT VEELNTNKES VIAIFVPAEN SKPSVNSFIS AQKETTEMED 

       310        320        330        340        350        360 
TDIEDSLYKD VDYGTEVLQI EHSYCRQDIN KEHLWQKVSK LHSKITLLEL KEQQTLGRLK 

       370        380        390 
SLEALIRQLK QENWLSEENV KIIENHFTTY EVTMI 

« Hide

Isoform 2 [UniParc].

Checksum: 5D82A93B5E7E2D5D
Show »

FASTA35340,237

References

« Hide 'large scale' references
[1]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death."
Balakrishnan M.P., Cilenti L., Mashak Z., Popat P., Alnemri E.S., Zervos A.S.
Am. J. Physiol. 297:H643-H653(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION IN CELL CYCLE, INTERACTION WITH HTRA2, CLEAVAGE BY HTRA2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH236947 Genomic DNA. Translation: EAL24383.1. Sequence problems.
BC053634 mRNA. Translation: AAH53634.1. Different initiation.
RefSeqNP_001123947.1. NM_001130475.2.
NP_001274527.1. NM_001287598.1.
NP_001274528.1. NM_001287599.1.
NP_001274530.1. NM_001287601.1.
NP_872335.2. NM_182529.3.
UniGeneHs.707689.

3D structure databases

ProteinModelPortalQ7Z6K1.
SMRQ7Z6K1. Positions 1-86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127964. 4 interactions.
IntActQ7Z6K1. 2 interactions.
MINTMINT-1198970.
STRING9606.ENSP00000400500.

PTM databases

PhosphoSiteQ7Z6K1.

Polymorphism databases

DMDM189029912.

Proteomic databases

PaxDbQ7Z6K1.
PRIDEQ7Z6K1.

Protocols and materials databases

DNASU168451.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313516; ENSP00000322440; ENSG00000177683. [Q7Z6K1-2]
ENST00000415914; ENSP00000400500; ENSG00000177683. [Q7Z6K1-1]
GeneID168451.
KEGGhsa:168451.
UCSCuc003vfl.3. human. [Q7Z6K1-1]

Organism-specific databases

CTD168451.
GeneCardsGC07M108194.
H-InvDBHIX0201115.
HGNCHGNC:23188. THAP5.
HPAHPA043170.
HPA051488.
MIM612534. gene.
neXtProtNX_Q7Z6K1.
PharmGKBPA134905837.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41114.
HOGENOMHOG000154564.
HOVERGENHBG108566.
InParanoidQ7Z6K1.
OMAMPRYCAA.
OrthoDBEOG7VDXPD.
PhylomeDBQ7Z6K1.
TreeFamTF335838.

Gene expression databases

ArrayExpressQ7Z6K1.
BgeeQ7Z6K1.
GenevestigatorQ7Z6K1.

Family and domain databases

InterProIPR026518. THAP5_mammal.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERPTHR23080:SF1. PTHR23080:SF1. 1 hit.
PfamPF05485. THAP. 1 hit.
[Graphical view]
SMARTSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTHAP5. human.
GenomeRNAi168451.
NextBio88741.
PROQ7Z6K1.
SOURCESearch...

Entry information

Entry nameTHAP5_HUMAN
AccessionPrimary (citable) accession number: Q7Z6K1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM