Q7Z6K1 (THAP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
THAP domain-containing protein 5

Gene names

Name:

THAP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. Ref.3
Subunit structure	Interacts with HTRA2; under apoptotic conditions. Ref.3
Subcellular location	Nucleus Ref.3.
Tissue specificity	Highly expressed in the heart. Also found in brain and skeletal muscle. Ref.3
Post-translational modification	Cleaved by HTRA2 during apoptosis.
Sequence similarities	Contains 1 THAP-type zinc finger.
Sequence caution	The sequence AAH53634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAL24383.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell cycle Inferred from mutant phenotype Ref.3. Source: UniProtKB
Cellular_component	nucleus Inferred from direct assay Ref.3. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6K1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6K1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	THAP domain-containing protein 5		PRO_0000333817
Regions
	Zinc finger	1 – 84	84	THAP-type
	Coiled coil	348 – 382	35	Potential
	Motif	321 – 324	4	HCFC1-binding motif (HBM) By similarity
Natural variations
	Alternative sequence	1 – 42	42	Missing in isoform 2.		VSP_033558

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 8AA3BE0E30DDB36A	FASTA	395	45,416
	10 20 30 40 50 60 MPRYCAAICC KNRRGRNNKD RKLSFYPFPL HDKERLEKWL KNMKRDSWVP SKYQFLCSDH 70 80 90 100 110 120 FTPDSLDIRW GIRYLKQTAV PTIFSLPEDN QGKDPSKKKS QKKNLEDEKE VCPKAKSEES 130 140 150 160 170 180 FVLNETKKNI VNTDVPHQHP ELLHSSSLVK PPAPKTGSIQ NNMLTLNLVK QHTGKPESTL 190 200 210 220 230 240 ETSVNQDTGR GGFHTCFENL NSTTITLTTS NSESIHQSLE TQEVLEVTTS HLANPNFTSN 250 260 270 280 290 300 SMEIKSAQEN PFLFSTINQT VEELNTNKES VIAIFVPAEN SKPSVNSFIS AQKETTEMED 310 320 330 340 350 360 TDIEDSLYKD VDYGTEVLQI EHSYCRQDIN KEHLWQKVSK LHSKITLLEL KEQQTLGRLK 370 380 390 SLEALIRQLK QENWLSEENV KIIENHFTTY EVTMI
	Isoform 2 [UniParc]. Checksum: 5D82A93B5E7E2D5D	FASTA	353	40,237
	10 20 30 40 50 60 MKRDSWVPSK YQFLCSDHFT PDSLDIRWGI RYLKQTAVPT IFSLPEDNQG KDPSKKKSQK 70 80 90 100 110 120 KNLEDEKEVC PKAKSEESFV LNETKKNIVN TDVPHQHPEL LHSSSLVKPP APKTGSIQNN 130 140 150 160 170 180 MLTLNLVKQH TGKPESTLET SVNQDTGRGG FHTCFENLNS TTITLTTSNS ESIHQSLETQ 190 200 210 220 230 240 EVLEVTTSHL ANPNFTSNSM EIKSAQENPF LFSTINQTVE ELNTNKESVI AIFVPAENSK 250 260 270 280 290 300 PSVNSFISAQ KETTEMEDTD IEDSLYKDVD YGTEVLQIEH SYCRQDINKE HLWQKVSKLH 310 320 330 340 350 SKITLLELKE QQTLGRLKSL EALIRQLKQE NWLSEENVKI IENHFTTYEV TMI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death." Balakrishnan M.P., Cilenti L., Mashak Z., Popat P., Alnemri E.S., Zervos A.S. Am. J. Physiol. 297:H643-H653(2009) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE FUNCTION IN CELL CYCLE, INTERACTION WITH HTRA2, CLEAVAGE BY HTRA2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH236947 Genomic DNA. Translation: EAL24383.1. Sequence problems. BC053634 mRNA. Translation: AAH53634.1. Different initiation.
IPI	IPI00293093. IPI00893020.
RefSeq	NP_001123947.1. NM_001130475.1. NP_872335.2. NM_182529.2.
UniGene	Hs.707689.
3D structure databases
ProteinModelPortal	Q7Z6K1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z6K1. 1 interaction.
MINT	MINT-1198970.
STRING	9606.ENSP00000400500.
PTM databases
PhosphoSite	Q7Z6K1.
Polymorphism databases
DMDM	189029912.
Proteomic databases
PaxDb	Q7Z6K1.
PRIDE	Q7Z6K1.
Protocols and materials databases
DNASU	168451.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313516; ENSP00000322440; ENSG00000177683. ENST00000415914; ENSP00000400500; ENSG00000177683.
GeneID	168451.
KEGG	hsa:168451.
UCSC	uc003vfl.3. human.
Organism-specific databases
CTD	168451.
GeneCards	GC07M108194.
H-InvDB	HIX0201115.
HGNC	HGNC:23188. THAP5.
HPA	HPA043170.
MIM	612534. gene.
neXtProt	NX_Q7Z6K1.
PharmGKB	PA134905837.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41114.
HOGENOM	HOG000154564.
HOVERGEN	HBG108566.
InParanoid	Q7Z6K1.
OMA	MPRYCAA.
OrthoDB	EOG4STS5M.
Gene expression databases
ArrayExpress	Q7Z6K1.
Bgee	Q7Z6K1.
Genevestigator	Q7Z6K1.
Family and domain databases
InterPro	IPR026518. THAP5_mammal. IPR006612. Znf_C2CH. [Graphical view]
PANTHER	PTHR23080:SF1. PTHR23080:SF1. 1 hit.
Pfam	PF05485. THAP. 1 hit. [Graphical view]
SMART	SM00692. DM3. 1 hit. SM00980. THAP. 1 hit. [Graphical view]
PROSITE	PS50950. ZF_THAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	THAP5. human.
GenomeRNAi	168451.
NextBio	88741.
SOURCE	Search...

Entry information

Entry name

THAP5_HUMAN

Accession

Primary (citable) accession number: Q7Z6K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.