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Q7Z6K1

- THAP5_HUMAN

UniProt

Q7Z6K1 - THAP5_HUMAN

Protein

THAP domain-containing protein 5

Gene

THAP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 8484THAP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protease binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. negative regulation of cell cycle Source: UniProtKB

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    THAP domain-containing protein 5
    Gene namesi
    Name:THAP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:23188. THAP5.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134905837.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395THAP domain-containing protein 5PRO_0000333817Add
    BLAST

    Post-translational modificationi

    Cleaved by HTRA2 during apoptosis.

    Proteomic databases

    PaxDbiQ7Z6K1.
    PRIDEiQ7Z6K1.

    PTM databases

    PhosphoSiteiQ7Z6K1.

    Expressioni

    Tissue specificityi

    Highly expressed in the heart. Also found in brain and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z6K1.
    BgeeiQ7Z6K1.
    GenevestigatoriQ7Z6K1.

    Organism-specific databases

    HPAiHPA043170.
    HPA051488.

    Interactioni

    Subunit structurei

    Interacts with HTRA2; under apoptotic conditions.1 Publication

    Protein-protein interaction databases

    BioGridi127964. 4 interactions.
    IntActiQ7Z6K1. 2 interactions.
    MINTiMINT-1198970.
    STRINGi9606.ENSP00000400500.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z6K1.
    SMRiQ7Z6K1. Positions 1-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili348 – 38235Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi321 – 3244HCFC1-binding motif (HBM)By similarity

    Sequence similaritiesi

    Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 8484THAP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG41114.
    HOGENOMiHOG000154564.
    HOVERGENiHBG108566.
    InParanoidiQ7Z6K1.
    OMAiPLHDKER.
    OrthoDBiEOG7VDXPD.
    PhylomeDBiQ7Z6K1.
    TreeFamiTF335838.

    Family and domain databases

    InterProiIPR006612. Znf_C2CH.
    [Graphical view]
    PfamiPF05485. THAP. 1 hit.
    [Graphical view]
    SMARTiSM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view]
    PROSITEiPS50950. ZF_THAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z6K1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRYCAAICC KNRRGRNNKD RKLSFYPFPL HDKERLEKWL KNMKRDSWVP    50
    SKYQFLCSDH FTPDSLDIRW GIRYLKQTAV PTIFSLPEDN QGKDPSKKKS 100
    QKKNLEDEKE VCPKAKSEES FVLNETKKNI VNTDVPHQHP ELLHSSSLVK 150
    PPAPKTGSIQ NNMLTLNLVK QHTGKPESTL ETSVNQDTGR GGFHTCFENL 200
    NSTTITLTTS NSESIHQSLE TQEVLEVTTS HLANPNFTSN SMEIKSAQEN 250
    PFLFSTINQT VEELNTNKES VIAIFVPAEN SKPSVNSFIS AQKETTEMED 300
    TDIEDSLYKD VDYGTEVLQI EHSYCRQDIN KEHLWQKVSK LHSKITLLEL 350
    KEQQTLGRLK SLEALIRQLK QENWLSEENV KIIENHFTTY EVTMI 395
    Length:395
    Mass (Da):45,416
    Last modified:May 20, 2008 - v2
    Checksum:i8AA3BE0E30DDB36A
    GO
    Isoform 2 (identifier: Q7Z6K1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.

    Show »
    Length:353
    Mass (Da):40,237
    Checksum:i5D82A93B5E7E2D5D
    GO

    Sequence cautioni

    The sequence AAH53634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAL24383.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_033558Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH236947 Genomic DNA. Translation: EAL24383.1. Sequence problems.
    BC053634 mRNA. Translation: AAH53634.1. Different initiation.
    CCDSiCCDS34734.2. [Q7Z6K1-2]
    CCDS47687.1. [Q7Z6K1-1]
    RefSeqiNP_001123947.1. NM_001130475.2. [Q7Z6K1-1]
    NP_001274527.1. NM_001287598.1.
    NP_001274528.1. NM_001287599.1.
    NP_001274530.1. NM_001287601.1.
    NP_872335.2. NM_182529.3. [Q7Z6K1-2]
    UniGeneiHs.707689.

    Genome annotation databases

    EnsembliENST00000313516; ENSP00000322440; ENSG00000177683. [Q7Z6K1-2]
    ENST00000415914; ENSP00000400500; ENSG00000177683. [Q7Z6K1-1]
    GeneIDi168451.
    KEGGihsa:168451.
    UCSCiuc003vfl.3. human. [Q7Z6K1-1]

    Polymorphism databases

    DMDMi189029912.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH236947 Genomic DNA. Translation: EAL24383.1 . Sequence problems.
    BC053634 mRNA. Translation: AAH53634.1 . Different initiation.
    CCDSi CCDS34734.2. [Q7Z6K1-2 ]
    CCDS47687.1. [Q7Z6K1-1 ]
    RefSeqi NP_001123947.1. NM_001130475.2. [Q7Z6K1-1 ]
    NP_001274527.1. NM_001287598.1.
    NP_001274528.1. NM_001287599.1.
    NP_001274530.1. NM_001287601.1.
    NP_872335.2. NM_182529.3. [Q7Z6K1-2 ]
    UniGenei Hs.707689.

    3D structure databases

    ProteinModelPortali Q7Z6K1.
    SMRi Q7Z6K1. Positions 1-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127964. 4 interactions.
    IntActi Q7Z6K1. 2 interactions.
    MINTi MINT-1198970.
    STRINGi 9606.ENSP00000400500.

    PTM databases

    PhosphoSitei Q7Z6K1.

    Polymorphism databases

    DMDMi 189029912.

    Proteomic databases

    PaxDbi Q7Z6K1.
    PRIDEi Q7Z6K1.

    Protocols and materials databases

    DNASUi 168451.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313516 ; ENSP00000322440 ; ENSG00000177683 . [Q7Z6K1-2 ]
    ENST00000415914 ; ENSP00000400500 ; ENSG00000177683 . [Q7Z6K1-1 ]
    GeneIDi 168451.
    KEGGi hsa:168451.
    UCSCi uc003vfl.3. human. [Q7Z6K1-1 ]

    Organism-specific databases

    CTDi 168451.
    GeneCardsi GC07M108194.
    H-InvDB HIX0201115.
    HGNCi HGNC:23188. THAP5.
    HPAi HPA043170.
    HPA051488.
    MIMi 612534. gene.
    neXtProti NX_Q7Z6K1.
    PharmGKBi PA134905837.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41114.
    HOGENOMi HOG000154564.
    HOVERGENi HBG108566.
    InParanoidi Q7Z6K1.
    OMAi PLHDKER.
    OrthoDBi EOG7VDXPD.
    PhylomeDBi Q7Z6K1.
    TreeFami TF335838.

    Miscellaneous databases

    ChiTaRSi THAP5. human.
    GenomeRNAii 168451.
    NextBioi 88741.
    PROi Q7Z6K1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z6K1.
    Bgeei Q7Z6K1.
    Genevestigatori Q7Z6K1.

    Family and domain databases

    InterProi IPR006612. Znf_C2CH.
    [Graphical view ]
    Pfami PF05485. THAP. 1 hit.
    [Graphical view ]
    SMARTi SM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50950. ZF_THAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death."
      Balakrishnan M.P., Cilenti L., Mashak Z., Popat P., Alnemri E.S., Zervos A.S.
      Am. J. Physiol. 297:H643-H653(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION IN CELL CYCLE, INTERACTION WITH HTRA2, CLEAVAGE BY HTRA2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTHAP5_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z6K1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3