Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z6J6

- FRMD5_HUMAN

UniProt

Q7Z6J6 - FRMD5_HUMAN

Protein

FERM domain-containing protein 5

Gene

FRMD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FERM domain-containing protein 5
    Gene namesi
    Name:FRMD5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:28214. FRMD5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. cytoskeleton Source: InterPro
    3. extrinsic component of membrane Source: InterPro
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671751.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570FERM domain-containing protein 5PRO_0000247446Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z6J6.
    PaxDbiQ7Z6J6.
    PRIDEiQ7Z6J6.

    PTM databases

    PhosphoSiteiQ7Z6J6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z6J6.
    BgeeiQ7Z6J6.
    CleanExiHS_FRMD5.
    GenevestigatoriQ7Z6J6.

    Organism-specific databases

    HPAiHPA011746.
    HPA013961.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNND1O607163EBI-727282,EBI-701927

    Protein-protein interaction databases

    BioGridi124407. 1 interaction.
    IntActiQ7Z6J6. 19 interactions.
    MINTiMINT-1396945.
    STRINGi9606.ENSP00000403067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z6J6.
    SMRiQ7Z6J6. Positions 19-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei504 – 52421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 298282FERMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331698.
    HOGENOMiHOG000231815.
    HOVERGENiHBG057180.
    InParanoidiQ7Z6J6.
    OMAiHGGPEEE.
    OrthoDBiEOG7M98FW.
    PhylomeDBiQ7Z6J6.
    TreeFamiTF343477.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR000798. Ez/rad/moesin_like.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    [Graphical view]
    PRINTSiPR00935. BAND41.
    PR00661. ERMFAMILY.
    SMARTiSM00295. B41. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS50057. FERM_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z6J6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL    50
    NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD 100
    PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDS 150
    GKHPEGYSSK FQFFPKHSEK LERKIAEIHK TELSGQTPAT SELNFLRKAQ 200
    TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK 250
    FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS 300
    QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR 350
    SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT 400
    FLPHVRSSRT DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN 450
    GATCSIEEEK ESEASTPTAT EVEALGGELR ALCQGHSGPE EEQVNKFVLS 500
    VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE FEQFHYQYFC 550
    PLRRWFACKI RSVVSLLIDT 570
    Length:570
    Mass (Da):65,065
    Last modified:October 1, 2003 - v1
    Checksum:i8235A774CA2A6DE3
    GO
    Isoform 2 (identifier: Q7Z6J6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-95: Missing.

    Show »
    Length:555
    Mass (Da):63,244
    Checksum:i7D2FB053701EC0D5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 9515Missing in isoform 2. 1 PublicationVSP_019982Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090572 mRNA. Translation: BAC03480.1.
    BC053647 mRNA. Translation: AAH53647.1.
    CCDSiCCDS10107.2. [Q7Z6J6-1]
    RefSeqiNP_116281.2. NM_032892.4.
    UniGeneiHs.578544.

    Genome annotation databases

    EnsembliENST00000417257; ENSP00000403067; ENSG00000171877. [Q7Z6J6-1]
    GeneIDi84978.
    KEGGihsa:84978.
    UCSCiuc001ztl.3. human. [Q7Z6J6-1]

    Polymorphism databases

    DMDMi74738821.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090572 mRNA. Translation: BAC03480.1 .
    BC053647 mRNA. Translation: AAH53647.1 .
    CCDSi CCDS10107.2. [Q7Z6J6-1 ]
    RefSeqi NP_116281.2. NM_032892.4.
    UniGenei Hs.578544.

    3D structure databases

    ProteinModelPortali Q7Z6J6.
    SMRi Q7Z6J6. Positions 19-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124407. 1 interaction.
    IntActi Q7Z6J6. 19 interactions.
    MINTi MINT-1396945.
    STRINGi 9606.ENSP00000403067.

    PTM databases

    PhosphoSitei Q7Z6J6.

    Polymorphism databases

    DMDMi 74738821.

    Proteomic databases

    MaxQBi Q7Z6J6.
    PaxDbi Q7Z6J6.
    PRIDEi Q7Z6J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000417257 ; ENSP00000403067 ; ENSG00000171877 . [Q7Z6J6-1 ]
    GeneIDi 84978.
    KEGGi hsa:84978.
    UCSCi uc001ztl.3. human. [Q7Z6J6-1 ]

    Organism-specific databases

    CTDi 84978.
    GeneCardsi GC15M044162.
    HGNCi HGNC:28214. FRMD5.
    HPAi HPA011746.
    HPA013961.
    neXtProti NX_Q7Z6J6.
    PharmGKBi PA142671751.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331698.
    HOGENOMi HOG000231815.
    HOVERGENi HBG057180.
    InParanoidi Q7Z6J6.
    OMAi HGGPEEE.
    OrthoDBi EOG7M98FW.
    PhylomeDBi Q7Z6J6.
    TreeFami TF343477.

    Miscellaneous databases

    ChiTaRSi FRMD5. human.
    GenomeRNAii 84978.
    NextBioi 75538.
    PROi Q7Z6J6.

    Gene expression databases

    ArrayExpressi Q7Z6J6.
    Bgeei Q7Z6J6.
    CleanExi HS_FRMD5.
    Genevestigatori Q7Z6J6.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR000798. Ez/rad/moesin_like.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00935. BAND41.
    PR00661. ERMFAMILY.
    SMARTi SM00295. B41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS50057. FERM_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Astrocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFRMD5_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z6J6
    Secondary accession number(s): Q8NBG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3