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Q7Z6J6

- FRMD5_HUMAN

UniProt

Q7Z6J6 - FRMD5_HUMAN

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Protein
FERM domain-containing protein 5
Gene
FRMD5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 5
Gene namesi
Name:FRMD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:28214. FRMD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei504 – 52421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. cytoskeleton Source: InterPro
  3. extrinsic component of membrane Source: InterPro
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671751.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570FERM domain-containing protein 5
PRO_0000247446Add
BLAST

Proteomic databases

MaxQBiQ7Z6J6.
PaxDbiQ7Z6J6.
PRIDEiQ7Z6J6.

PTM databases

PhosphoSiteiQ7Z6J6.

Expressioni

Gene expression databases

ArrayExpressiQ7Z6J6.
BgeeiQ7Z6J6.
CleanExiHS_FRMD5.
GenevestigatoriQ7Z6J6.

Organism-specific databases

HPAiHPA011746.
HPA013961.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNND1O607163EBI-727282,EBI-701927

Protein-protein interaction databases

BioGridi124407. 1 interaction.
IntActiQ7Z6J6. 19 interactions.
MINTiMINT-1396945.
STRINGi9606.ENSP00000403067.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6J6.
SMRiQ7Z6J6. Positions 19-296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 298282FERM
Add
BLAST

Sequence similaritiesi

Contains 1 FERM domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331698.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ7Z6J6.
OMAiHGGPEEE.
OrthoDBiEOG7M98FW.
PhylomeDBiQ7Z6J6.
TreeFamiTF343477.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR000798. Ez/rad/moesin_like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z6J6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL    50
NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD 100
PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDS 150
GKHPEGYSSK FQFFPKHSEK LERKIAEIHK TELSGQTPAT SELNFLRKAQ 200
TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK 250
FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS 300
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR 350
SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT 400
FLPHVRSSRT DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN 450
GATCSIEEEK ESEASTPTAT EVEALGGELR ALCQGHSGPE EEQVNKFVLS 500
VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE FEQFHYQYFC 550
PLRRWFACKI RSVVSLLIDT 570
Length:570
Mass (Da):65,065
Last modified:October 1, 2003 - v1
Checksum:i8235A774CA2A6DE3
GO
Isoform 2 (identifier: Q7Z6J6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Show »
Length:555
Mass (Da):63,244
Checksum:i7D2FB053701EC0D5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 9515Missing in isoform 2.
VSP_019982Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090572 mRNA. Translation: BAC03480.1.
BC053647 mRNA. Translation: AAH53647.1.
CCDSiCCDS10107.2. [Q7Z6J6-1]
RefSeqiNP_116281.2. NM_032892.4.
UniGeneiHs.578544.

Genome annotation databases

EnsembliENST00000417257; ENSP00000403067; ENSG00000171877. [Q7Z6J6-1]
GeneIDi84978.
KEGGihsa:84978.
UCSCiuc001ztl.3. human. [Q7Z6J6-1]

Polymorphism databases

DMDMi74738821.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090572 mRNA. Translation: BAC03480.1 .
BC053647 mRNA. Translation: AAH53647.1 .
CCDSi CCDS10107.2. [Q7Z6J6-1 ]
RefSeqi NP_116281.2. NM_032892.4.
UniGenei Hs.578544.

3D structure databases

ProteinModelPortali Q7Z6J6.
SMRi Q7Z6J6. Positions 19-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124407. 1 interaction.
IntActi Q7Z6J6. 19 interactions.
MINTi MINT-1396945.
STRINGi 9606.ENSP00000403067.

PTM databases

PhosphoSitei Q7Z6J6.

Polymorphism databases

DMDMi 74738821.

Proteomic databases

MaxQBi Q7Z6J6.
PaxDbi Q7Z6J6.
PRIDEi Q7Z6J6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000417257 ; ENSP00000403067 ; ENSG00000171877 . [Q7Z6J6-1 ]
GeneIDi 84978.
KEGGi hsa:84978.
UCSCi uc001ztl.3. human. [Q7Z6J6-1 ]

Organism-specific databases

CTDi 84978.
GeneCardsi GC15M044162.
HGNCi HGNC:28214. FRMD5.
HPAi HPA011746.
HPA013961.
neXtProti NX_Q7Z6J6.
PharmGKBi PA142671751.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331698.
HOGENOMi HOG000231815.
HOVERGENi HBG057180.
InParanoidi Q7Z6J6.
OMAi HGGPEEE.
OrthoDBi EOG7M98FW.
PhylomeDBi Q7Z6J6.
TreeFami TF343477.

Miscellaneous databases

ChiTaRSi FRMD5. human.
GenomeRNAii 84978.
NextBioi 75538.
PROi Q7Z6J6.

Gene expression databases

ArrayExpressi Q7Z6J6.
Bgeei Q7Z6J6.
CleanExi HS_FRMD5.
Genevestigatori Q7Z6J6.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR000798. Ez/rad/moesin_like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view ]
PRINTSi PR00935. BAND41.
PR00661. ERMFAMILY.
SMARTi SM00295. B41. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Astrocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFRMD5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J6
Secondary accession number(s): Q8NBG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi