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Protein

FERM domain-containing protein 5

Gene

FRMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

  • actomyosin structure organization Source: GO_Central
  • negative regulation of cell motility Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • regulation of cell migration Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 5
Gene namesi
Name:FRMD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28214. FRMD5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • adherens junction Source: UniProtKB
  • cytoskeleton Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84978.
OpenTargetsiENSG00000171877.
PharmGKBiPA142671751.

Polymorphism and mutation databases

DMDMi74738821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474461 – 570FERM domain-containing protein 5Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei375PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z6J6.
PaxDbiQ7Z6J6.
PeptideAtlasiQ7Z6J6.
PRIDEiQ7Z6J6.

PTM databases

iPTMnetiQ7Z6J6.
PhosphoSitePlusiQ7Z6J6.

Expressioni

Gene expression databases

BgeeiENSG00000171877.
CleanExiHS_FRMD5.
ExpressionAtlasiQ7Z6J6. baseline and differential.
GenevisibleiQ7Z6J6. HS.

Organism-specific databases

HPAiHPA011746.
HPA013961.

Interactioni

Subunit structurei

Interacts with CTNND1 (PubMed:22846708). Interacts with ITGB5 (via cytoplasmic domain) and ROCK1 (PubMed:25448675).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124407. 20 interactors.
IntActiQ7Z6J6. 21 interactors.
MINTiMINT-1396945.
STRINGi9606.ENSP00000403067.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6J6.
SMRiQ7Z6J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 298FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 353Interaction with ROCK11 PublicationAdd BLAST46

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3530. Eukaryota.
ENOG410XSWH. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ7Z6J6.
OMAiCQGHGRP.
OrthoDBiEOG091G06EA.
PhylomeDBiQ7Z6J6.
TreeFamiTF343477.

Family and domain databases

CDDicd14473. FERM_B-lobe. 1 hit.
Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
PfamiView protein in Pfam
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiView protein in SMART
SM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL
60 70 80 90 100
NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD
110 120 130 140 150
PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDS
160 170 180 190 200
GKHPEGYSSK FQFFPKHSEK LERKIAEIHK TELSGQTPAT SELNFLRKAQ
210 220 230 240 250
TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK
260 270 280 290 300
FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
310 320 330 340 350
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR
360 370 380 390 400
SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT
410 420 430 440 450
FLPHVRSSRT DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN
460 470 480 490 500
GATCSIEEEK ESEASTPTAT EVEALGGELR ALCQGHSGPE EEQVNKFVLS
510 520 530 540 550
VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE FEQFHYQYFC
560 570
PLRRWFACKI RSVVSLLIDT
Length:570
Mass (Da):65,065
Last modified:October 1, 2003 - v1
Checksum:i8235A774CA2A6DE3
GO
Isoform 2 (identifier: Q7Z6J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Show »
Length:555
Mass (Da):63,244
Checksum:i7D2FB053701EC0D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01998281 – 95Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090572 mRNA. Translation: BAC03480.1.
BC053647 mRNA. Translation: AAH53647.1.
CCDSiCCDS10107.2. [Q7Z6J6-1]
RefSeqiNP_116281.2. NM_032892.4.
UniGeneiHs.578544.

Genome annotation databases

EnsembliENST00000417257; ENSP00000403067; ENSG00000171877. [Q7Z6J6-1]
GeneIDi84978.
KEGGihsa:84978.
UCSCiuc001ztl.5. human. [Q7Z6J6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFRMD5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J6
Secondary accession number(s): Q8NBG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot