Q7Z6J6 (FRMD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FERM domain-containing protein 5

Gene names

Name:

FRMD5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 FERM domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro cytoskeleton Inferred from electronic annotation. Source: InterPro extrinsic to membrane Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z6J6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z6J6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	FERM domain-containing protein 5		PRO_0000247446
Regions
	Transmembrane	504 – 524	21	Helical; Potential
	Domain	17 – 298	282	FERM
Natural variations
	Alternative sequence	81 – 95	15	Missing in isoform 2.		VSP_019982

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8235A774CA2A6DE3	FASTA	570	65,065
	10 20 30 40 50 60 MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL NLLEKDYFGI 70 80 90 100 110 120 RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD PAALKEEITR YLVFLQIKRD 130 140 150 160 170 180 LYHGRLLCKT SDAALLAAYI LQAEIGDYDS GKHPEGYSSK FQFFPKHSEK LERKIAEIHK 190 200 210 220 230 240 TELSGQTPAT SELNFLRKAQ TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF 250 260 270 280 290 300 IKWNEVTKLK FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS 310 320 330 340 350 360 QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR SCPSITHGPR 370 380 390 400 410 420 LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT FLPHVRSSRT DSNERVAVIA 430 440 450 460 470 480 DEAYSPADSV LPTPVAEHSL ELMLLSRQIN GATCSIEEEK ESEASTPTAT EVEALGGELR 490 500 510 520 530 540 ALCQGHSGPE EEQVNKFVLS VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE 550 560 570 FEQFHYQYFC PLRRWFACKI RSVVSLLIDT
	Isoform 2 [UniParc]. Checksum: 7D2FB053701EC0D5	FASTA	555	63,244
	10 20 30 40 50 60 MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL NLLEKDYFGI 70 80 90 100 110 120 RFVDPDKQRH WLEFTKSVVK FYPADPAALK EEITRYLVFL QIKRDLYHGR LLCKTSDAAL 130 140 150 160 170 180 LAAYILQAEI GDYDSGKHPE GYSSKFQFFP KHSEKLERKI AEIHKTELSG QTPATSELNF 190 200 210 220 230 240 LRKAQTLETY GVDPHPCKDV SGNAAFLAFT PFGFVVLQGN KRVHFIKWNE VTKLKFEGKT 250 260 270 280 290 300 FYLYVSQKEE KKIILTYFAP TPEACKHLWK CGIENQAFYK LEKSSQVRTV SSSNLFFKGS 310 320 330 340 350 360 RFRYSGRVAK EVMESSAKIK REPPEIHRAG MVPSRSCPSI THGPRLSSVP RTRRRAVHIS 370 380 390 400 410 420 IMEGLESLRD SAHSTPVRST SHGDTFLPHV RSSRTDSNER VAVIADEAYS PADSVLPTPV 430 440 450 460 470 480 AEHSLELMLL SRQINGATCS IEEEKESEAS TPTATEVEAL GGELRALCQG HSGPEEEQVN 490 500 510 520 530 540 KFVLSVLRLL LVTMGLLFVL LLLLIILTES DLDIAFFRDI RQTPEFEQFH YQYFCPLRRW 550 FACKIRSVVS LLIDT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Astrocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK090572 mRNA. Translation: BAC03480.1. BC053647 mRNA. Translation: AAH53647.1.
IPI	IPI00252153. IPI00414040.
RefSeq	NP_116281.2. NM_032892.3.
UniGene	Hs.578544.
3D structure databases
ProteinModelPortal	Q7Z6J6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z6J6. 1 interaction.
MINT	MINT-1396945.
STRING	9606.ENSP00000403067.
PTM databases
PhosphoSite	Q7Z6J6.
Polymorphism databases
DMDM	74738821.
Proteomic databases
PaxDb	Q7Z6J6.
PRIDE	Q7Z6J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000417257; ENSP00000403067; ENSG00000171877.
GeneID	84978.
KEGG	hsa:84978.
UCSC	uc001ztl.3. human.
Organism-specific databases
CTD	84978.
GeneCards	GC15M044162.
HGNC	HGNC:28214. FRMD5.
HPA	HPA011746. HPA013961.
neXtProt	NX_Q7Z6J6.
PharmGKB	PA142671751.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG331698.
HOGENOM	HOG000231815.
HOVERGEN	HBG057180.
InParanoid	Q7Z6J6.
OMA	HGRPEEE.
OrthoDB	EOG42V8FZ.
PhylomeDB	Q7Z6J6.
Gene expression databases
ArrayExpress	Q7Z6J6.
Bgee	Q7Z6J6.
CleanEx	HS_FRMD5.
Genevestigator	Q7Z6J6.
GermOnline	ENSG00000171877. Homo sapiens.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR000798. Ez/rad/moesin_like. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_like_dom. [Graphical view]
Pfam	PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. [Graphical view]
PRINTS	PR00935. BAND41. PR00661. ERMFAMILY.
SMART	SM00295. B41. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. False negative. PS50057. FERM_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FRMD5. human.
GenomeRNAi	84978.
NextBio	75538.

Entry information

Entry name

FRMD5_HUMAN

Accession

Primary (citable) accession number: Q7Z6J6
Secondary accession number(s): Q8NBG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.