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Protein

FERM domain-containing protein 5

Gene

FRMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 5
Gene namesi
Name:FRMD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28214. FRMD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei504 – 52421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671751.

Polymorphism and mutation databases

DMDMi74738821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570FERM domain-containing protein 5PRO_0000247446Add
BLAST

Proteomic databases

MaxQBiQ7Z6J6.
PaxDbiQ7Z6J6.
PRIDEiQ7Z6J6.

PTM databases

PhosphoSiteiQ7Z6J6.

Expressioni

Gene expression databases

BgeeiQ7Z6J6.
CleanExiHS_FRMD5.
ExpressionAtlasiQ7Z6J6. baseline and differential.
GenevisibleiQ7Z6J6. HS.

Organism-specific databases

HPAiHPA011746.
HPA013961.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNND1O607163EBI-727282,EBI-701927

Protein-protein interaction databases

BioGridi124407. 4 interactions.
IntActiQ7Z6J6. 19 interactions.
MINTiMINT-1396945.
STRINGi9606.ENSP00000403067.

Structurei

3D structure databases

ProteinModelPortaliQ7Z6J6.
SMRiQ7Z6J6. Positions 19-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 298282FERMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331698.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ7Z6J6.
OMAiHISIMEX.
OrthoDBiEOG7M98FW.
PhylomeDBiQ7Z6J6.
TreeFamiTF343477.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin_like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL
60 70 80 90 100
NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD
110 120 130 140 150
PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDS
160 170 180 190 200
GKHPEGYSSK FQFFPKHSEK LERKIAEIHK TELSGQTPAT SELNFLRKAQ
210 220 230 240 250
TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK
260 270 280 290 300
FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
310 320 330 340 350
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR
360 370 380 390 400
SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT
410 420 430 440 450
FLPHVRSSRT DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN
460 470 480 490 500
GATCSIEEEK ESEASTPTAT EVEALGGELR ALCQGHSGPE EEQVNKFVLS
510 520 530 540 550
VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE FEQFHYQYFC
560 570
PLRRWFACKI RSVVSLLIDT
Length:570
Mass (Da):65,065
Last modified:October 1, 2003 - v1
Checksum:i8235A774CA2A6DE3
GO
Isoform 2 (identifier: Q7Z6J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Show »
Length:555
Mass (Da):63,244
Checksum:i7D2FB053701EC0D5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 9515Missing in isoform 2. 1 PublicationVSP_019982Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090572 mRNA. Translation: BAC03480.1.
BC053647 mRNA. Translation: AAH53647.1.
CCDSiCCDS10107.2. [Q7Z6J6-1]
RefSeqiNP_116281.2. NM_032892.4.
UniGeneiHs.578544.

Genome annotation databases

EnsembliENST00000417257; ENSP00000403067; ENSG00000171877. [Q7Z6J6-1]
GeneIDi84978.
KEGGihsa:84978.
UCSCiuc001ztl.3. human. [Q7Z6J6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090572 mRNA. Translation: BAC03480.1.
BC053647 mRNA. Translation: AAH53647.1.
CCDSiCCDS10107.2. [Q7Z6J6-1]
RefSeqiNP_116281.2. NM_032892.4.
UniGeneiHs.578544.

3D structure databases

ProteinModelPortaliQ7Z6J6.
SMRiQ7Z6J6. Positions 19-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124407. 4 interactions.
IntActiQ7Z6J6. 19 interactions.
MINTiMINT-1396945.
STRINGi9606.ENSP00000403067.

PTM databases

PhosphoSiteiQ7Z6J6.

Polymorphism and mutation databases

DMDMi74738821.

Proteomic databases

MaxQBiQ7Z6J6.
PaxDbiQ7Z6J6.
PRIDEiQ7Z6J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417257; ENSP00000403067; ENSG00000171877. [Q7Z6J6-1]
GeneIDi84978.
KEGGihsa:84978.
UCSCiuc001ztl.3. human. [Q7Z6J6-1]

Organism-specific databases

CTDi84978.
GeneCardsiGC15M044162.
HGNCiHGNC:28214. FRMD5.
HPAiHPA011746.
HPA013961.
neXtProtiNX_Q7Z6J6.
PharmGKBiPA142671751.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG331698.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231815.
HOVERGENiHBG057180.
InParanoidiQ7Z6J6.
OMAiHISIMEX.
OrthoDBiEOG7M98FW.
PhylomeDBiQ7Z6J6.
TreeFamiTF343477.

Miscellaneous databases

ChiTaRSiFRMD5. human.
GenomeRNAii84978.
NextBioi75538.
PROiQ7Z6J6.

Gene expression databases

BgeeiQ7Z6J6.
CleanExiHS_FRMD5.
ExpressionAtlasiQ7Z6J6. baseline and differential.
GenevisibleiQ7Z6J6. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin_like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Astrocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFRMD5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J6
Secondary accession number(s): Q8NBG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.