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Protein

General receptor for phosphoinositides 1-associated scaffold protein

Gene

GRASP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ7Z6J2.

Names & Taxonomyi

Protein namesi
Recommended name:
General receptor for phosphoinositides 1-associated scaffold protein
Short name:
GRP1-associated scaffold protein
Gene namesi
Name:GRASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18707. GRASP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38651.

Polymorphism and mutation databases

DMDMi74738818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395General receptor for phosphoinositides 1-associated scaffold proteinPRO_0000087584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphothreonineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei237 – 2371PhosphotyrosineCombined sources
Modified residuei387 – 3871PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z6J2.
PaxDbiQ7Z6J2.
PeptideAtlasiQ7Z6J2.
PRIDEiQ7Z6J2.

PTM databases

iPTMnetiQ7Z6J2.
PhosphoSiteiQ7Z6J2.

Expressioni

Gene expression databases

BgeeiENSG00000161835.
CleanExiHS_GRASP.
ExpressionAtlasiQ7Z6J2. baseline and differential.
GenevisibleiQ7Z6J2. HS.

Organism-specific databases

HPAiHPA040664.

Interactioni

Subunit structurei

Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ7Z6J2. 1 interaction.
STRINGi9606.ENSP00000293662.

Structurei

Secondary structure

1
395
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi98 – 1058Combined sources
Beta strandi114 – 1218Combined sources
Beta strandi130 – 1389Combined sources
Helixi143 – 1464Combined sources
Beta strandi154 – 1585Combined sources
Helixi168 – 17710Combined sources
Turni178 – 1803Combined sources
Beta strandi181 – 1888Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PNTX-ray2.15A/B97-188[»]
ProteinModelPortaliQ7Z6J2.
SMRiQ7Z6J2. Positions 98-192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z6J2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 19090PDZPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 25878Interaction with PSCD3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi295 – 32430Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG410ZJVP. LUCA.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ7Z6J2.
OMAiSVEMCTF.
OrthoDBiEOG091G0NRM.
PhylomeDBiQ7Z6J2.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLRRLRKLQ QKEEAAATPD PAARTPDSEV APAAPVPTPG PPAAAATPGP
60 70 80 90 100
PADELYAALE DYHPAELYRA LAVSGGTLPR RKGSGFRWKN LSQSPEQQRK
110 120 130 140 150
VLTLEKEDNQ TFGFEIQTYG LHHREEQRVE MVTFVCRVHE SSPAQLAGLT
160 170 180 190 200
PGDTIASVNG LNVEGIRHRE IVDIIKASGN VLRLETLYGT SIRKAELEAR
210 220 230 240 250
LQYLKQTLYE KWGEYRSLMV QEQRLVHGLV VKDPSIYDTL ESVRSCLYGA
260 270 280 290 300
GLLPGSLPFG PLLAVPGRPR GGARRARGDA DDAVYHTCFF GDSEPPALPP
310 320 330 340 350
PPPPARAFGP GPAETPAVGP GPGPRAALSR SASVRCAGPG GGGGGGAPGA
360 370 380 390
LWTEAREQAL CGPGLRKTKY RSFRRRLLKF IPGLNRSLEE EESQL
Length:395
Mass (Da):42,623
Last modified:October 1, 2003 - v1
Checksum:iB042CA2298753CB9
GO
Isoform 2 (identifier: Q7Z6J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.
     144-151: AQLAGLTP → MTLLPSKG

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):26,904
Checksum:i8A71C34EA285BE1E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 143143Missing in isoform 2. 1 PublicationVSP_015707Add
BLAST
Alternative sequencei144 – 1518AQLAGLTP → MTLLPSKG in isoform 2. 1 PublicationVSP_015708

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035500 mRNA. Translation: AAH35500.1.
BC052967 mRNA. Translation: AAH52967.1.
BC053666 mRNA. Translation: AAH53666.1.
CCDSiCCDS61124.1. [Q7Z6J2-2]
CCDS8817.1. [Q7Z6J2-1]
RefSeqiNP_001258785.1. NM_001271856.1. [Q7Z6J2-2]
NP_859062.1. NM_181711.3. [Q7Z6J2-1]
UniGeneiHs.407202.

Genome annotation databases

EnsembliENST00000293662; ENSP00000293662; ENSG00000161835. [Q7Z6J2-1]
ENST00000552049; ENSP00000449492; ENSG00000161835. [Q7Z6J2-2]
GeneIDi160622.
KEGGihsa:160622.
UCSCiuc001rzo.3. human. [Q7Z6J2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035500 mRNA. Translation: AAH35500.1.
BC052967 mRNA. Translation: AAH52967.1.
BC053666 mRNA. Translation: AAH53666.1.
CCDSiCCDS61124.1. [Q7Z6J2-2]
CCDS8817.1. [Q7Z6J2-1]
RefSeqiNP_001258785.1. NM_001271856.1. [Q7Z6J2-2]
NP_859062.1. NM_181711.3. [Q7Z6J2-1]
UniGeneiHs.407202.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PNTX-ray2.15A/B97-188[»]
ProteinModelPortaliQ7Z6J2.
SMRiQ7Z6J2. Positions 98-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z6J2. 1 interaction.
STRINGi9606.ENSP00000293662.

PTM databases

iPTMnetiQ7Z6J2.
PhosphoSiteiQ7Z6J2.

Polymorphism and mutation databases

DMDMi74738818.

Proteomic databases

EPDiQ7Z6J2.
PaxDbiQ7Z6J2.
PeptideAtlasiQ7Z6J2.
PRIDEiQ7Z6J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293662; ENSP00000293662; ENSG00000161835. [Q7Z6J2-1]
ENST00000552049; ENSP00000449492; ENSG00000161835. [Q7Z6J2-2]
GeneIDi160622.
KEGGihsa:160622.
UCSCiuc001rzo.3. human. [Q7Z6J2-1]

Organism-specific databases

CTDi160622.
GeneCardsiGRASP.
H-InvDBHIX0026388.
HIX0037038.
HGNCiHGNC:18707. GRASP.
HPAiHPA040664.
MIMi612027. gene.
neXtProtiNX_Q7Z6J2.
PharmGKBiPA38651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG410ZJVP. LUCA.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ7Z6J2.
OMAiSVEMCTF.
OrthoDBiEOG091G0NRM.
PhylomeDBiQ7Z6J2.
TreeFamiTF316315.

Enzyme and pathway databases

SignaLinkiQ7Z6J2.

Miscellaneous databases

ChiTaRSiGRASP. human.
EvolutionaryTraceiQ7Z6J2.
GenomeRNAii160622.
PROiQ7Z6J2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161835.
CleanExiHS_GRASP.
ExpressionAtlasiQ7Z6J2. baseline and differential.
GenevisibleiQ7Z6J2. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRASP_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J2
Secondary accession number(s): Q6PIF8, Q7Z741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.