##gff-version 3
Q7Z6J0	UniProtKB	Chain	1	888	.	.	.	ID=PRO_0000334151;Note=E3 ubiquitin-protein ligase SH3RF1	
Q7Z6J0	UniProtKB	Domain	134	193	.	.	.	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192	
Q7Z6J0	UniProtKB	Domain	196	259	.	.	.	Note=SH3 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192	
Q7Z6J0	UniProtKB	Domain	445	506	.	.	.	Note=SH3 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192	
Q7Z6J0	UniProtKB	Domain	829	888	.	.	.	Note=SH3 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192	
Q7Z6J0	UniProtKB	Zinc finger	12	53	.	.	.	Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175	
Q7Z6J0	UniProtKB	Region	108	128	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Region	275	321	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Region	292	362	.	.	.	Note=Interaction with RAC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164	
Q7Z6J0	UniProtKB	Region	440	543	.	.	.	Note=Interaction with AKT2;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q7Z6J0	UniProtKB	Region	516	548	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Region	620	639	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Region	684	741	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Compositional bias	108	126	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Compositional bias	304	321	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Compositional bias	516	541	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Compositional bias	690	706	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q7Z6J0	UniProtKB	Modified residue	304	304	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:17535800,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17535800,PMID:20068231,PMID:23186163	
Q7Z6J0	UniProtKB	Modified residue	532	532	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163	
Q7Z6J0	UniProtKB	Modified residue	735	735	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q69ZI1	
Q7Z6J0	UniProtKB	Alternative sequence	394	441	.	.	.	ID=VSP_033622;Note=In isoform 2. TLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHL->APPPLLLLLEWDRGPWQDPLTRLHIYGRRLAPVCMLLYIHTLLGKRIN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
Q7Z6J0	UniProtKB	Alternative sequence	442	888	.	.	.	ID=VSP_033623;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
Q7Z6J0	UniProtKB	Natural variant	663	663	.	.	.	ID=VAR_043342;Note=P->S;Dbxref=dbSNP:rs3811813	
Q7Z6J0	UniProtKB	Mutagenesis	14	14	.	.	.	Note=Loss of Ubl activity. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17420289;Dbxref=PMID:17420289	
Q7Z6J0	UniProtKB	Mutagenesis	28	28	.	.	.	Note=Significant reduction in autoubiquitination%3B when associated with A-30. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164	
Q7Z6J0	UniProtKB	Mutagenesis	30	30	.	.	.	Note=Significant reduction in autoubiquitination%3B when associated with A-28. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20696164;Dbxref=PMID:20696164	
Q7Z6J0	UniProtKB	Mutagenesis	304	304	.	.	.	Note=Decreased level of phosphorylation and no change in the ability to induce apoptosis. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17535800;Dbxref=PMID:17535800	
Q7Z6J0	UniProtKB	Mutagenesis	304	304	.	.	.	Note=Decreased level of phosphorylation and Rac-binding ability and important loss of the ability to induce apoptosis. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17535800;Dbxref=PMID:17535800	
Q7Z6J0	UniProtKB	Mutagenesis	304	304	.	.	.	Note=Decreased Rac-binding ability. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17535800;Dbxref=PMID:17535800